Acupuncture for upper-extremity rehabilitation in chronic stroke: a randomized sham-controlled study

Wayne, P. M.

Krebs, D. E.

Macklin, E. A.

Schnyer, R.

Kaptchuk, T. J.

Parker, S. W.

Scarborough, D. M.

McGibbon, C. A.

Schaechter, J. D.

Stein, J.

Stason, W. B.

2005

86(12)

2248-2255

RCT

Acu Versus Sham

Acupuncture

Stroke

CVA

Electroacupuncture

Non Penetrating Sham, Electrical

Non Penetrating Sham, Mechanical

Paralysis

RCT

Restricted Modalities, Acupuncture Only

Scalp Acupuncture

Semi-Individualized Acupuncture Protocol

Sham Acupoint Control

Sham Control

Traditional Diagnosis Based Point Selection

TCM Acupuncture Style

OBJECTIVE: To compare the effects of traditional Chinese acupuncture with sham acupuncture on upper-extremity (UE) function and quality of life (QOL) in patients with chronic hemiparesis from stroke. DESIGN: A prospective, sham-controlled, randomized controlled trial (RCT). SETTING: Patients recruited through a hospital stroke rehabilitation program. PARTICIPANTS: Thirty-three subjects who incurred a stroke 0.8 to 24 years previously and had moderate to severe UE functional impairment. INTERVENTIONS: Active acupuncture tailored to traditional Chinese medicine diagnoses, including electroacupuncture, or sham acupuncture. Up to 20 treatment sessions (mean, 16.9) over a mean of 10.5 weeks. MAIN OUTCOME MEASURES: UE motor function, spasticity, grip strength, range of motion (ROM), activities of daily living, QOL, and mood. All outcomes were measured at baseline and after treatment. RESULTS: Intention-to-treat (ITT) analyses found no statistically significant differences in outcomes between active and sham acupuncture groups. Analyses of protocol-compliant subjects revealed significant improvement in wrist spasticity (P<.01) and both wrist (P<.01) and shoulder (P<.01) ROM in the active acupuncture group, and improvement trends in UE motor function (P=.09) and digit ROM (P=.06). CONCLUSIONS: Based on ITT analyses, we conclude that acupuncture does not improve UE function or QOL in patients with chronic stroke symptoms. However, gains in UE function observed in protocol-compliant subjects suggest traditional Chinese acupuncture may help patients with chronic stroke symptoms. These results must be interpreted cautiously because of small sample sizes and multiple, unadjusted, post hoc comparisons. A larger, more definitive RCT using a similar design is feasible and warranted

Stroke

>1/WK

33

1/1/1970