AcuTrials

The effect of low-concentration atropine combined with auricular acupoint stimulation in myopia control

Item

Title

The effect of low-concentration atropine combined with auricular acupoint stimulation in myopia control

Author(s)

Journal Publication

Complementary Therapies in Medicine

Date

2014

volume

22(3)

pages

449-455

Research Type

RCT

Abstract

OBJECTIVES: To compare the effect of myopia control between patients treated with low-concentration atropine eye drops combined with auricular acupoint stimulation and those treated with atropine alone. DESIGN AND SETTINGS: Single-blinded randomized controlled clinical trial in a regional teaching hospital. INTERVENTIONS: The patients received either topical 0.125% atropine nightly plus auricular acupoint stimulation (0.125A+ACU group) or topical 0.125% atropine alone nightly (0.125A group). MAIN OUTCOME MEASURES: The changes in spherical equivalent (SE), axial length (AL), anterior chamber depth (ACD), and intraocular pressure (IOP) per year were compared between the two groups. RESULTS: Seventy-three of 110 total patients (66.4%) completed at least 6 months of follow-up. Patients in the 0.125A+ACU group had less myopic progression and AL elongation (-0.41 diopter and 0.24mm/year) than those in the 0.125A group (-0.66 diopter and 0.32mm/year) (mean follow-up 14.7 months, p<0.0001 and p=0.02, respectively). The ACD increased more in the 0.125A+ACU group than in the 0.125A group (0.076mm vs. 0.023mm/year, p=0.0004). IOP decreased more in the 0.125A+ACU group than in the 0.125A group (-1.01mmHg vs. -0.13mmHg/year, p=0.007). A decrease of 1mmHg of IOP correlated with a decrease of myopic progression of 0.021 diopter/year (p=0.006). CONCLUSIONS: Patients treated with 0.125% atropine eye drops plus auricular acupoint stimulation had less myopic progression, less axial length elongation, more anterior chamber deepening, and greater IOP reductions than those treated with 0.125% atropine alone. Auricular acupoint stimulation in combination with low-concentration topical atropine was beneficial for myopia control.

doi

10.1016/j.ctim.2014.03.004

pmid

Accession Number: 103827662. Language: English. Entry Date: 20150501. Revision Date: 20150710. Publication Type: Journal Article; research; randomized controlled trial. Journal Subset: Alternative/Complementary Therapies; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 9308777.

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