Gender-Related Differences in Outcomes on Acupuncture and Moxibustion Treatment Among Depression Patients



Gender-Related Differences in Outcomes on Acupuncture and Moxibustion Treatment Among Depression Patients

Journal Publication

Journal of Alternative & Complementary Medicine







Research Type



MENTAL depression -- Treatment
ANALYSIS of variance
MENTAL depression
HAMILTON Depression Inventory
RESEARCH -- Finance
SAMPLING (Statistics)
SEX distribution (Demography)
T-test (Statistics)
SAMPLE size (Statistics)
STATISTICAL power analysis
RANDOMIZED controlled trials
TREATMENT effectiveness
PRE-tests & post-tests
REPEATED measures design
DATA analysis -- Software
DESCRIPTIVE statistics
MANN Whitney U Test


Objectives: This study sought to (1) assess the effectiveness of acupuncture and moxibustion with a method of soothing the liver and regulating the mind on the quality of life among patients with depression and (2) study the sex differences of acupuncture and moxibustion in the treatment of depression on the basis of patient-reported outcomes. Methods: In a single-blind, randomized, controlled trial conducted in Guangdong Province, China, in January and December 2010, 163 patients who met the criteria for depression were enrolled. Eligible patients were allocated to three treatment groups (soothing liver and regulating mind group, acupoint shallow puncturing group, and non-acupoint shallow puncturing group). In all three groups, the treatment was given twice a week for 12 weeks. The Hamilton Depression Rating Scale (HAMD) and Symptom Checklist 90 (SCL90) were used to quantitatively assess patients before and 1 and 3 months after treatment. Results: Non-statistically significant differences in the acupuncture and moxibustion therapeutic effects of soothing liver and regulating mind treatment were found between men and women ( p>0.05). An item-by-item analysis of the SCL90 and HAMD scores showed sex differences between the efficacy of the soothing liver and regulating mind group and the group receiving acupoint shallow puncturing. Women obtained lower scores in somatization, interpersonal relationship, anxiety, terror, and extremeness items and HAMD scores in the soothing liver and regulating mind group than in the acupoint shallow puncturing group ( p<0.05), while men showed no significant differences between the soothing liver and regulating mind group and the acupoint shallow puncturing group ( p>0.05). Conclusions: The therapeutic effect of soothing liver and regulating mind is similar for both sexes, but women were more sensitive to the efficacy of the soothing liver and regulating mind treatment compared with other methods. These findings could indicate an important issue to consider for the different acupuncture and moxibustion treatments for depression in men and women.


Accession Number: 110727194; Source Information: Nov2015, Vol. 21 Issue 11, p673; Subject Term: MENTAL depression -- Treatment; Subject Term: ACUPUNCTURE; Subject Term: ACUPUNCTURE points; Subject Term: ALTERNATIVE medicine; Subject Term: ANALYSIS of variance; Subject Term: CHI-squared test; Subject Term: MENTAL depression; Subject Term: HAMILTON Depression Inventory; Subject Term: LONGITUDINAL method; Subject Term: MATHEMATICS; Subject Term: MOXIBUSTION; Subject Term: MULTIVARIATE analysis; Subject Term: NOSOLOGY; Subject Term: PROBABILITY theory; Subject Term: PSYCHOLOGICAL tests; Subject Term: QUALITY of life; Subject Term: RESEARCH -- Finance; Subject Term: SAMPLING (Statistics); Subject Term: SEX distribution (Demography); Subject Term: T-test (Statistics); Subject Term: SAMPLE size (Statistics); Subject Term: STATISTICAL power analysis; Subject Term: RANDOMIZED controlled trials; Subject Term: TREATMENT effectiveness; Subject Term: PRE-tests & post-tests; Subject Term: REPEATED measures design; Subject Term: BLIND experiment; Subject Term: DATA analysis -- Software; Subject Term: DESCRIPTIVE statistics; Subject Term: MANN Whitney U Test; Subject Term: ; Geographic Subject: CHINA; Geographic Subject: ; Number of Pages: 8p; ; Illustrations: 3 Charts, 1 Graph; ; Document Type: Article;

has study population number


Item sets