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Author Beal, M. W.; Nield-Anderson, L. url  openurl
  Title Acupuncture for symptom relief in HIV-positive adults: lessons learned from a pilot study Type of Study RCT
  Year 2000 Publication (up) Abbreviated Journal Altern Ther Health Med  
  Volume 6 Issue 5 Pages 33-42  
  Keywords Acu Versus Sham; Acupuncture; AcuTrials; HIV Infections; Penetrating Sham; Non Specific Acupoint Control; RCT; Restricted Modalities, Acupuncture Only; Semi-Individualized Acupuncture Protocol; Superficial Needling Depth; Sham Control; Symptom Based Point Selection; TCM Acupuncture Style; Traditional Diagnosis Based Point Selection; HIV Infections  
  Abstract CONTEXT: Although acupuncture is used by many people with HIV disease as a complementary treatment to Western medicine, there is a lack of scientifically sound research on patient responses and outcomes. OBJECTIVE: To explore the feasibility of conducting a larger study investigating the efficacy of acupuncture on symptom distress, psychological distress, and quality of life in HIV-infected individuals. DESIGN: This pilot study used a block randomization, single-blinded design. SETTING: Yale University General Clinical Research Center. PARTICIPANTS: Eleven HIV-positive participants. INTERVENTION: Patients were grouped by CD4 cell counts and received acupuncture treatments twice each week for 3 weeks. The experimental group received a protocol with 2 components: one tailored to the individual's symptoms and a second standardized component treatment designed to promote health and immune function. The control-needling group received a standardized acupuncture involving stimulation of acupuncture points identified as “clinically irrelevant” in treating the conditions under investigation (i.e., acupuncture points that have consistently not been cited as helpful for symptoms of relevant conditions or immune disorders). MAIN OUTCOME MEASURES: The HIV-Symptom List was administered to gather data on symptom distress, the Brief Symptom Inventory was used to gather data on psychological distress, and the Functional Assessment of HIV Infection was administered to collect data on quality of life. RESULTS: Preliminary data from small numbers of participants showed trends toward improvement in symptoms and quality of life. CONCLUSIONS: A follow-up pilot study will focus on the use of acupuncture to relieve gastrointestinal symptoms in people with HIV  
  Address Yale University School of Nursing, New Haven, Conn., USA  
  Publisher
  Language Number of Treatments 6  
  Treatment Follow-up N/A Frequency >1/WK Number of Participants 11  
  Time in Treatment 3 Weeks Condition HIV Infections
  Disease Category HIV Infections OCSI Score  
  Notes Approved no  
  Call Number Serial 63  
Permanent link to this record
 

 
Author Carlsson, C. P.; Axemo, P.; al, Bodin A et url  openurl
  Title Manual acupuncture reduces hyperemesis gravidarum: A placebo-controlled, randomized, single-blind, cross-over study Type of Study RCT
  Year 2000 Publication (up) Abbreviated Journal J Pain Symptom Manage  
  Volume 20 Issue Pages 273-279  
  Keywords Acu Versus Sham; Acupuncture; AcuTrials; Cross-Over Design; Emesis; Fixed Acupuncture Protocol; Hyperemesis Gravidarum; Penetrating Sham; Morning Sickness; Non Specific Acupoint Control; RCT; Restricted Modalities, Acupuncture Only; Superficial Needling Depth; Sham Control; TCM Acupuncture Style; Vomiting; Women's Health; Pregnancy Complications  
  Abstract Hyperemesis gravidarum, severe vomiting, develops in about 1-2% of all pregnancies. Acupuncture on the point PC6 above the wrist on the palmar side has been found to prevent some types of nausea and vomiting. The purpose of the present study was to see if acupuncture, in addition to standard treatment, could hasten the improvement of hyperemesis gravidarum. Thirty-three women with hyperemesis were evaluated in a randomized, single-blind, crossover comparison of two methods of acupuncture, active (deep) PC6 acupuncture or placebo (superficial) acupuncture. The women estimated their degree of nausea on a visual analogue scale (VAS). The daily number of emesis episodes were documented. Crossover analyses showed that there was a significantly faster reduction of nausea VAS and more women who stopped vomiting after active acupuncture than after placebo acupuncture. This study suggests that active PC6 acupuncture, in combination with standard treatment, could make women with hyperemesis gravidarum better faster than placebo acupuncture  
  Address  
  Publisher
  Language Number of Treatments 6  
  Treatment Follow-up N/A Frequency >1/WK Number of Participants 40  
  Time in Treatment 1 Week Condition Hyperemesis Gravidarum
  Disease Category Pregnancy Complications OCSI Score 74  
  Notes Approved no  
  Call Number Serial 114  
Permanent link to this record
 

 
Author Engelhardt, P. F.; Daha, L. K.; Zils, T.; Simak, R.; Konig, K.; Pfluger, H. url  openurl
  Title Acupuncture in the treatment of psychogenic erectile dysfunction: first results of a prospective randomized placebo-controlled study Type of Study RCT
  Year 2003 Publication (up) Abbreviated Journal Int J Impot Res  
  Volume 15 Issue 5 Pages 343-346  
  Keywords Acu Versus Sham; Acupuncture; AcuTrials; Cross-Over Design; Erectile Dysfunction; Fixed Acupuncture Protocol; Impotence; Penetrating Sham; Genital Diseases, Male; Non Specific Acupoint Control; RCT; Restricted Modalities, Acupuncture Only; Sham Control; Standard Needling Depth; TCM Acupuncture Style; Sexual Dysfunctions, Psychological;  
  Abstract In a prospective study, we investigated the potentially curative effect of acupuncture in patients with psychogenic erectile dysfunction (pED). A total of 22 patients with pED were randomized into two groups. They were either treated with acupunture specific against ED (treatment group) or acupuncture specific against headache (placebo group). Nonresponders of the placebo group were crossed over to the treatment group. Prior to acupuncture, serum sexual hormone levels, IIEF score, nocturnal penile tumescence testing for three nights (Rigiscan) and the erectile response to 50 mg sildenafil were evaluated. Out of 21 patients, 20 completed the study, including 10 patients after crossover. A satisfactory response was achieved in 68.4% of the treatment group and in 9% of the placebo group (P=0.0017). Another 21.05% of the pateints had improved errections, that is, sufficient rigidity under simultaneous treatment with 50 gm sildenafil. The results of our pilot study indicate that acupuncture can be an effective treatment option in more than two-thirds of patients with psychogenic erectile dysfunction.International Journal of Impotence Research (2003) 15, 343-346. doi:10.1038/sj.ijir.3901021  
  Address 1Department of Urology and Ludwig-Boltzmann-Institute of Andrology and Urology  
  Publisher
  Language Number of Treatments 11  
  Treatment Follow-up N/A Frequency >1/WK Number of Participants 22  
  Time in Treatment 6 Weeks Condition Erectile Dysfunction
  Disease Category Genital Diseases, Male OCSI Score  
  Notes Approved no  
  Call Number Serial 294  
Permanent link to this record
 

 
Author Korpan, M. I.; Dezu, Y.; Schneider, B.; Leitha, T.; Fialka-Moser, V. openurl 
  Title Acupuncture in the treatment of posttraumatic pain syndrome Type of Study RCT
  Year 1999 Publication (up) Abbreviated Journal Acta Orthop Belg  
  Volume 65 Issue 2 Pages 197-201  
  Keywords Acu Versus Sham; Pain; RCT; TCM Acupuncture Style; Acupuncture; AcuTrials; Reflex Sympathetic Dystrophy; Semi-Individualized Acupuncture Protocol; Restricted Modalities, Acupuncture Only; Superficial Needling Depth; Sham Acupoint Control; Penetrating Sham; Non Specific Acupoint Control;  
  Abstract To test the hypothesis that classical Chinese acupuncture provides an additional benefit subjectively as well as objectively in patients suffering from reflex sympathetic dystrophy, a double-blind, placebo-controlled prospective trial was performed. Fourteen patients suffering clinically and scintigraphically from acute CRPS of the upper limb lasting of more than one but less than 6 months were studied. Patients were randomly assigned to either the classical acupuncture (group A) or sham acupuncture (group S), which was applied five times a week for three weeks and required 30 minutes. Both groups received the same defined standard treatment. The current state of pain was assessed by means of a visual analogue scale. Subjective success of treatment was rated by the patients by means of a rating scale. Each patient underwent a clinical examination and was investigated by 5-phase bone scan in order to confirm the diagnosis. The current state of pain as well as clinical parameters were almost identical in patients of group A and of group S at the beginning. During therapy clinical parameters as well as pain improved in both groups and reached nearly normal levels after 6 months. Owing to the small number of patients in our study, no differences between sham and treatment group could be recognized. For a definitive statement the treatment of further patients in both groups is planned. Determinations of the effect of acupuncture on clinical parameters, based on long-term follow-ups are projected  
  Address Department of Physical Medicine and Rehabilitation, University of Vienna, Austria  
  Publisher
  Language Number of Treatments 15  
  Treatment Follow-up 24 Weeks Frequency >1/WK Number of Participants 14  
  Time in Treatment 3 Weeks Condition Pain
  Disease Category Pain OCSI Score 40  
  Notes Approved no  
  Call Number Serial 601  
Permanent link to this record
 

 
Author Manber, R.; Schnyer, R. N.; Allen, J. J.; Rush, A. J.; Blasey, C. M. url  openurl
  Title Acupuncture: a promising treatment for depression during pregnancy Type of Study RCT
  Year 2004 Publication (up) Abbreviated Journal J Affect Disord  
  Volume 83 Issue 1 Pages 89-95  
  Keywords CAM Control; Acu Versus > 1 Control; Acupuncture; AcuTrials; Depression; Depressive Disorder; Individualized Acupuncture Protocol; Penetrating Sham; Massage; Non Specific Acupoint Control; RCT; Restricted Modalities, Acupuncture Only; Sham Control; Standard Needling Depth; TCM Acupuncture Style; Traditional Diagnosis Based Point Selection; Women's Health; Depression, Postpartum; Pregnancy Complications  
  Abstract BACKGROUND: Few medically acceptable treatments for depression during pregnancy are available. The aim of this randomized controlled pilot study was to determine whether acupuncture holds promise as a treatment for depression during pregnancy. METHODS: Sixty-one pregnant women with major depressive disorder and a 17-item Hamilton Rating Scale for Depression (HRSD(17)) score >/=14 were randomly assigned to one of three treatments, delivered over 8 weeks: an active acupuncture (SPEC, N=20), an active control acupuncture (NSPEC, N=21), and massage (MSSG, N=20). Acupuncture treatments were standardized, but individually tailored, and were provided in a double-blind fashion. Responders to acute phase treatment (HRSD(17) score<14 and >/=50% reduction from baseline) continued the treatment they were initially randomized to until 10 weeks postpartum. RESULTS: Response rates at the end of the acute phase were statistically significantly higher for SPEC (69%) than for MSSG (32%), with an intermediate NSPEC response rate (47%). The SPEC group also exhibited a significantly higher average rate of reduction in BDI scores from baseline to the end of the first month of treatment than the MSSG group. Responders to the acute phase of all treatments combined had significantly lower depression scores at 10 weeks postpartum than nonresponders. LIMITATIONS: Generalizability is limited by the small sample and its relative homogeneity. CONCLUSION: Acupuncture holds promise for the treatment of depression during pregnancy  
  Address Department of Psychiatry and Behavioral Sciences, Stanford University. 401, Quarry Rd., Stanford, CA 94305, United States  
  Publisher
  Language Number of Treatments 24  
  Treatment Follow-up 2 Weeks Frequency >1/WK Number of Participants 61  
  Time in Treatment 16 Weeks Condition Depression, Postpartum
  Disease Category Pregnancy Complications OCSI Score 68  
  Notes Approved no  
  Call Number Serial 813  
Permanent link to this record
 

 
Author Margolin, A.; Kleber, H. D.; Avants, S. K.; Konefal, J.; Gawin, F.; Stark, E.; Sorensen, J.; Midkiff, E.; Wells, E.; Jackson, T. R.; Bullock, M.; Culliton, P. D.; Boles, S.; Vaughan, R. url  openurl
  Title Acupuncture for the treatment of cocaine addiction: a randomized controlled trial Type of Study RCT
  Year 2002 Publication (up) Abbreviated Journal JAMA  
  Volume 287 Issue 1 Pages 55-63  
  Keywords CAM Control; Acu Versus > 1 Control; AcuTrials; Drug Addiction; Auricular Acupuncture; Fixed Acupuncture Protocol; Penetrating Sham; NADA Protocol Acupuncture Style; Non Specific Acupoint Control; RCT; Relaxation Techniques; Restricted Modalities, Acupuncture Only; Sham Control; Standard Needling Depth; Substance-Related Disorders; Cocaine-Related Disorders; Substance Abuse; Drug Addiction  
  Abstract CONTEXT: Auricular acupuncture is widely used to treat cocaine addiction in the United States and Europe. However, evidence from controlled studies regarding this treatment's effectiveness has been inconsistent. OBJECTIVE: To investigate the effectiveness of auricular acupuncture as a treatment for cocaine addiction. DESIGN: Randomized, controlled, single-blind clinical trial conducted from November 1996 to April 1999. SETTING: Six community-based clinics in the United States: 3 hospital-affiliated clinics and 3 methadone maintenance programs. PATIENTS: Six hundred twenty cocaine-dependent adult patients (mean age, 38.8 years; 69.2% men); 412 used cocaine only and 208 used both opiates and cocaine and were receiving methadone maintenance. INTERVENTION: Patients were randomly assigned to receive auricular acupuncture (n = 222), a needle-insertion control condition (n = 203), or a relaxation control condition (n = 195). Treatments were offered 5 times weekly for 8 weeks. Concurrent drug counseling was also offered to patients in all conditions. MAIN OUTCOME MEASURES: Cocaine use during treatment and at the 3- and 6-month postrandomization follow-up based on urine toxicology screens; retention in treatment. RESULTS: Intent-to-treat analysis of urine samples showed a significant overall reduction in cocaine use (odds ratio, 1.40; 95% confidence interval, 1.11-1.74; P =.002) but no differences by treatment condition (P =.90 for acupuncture vs both control conditions). There were also no differences between the conditions in treatment retention (44%-46% for the full 8 weeks). Counseling sessions in all 3 conditions were poorly attended. CONCLUSIONS: Within the clinical context of this study, acupuncture was not more effective than a needle insertion or relaxation control in reducing cocaine use. Our study does not support the use of acupuncture as a stand-alone treatment for cocaine addiction or in contexts in which patients receive only minimal concurrent psychosocial treatment. Research will be needed to examine acupuncture's contribution to addiction treatment when provided in an ancillary role  
  Address  
  Publisher
  Language Number of Treatments 40  
  Treatment Follow-up 16 Weeks Frequency >1/WK Number of Participants 620  
  Time in Treatment 8 Weeks Condition Cocaine-Related Disorders
  Disease Category Substance-Related Disorders OCSI Score 79  
  Notes Approved no  
  Call Number Serial 828  
Permanent link to this record
 

 
Author Otto, K. C.; Quinn, C.; Sung, Y. F. url  openurl
  Title Auricular acupuncture as an adjunctive treatment for cocaine addiction. A pilot study Type of Study RCT
  Year 1998 Publication (up) Abbreviated Journal Am J Addict  
  Volume 7 Issue 2 Pages 164-170  
  Keywords Acu Versus Sham; Acupuncture; AcuTrials; Auricular Acupuncture; Fixed Acupuncture Protocol; Penetrating Sham; NADA Protocol Acupuncture Style; Non Specific Acupoint Control; Pilot Study; RCT; Restricted Modalities, Acupuncture Only; Superficial Needling Depth; Sham Control; Substance-Related Disorders; Cocaine-Related Disorders; Group Acupuncture Style; Drug Addiction; Substance Abuse  
  Abstract The authors conducted a single-blind study of auricular acupuncture in 36 cocaine-dependent inpatient veterans on a substance abuse treatment unit to determine whether the treatment could help reduce craving, increase treatment retention, and prevent relapse. Acupuncture was given on a predetermined schedule to both treatment and control groups, with status assessed regularly by independent, blinded raters. The study failed to show a significant difference between treatment and control groups. However, the study patients, as a whole, did remain in treatment longer than a retrospectively analyzed group who received no acupuncture  
  Address  
  Publisher
  Language Number of Treatments 24  
  Treatment Follow-up 52 Weeks Frequency >1/WK Number of Participants 36  
  Time in Treatment 12 Weeks Condition Cocaine-Related Disorders
  Disease Category Substance-Related Disorders OCSI Score  
  Notes Approved no  
  Call Number Serial 921  
Permanent link to this record
 

 
Author Rampes, H.; Pereira, S.; Mortimer, A.et al openurl 
  Title Does electroacupuncture reduce craving for alcohol? A randomized controlled study Type of Study RCT
  Year 1997 Publication (up) Abbreviated Journal Compl Ther Med  
  Volume 5 Issue Pages 19-26  
  Keywords Acu + Usual Care Versus > 1 Control; AcuTrials; Alcoholism; Auricular Acupuncture; Electroacupuncture; Fixed Acupuncture Protocol; Penetrating Sham; NADA Protocol Acupuncture Style; Non Specific Acupoint Control; RCT; Restricted Modalities, Acupuncture Only; Sham Control; Usual Care Control, Unspecified; TCM Acupuncture Style; Substance-Related Disorders; Alcohol-Related Disorders; Group Acupuncture Style; Drug Addiction; Substance Abuse  
  Abstract  
  Address  
  Publisher
  Language Number of Treatments 6  
  Treatment Follow-up 18 Weeks Frequency 1/WK Number of Participants 59  
  Time in Treatment 6 Weeks Condition Alcohol-Related Disorders
  Disease Category Substance-Related Disorders OCSI Score  
  Notes Approved no  
  Call Number Serial 972  
Permanent link to this record
 

 
Author Rusy, L. M.; Hoffman, G. M.; Weisman, S. J. url  openurl
  Title Electroacupuncture prophylaxis of postoperative nausea and vomiting following pediatric tonsillectomy with or without adenoidectomy Type of Study RCT
  Year 2002 Publication (up) Abbreviated Journal Anesthesiology  
  Volume 96 Issue 2 Pages 300-305  
  Keywords Acu Versus > 1 Control; AcuTrials; Adenoidectomy; Anesthesia; Electroacupuncture; Emesis; Fixed Acupuncture Protocol; Penetrating Sham; Nausea; Non Specific Acupoint Control; Non Penetrating Sham, Electrical; Pediatrics; Postoperative Nausea and Vomiting; RCT; Restricted Modalities, Acupuncture Only; Sham Control; Standard Needling Depth; TCM Acupuncture Style; Tonsillectomy; Vomiting  
  Abstract BACKGROUND: Electrical stimulation of acupuncture point P6 reduces the incidence of postoperative nausea or vomiting (PONV) in adult patients. However, acupressure, laser stimulation of P6, and acupuncture during anesthesia have not been effective for reducing PONV in the pediatric population. The authors studied the effect of electrical P6 acupuncture in awake pediatric patients who had undergone surgery associated with a high incidence of PONV. METHODS: Patients aged 4-18 yr undergoing tonsillectomy with or without adenoidectomy were randomly assigned to acupuncture, sham acupuncture, or control groups. Acupuncture needles at P6 and a neutral point were placed while patients were anesthetized, and low-frequency electrical stimulation was applied to these points for 20 min in the recovery room while the patients were awake (P6 Acu group). This treatment was compared with sham needles along the arm at acupuncture points not associated with antiemesis (sham group) and a no-needle control group. The arms were wrapped to prevent identification of treatment group, and anesthetic, analgesic, and surgical technique were standardized. Assessed outcomes were occurrence of nausea, occurrence and number of episodes of vomiting, time to vomiting, and use of antiemetic rescue medication. RESULTS: One hundred twenty patients were enrolled in the study, 40 per group. There were no differences in age, weight, sex, or opioid administration between groups. The PONV incidence was significantly lower with P6 acupuncture (25 of 40 or 63%; odds ratio, 0.135; number needed to treat, 3.3; P < 0.001) compared with controls (37 of 40 or 93%). Sham puncture had no effect on PONV (35 of 40 or 88%; P = not significant). Occurrence of nausea was significantly less in P6 Acu (24 of 40 or 60%; odds ratio, 0.121; P < 0.01), but not in the sham group (34 of 40 or 85%) compared with the control group (37 of 40 or 93%). Vomiting occurred in 25 of 40 or 63% in P6 Acu; 35 of 40 or 88% in the sham group, and 31 in 40 or 78% in the control group (P = not significant). Patients receiving sham puncture vomited significantly earlier (P < 0.02) and needed more rescue treatment (33 of 40 or 83%; odds ratio, 3.48; P < 0.02) compared with P6 Acu (23 of 40 or 58%) and the control group (24 of 40 or 60%). CONCLUSIONS: Perioperative P6 electroacupuncture in awake patients significantly reduced the occurrence of nausea compared with the sham and control groups, but it did not significantly reduce the incidence or number of episodes of emesis or the use of rescue antiemetics. Sham acupuncture may exacerbate the severity but not the incidence of emesis. The efficacy of P6 acupuncture for PONV prevention is similar to commonly used pharmacotherapies. Its appropriate role in prevention and treatment of PONV requires further study  
  Address  
  Publisher
  Language Number of Treatments 1  
  Treatment Follow-up 1 day Frequency N/A Number of Participants 120  
  Time in Treatment 1 Day Condition Postoperative Nausea and Vomiting
  Disease Category Vomiting OCSI Score 60  
  Notes Approved no  
  Call Number Serial 1005  
Permanent link to this record
 

 
Author Sapir-Weise, R.; Berglund, M.; Frank, A.; Kristenson, H. url  openurl
  Title Acupuncture in alcoholism treatment: a randomized out-patient study Type of Study RCT
  Year 1999 Publication (up) Abbreviated Journal Alcohol Alcohol  
  Volume 34 Issue 4 Pages 629-635  
  Keywords Acu + Usual Care Versus Sham + Usual Care; AcuTrials; Alcoholism; Auricular Acupuncture; Fixed Acupuncture Protocol; Penetrating Sham; Near Verum Acupoint Control; Non Specific Acupoint Control; RCT; Restricted Modalities, Acupuncture Only; Sham Control; Standard Needling Depth; TCM Acupuncture Style; Substance-Related Disorders; Alcohol-Related Disorders; Group Acupuncture Style; Drug Addiction; Substance Abuse  
  Abstract Seventy-two alcoholics were treated with acupuncture to the ear in a randomized single-blind controlled design over 10 weeks. Orthodox points and incorrect points 3-5 mm from orthodox points were used. No initial differences were found regarding social characteristics, the responses to the Swedish version of the Alcohol Use Inventory and the Three-dimensional Personality Questionnaire, indicating a successful randomization. There were non-significant tendencies towards gender differential response after acupuncture treatment (P = 0.07). There was no difference in the number of drinking days or level of craving between treatment and control patients. Among females, those in the treatment group reported reduction of anxiety after 1 month, more often than those in the control group (P < 0.05). Response to acupuncture was not related to personality or drinking pattern. Patients' experience of needle placement was similar in the study and control groups. The effects of acupuncture were less pronounced than those previously reported  
  Address Department of Alcohol and Drug Diseases, Malmoe University Hospital, Lund University, Sweden  
  Publisher
  Language Number of Treatments 30  
  Treatment Follow-up 14 Weeks Frequency >1/WK Number of Participants 72  
  Time in Treatment 10 Weeks Condition Alcohol-Related Disorders
  Disease Category Substance-Related Disorders OCSI Score 65  
  Notes Approved no  
  Call Number Serial 1015  
Permanent link to this record
 

 
Author Shen, J.; Wenger, N.; Glaspy, J.; Hays, R. D.; Albert, P. S.; Choi, C.; Shekelle, P. G. url  openurl
  Title Electroacupuncture for control of myeloablative chemotherapy-induced emesis: A randomized controlled trial Type of Study RCT
  Year 2000 Publication (up) Abbreviated Journal JAMA  
  Volume 284 Issue 21 Pages 2755-2761  
  Keywords Acu Versus > 1 Control; AcuTrials; Breast Cancer; Breast Neoplasms; Cancer; Chemotherapy; Electroacupuncture; Emesis; Fixed Acupuncture Protocol; Penetrating Sham; Nausea; Non Specific Acupoint Control; RCT; Restricted Modalities, Acupuncture Only; Superficial Needling Depth; Sham Control; Usual Care Control, Pharmaceutical; TCM Acupuncture Style; Vomiting; Women's Health  
  Abstract CONTEXT: High-dose chemotherapy poses considerable challenges to emesis management. Although prior studies suggest that acupuncture may reduce nausea and emesis, it is unclear whether such benefit comes from the nonspecific effects of attention and clinician-patient interaction. OBJECTIVE: To compare the effectiveness of electroacupuncture vs minimal needling and mock electrical stimulation or antiemetic medications alone in controlling emesis among patients undergoing a highly emetogenic chemotherapy regimen. DESIGN: Three-arm, parallel-group, randomized controlled trial conducted from March 1996 to December 1997, with a 5-day study period and a 9-day follow-up. SETTING: Oncology center at a university medical center. PATIENTS: One hundred four women (mean age, 46 years) with high-risk breast cancer. INTERVENTIONS: Patients were randomly assigned to receive low-frequency electroacupuncture at classic antiemetic acupuncture points once daily for 5 days (n = 37); minimal needling at control points with mock electrostimulation on the same schedule (n = 33); or no adjunct needling (n = 34). All patients received concurrent triple antiemetic pharmacotherapy and high-dose chemotherapy (cyclophosphamide, cisplatin, and carmustine). MAIN OUTCOME MEASURES: Total number of emesis episodes occurring during the 5-day study period and the proportion of emesis-free days, compared among the 3 groups. RESULTS: The number of emesis episodes occurring during the 5 days was lower for patients receiving electroacupuncture compared with those receiving minimal needling or pharmacotherapy alone (median number of episodes, 5, 10, and 15, respectively; P<.001). The electroacupuncture group had fewer episodes of emesis than the minimal needling group (P<.001), whereas the minimal needling group had fewer episodes of emesis than the antiemetic pharmacotherapy alone group (P =.01). The differences among groups were not significant during the 9-day follow-up period (P =.18). CONCLUSIONS: In this study of patients with breast cancer receiving high-dose chemotherapy, adjunct electroacupuncture was more effective in controlling emesis than minimal needling or antiemetic pharmacotherapy alone, although the observed effect had limited duration. JAMA. 2000;284:2755-2761  
  Address National Institutes of Health, Laboratory of Clinical Studies/NIAAA, Room 6 S-240, Mail Stop 1610, 10 Center Dr, Bldg 10, Bethesda, MD 20892-1610, USA  
  Publisher
  Language Number of Treatments 5  
  Treatment Follow-up 1.5 Weeks Frequency >1/WK Number of Participants 104  
  Time in Treatment 1 Week Condition Vomiting, Anticipatory
  Disease Category Vomiting OCSI Score 87  
  Notes Approved no  
  Call Number Serial 1035  
Permanent link to this record
 

 
Author Stavem, K.; Rossberg, E.; Larsson, P. G. url  openurl
  Title Health-related quality of life outcomes in a trial of acupuncture, sham acupuncture and conventional treatment for chronic sinusitis Type of Study RCT
  Year 2008 Publication (up) Abbreviated Journal BMC Res Notes  
  Volume 1 Issue 1 Pages 37-  
  Keywords Acu Versus > 1 Control; Acupuncture; AcuTrials; Individualized Acupuncture Protocol; Penetrating Sham; Non Specific Acupoint Control; RCT; Restricted Modalities, Acupuncture Only; Superficial Needling Depth; Sham Acupoint Control; Sham Control; Usual Care Control, Pharmaceutical; TCM Acupuncture Style; Sinusitis; Respiratory Tract Diseases  
  Abstract ABSTRACT: BACKGROUND: Acupuncture is commonly used to treat chronic sinusitis, though there is little documentation on the effect. This study presents the health-related quality of life (HRQoL) outcomes in a trial comparing traditional Chinese acupuncture, sham acupuncture, and conventional treatment for chronic sinusitis. FINDINGS: In a three-armed single blind randomized controlled study, we recruited 65 patients with symptoms of sinusitis >3 months and signs of sinusitis on computed tomography (CT). Patients were randomized to one of three study arms: (1) 2-4 weeks of medication with antibiotics, corticosteroids, 0.9 % sodium chloride solution, and local decongestants (n=21), (2) ten treatments with traditional Chinese acupuncture (n=25), or (3) ten treatments with minimal acupuncture at non-acupoints (n=19). Change in HRQoL was assessed over 12 weeks using the Chronic Sinusitis Survey (CSS) and Short form 36 (SF-36) questionnaires. In the study, we found only a non-significant difference on the CSS symptom scale between conventional medical therapy and traditional Chinese acupuncture. On the SF-36 scale role-physical the change was larger in the conventional group than in the sham group (p=0.02), and on the mental health scale the change in the conventional therapy arm was larger than in the traditional Chinese acupuncture group (p=0.03). There was no difference in effect on HRQoL on any scale between the sham and traditional Chinese acupuncture groups. CONCLUSIONS: There was no clear evidence of the superiority of one treatment over another on short-term HRQoL outcomes, although there was a statistically non-significant advantage of conventional therapy in a few dimensions  
  Address  
  Publisher
  Language Number of Treatments 10  
  Treatment Follow-up 8 Weeks Frequency >1/WK Number of Participants 66  
  Time in Treatment 4 Weeks Condition Sinusitis
  Disease Category Respiratory Tract Diseases OCSI Score  
  Notes Approved no  
  Call Number Serial 1100  
Permanent link to this record
 

 
Author Tandon, M. K.; Soh, P. F. url  openurl
  Title Comparison of real and placebo acupuncture in histamine-induced asthma. A double-blind crossover study Type of Study RCT
  Year 1989 Publication (up) Abbreviated Journal Chest  
  Volume 96 Issue 1 Pages 102-105  
  Keywords Acu Versus Sham; Acupuncture; AcuTrials; Asthma; Bronchial Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cross-Over Design; Fixed Acupuncture Protocol; Penetrating Sham; Non Specific Acupoint Control; RCT; Respiratory Tract Diseases; Restricted Modalities, Acupuncture Only; Standard Needling Depth; TCM Acupuncture Style  
  Abstract A double-blind crossover study of the effects of real and placebo acupuncture on bronchial reactivity to histamine was carried out on 16 patients with moderately severe asthma. Treatment with real or placebo acupuncture failed to modulate the bronchial hyperreactivity to histamine. These results suggest that a single treatment with acupuncture is unlikely to provide improvement in the management of acute bronchial asthma  
  Address  
  Publisher
  Language Number of Treatments 1  
  Treatment Follow-up N/A Frequency N/A Number of Participants 16  
  Time in Treatment 1 Day Condition Asthma
  Disease Category Respiratory Tract Diseases OCSI Score  
  Notes Approved no  
  Call Number Serial 1146  
Permanent link to this record
 

 
Author Waite, N. R.; Clough, J. B. url  openurl
  Title A single-blind, placebo-controlled trial of a simple acupuncture treatment in the cessation of smoking Type of Study RCT
  Year 1998 Publication (up) Abbreviated Journal Br J Gen Pract  
  Volume 48 Issue 433 Pages 1487-1490  
  Keywords Acu Versus Sham; AcuTrials; Drug Addiction; Auricular Acupressure; Auricular Electroacupuncture; Ear Seeds; Fixed Acupuncture Protocol; Penetrating Sham; NADA Protocol Acupuncture Style; Non Specific Acupoint Control; RCT; Restricted Modalities, Acupuncture + Other; Superficial Needling Depth; Sham Control; Smoking Cessation; Tobacco Use Disorder; Substance-Related Disorders; Substance Abuse  
  Abstract BACKGROUND: Tobacco smoking is a major cause of preventable disease and premature death. Physicians should play an active role in the control of smoking by encouraging cessation and helping the smoker to choose the most suitable aid to cessation. AIM: To evaluate a simple, ear acupuncture treatment for the cessation of smoking. METHOD: Randomized, single-blind, placebo-controlled trial of 78 currently smoking volunteers from the general public. Volunteers attended an acupuncture clinic in a general practice setting and were given a single treatment of electroacupuncture using two needles at either an active or a placebo site plus self-retained ear seeds for two weeks. The major outcome measure was biochemically validated total cessation of smoking at six months. RESULTS: A total of 12.5% of the active treatment group compared with 0% of the placebo group ceased smoking at six months (P = 0.055, 95% confidence interval -0.033 to 0.323). CONCLUSION: This simple ear electroacupuncture treatment was significantly more effective in helping volunteers to quit smoking than placebo treatment  
  Address  
  Publisher
  Language Number of Treatments 1  
  Treatment Follow-up 24 Weeks Frequency N/A Number of Participants 78  
  Time in Treatment 2 Weeks Condition Tobacco Use Disorder
  Disease Category Substance-Related Disorders OCSI Score 77  
  Notes Approved no  
  Call Number Serial 1225  
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Author Wang, S. M.; Kain, Z. N. url  openurl
  Title Auricular acupuncture: a potential treatment for anxiety Type of Study RCT
  Year 2001 Publication (up) Abbreviated Journal Curr Res Anesth Analg  
  Volume 92 Issue 2 Pages 548-553  
  Keywords CAM Control; Acu Versus > 1 Control; AcuTrials; Anxiety; Auricular Acupuncture; Fixed Acupuncture Protocol; Penetrating Sham; Non Specific Acupoint Control; Press Tacks; Psychological Disorders; RCT; Restricted Modalities, Acupuncture Only; Sham Control; Standard Needling Depth; TCM Acupuncture Style; Healthy Subjects  
  Abstract Acupuncture can be an effective treatment for chronic anxiety disorders. The purpose of this study was to assess the effectiveness of acupuncture in reducing anxiety in a volunteer population. If found effective, this modality could be introduced as a treatment of anxiety before surgery. Adult volunteers (n = 55), were randomized to three treatment groups: a) Shenmen group--bilateral auricular acupuncture at the “shenmen” point; b) Relaxation group-bilateral auricular acupuncture at a “relaxation” point; and c) Sham group-bilateral auricular acupuncture at a “sham” point. Press-acupuncture needles were inserted at the respective auricular areas for 48 h. State anxiety, blood pressure, heart rate, and electrodermal activity were assessed at 30 min, 24 h, and 48 h after insertion. Analyzing anxiety levels using repeated-measures analysis of variance has demonstrated a significant difference [F (2,51) =8.8, P = 0.001] between the three treatment groups. Post hoc analysis demonstrated that patients in the Relaxation group were significantly less anxious at 30 min (P = 0.007) and 24 h (P = 0.035) as compared with patients in both the Shenmen group and the Sham group, and less anxious at 48 h (P = 0.042) as compared with patients in Shenmen group. Repeated-measures analysis of variance performed for electrodermal activity, blood pressure, and heart rate demonstrated no group differences (P = ns). We conclude that auricular acupuncture at the “relaxation” point can decrease the anxiety level in a population of healthy volunteers  
  Address  
  Publisher
  Language Number of Treatments 1  
  Treatment Follow-up 2 Days Frequency N/A Number of Participants 55  
  Time in Treatment 1 Day Condition Anxiety
  Disease Category Mental Disorders OCSI Score 67  
  Notes Approved no  
  Call Number Serial 1257  
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Author Wang, S. M.; Maranets, I.; Weinberg, M. E.; Caldwell-Andrews, A. A.; Kain, Z. N. url  openurl
  Title Parental auricular acupuncture as an adjunct for parental presence during induction of anesthesia Type of Study RCT
  Year 2004 Publication (up) Abbreviated Journal Anesthesiology  
  Volume 100 Issue 6 Pages 1399-1404  
  Keywords Acu Versus Sham; AcuTrials; Anesthesia; Anxiety; Auricular Acupuncture; Fixed Acupuncture Protocol; Penetrating Sham; Non Specific Acupoint Control; Press Tacks; Psychological Disorders; RCT; Relaxation; Restricted Modalities, Acupuncture + Other; Sham Control; Standard Needling Depth; TCM Acupuncture Style; Mental Disorders  
  Abstract BACKGROUND: The purpose of this study was to determine whether parental auricular acupuncture reduces parental preoperative anxiety and thus allows children to benefit from parental presence during induction of anesthesia. METHODS: Mothers of children who were scheduled to undergo surgery were randomly assigned to an acupuncture intervention group (auricular press needles at relaxation, tranquilizer point, and master cerebral point) or a sham acupuncture control group (auricular press needles at the shoulder, wrist, and extraneous auricular point). The intervention was performed at least 30 min before the child's induction of anesthesia. All mothers were present during induction of anesthesia. The behavioral and physiologic anxiety of mothers and children were rated during the perioperative process. RESULTS:: Multivariable analysis examining maternal anxiety as a function of group found a group-by-time interaction (F1,65 = 4.1, P = 0.04). That is, after induction, maternal anxiety in the acupuncture group was significantly lower (42.9 +/- 10 vs. 49.5 +/- 11; P = 0.014). A multivariate model (F1,65 = 4.8, P =0.031) also showed that children whose mothers received the acupuncture intervention were significantly less anxious on entrance to the operating room (34.9 +/- 20 vs. 47.4 +/- 26; P = 0.03) and during introduction of the anesthesia mask (38.6 +/- 25 vs. 55.6 +/- 31; P = 0.016). There were no significant differences in maternal blood pressure and heart rate between the two groups. CONCLUSIONS:: Auricular acupuncture significantly decreased maternal anxiety during the preoperative period. Children of mothers who underwent acupuncture intervention benefitted from the reduction of maternal anxiety during the induction of anesthesia  
  Address Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut 06520-8051, USA. Shu-Ming.Wang@yale.edu  
  Publisher
  Language Number of Treatments 1  
  Treatment Follow-up N/A Frequency N/A Number of Participants 67  
  Time in Treatment N/A Condition Anxiety
  Disease Category Mental Disorders OCSI Score 74  
  Notes Approved no  
  Call Number Serial 1258  
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Author Wang, S. M.; Peloquin, C.; Kain, Z. N. url  openurl
  Title The use of auricular acupuncture to reduce preoperative anxiety Type of Study RCT
  Year 2001 Publication (up) Abbreviated Journal Curr Res Anesth Analg  
  Volume 93 Issue 5 Pages 1178-80, table  
  Keywords Acu Versus > 1 Control; AcuTrials; Anxiety; Auricular Acupuncture; Fixed Acupuncture Protocol; Penetrating Sham; Psychological Disorders; RCT; Restricted Modalities, Acupuncture Only; Non Specific Acupoint Control; Sham Control; Standard Needling Depth; TCM Acupuncture Style; CAM Control; Acu Versus Acu;  
  Abstract IMPLICATIONS: Ear acupuncture can decrease preoperative anxiety in adults undergoing outpatient surgery  
  Address  
  Publisher
  Language Number of Treatments 1  
  Treatment Follow-up N/A Frequency N/A Number of Participants 91  
  Time in Treatment 1 Day Condition Preoperative Anxiety
  Disease Category Mental Disorders OCSI Score 67  
  Notes Approved no  
  Call Number Serial 1259  
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Author Washburn, A. M.; Fullilove, R. E.; Fullilove, M. T.; Keenan, P. A.; McGee, B.; Morris, K. A.; Sorensen, J. L.; Clark, W. W. url  openurl
  Title Acupuncture heroin detoxification: a single-blind clinical trial Type of Study RCT
  Year 1993 Publication (up) Abbreviated Journal J Subst Abuse Treat  
  Volume 10 Issue 4 Pages 345-351  
  Keywords Acu Versus Sham; Acupuncture; AcuTrials; Drug Addiction; Auricular Acupuncture; Detoxification; Fixed Acupuncture Protocol; Penetrating Sham; NADA Protocol Acupuncture Style; Non Specific Acupoint Control; RCT; Restricted Modalities, Acupuncture Only; Sham Control; Standard Needling Depth; Substance-Related Disorders; Heroin Dependence; Group Acupuncture Style; Substance Abuse  
  Abstract The increasing prevalence of HIV infection among injection drug users mandates the development of innovative treatments. While extensive clinical experience suggests that acupuncture detoxification is both safe and acceptable to those in withdrawal, little research has been conducted to assess its efficacy as a treatment modality. In this first controlled study of acupuncture heroin detoxification, 100 addicted persons were randomly assigned, in a single-blind design, to the standard auricular acupuncture treatment used for addiction or to a “sham” treatment that used points that were geographically close to the standard points. Attrition was high for both groups, but subjects assigned to the standard treatment attended the acupuncture clinic more days and stayed in treatment longer than those assigned to the sham condition. Additionally, attendance varied inversely with self-reports of frequency of drug use, suggesting that those with lighter habits found the treatment modality more helpful. Limitations of the study are discussed  
  Address University of California, San Francisco  
  Publisher
  Language Number of Treatments 3  
  Treatment Follow-up N/A Frequency 1/WK Number of Participants 100  
  Time in Treatment 3 Weeks Condition Heroin Dependence
  Disease Category Substance-Related Disorders OCSI Score  
  Notes Approved no  
  Call Number Serial 1276  
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Author Liu, C. Z.; Xie, J. P.; Wang, L. P.; Liu, Y. Q.; Song, J. S.; Chen, Y. Y.; Shi, G. X.; Zhou, W.; Gao, S. Z.; Li, S. L.; Xing, J. M.; Ma, L. X.; Wang, Y. X.; Zhu, J.; Liu, J. P. url  doi
openurl 
  Title A Randomized Controlled Trial of Single Point Acupuncture in Primary Dysmenorrhea Type of Study RCT
  Year 2014 Publication (up) Abbreviated Journal Pain Med  
  Volume Issue Pages 1-11  
  Keywords RCT; Menstruation Disturbances; Dysmenorrhea; Acu Versus Sham; Electroacupuncture; TCM Acupuncture Style; Fixed Acupuncture Protocol; Restricted Modalities, Acupuncture Only; Sham Control; Penetrating Sham; Standard Needling Depth; Sham Acupoint Control; Non Specific Acupoint Control; Women's Health; Gynecology  
  Abstract BACKGROUND: Acupuncture is often used for primary dysmenorrhea. But there is no convincing evidence due to low methodological quality. We aim to assess immediate effect of acupuncture at specific acupoint compared with unrelated acupoint and nonacupoint on primary dysmenorrhea. METHODS: The Acupuncture Analgesia Effect in Primary Dysmenorrhoea-II is a multicenter controlled trial conducted in six large hospitals of China. Patients who met inclusion criteria were randomly assigned to classic acupoint (N = 167), unrelated acupoint (N = 167), or non-acupoint (N = 167) group on a 1:1:1 basis. They received three sessions with electro-acupuncture at a classic acupoint (Sanyinjiao, SP6), or an unrelated acupoint (Xuanzhong, GB39), or nonacupoint location, respectively. The primary outcome was subjective pain as measured by a 100-mm visual analog scale (VAS). Measurements were obtained at 0, 5, 10, 30, and 60 minutes following the first intervention. In addition, patients scored changes of general complaints using Cox retrospective symptom scales (RSS-Cox) and 7-point verbal rating scale (VRS) during three menstrual cycles. Secondary outcomes included VAS score for average pain, pain total time, additional in-bed time, and proportion of participants using analgesics during three menstrual cycles. FINDINGS: Five hundred and one people underwent random assignment. The primary comparison of VAS scores following the first intervention demonstrated that classic acupoint group was more effective both than unrelated acupoint (-4.0 mm, 95% CI -7.1 to -0.9, P = 0.010) and nonacupoint (-4.0 mm, 95% CI -7.0 to -0.9, P = 0.012) groups. However, no significant differences were detected among the three acupuncture groups for RSS-Cox or VRS outcomes. The per-protocol analysis showed similar pattern. No serious adverse events were noted. CONCLUSION: Specific acupoint acupuncture produced a statistically, but not clinically, significant effect compared with unrelated acupoint and nonacupoint acupuncture in primary dysmenorrhea patients. Future studies should focus on effects of multiple points acupuncture on primary dysmenorrhea.  
  Address School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China; Acupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, Beijing, China.  
  Publisher
  Language Number of Treatments 3  
  Treatment Follow-up 4 Weeks Frequency >1/WK Number of Participants 501  
  Time in Treatment 3 Days Condition Dysmenorrhea
  Disease Category Menstruation Disturbances OCSI Score  
  Notes Approved no  
  Call Number Serial 740  
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Author Vas, J.; Aranda-Regules, J. M.; Modesto, M.; Ramos-Monserrat, M.; Baron, M.; Aguilar, I.; Benitez-Parejo, N.; Ramirez-Carmona, C.; Rivas-Ruiz, F. url  doi
openurl 
  Title Using moxibustion in primary healthcare to correct non-vertex presentation: a multicentre randomised controlled trial Type of Study RCT
  Year 2013 Publication (up) Acupuncture in medicine : journal of the British Medical Acupuncture Society Abbreviated Journal Acupunct Med  
  Volume 31 Issue 1 Pages 31-38  
  Keywords AcuTrials; RCT; Labor, Obstetric; Breech Presentation; Moxibustion; Acu + Usual Care Versus > 1 Control; TCM Acupuncture Style; Fixed Acupuncture Protocol; Restricted Modalities, Acupuncture Only; Sham Control; Non Specific Acupoint Control; Usual Care Control, Multimodality  
  Abstract OBJECTIVE: To compare the effectiveness of additional moxibustion at point BL67 with moxibustion at a non-specific acupuncture point and with usual care alone to correct non-vertex presentation. METHODS: This was a multicentre randomised controlled trial in which 406 low-risk pregnant women with a fetus in ultrasound breech presentation, with a gestational age of 33-35 weeks, were assigned to (1) true moxibustion at point BL67 plus usual care; (2) moxibustion at SP1, a non-specific acupuncture point (sham moxibustion) plus usual care; or (3) usual care alone. The primary outcome was cephalic presentation at birth. Women were recruited at health centres in primary healthcare. RESULTS: In the true moxibustion group, 58.1% of the full-term presentations were cephalic compared with 43.4% in the sham moxibustion group (RR 1.34, 95% CI 1.05 to 1.70) and 44.8% of those in the usual care group (RR 1.29, 95% CI 1.02 to 1.64). The reduction in RR of the primary outcome in women allocated to the true moxibustion group compared with the usual care group was 29.7% (95% CI 3.1% to 55.2%) and the number needed to treat was 8 (95% CI 4 to 72). There were no severe adverse effects during the treatment. CONCLUSIONS: Moxibustion at acupuncture point BL67 is effective and safe to correct non-vertex presentation when used between 33 and 35 weeks of gestation. We believe that moxibustion represents a treatment option that should be considered to achieve version of the non-vertex fetus. TRIAL REGISTRATION: Current Controlled Trials ISRCTN10634508.  
  Address Pain Treatment Unit, Dona Mercedes Primary Health Care Centre, Andalusian Public Health System, Dos Hermanas, Sevilla 41700, Spain. jorgef.vas.sspa@juntadeandalucia.es  
  Publisher
  Language Number of Treatments 14  
  Treatment Follow-up 3 Weeks Frequency >1/WK Number of Participants 406  
  Time in Treatment 2 Weeks Condition Breech Presentation
  Disease Category Labor, Obstetric OCSI Score  
  Notes Approved no  
  Call Number Serial 1200  
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