Heat-sensitive moxibustion in patients with osteoarthritis of the knee: a three-armed multicentre randomised active control trial
Item
Title
Heat-sensitive moxibustion in patients with osteoarthritis of the knee: a three-armed multicentre randomised active control trial
Author(s)
Rixin Chen See all items with this value
Mingren Chen See all items with this value
Tongsheng Su See all items with this value
Meiqi Zhou See all items with this value
Jianhua Sun See all items with this value
Jun Xiong See all items with this value
Zhenhai Chi See all items with this value
Dingyi Xie See all items with this value
Bo Zhang See all items with this value
Journal Publication
Acupuncture in Medicine See all items with this value
Date
2015
volume
33(4)
pages
262-269
Research Type
RCT
Keywords
KNEE -- Diseases -- Treatment See all items with this value
OSTEOARTHRITIS -- Treatment See all items with this value
Thermotherapy See all items with this value
ACUPUNCTURE points See all items with this value
CHI-squared test See all items with this value
CONFIDENCE intervals See all items with this value
FISHER exact test See all items with this value
MEDICAL cooperation See all items with this value
Moxibustion See all items with this value
Research See all items with this value
RESEARCH -- Finance See all items with this value
SAMPLING (Statistics) See all items with this value
RANDOMIZED controlled trials See all items with this value
TREATMENT effectiveness See all items with this value
DATA analysis -- Software See all items with this value
DESCRIPTIVE statistics See all items with this value
KRUSKAL-Wallis Test See all items with this value
Abstract
Background In China, heat-sensitive moxibustion (HSM) is used for knee osteoarthritis (KOA) to reduce pain and improve physical activity. However, there is little high-quality evidence of its effectiveness. Objective To evaluate the effectiveness of HSM in the treatment of KOA compared with usual care. Methods We performed a multicentre, randomised controlled trial. In total, 432 patients with KOA were randomly assigned to one of three groups (HSM, conventional moxibustion, or conventional injection with sodium hyaluronate). The primary end point was the guiding principle of clinical research on new drugs in the treatment of KOA (GPCRND-KOA). Measurements were obtained at baseline and after 1 and 6 months (month 7) of study. Result For GPCRND-KOA, there were significant differences among the three groups after treatment at months 1 and 7. Pairwise comparisons showed that HSM was more effective than the conventional drug. There was no difference in any measures between conventional moxibustion and the conventional drug. Compared with conventional moxibustion, HSM resulted in greater improvement in all outcomes. Conclusions This trial provided some evidence of the superiority of HSM in patients with KOA, suggesting that the observed differences might be due to superiority effects of a heat-sensitive point, although the effect of expectation cannot be ruled out.
pmid
Accession Number: 109111930; Source Information: Aug2015, Vol. 33 Issue 4, p262; Subject Term: KNEE -- Diseases -- Treatment; Subject Term: OSTEOARTHRITIS -- Treatment; Subject Term: THERMOTHERAPY; Subject Term: ACUPUNCTURE points; Subject Term: CHI-squared test; Subject Term: CONFIDENCE intervals; Subject Term: FISHER exact test; Subject Term: MEDICAL cooperation; Subject Term: MOXIBUSTION; Subject Term: RESEARCH; Subject Term: RESEARCH -- Finance; Subject Term: SAMPLING (Statistics); Subject Term: RANDOMIZED controlled trials; Subject Term: TREATMENT effectiveness; Subject Term: DATA analysis -- Software; Subject Term: DESCRIPTIVE statistics; Subject Term: KRUSKAL-Wallis Test; Subject Term: ; Geographic Subject: CHINA; Geographic Subject: ; Number of Pages: 8p; ; Illustrations: 1 Diagram, 4 Charts; ; Document Type: Article;
View on Pubmed
has study population number
0