Plasma nesfatin-1 level in obese patients after acupuncture: a randomised controlled trial
Item
Title
Plasma nesfatin-1 level in obese patients after acupuncture: a randomised controlled trial
Author(s)
Yongfang Guo See all items with this value
Mingqing Xing See all items with this value
Wenjuan Sun See all items with this value
Xiaoyan Yuan See all items with this value
Hongyan Dai See all items with this value
Huamin Ding See all items with this value
Journal Publication
Acupuncture in Medicine See all items with this value
Date
2014
volume
32(4)
pages
313-317
Research Type
RCT
Keywords
Obesity -- Blood See all items with this value
Acupuncture -- Evaluation See all items with this value
Nerve Tissue Proteins -- Blood See all items with this value
Calcium Binding Proteins -- Blood See all items with this value
Proteins -- Blood See all items with this value
Treatment Outcomes See all items with this value
Randomized Controlled Trials See all items with this value
Data Analysis Software See all items with this value
T-Tests See all items with this value
Mann-Whitney U Test See all items with this value
Descriptive Statistics See all items with this value
Pearson's Correlation Coefficient See all items with this value
Middle Age See all items with this value
Funding Source See all items with this value
Abstract
Background Nesfatin-1 is an anorexigenic hormone suggested to regulate obesity. Objective To investigate the relationship between nesfatin-1 level and anthropometric and metabolic parameters in obese patients, and examine the change in plasma nesfatin-1 level after acupuncture treatment. Methods 64 obese adult patients without diabetes and 58 normal weight control subjects were enrolled in this study. The obese patients were randomly divided into an acupuncture plus diet group (n=32) and a diet only group (n=32). Measurements were repeated after 45 days. Results Body mass index (BMI), waist and hip circumferences, serum insulin, lipoprotein and insulin resistance measures were significantly higher, and plasma nesfatin-1 level was significantly lower, in obese patients than in normal weight controls. In addition, negative correlations were found between plasma nesfatin-1 level and BMI, waist and hip circumferences. Weight reduction in participants after acupuncture and diet restriction was 7.0% and 4.3%, respectively. Plasma nesfatin-1 level increased from 2.75±1.16 to 3.44±1.28 ng/mL and from 2.86±1.07 to 3.23±1.06 ng/mL in acupuncture and diet groups, respectively; the difference was significant, p<0.05. Conclusions Plasma nesfatin-1 level is reduced in obese adults, and is increased after acupuncture. The beneficial effect of acupuncture on obesity is associated with increased plasma nesfatin-1 level.
doi
10.1136/acupmed-2014-010530
pmid
Accession Number: 103988642. Language: English. Entry Date: 20140815. Revision Date: 20150710. Publication Type: Journal Article; research; tables/charts; randomized controlled trial. Journal Subset: Alternative/Complementary Therapies; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. Grant Information: National Natural Science Foundation of China.. NLM UID: 9304117.