AcuTrials

Effect and Potential Mechanism of Electroacupuncture Add-On Treatment in Patients with Parkinson’s Disease

Wang, F. See all items with this value

Sun, L. See all items with this value

Zhang, X.-zhe See all items with this value

Jia, J. See all items with this value

Liu, Z. See all items with this value

Huang, X.-yan See all items with this value

Yu, S.-yang See all items with this value

Zuo, L.-jun See all items with this value

Cao, C.-jie See all items with this value

Wang, X.-min See all items with this value

Zhang, W. See all items with this value

Evidence-based Complementary & Alternative Medicine (eCAM) See all items with this value

2015

2015

RCT

PARKINSON'S disease -- Drug therapy See all items with this value

PARKINSON'S disease -- Treatment See all items with this value

Dopa See all items with this value

ACUPUNCTURE points See all items with this value

BIOCHEMICAL markers See all items with this value

CHI-squared test See all items with this value

COMBINED modality therapy See all items with this value

Electroacupuncture See all items with this value

HAMILTON Depression Inventory See all items with this value

Neurotransmitters See all items with this value

NITRIC oxide See all items with this value

ORAL medication See all items with this value

PARKINSON'S disease See all items with this value

PLACEBOS (Medicine) See all items with this value

PSYCHOLOGICAL tests See all items with this value

QUALITY of life See all items with this value

RESEARCH -- Finance See all items with this value

SAMPLING (Statistics) See all items with this value

Statistics See all items with this value

T-test (Statistics) See all items with this value

SAMPLE size (Statistics) See all items with this value

PILOT projects See all items with this value

DATA analysis See all items with this value

STATISTICAL significance See all items with this value

RANDOMIZED controlled trials See all items with this value

TREATMENT effectiveness See all items with this value

DATA analysis -- Software See all items with this value

KRUSKAL-Wallis Test See all items with this value

Symptoms See all items with this value

China See all items with this value

Objectives. To explore effectiveness and mechanisms of electroacupuncture (EA) add-on treatment in Parkinson’s disease (PD) patients. Methods. Fifty PD patients were randomly assigned to drug plus EA (D + EA) group and drug alone (D) group. Subjects in D + EA group received stimulation in points of bilateral fengfu, fengchi, hegu, and central dazhui. Participants were evaluated by scales for motor and nonmotor symptoms. Levels of neuroinflammatory factors and neurotransmitters in serum were detected. Results. EA add-on treatment remarkably reduced scores of Unified Parkinson’s Disease Rating Scale (UPDRS) III and its subitems of tremor, rigidity, and bradykinesia and conspicuously decreased UPDRS III scores in patients with bradykinesia-rigidity and mixed types and mild severity. Depression and sleep disturbances were eased, which were reflected by decreased scores of Hamilton Depression Rating Scale, Pittsburgh Sleep Quality Index, and elevated noradrenaline level. Effects of EA add-on treatment on motor symptoms and sleep disturbances were superior to drug alone treatment, markedly improving life quality of PD patients. EA add-on treatment decreased nitric oxide level in serum. Conclusions. EA add-on treatment is effective on most motor symptoms and some nonmotor symptoms and is particularly efficacious in PD patients at early stage. Antineuroinflammation may be a mechanism of EA add-on treatment.

Accession Number: 109084118; Source Information: 8/13/2015, Vol. 2015, p1; Subject Term: PARKINSON'S disease -- Drug therapy; Subject Term: PARKINSON'S disease -- Treatment; Subject Term: DOPA; Subject Term: ACUPUNCTURE points; Subject Term: BIOCHEMICAL markers; Subject Term: CHI-squared test; Subject Term: COMBINED modality therapy; Subject Term: ELECTROACUPUNCTURE; Subject Term: HAMILTON Depression Inventory; Subject Term: NEUROTRANSMITTERS; Subject Term: NITRIC oxide; Subject Term: ORAL medication; Subject Term: PARKINSON'S disease; Subject Term: PLACEBOS (Medicine); Subject Term: PSYCHOLOGICAL tests; Subject Term: QUALITY of life; Subject Term: RESEARCH -- Finance; Subject Term: SAMPLING (Statistics); Subject Term: STATISTICS; Subject Term: T-test (Statistics); Subject Term: SAMPLE size (Statistics); Subject Term: PILOT projects; Subject Term: DATA analysis; Subject Term: STATISTICAL significance; Subject Term: RANDOMIZED controlled trials; Subject Term: TREATMENT effectiveness; Subject Term: DATA analysis -- Software; Subject Term: KRUSKAL-Wallis Test; Subject Term: SYMPTOMS; Subject Term: ; Geographic Subject: CHINA; Geographic Subject: ; Number of Pages: 11p; ; Illustrations: 5 Charts; ; Document Type: Article;

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