AcuTrials

Heat-sensitive moxibustion in patients with osteoarthritis of the knee: a three-armed multicentre randomised active control trial

Rixin Chen See all items with this value

Mingren Chen See all items with this value

Tongsheng Su See all items with this value

Meiqi Zhou See all items with this value

Jianhua Sun See all items with this value

Jun Xiong See all items with this value

Zhenhai Chi See all items with this value

Dingyi Xie See all items with this value

Bo Zhang See all items with this value

Acupuncture in Medicine See all items with this value

2015

33(4)

262-269

RCT

KNEE -- Diseases -- Treatment See all items with this value

OSTEOARTHRITIS -- Treatment See all items with this value

Thermotherapy See all items with this value

ACUPUNCTURE points See all items with this value

CHI-squared test See all items with this value

CONFIDENCE intervals See all items with this value

FISHER exact test See all items with this value

MEDICAL cooperation See all items with this value

Moxibustion See all items with this value

Research See all items with this value

RESEARCH -- Finance See all items with this value

SAMPLING (Statistics) See all items with this value

RANDOMIZED controlled trials See all items with this value

TREATMENT effectiveness See all items with this value

DATA analysis -- Software See all items with this value

DESCRIPTIVE statistics See all items with this value

KRUSKAL-Wallis Test See all items with this value

China See all items with this value

Background In China, heat-sensitive moxibustion (HSM) is used for knee osteoarthritis (KOA) to reduce pain and improve physical activity. However, there is little high-quality evidence of its effectiveness. Objective To evaluate the effectiveness of HSM in the treatment of KOA compared with usual care. Methods We performed a multicentre, randomised controlled trial. In total, 432 patients with KOA were randomly assigned to one of three groups (HSM, conventional moxibustion, or conventional injection with sodium hyaluronate). The primary end point was the guiding principle of clinical research on new drugs in the treatment of KOA (GPCRND-KOA). Measurements were obtained at baseline and after 1 and 6 months (month 7) of study. Result For GPCRND-KOA, there were significant differences among the three groups after treatment at months 1 and 7. Pairwise comparisons showed that HSM was more effective than the conventional drug. There was no difference in any measures between conventional moxibustion and the conventional drug. Compared with conventional moxibustion, HSM resulted in greater improvement in all outcomes. Conclusions This trial provided some evidence of the superiority of HSM in patients with KOA, suggesting that the observed differences might be due to superiority effects of a heat-sensitive point, although the effect of expectation cannot be ruled out.

Accession Number: 109111930; Source Information: Aug2015, Vol. 33 Issue 4, p262; Subject Term: KNEE -- Diseases -- Treatment; Subject Term: OSTEOARTHRITIS -- Treatment; Subject Term: THERMOTHERAPY; Subject Term: ACUPUNCTURE points; Subject Term: CHI-squared test; Subject Term: CONFIDENCE intervals; Subject Term: FISHER exact test; Subject Term: MEDICAL cooperation; Subject Term: MOXIBUSTION; Subject Term: RESEARCH; Subject Term: RESEARCH -- Finance; Subject Term: SAMPLING (Statistics); Subject Term: RANDOMIZED controlled trials; Subject Term: TREATMENT effectiveness; Subject Term: DATA analysis -- Software; Subject Term: DESCRIPTIVE statistics; Subject Term: KRUSKAL-Wallis Test; Subject Term: ; Geographic Subject: CHINA; Geographic Subject: ; Number of Pages: 8p; ; Illustrations: 1 Diagram, 4 Charts; ; Document Type: Article;

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