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Author Hu, Z.; Wang, Y. openurl 
  Title Mechanism Study on Acupuncture for Non-insulin Resistant Polycystic Ovary Syndrome Type of Study RCT
  Year 2011 Publication Journal of Acupuncture and Tuina Science Abbreviated Journal J Acupunct Tuina Sci  
  Volume 9 Issue 5 Pages 298-300  
  Keywords AcuTrials; RCT; Genital Diseases, Female; Polycystic Ovarian Syndrome; Women's Health; Gynecology; PCOS; Acu Versus CAM Control; Acu Versus Acu; CAM Control; Electroacupuncture; TCM Acupuncture Style; Fixed Acupuncture Protocol; Restricted Modalities, Acupuncture Only; Wei Wan Xia Shu  
  Abstract Objective: To investigate the action mechanism of acupuncture for non.insulin resistant polycystic ovary syndrome (PCOS). Methods: A total of 46 cases with non`insulin resistant PCOS were randomly allocated into an observation group of 23 cases and a control group of 23 cases. Cases in the observation group were treated by needling bilateral Weiwanxiashu (Ex-B 3), whereas those in the control group were treated by needling bilateral Sanyinjiao (SP 6). After 3-month treatments, a comparison was made on the changes of ovulations rates, Follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone(T), fasting insulin and body mass index (BMI). Results: There were statistical differences in ovulation rates and LH/FSH before and after the treatment in the observation group (P<0.05), along with a statistical difference in testosterone changes (P<0.01). There were also statistical differences in LH and LH/FSH before and after the treatment in the control group (P<0.05); however, there were no statistical differences in ovulation rates and testosterone changes (P>0.05). There was significant difference in testosterone changes between the two groups after the treatment (P<0.01), along with a statistical difference in ovulation rates between the two groups (P<0.05). However, there were no statistical differences in LH/FSH and BMI between the two groups. Conclusion: Needling Weiwanxiashu (Ex-B 3)and Sanyinjiao (SP 6 can both improve the endocrine disorder of patients with non-insulin resistant PCOS; however, needling Weiwanxiashu (Ex-B 3) can obtain a better result than Sanyinjiao (SP 6) in increasing the insulin sensitivity and preventing insulin resistance.  
  Address Shanghai Hospital of Integrated Chinese and Western Medicine, Shanghai 200082, P.R. China  
  Publisher
  Language Number of Treatments  
  Treatment Follow-up N/A Frequency >1/WK Number of Participants 46  
  Time in Treatment 12 Weeks Condition Polycystic Ovarian Syndrome
  Disease Category Genital Diseases, Female OCSI Score  
  Notes Approved no  
  Call Number Serial 473  
Permanent link to this record
 

 
Author Jo, J.; Lee, Y.J. url  doi
openurl 
  Title Effectiveness of acupuncture in women with polycystic ovarian syndrome undergoing in vitro fertilisation or intracytoplasmic sperm injection: a systematic review and meta-analysis Type of Study Systematic Review
  Year 2017 Publication Acupuncture in Medicine : Journal of the British Medical Acupuncture Society Abbreviated Journal Acupunct Med  
  Volume 35 Issue Pages 162-170  
  Keywords AcuTrials; Systematic Review; Genital Diseases, Female; Polycystic Ovarian Syndrome; Women's Health; Gynecology; PCOS; Infertility, Female  
  Abstract OBJECTIVES: The aim of this systematic review was to assess the evidence from randomised controlled trials (RCTs) on the efficacy, effectiveness and safety of acupuncture in women with polycystic ovarian syndrome (PCOS) undergoing in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI). METHODS: We searched a total of 15 databases through October 2015. The participants were women with PCOS (diagnosed using the Rotterdam criteria) undergoing IVF or ICSI. Eligible trials were those with intervention groups receiving manual acupuncture (MA) or electroacupuncture (EA), and control groups receiving sham acupuncture, no treatment or other treatments. Outcomes included the clinical pregnancy rate (CPR), live birth rate (LBR), ongoing pregnancy rate (OPR) and incidence of ovarian hyperstimulation syndrome (OHSS) and adverse events (AEs). For statistical pooling, the risk ratio (RR) and its 95% (confidence interval) CI was calculated using a random effects model. RESULTS: Four RCTs including 430 participants were selected. All trials compared acupuncture (MA/EA) against no treatment. Acupuncture significantly increased the CPR (RR 1.33, 95% CI 1.03 to 1.71) and OPR (RR 2.03, 95% CI 1.08 to 3.81) and decreased the risk of OHSS (RR 0.63, 95% CI 0.42 to 0.94); however, there was no significant difference in the LBR (RR 1.61, 95% CI 0.73 to 3.58). None of the RCTs reported on AEs. CONCLUSIONS: Acupuncture may increase the CPR and OPR and decrease the risk of OHSS in women with PCOS undergoing IVF or ICSI. Further studies are needed to confirm the efficacy and safety of acupuncture as an adjunct to assisted reproductive technology in this particular population.  
  Address Department of Korean Gynecology, Jaseng Hospital of Korean Medicine, Seoul, Republic of Korea  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Genital Diseases, Female Condition Polycystic Ovarian Syndrome
  Disease Category Genital Diseases OCSI Score  
  Notes PMID:28077366 Approved yes  
  Call Number OCOM @ refbase @ Serial 2175  
Permanent link to this record
 

 
Author Jo, J.; Lee, Y.J.; Lee, H. url  doi
openurl 
  Title Acupuncture for polycystic ovarian syndrome: A systematic review and meta-analysis Type of Study Systematic Review
  Year 2017 Publication Medicine Abbreviated Journal Medicine (Baltimore)  
  Volume 96 Issue 23 Pages 1-10  
  Keywords AcuTrials; Systematic Review; Genital Diseases, Female; Polycystic Ovarian Syndrome; Women's Health; Gynecology; PCOS; Acupuncture  
  Abstract BACKGROUND: This systematic review aimed at summarizing and evaluating the evidence from randomized controlled trials (RCTs) using acupuncture to treat polycystic ovarian syndrome (PCOS), specifically focusing on ovulation rate, menstrual rate, and related hormones. METHODS: Fifteen databases were searched electronically through February 2016. Our review included RCTs of women with PCOS; these RCTs compared acupuncture with sham acupuncture, medication, or no treatment. Two reviewers independently extracted data. Data were pooled and expressed as mean differences (MDs) for continuous outcomes and risk ratios for dichotomous outcomes, with 95% confidence intervals (CIs) using a random-effects model. RESULTS: We found a low level of evidence that acupuncture is more likely to improve ovulation rate (MD 0.35, 95% CI: 0.14-0.56) and menstruation rate (MD 0.50, 95% CI: 0.32-0.68) compared with no acupuncture. We found statistically significant pooled benefits of acupuncture treatment as an adjunct to medication in luteinizing hormone (LH), LH/follicular stimulating hormone (FSH) ratio, testosterone, fasting insulin, and pregnancy rates, but the level of evidence was low/very low. CONCLUSION: There is limited evidence to judge the efficacy and safety of acupuncture on key reproductive outcomes in women with PCOS. Large-scale, long-term RCTs with rigorous methodological input are needed.  
  Address Department of Korean Gynecology, Conmaul Hospital of Korean Medicine  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition Polycystic Ovarian Syndrome
  Disease Category Genital Diseases, Female OCSI Score  
  Notes Approved no  
  Call Number OCOM @ refbase @ Serial 2419  
Permanent link to this record
 

 
Author Leonhardt, H.; Hellstrom, M.; Gull, B.; Lind, A.-K.; Nilsson, L.; Janson, P.O.; Stener-Victorin, E. url  doi
openurl 
  Title Serum anti-Mullerian hormone and ovarian morphology assessed by magnetic resonance imaging in response to acupuncture and exercise in women with polycystic ovary syndrome: secondary analyses of a randomized controlled trial Type of Study RCT
  Year 2015 Publication Acta Obstetricia et Gynecologica Scandinavica Abbreviated Journal Acta Obstet Gynecol Scand  
  Volume 94 Issue 3 Pages 279-287  
  Keywords Genital Diseases, Female; Polycystic Ovarian Syndrome; Women's Health; Gynecology; PCOS; RCT; Acu Versus > 1 Control; Electroacupuncture; Unspecified Acupuncture Style; Fixed Acupuncture Protocol; Restricted Modalities, Acupuncture Only; No Treatment Control; Usual Care Control, Physical  
  Abstract OBJECTIVE: To investigate whether electro-acupuncture or physical exercise influence serum anti-Mullerian hormone (AMH), antral follicle count (AFC) or ovarian volume in women with polycystic ovary syndrome (PCOS). DESIGN: Secondary analyses of a prospective, randomized controlled clinical trial. SETTING: University Hospital, Sweden. PATIENTS: Seventy-four women with PCOS recruited from the general population. INTERVENTIONS: Women with PCOS were randomized to 16 weeks of electro-acupuncture (14 treatments), exercise (at least three times/week), or no intervention. MAIN OUTCOME MEASURES: Serum AMH recorded at baseline, after 16 weeks of intervention, and at follow up at 32 weeks. AFC, and ovarian volume assessed by magnetic resonance imaging at baseline and at follow up at 32 weeks. RESULTS: After 16 weeks of intervention, serum levels of AMH were significantly decreased in the electro-acupuncture group by 17.5% (p < 0.001), and differed from the change in the exercise group. AMH remained decreased by 15% (p = 0.004) also at follow up at 32 weeks, but did not differ from the exercise or the no intervention groups. There was a decrease by 8.5% (p = 0.015) in ovarian volume between baseline and follow up in the electro-acupuncture group, and by 11.7% (p = 0.01) in AFC in the physical exercise group. No other variables were affected. CONCLUSIONS: This study is the first to demonstrate that acupuncture reduces serum AMH levels and ovarian volume. Physical exercise did not influence circulating AMH or ovarian volume. Despite a within-group decrease in AFC, exercise did not lead to a between-group difference.  
  Address Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg, Sweden  
  Publisher
  Language English Number of Treatments 14  
  Treatment Follow-up 32 Weeks Frequency <1/WK Number of Participants 74  
  Time in Treatment 16 Weeks Condition Polycystic Ovarian Syndrome
  Disease Category Genital Diseases, Female OCSI Score  
  Notes PMID:25545309 Approved yes  
  Call Number OCOM @ refbase @ Serial 1989  
Permanent link to this record
 

 
Author Lim, C.E.D.; Ng, R.W.C.; Xu, K.; Cheng, N.C.L.; Xue, C.C.L.; Liu, J.P.; Chen, N. url  doi
openurl 
  Title Acupuncture for polycystic ovarian syndrome Type of Study Systematic Review
  Year 2016 Publication The Cochrane Database of Systematic Reviews Abbreviated Journal Cochrane Database Syst Rev  
  Volume Issue 5 Pages Cd007689  
  Keywords Systematic Review; Genital Diseases, Female; Polycystic Ovarian Syndrome; Women's Health; Gynecology; PCOS; Acupuncture  
  Abstract BACKGROUND: Polycystic ovarian syndrome (PCOS) is characterised by the clinical signs of oligo-amenorrhoea, infertility and hirsutism. Conventional treatment of PCOS includes a range of oral pharmacological agents, lifestyle changes and surgical modalities. Beta-endorphin presents in the follicular fluid of both normal and polycystic ovaries. It was demonstrated that the beta-endorphin levels in ovarian follicular fluid of otherwise healthy women who were undergoing ovulation were much higher than the levels measured in plasma. Given that acupuncture has an impact on beta-endorphin production, which may affect gonadotropin-releasing hormone (GnRH) secretion, it is postulated that acupuncture may have a role in ovulation induction and fertility. OBJECTIVES: To assess the effectiveness and safety of acupuncture treatment of oligo/anovulatory women with polycystic ovarian syndrome (PCOS). SEARCH METHODS: We identified relevant studies from databases including the Cochrane Central Register of Controlled Trials (CENTRAL), Ovid MEDLINE, EMBASE, PsycINFO, CNKI and trial registries. The data are current to 19 October 2015. SELECTION CRITERIA: We included randomised controlled trials (RCTs) that studied the efficacy of acupuncture treatment for oligo/anovulatory women with PCOS. We excluded quasi- or pseudo-RCTs. Primary outcomes were live birth and ovulation (primary outcomes), and secondary outcomes were clinical pregnancy, restoration of menstruation, multiple pregnancy, miscarriage and adverse events. We assessed the quality of the evidence using GRADE methods. DATA COLLECTION AND ANALYSIS: Two review authors independently selected the studies, extracted data and assessed risk of bias. We calculated Mantel-Haenszel odds ratios (ORs) and mean difference (MD) and 95% confidence intervals (CIs). MAIN RESULTS: We included five RCTs with 413 women. They compared true acupuncture versus sham acupuncture (two RCTs), true acupuncture versus relaxation (one RCT), true acupuncture versus clomiphene (one RCT) and electroacupuncture versus physical exercise (one RCT). Four of the studies were at high risk of bias in at least one domain.No study reported live birth rate. Two studies reported clinical pregnancy and found no evidence of a difference between true acupuncture and sham acupuncture (OR 2.72, 95% CI 0.69 to 10.77, two RCTs, 191 women, very low quality evidence).Three studies reported ovulation. One RCT reported number of women who had three ovulations during three months of treatment but not ovulation rate. One RCT found no evidence of a difference in mean ovulation rate between true and sham acupuncture (MD -0.03, 95% CI -0.14 to 0.08, one RCT, 84 women, very low quality evidence). However, one other RCT reported very low quality evidence to suggest that true acupuncture might be associated with higher ovulation frequency than relaxation (MD 0.35, 95% CI 0.14 to 0.56, one RCT, 28 women).Two studies reported menstrual frequency. One RCT reported true acupuncture reduced days between menstruation more than sham acupuncture (MD 220.35, 95% CI 252.85 to 187.85, 146 women). One RCT reported electroacupuncture increased menstrual frequency more than no intervention (0.37, 95% CI 0.21 to 0.53, 31 women).There was no evidence of a difference between the groups in adverse events. Evidence was very low quality with very wide CIs and very low event rates.Overall evidence was low or very low quality. The main limitations were failure to report important clinical outcomes and very serious imprecision. AUTHORS' CONCLUSIONS: Thus far, only a limited number of RCTs have been reported. At present, there is insufficient evidence to support the use of acupuncture for treatment of ovulation disorders in women with PCOS.  
  Address Faculty of Science, University of Technology Sydney, C/O Earlwood Medical Centre,, 356 Homer Street, Earlwood, New South Wales, Australia, 2206  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition Polycystic Ovarian Syndrome
  Disease Category Genital Diseases, Female OCSI Score  
  Notes PMID:27136291 Approved yes  
  Call Number OCOM @ refbase @ Serial 2060  
Permanent link to this record
 

 
Author Ren, L.-N.; Guo, L.-H.; Ma, W.-Z.; Zhang, R. url  openurl
  Title [A meta-analysis on acupuncture treatment of polycystic ovary syndrome] Type of Study Systematic Review
  Year 2014 Publication Zhen ci yan jiu = Acupuncture Research / [Zhongguo yi xue ke xue Yuan Yi xue Qing bao yan jiu suo Bian ji] Abbreviated Journal Zhen Ci Yan Jiu  
  Volume 39 Issue 3 Pages 238-246  
  Keywords Systematic Review; Meta-analysis; PCOS; Genital Diseases, Female; Polycystic Ovarian Syndrome; Women's Health; Gynecology  
  Abstract OBJECTIVE: To evaluate the effect and safety of acupuncture treatment of polycystic ovary syndrome (PCOS) by using systematic review in view of evidence-based medicine (EBM). METHODS: Original articles about acupuncture treatment of PCOS published from the database-established year to November of 2013 were searched from the Chinese National Knowledge Infrastructure Database (CNKI), Chongqing VIP Chinese Science and Technology Periodical Database (VIP), Chinese Biomedical Library (CBM), Wanfang Data, PubMed, and the Cochrane Library and the associated references-indicated papers by using keywords of polycystic ovary syndrome, randomization, acupoint, acupuncture, acupuncture plus moxibustion, acupuncture plus acupoint-embedment of catgut, and acupuncture plus otopoint application. Those articles about treatment of PCOS with simple abdominal acupuncture, simple acupoint-embedment of catgut, simple otopoint-pellet-pressure, and simple moxibustion treatment, and simple abstracts were excluded. If the articles re-published in both Chinese and English and in academic conferences and journals, one of them with higher quality was included. Two independent reviewers extracted data from located articles in a pre-defined structured way, and the Meta-analysis was conducted using software RevMan 5.2, otherwise using the qualitative analysis. RESULTS: A total of 31 articles (28 in Chinese, 3 in English) containing 2,321 cases of PCOS patients met the included criteria. Meta-analysis showed that the clinical efficacy of simple acupuncture was the same as that of western medicine, and the efficacy of acupuncture combined with Chinese herbal medicine interventions was obviously higher than that of western medicine (P < 0.05). In addition, simple acupuncture intervention and acupuncture combined with Chinese herbal medicines or with moxibustion treatment have advantages in reducing serum luteinizing hormone/follicle-stimulating hormone (LH/FSH), insulin resistance (IR), testosterone (T), and body mass index (BMI). However, the quality of the collected articles is generally lower due to unclear bias, no sample quantity estimation, incorrect randomization methods, no follow-up survey, etc. CONCLUSION: Acupuncture therapy may be effective for PCOS, but needs to be confirmed further by larger sample randomized controlled trials.  
  Address  
  Publisher
  Language Chinese Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition Polycystic Ovarian Syndrome
  Disease Category Genital Diseases, Female OCSI Score  
  Notes PMID:25069203 Approved yes  
  Call Number OCOM @ refbase @ Serial 2106  
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