AcuTrials

Acupuncture for sleep quality, BDNF levels and immunosenescence: a randomized controlled study

Item

Title

Acupuncture for sleep quality, BDNF levels and immunosenescence: a randomized controlled study

Journal Publication

Neuroscience Letters

Date

2015

volume

587

pages

35-40

Research Type

RCT

Abstract

Poor sleep in elderly populations is associated with detrimental neuropsychological, and physiological changes including premature immunosenescence and reduced brain derived neurotrophic factor (BDNF). Here, we evaluated the effects of acupuncture on sleep quality, psychological distress and immunosenescence in elderly, as well as effects on BDNF levels. Forty-eight community-dwelling elderly were randomized into true or placebo acupuncture, and intervention consisted of ten sessions. Sleep quality, depression and stress scores were evaluated by the Pittsburgh sleep quality index (PSQI), beck depression inventory (BDI II) and perceived stress scale (PSS), respectively, before and after the intervention. Lymphocyte subsets commonly associated with stress, sleep impairment and immunosenescence were phenotyped by flow cytometry. BDNF plasma levels were assessed by ELISAs. Acupuncture was highly effective for improving sleep quality (-53.23%; p<0.01), depression (-48.41%; p<0.01), and stress (-25.46%; p<0.01). However, neither lymphocyte subpopulations nor BDNF levels changed following the intervention.

doi

10.1016/j.neulet.2014.12.016

pmid

PMID:25511549

Language

English

Frequency of Treatment

>1/wk

Time in Treatment

5 weeks

has health condition studied

Sleep Disorders

has study population number

48

Item sets