Effect and Potential Mechanism of Electroacupuncture Add-On Treatment in Patients with Parkinson’s Disease
Item
Title
Effect and Potential Mechanism of Electroacupuncture Add-On Treatment in Patients with Parkinson’s Disease
Author(s)
Wang, F. See all items with this value
Sun, L. See all items with this value
Zhang, X.-zhe See all items with this value
Jia, J. See all items with this value
Liu, Z. See all items with this value
Huang, X.-yan See all items with this value
Yu, S.-yang See all items with this value
Zuo, L.-jun See all items with this value
Cao, C.-jie See all items with this value
Wang, X.-min See all items with this value
Zhang, W. See all items with this value
Journal Publication
Evidence-based Complementary & Alternative Medicine (eCAM) See all items with this value
Date
2015
volume
2015
Research Type
RCT
Keywords
PARKINSON'S disease -- Drug therapy See all items with this value
PARKINSON'S disease -- Treatment See all items with this value
ACUPUNCTURE points See all items with this value
BIOCHEMICAL markers See all items with this value
CHI-squared test See all items with this value
COMBINED modality therapy See all items with this value
Electroacupuncture See all items with this value
HAMILTON Depression Inventory See all items with this value
Neurotransmitters See all items with this value
NITRIC oxide See all items with this value
ORAL medication See all items with this value
PARKINSON'S disease See all items with this value
PLACEBOS (Medicine) See all items with this value
PSYCHOLOGICAL tests See all items with this value
QUALITY of life See all items with this value
RESEARCH -- Finance See all items with this value
SAMPLING (Statistics) See all items with this value
Statistics See all items with this value
T-test (Statistics) See all items with this value
SAMPLE size (Statistics) See all items with this value
PILOT projects See all items with this value
DATA analysis See all items with this value
STATISTICAL significance See all items with this value
RANDOMIZED controlled trials See all items with this value
TREATMENT effectiveness See all items with this value
DATA analysis -- Software See all items with this value
KRUSKAL-Wallis Test See all items with this value
Symptoms See all items with this value
Abstract
Objectives. To explore effectiveness and mechanisms of electroacupuncture (EA) add-on treatment in Parkinson’s disease (PD) patients. Methods. Fifty PD patients were randomly assigned to drug plus EA (D + EA) group and drug alone (D) group. Subjects in D + EA group received stimulation in points of bilateral fengfu, fengchi, hegu, and central dazhui. Participants were evaluated by scales for motor and nonmotor symptoms. Levels of neuroinflammatory factors and neurotransmitters in serum were detected. Results. EA add-on treatment remarkably reduced scores of Unified Parkinson’s Disease Rating Scale (UPDRS) III and its subitems of tremor, rigidity, and bradykinesia and conspicuously decreased UPDRS III scores in patients with bradykinesia-rigidity and mixed types and mild severity. Depression and sleep disturbances were eased, which were reflected by decreased scores of Hamilton Depression Rating Scale, Pittsburgh Sleep Quality Index, and elevated noradrenaline level. Effects of EA add-on treatment on motor symptoms and sleep disturbances were superior to drug alone treatment, markedly improving life quality of PD patients. EA add-on treatment decreased nitric oxide level in serum. Conclusions. EA add-on treatment is effective on most motor symptoms and some nonmotor symptoms and is particularly efficacious in PD patients at early stage. Antineuroinflammation may be a mechanism of EA add-on treatment.
pmid
Accession Number: 109084118; Source Information: 8/13/2015, Vol. 2015, p1; Subject Term: PARKINSON'S disease -- Drug therapy; Subject Term: PARKINSON'S disease -- Treatment; Subject Term: DOPA; Subject Term: ACUPUNCTURE points; Subject Term: BIOCHEMICAL markers; Subject Term: CHI-squared test; Subject Term: COMBINED modality therapy; Subject Term: ELECTROACUPUNCTURE; Subject Term: HAMILTON Depression Inventory; Subject Term: NEUROTRANSMITTERS; Subject Term: NITRIC oxide; Subject Term: ORAL medication; Subject Term: PARKINSON'S disease; Subject Term: PLACEBOS (Medicine); Subject Term: PSYCHOLOGICAL tests; Subject Term: QUALITY of life; Subject Term: RESEARCH -- Finance; Subject Term: SAMPLING (Statistics); Subject Term: STATISTICS; Subject Term: T-test (Statistics); Subject Term: SAMPLE size (Statistics); Subject Term: PILOT projects; Subject Term: DATA analysis; Subject Term: STATISTICAL significance; Subject Term: RANDOMIZED controlled trials; Subject Term: TREATMENT effectiveness; Subject Term: DATA analysis -- Software; Subject Term: KRUSKAL-Wallis Test; Subject Term: SYMPTOMS; Subject Term: ; Geographic Subject: CHINA; Geographic Subject: ; Number of Pages: 11p; ; Illustrations: 5 Charts; ; Document Type: Article;
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