AcuTrials

Efficacy of Acupuncture versus Combined Oral Contraceptive Pill in Treatment of Moderate-to-Severe Dysmenorrhea: A Randomized Controlled Trial

Item

Title

Efficacy of Acupuncture versus Combined Oral Contraceptive Pill in Treatment of Moderate-to-Severe Dysmenorrhea: A Randomized Controlled Trial

Author(s)

Journal Publication

Evidence-based Complementary & Alternative Medicine (eCAM)

Date

2015

volume

2015

Research Type

RCT

Keywords

DYSMENORRHEA -- Treatment
ORAL contraceptives -- Therapeutic use
ACUPUNCTURE points
FISHER exact test
LONGITUDINAL method
RESEARCH -- Finance
SAMPLING (Statistics)
T-test (Statistics)
RANDOMIZED controlled trials
TREATMENT effectiveness
REPEATED measures design
DATA analysis -- Software
ONE-way analysis of variance

Abstract

This open-label randomized controlled trial was designed to compare the efficacy of acupuncture and combined oral contraceptive (COC) pill in treating moderate-to-severe primary dysmenorrhea. Fifty-two participants were randomly assigned to receive either acupuncture (n = 27) or COC (n = 25) for three menstrual cycles. Mefenamic acid was prescribed as a recue analgesic drug with both groups. The statistical approach used for efficacy and safety assessments was intention-to-treat analysis. By the end of the study, both treatments had resulted in significant improvement over baselines in all outcomes, that is, maximal dysmenorrhea pain scores, days suffering from dysmenorrhea, amount of rescue analgesic used, and quality of life assessed by SF-36 questionnaire. Over the three treatment cycles, COC caused greater reduction in maximal pain scores than acupuncture, while improvements in the remaining outcomes were comparable. Responders were defined as participants whose maximal dysmenorrhea pain scores decreased at least 33% below their baseline. Response rates following both interventions at the end of the study were not statistically different. Acupuncture commonly caused minimal local side effects but did not cause any hormone-related side effects as did COC. In conclusion, acupuncture is an alternative option for relieving dysmenorrhea, especially when COC is not a favorable choice.

pmid

Accession Number: 109030798; Source Information: 8/4/2015, Vol. 2015, p1; Subject Term: DYSMENORRHEA -- Treatment; Subject Term: ORAL contraceptives -- Therapeutic use; Subject Term: ACUPUNCTURE; Subject Term: ACUPUNCTURE points; Subject Term: CHI-squared test; Subject Term: DYSMENORRHEA; Subject Term: FISHER exact test; Subject Term: HEALTH surveys; Subject Term: LONGITUDINAL method; Subject Term: QUALITY of life; Subject Term: QUESTIONNAIRES; Subject Term: RESEARCH -- Finance; Subject Term: SAMPLING (Statistics); Subject Term: T-test (Statistics); Subject Term: RANDOMIZED controlled trials; Subject Term: TREATMENT effectiveness; Subject Term: REPEATED measures design; Subject Term: DATA analysis -- Software; Subject Term: ONE-way analysis of variance; Subject Term: ; Geographic Subject: THAILAND; Geographic Subject: ; Number of Pages: 10p; ; Illustrations: 2 Diagrams, 3 Charts, 1 Graph; ; Document Type: Article;

has study population number

0

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