Lifestyle-Related Factors in the Self-Management of Chemotherapy-Induced Peripheral Neuropathy in Colorectal Cancer: A Systematic Review

Derksen, T.M.E.

Bours, M.J.L.

Mols, F.

Weijenberg, M.P.

Evidence-based Complementary & Alternative Medicine (eCAM)

2017

Systematic Review

ALTERNATIVE medicine

ANTINEOPLASTIC agents

COLON tumors

DIETARY supplements

Exercise

INFORMATION storage & retrieval systems -- Medicine

Medline

PERIPHERAL neuropathy

ONLINE information services

QUALITY of life

RECTUM -- Tumors

HEALTH self-care

SYSTEMATIC reviews (Medical research)

Oxaliplatin

Lifestyles

Background. Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse effect of chemotherapy treatment in colorectal cancer (CRC), negatively affecting the daily functioning and quality of life of CRC patients. Currently, there are no established treatments to prevent or reduce CIPN. The purpose of this systematic review was to identify lifestyle-related factors that can aid in preventing or reducing CIPN, as such factors may promote self-management options for CRC patients suffering from CIPN. Methods. A literature search was conducted through PubMed, Embase, and Google Scholar. Original research articles investigating oxaliplatin-related CIPN in CRC were eligible for inclusion. Results. In total, 22 articles were included, which suggested that dietary supplements, such as antioxidants and herbal extracts, as well as physical exercise and complementary therapies, such as acupuncture, may have beneficial effects on preventing or reducing CIPN symptoms. However, many of the reviewed articles presented various limitations, including small sample sizes and heterogeneity in study design and measurements of CIPN. Conclusions. No strong conclusions can be drawn regarding the role of lifestyle-related factors in the management of CIPN in CRC patients. Certain dietary supplements and physical exercise may be beneficial for the management of CIPN, but further research is warranted.

Accession Number: 121885369; Source Information: 3/16/2017, p1; Subject Term: ALTERNATIVE medicine; Subject Term: ANTINEOPLASTIC agents; Subject Term: COLON tumors; Subject Term: DIETARY supplements; Subject Term: EXERCISE; Subject Term: INFORMATION storage & retrieval systems -- Medicine; Subject Term: MEDLINE; Subject Term: PERIPHERAL neuropathy; Subject Term: ONLINE information services; Subject Term: QUALITY of life; Subject Term: RECTUM -- Tumors; Subject Term: HEALTH self-care; Subject Term: SYSTEMATIC reviews (Medical research); Subject Term: OXALIPLATIN; Subject Term: LIFESTYLES; Subject Term: ; Number of Pages: 14p; ; Illustrations: 1 Diagram, 1 Chart; ; Document Type: Article;

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