The effect of acupuncture on patients with rheumatoid arthritis: a randomized, placebo-controlled cross-over study

David, J.

Townsend, S.

Sathanathan, R.

Kriss, S.

Dore, C. J.

1999

38(9)

864-869

RCT

Acu Versus Sham

Acupuncture

Arthritis

Arthritis, Rheumatoid

Autoimmune Diseases

Cross-Over Design

Fixed Acupuncture Protocol

Non Penetrating Sham, Mechanical

Pain

RCT

Restricted Modalities, Acupuncture Only

Sham Control

TCM Acupuncture Style

Verum Acupoint Control

OBJECTIVE: Acupuncture is commonly used by patients with chronic painful musculoskeletal disorders. There are, however, few well-designed studies of its efficacy. This paper describes a randomized placebo-controlled cross-over design to evaluate acupuncture as a useful treatment adjunct in the management of patients with rheumatoid arthritis (RA). METHODS: Sixty-four patients were centrally randomized from a hospital-based rheumatology out-patient clinic. Fifty-six patients were suitable for study, all were on second-line therapy and aged 18-75 yr. There had been no change in therapy for the preceding 3 months. Patients who had previous acupuncture, anticoagulation, fear of needles or infection were excluded. Single-point (Liver 3) acupuncture or placebo was given with an intervening 6 week wash-out period. The acupuncturist, patient and statistician were blinded as far as possible. The outcome measures included the inflammatory markers (erythrocyte sedimentation rate and C-reactive protein), visual analogue scale of pain, global patient assessment, 28 swollen and tender joint count, and a general health questionnaire. RESULTS: The results demonstrated no significant effect of treatment or period and no significant interaction between treatment and period for any outcome variable. No adverse effects were reported. CONCLUSION: Acupuncture of this type cannot be considered as a useful adjunct to therapy in patients with RA. Possible reasons why this is the case are discussed

Arthritis

1/WK

56

5 Weeks