AcuTrials

Electroacupuncture prevents endothelial dysfunction induced by ischemia-reperfusion injury via a cyclooxygenase-2-dependent mechanism: A randomized controlled crossover trial

Item

Title

Electroacupuncture prevents endothelial dysfunction induced by ischemia-reperfusion injury via a cyclooxygenase-2-dependent mechanism: A randomized controlled crossover trial

Journal Publication

Date

2017

volume

12(6)

Research Type

RCT

Keywords

Cardiovascular Diseases
Reperfusion Injury
Vascular Diseases
Cross-Over Design
Acu Versus Usual Care
Electroacupuncture
Korean Acupuncture Style
Fixed Acupuncture Protocol
Restricted Modalities
Superficial Needling Depth
Near Verum Acupoint Control

Abstract

OBJECTIVE: Exploring clinically effective methods to reduce ischemia-reperfusion (IR) injury in humans is critical. Several drugs have shown protective effects, but studies using other interventions have been rare. Electroacupuncture (EA) has induced similar protection in several animal studies but no study has investigated how the effects could be translated and reproduced in humans. This study aimed to explore the potential effect and mechanisms of EA in IR-induced endothelial dysfunction in humans. METHODS: This is a prospective, randomized, crossover, sham-controlled trial consisting of two protocols. Protocol 1 was a crossover study to investigate the effect of EA on IR-induced endothelial dysfunction. Twenty healthy volunteers were randomly assigned to EA or sham EA (sham). Flow mediated dilation (FMD) of the brachial artery (BA), nitroglycerin-mediated endothelial independent dilation, blood pressure before and after IR were measured. In protocol 2, seven volunteers were administered COX-2 inhibitor celecoxib (200 mg orally twice daily) for five days. After consumption, volunteers underwent FMD before and after IR identical to protocol 1. RESULTS: In protocol 1, baseline BA diameter, Pre-IR BA diameter and FMD were similar between the two groups (p = NS). After IR, sham group showed significantly blunted FMD (Pre-IR: 11.41 +/- 3.10%, Post-IR: 4.49 +/- 2.04%, p < 0.001). However, EA protected this blunted FMD (Pre-IR: 10.96 +/- 5.30%, Post-IR: 9.47 +/- 5.23%, p = NS, p < 0.05 compared with sham EA after IR). In protocol 2, this protective effect was completely abolished by pre-treatment with celecoxib (Pre-IR: 11.05 +/- 3.27%; Post-IR: 4.20 +/- 1.68%, p = 0.001). CONCLUSION: EA may prevent IR-induced endothelial dysfunction via a COX-2 dependent mechanism.

doi

10.1371/journal.pone.0178838

pmid

PMID:28591155; PMCID:PMC5462401

Language

English

Frequency of Treatment

1/WK

Time in Treatment

2 Weeks

has health condition studied

Cardiovascular Diseases

has study population number

20

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