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Author Bezerra, A.G.; Pires, G.N.; Andersen, M.L.; Tufik, S.; Hachul, H. url  openurl
  Title Acupuncture to Treat Sleep Disorders in Postmenopausal Women: A Systematic Review Type of Study Journal Article
  Year 2015 Publication Evidence-based Complementary & Alternative Medicine (eCAM) Abbreviated Journal Evidence-based Complementary & Alternative Medicine (eCAM)  
  Volume (down) 2015 Issue Pages 1-16  
  Keywords SLEEP disorders -- Treatment; SLEEP -- Evaluation; Acupuncture; ACUPUNCTURE points; COMPARATIVE studies; LONGITUDINAL method; CASE study (Research); Medline; ONLINE information services; RESEARCH -- Finance; SLEEP apnea syndromes; SYSTEMATIC reviews (Medical research); Polysomnography; RANDOMIZED controlled trials; TREATMENT effectiveness; RESEARCH bias; Postmenopause  
  Abstract Sleep disorders are commonly observed among postmenopausal women, with negative effects on their quality of life. The search for complementary therapies for sleep disorders during postmenopausal period is of high importance, and acupuncture stands out as an appropriate possibility. The present review intended to systematically evaluate the available literature, compiling studies that have employed acupuncture as treatment to sleep disorders in postmenopausal women. A bibliographic search was performed in PubMed/Medline and Scopus. Articles which had acupuncture as intervention, sleep related measurements as outcomes, and postmenopausal women as target population were included and evaluated according to the Cochrane risk of bias tool and to the STRICTA guidelines. Out of 89 search results, 12 articles composed our final sample. A high heterogeneity was observed among these articles, which prevented us from performing a meta-analysis. Selected articles did not present high risk of bias and had a satisfactory compliance rate with STRICTA guidelines. In general, these studies presented improvements in sleep-related variables. Despite the overall positive effects, acupuncture still cannot be stated as a reliable treatment for sleep-related complaints, not due to inefficacy, but rather limited evidence. Nevertheless, results are promising and new comprehensive and controlled studies in the field are encouraged.  
  Address  
  Publisher Hindawi Limited
  Language Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes Accession Number: 109322047; Source Information: 8/23/2015, Vol. 2015, p1; Subject Term: SLEEP disorders -- Treatment; Subject Term: SLEEP -- Evaluation; Subject Term: ACUPUNCTURE; Subject Term: ACUPUNCTURE points; Subject Term: COMPARATIVE studies; Subject Term: LONGITUDINAL method; Subject Term: CASE study (Research); Subject Term: MEDLINE; Subject Term: ONLINE information services; Subject Term: RESEARCH -- Finance; Subject Term: SLEEP apnea syndromes; Subject Term: SYSTEMATIC reviews (Medical research); Subject Term: POLYSOMNOGRAPHY; Subject Term: RANDOMIZED controlled trials; Subject Term: TREATMENT effectiveness; Subject Term: RESEARCH bias; Subject Term: POSTMENOPAUSE; Subject Term: ; Number of Pages: 16p; ; Illustrations: 1 Diagram, 3 Charts, 1 Graph; ; Document Type: Article; Approved no  
  Call Number OCOM @ refbase @ Serial 2267  
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Author Huang, M. I.; Nir, Y.; Chen, B.; Schnyer, R.; Manber, R. url  openurl
  Title A randomized controlled pilot study of acupuncture for postmenopausal hot flashes: effect on nocturnal hot flashes and sleep quality Type of Study RCT
  Year 2006 Publication Fertility and sterility Abbreviated Journal Fertil Steril  
  Volume (down) 86 Issue 3 Pages 700-710  
  Keywords Acu Versus Sham; Acupuncture; AcuTrials; Hot Flashes; Manualized Acupuncture Protocol; Non Penetrating Sham, Mechanical; Perimenopause; Pilot Study; Postmenopause; RCT; Sham Acupoint Control; Sham Control; Sleep Quality; TCM Acupuncture Style; Traditional Diagnosis Based Point Selection; Women's Health; Restricted Modalities, Acupuncture Only  
  Abstract OBJECTIVE: To assess the effectiveness of acupuncture on postmenopausal nocturnal hot flashes and sleep. DESIGN: Prospective randomized placebo-controlled study. SETTING: Stanford University School of Medicine and private acupuncture offices. INTERVENTION(S): Active or placebo acupuncture was administered for nine sessions over seven weeks. MAIN OUTCOME MEASURE(S): Severity and frequency of nocturnal hot flashes from daily diaries and Pittsburgh Sleep Quality Index (PSQI). PATIENT(S): Twenty-nine postmenopausal women experiencing at least seven moderate to severe hot flashes daily, with E(2) <18 pg/mL and FSH 30.0-110.0 IU/L. RESULT(S): Nocturnal hot-flash severity significantly decreased in the active acupuncture group (28%) compared with the placebo group (6%), P=.017. The frequency of nocturnal hot flashes also decreased in the active group (47%, P=.001), though it was not significantly different from the placebo group (24%, P=.170; effect size = 0.65). Treatment did not differentially influence sleep; however, correlations between improvements in PSQI and reductions in nocturnal hot flash severity and frequency were significant (P<.026). CONCLUSION(S): Acupuncture significantly reduced the severity of nocturnal hot flashes compared with placebo. Given the strength of correlations between improvements in sleep and reductions in nocturnal hot flashes, further exploration is merited  
  Address Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA  
  Publisher
  Language Number of Treatments 9  
  Treatment Follow-up 4 Weeks Frequency >1/WK Number of Participants 29  
  Time in Treatment 7 Weeks Condition Hot Flashes
  Disease Category Climacteric OCSI Score 83  
  Notes Approved no  
  Call Number Serial 476  
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Author Bokmand, S.; Flyger, H. url  doi
openurl 
  Title Acupuncture relieves menopausal discomfort in breast cancer patients: a prospective, double blinded, randomized study Type of Study RCT
  Year 2013 Publication Breast (Edinburgh, Scotland) Abbreviated Journal Breast  
  Volume (down) 22 Issue 3 Pages 320-323  
  Keywords AcuTrials; Climacteric; Menopause; RCT; Acu Versus > 1 Control; Acupuncture; TCM Acupuncture Style; Fixed Acupuncture Protocol; Restricted Modalities, Acupuncture Only; Sham Control; Penetrating Sham; Superficial Needling Depth; Near Verum Acupoint Control; Breast Cancer; Neoplasms; Women's Health; Postmenopause; Hot Flashes; Cancer  
  Abstract BACKGROUND: This study evaluates the effect of acupuncture on hot flashes and disturbed night sleep in patients treated for breast cancer. The effect of acupuncture was tested against a sham-acupuncture group and a no-treatment control group. Plasma estradiol was measured to rule out this as cause of effect. Side effects of the treatment were registered. METHODS: We randomized 94 women into the study: 31 had acupuncture, 29 had sham acupuncture and 34 had no treatment. FINDINGS: In the acupuncture group, 16 patients (52%) experienced a significant effect on hot flashes compared with seven patients (24%) in the sham group (p < 0.05). The effect came after the second acupuncture session and lasted for at least 12 weeks after last treatment. A statistically significant positive effect was seen on sleep in the acupuncture group compared with the sham-acupuncture and no-treatment groups. The effect was not correlated with increased levels of plasma estradiol. No side effects of acupuncture were registered. INTERPRETATION: We find that acupuncture significantly relieves hot flashes and sleep disturbances and is a good and safe treatment in women treated for breast cancer.  
  Address Department of Breast Surgery, Vejle Hospital, Denmark. sbok0003@heh.regionh.dk  
  Publisher
  Language Number of Treatments 5  
  Treatment Follow-up 12 Weeks Frequency 1/WK Number of Participants 94  
  Time in Treatment 5 Weeks Condition Menopause
  Disease Category Climacteric OCSI Score  
  Notes Approved no  
  Call Number Serial 82  
Permanent link to this record
 

 
Author Nedeljkovic, M.; Tian, L.; Ji, P.; Deglon-Fischer, A.; Stute, P.; Ocon, E.; Birkhauser, M.; Ausfeld-Hafter, B. url  doi
openurl 
  Title Effects of acupuncture and Chinese herbal medicine (Zhi Mu 14) on hot flushes and quality of life in postmenopausal women: results of a four-arm randomized controlled pilot trial Type of Study RCT
  Year 2014 Publication Menopause (New York, N.Y.) Abbreviated Journal Menopause  
  Volume (down) 21 Issue 1 Pages 15-24  
  Keywords Climacteric; Hot Flashes; Menopause; Postmenopause; RCT; Pilot Study; Acu Versus > 1 Control; Acupuncture; Herbal Formula; TCM Acupuncture Style; Semi-Individualized Acupuncture Protocol; Traditional Diagnosis Based Point Selection; Restricted Modalities, Acupuncture Only; Sham Control; Penetrating Sham; Superficial Needling Depth; Sham Acupoint Control; CAM Control; Placebo Herbal Formula  
  Abstract OBJECTIVE: The aim of this study was to evaluate the feasibility of a clinical trial investigating the effects of acupuncture (AP) and Chinese herbal medicine (CHM) on hot flushes and quality of life in postmenopausal women. METHODS: Forty postmenopausal women reporting at least 20 hot flushes per week were enrolled in a randomized controlled trial. They were randomly allocated to receive traditional Chinese medicine (TCM) AP, sham AP, verum CHM, or placebo CHM for 12 weeks. Follow-up assessment was conducted 12 weeks after intervention. Primary outcome measures included hot flush frequency and severity. As a secondary outcome measure, the severity of menopausal symptoms was assessed using the Menopause Rating Scale (MRS) II. RESULTS: TCM AP induced a significant decline in all outcome measures from pretreatment to posttreatment compared with sham AP (hot flush frequency, P = 0.016; hot flush severity, P = 0.013; MRS, P < 0.001). In the TCM AP group, a larger decrease in MRS scores persisted from pretreatment to follow-up (P = 0.048). No significant differences were noted between the verum CHM group and the placebo CHM group. Compared with the verum CHM group, there was a significant decrease in MRS scores (P = 0.002) and a trend toward a stronger decrease in hot flush severity (P = 0.06) in the TCM AP group from pretreatment to posttreatment. CONCLUSIONS: TCM AP is superior to sham AP and verum CHM in reducing menopausal symptoms, whereas verum CHM shows no significant improvements when compared with placebo CHM.  
  Address Institute of Complementary Medicine KIKOM, University of Bern, Bern, Switzerland  
  Publisher
  Language Number of Treatments 12  
  Treatment Follow-up 12 Weeks Frequency 1/WK Number of Participants 40  
  Time in Treatment 12 Weeks Condition Hot Flashes
  Disease Category Climacteric OCSI Score  
  Notes Approved no  
  Call Number Serial 901  
Permanent link to this record
 

 
Author Chien, T.-J.; Liu, C.-Y.; Chang, Y.-F.; Fang, C.-J.; Hsu, C.-H. url  openurl
  Title Acupuncture for Treating Aromatase Inhibitor-Related Arthralgia in Breast Cancer: A Systematic Review and Meta-Analysis Type of Study Journal Article
  Year 2015 Publication Journal of Alternative & Complementary Medicine Abbreviated Journal Journal of Alternative & Complementary Medicine  
  Volume (down) 21 Issue 5 Pages 251-260  
  Keywords CLINICAL trials -- Evaluation; RESEARCH methodology evaluation; ARTHRALGIA -- Treatment; ALTERNATIVE medicine; BREAST tumors; CHI-squared test; CINAHL (Information retrieval system); CONFIDENCE intervals; Cytokines; EXPERIMENTAL design; INFORMATION storage & retrieval systems -- Medical care; INFORMATION storage & retrieval systems -- Medicine; Medline; META-analysis; ONLINE information services; PHYSICAL therapy; PROBABILITY theory; WOMEN -- Health; SYSTEMATIC reviews (Medical research); EVIDENCE-based medicine; PROFESSIONAL practice; PAIN measurement; RANDOMIZED controlled trials; TREATMENT effectiveness; Postmenopause; AROMATASE inhibitors; DATA analysis -- Software; FUNCTIONAL assessment; Arthralgia; DESCRIPTIVE statistics; ACUPUNCTURE analgesia; Evaluation; Taiwan  
  Abstract Purpose: Acupuncture has been used as a complementary medical treatment for arthralgia and other types of pain. The objective of this review is to assess the effectiveness of acupuncture in the treatment of arthralgia in patients with breast cancer who were treated with aromatase inhibitors (AIs). Methods: A literature search was performed, without language restrictions, of 10 databases from their inception through February 2014. The literature reviewed included randomized clinical trials (RCTs) and clinical trials that compared real versus sham acupuncture for the treatment of AI-related musculoskeletal symptoms (AIMSS). The methodologic quality of these trials was assessed by using the modified Jadad Quality Scale. Meta-analytic software (RevMan 5.0) was used to analyze the data. Results: Five To compare the effects of real versus sham acupuncture, five RCTs were assessed by meta-analysis and quality analysis. Three of the RCTs reported favorable effects with regard to use of acupuncture in reducing pain and joint-related symptoms, while the other two RCTs did not. The meta-analysis showed trends toward reduced pain and stiffness in patients given acupuncture compared with those who received sham treatment ( n=82; pain, mean difference: ?2.07 [95% confidence interval (CI), ?4.72 to 0.57]; p=0.12; stiffness, mean difference: ?86.10 [95% CI, ?249.11 to 76.92]; p=0.30), although these differences were not statistically significant. Conclusions: Acupuncture has been reported as a safe and promising treatment for AIMSS, but the present analysis indicated that the effects were not statistically significant. Other outcome measurements, such as imaging studies, would be worth including in future studies to further confirm the efficacy of acupuncture in AIMSS.  
  Address  
  Publisher Mary Ann Liebert, Inc.
  Language Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes Accession Number: 102579991; Source Information: May2015, Vol. 21 Issue 5, p251; Subject Term: CLINICAL trials -- Evaluation; Subject Term: RESEARCH methodology evaluation; Subject Term: ARTHRALGIA -- Treatment; Subject Term: ALTERNATIVE medicine; Subject Term: BREAST tumors; Subject Term: CHI-squared test; Subject Term: CINAHL (Information retrieval system); Subject Term: CONFIDENCE intervals; Subject Term: CYTOKINES; Subject Term: EXPERIMENTAL design; Subject Term: INFORMATION storage & retrieval systems -- Medical care; Subject Term: INFORMATION storage & retrieval systems -- Medicine; Subject Term: MEDLINE; Subject Term: META-analysis; Subject Term: ONLINE information services; Subject Term: PHYSICAL therapy; Subject Term: PROBABILITY theory; Subject Term: WOMEN -- Health; Subject Term: SYSTEMATIC reviews (Medical research); Subject Term: EVIDENCE-based medicine; Subject Term: PROFESSIONAL practice; Subject Term: PAIN measurement; Subject Term: RANDOMIZED controlled trials; Subject Term: TREATMENT effectiveness; Subject Term: POSTMENOPAUSE; Subject Term: AROMATASE inhibitors; Subject Term: DATA analysis -- Software; Subject Term: FUNCTIONAL assessment; Subject Term: ARTHRALGIA; Subject Term: DESCRIPTIVE statistics; Subject Term: ACUPUNCTURE analgesia; Subject Term: EVALUATION; Subject Term: ; Geographic Subject: TAIWAN; Geographic Subject: ; Number of Pages: 10p; ; Document Type: Article; Approved no  
  Call Number OCOM @ refbase @ Serial 2265  
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Author Chien, T.-J.; Liu, C.-Y.; Chang, Y.-F.; Fang, C.-J.; Hsu, C.-H. url  doi
openurl 
  Title Acupuncture for Treating Aromatase Inhibitor-Related Arthralgia in Breast Cancer: A Systematic Review and Meta-Analysis Type of Study Journal Article
  Year 2015 Publication Journal of Alternative & Complementary Medicine Abbreviated Journal J Altern Complement Med  
  Volume (down) 21 Issue 5 Pages 251-260  
  Keywords Breast Neoplasms -- Drug Therapy; Aromatase Inhibitors -- Adverse Effects; Arthralgia -- Therapy; Acupuncture Analgesia; Human; Professional Practice, Evidence-Based; Systematic Review; Meta Analysis; Taiwan; Female; Women's Health; Alternative Therapies; Randomized Controlled Trials -- Evaluation; Clinical Trials -- Evaluation; Research Methodology -- Evaluation; Study Design -- Evaluation; Scales; Data Analysis Software; Arthralgia -- Etiology; Arthralgia -- Chemically Induced; Medline; PubMed; Embase; Cochrane Library; CINAHL Database; Physiotherapy Evidence Database; Checklists; Postmenopause; Pain Measurement -- Methods; Functional Assessment; Cytokines -- Blood; Confidence Intervals; P-Value; Chi Square Test; Descriptive Statistics; Treatment Outcomes  
  Abstract Purpose: Acupuncture has been used as a complementary medical treatment for arthralgia and other types of pain. The objective of this review is to assess the effectiveness of acupuncture in the treatment of arthralgia in patients with breast cancer who were treated with aromatase inhibitors (AIs). Methods: A literature search was performed, without language restrictions, of 10 databases from their inception through February 2014. The literature reviewed included randomized clinical trials (RCTs) and clinical trials that compared real versus sham acupuncture for the treatment of AI-related musculoskeletal symptoms (AIMSS). The methodologic quality of these trials was assessed by using the modified Jadad Quality Scale. Meta-analytic software (RevMan 5.0) was used to analyze the data. Results: Five To compare the effects of real versus sham acupuncture, five RCTs were assessed by meta-analysis and quality analysis. Three of the RCTs reported favorable effects with regard to use of acupuncture in reducing pain and joint-related symptoms, while the other two RCTs did not. The meta-analysis showed trends toward reduced pain and stiffness in patients given acupuncture compared with those who received sham treatment ( n=82; pain, mean difference: ?2.07 [95% confidence interval (CI), ?4.72 to 0.57]; p=0.12; stiffness, mean difference: ?86.10 [95% CI, ?249.11 to 76.92]; p=0.30), although these differences were not statistically significant. Conclusions: Acupuncture has been reported as a safe and promising treatment for AIMSS, but the present analysis indicated that the effects were not statistically significant. Other outcome measurements, such as imaging studies, would be worth including in future studies to further confirm the efficacy of acupuncture in AIMSS.  
  Address Medical Library, Mackay Memorial Hospital, Taipei, Taiwan.  
  Publisher Mary Ann Liebert, Inc.
  Language Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes Accession Number: 103798719. Language: English. Entry Date: 20150512. Revision Date: 20160502. Publication Type: Journal Article; meta analysis; research; systematic review; tables/charts. Journal Subset: Alternative/Complementary Therapies; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Evidence-Based Practice; Oncologic Care; Pain and Pain Management; Women's Health. Instrumentation: Jadad Scale [modified]. NLM UID: 9508124. Approved no  
  Call Number OCOM @ refbase @ 103798719 Serial 2307  
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Author Sandberg, M.; Wijma, K.; Wyon, Y.; Nedstrand, E.; Hammar, M. url  openurl
  Title Effects of electro-acupuncture on psychological distress in postmenopausal women Type of Study RCT
  Year 2002 Publication Complementary therapies in medicine Abbreviated Journal Complement Ther Med  
  Volume (down) 10 Issue 3 Pages 161-169  
  Keywords Acu Versus Sham; Acupuncture; AcuTrials; Climacteric; Depression; Depressive Disorder; Electroacupuncture; Fixed Acupuncture Protocol; Penetrating Sham; Menopause; Mental Disorders; Near Verum Acupoint Control; Restricted Modalities, Acupuncture Only; Superficial Needling Depth; Sham Control; TCM Acupuncture Style; Women's Health; Climacteric; Postmenopause  
  Abstract OBJECTIVES: To evaluate effects of electro-acupuncture (EA) on general psychological distress and relate to experience of climacteric symptoms in 30 postmenopausal women. DESIGN: A randomised single-blind controlled design was used to evaluate effects of EA and extremely superficial needle insertion, with the latter serving as a near-placebo control. SETTINGS: The Linkoping University Hospital in Sweden. Interventions: Fourteen treatments during 12 weeks with follow-ups at 3 and 6 months. OUTCOME MEASURES: General psychological well-being, mood and experience of climacteric symptoms. RESULTS: Mood Scale improved only in EA group and not until 12 weeks compared to baseline, from 110 to 129 (P = 0.01), and to 120 at 3-month follow-up (P = 0.04). Mood was significantly better than control at 8 (P = 0.05) and 12 weeks (P = 0.01). Visual analogue scale estimation of climacteric symptoms was decreased at 4 weeks in both groups, and lasted throughout the study period, in EA group from 5 to 2 (P = 0.04) and in control group from 5 to 3 (P = 0.02) at 6-month follow-up. Well-being was ameliorated from 4 weeks in EA and from 8 weeks in control group until end of study (P = 0.01, P = 0.03). No significant differences on climacteric symptoms or well-being existed between the groups. CONCLUSIONS: This study does not show that EA is better than superficial needle insertion for the amelioration of general psychological distress and experience of climacteric symptoms in women with vasomotor symptoms after menopause. However, the more pronounced effect on mood suggests that EA might have additional effects compared with superficial needle insertion  
  Address Division of Rehabilitation Medicine, Faculty of Health Sciences, University Hospital, Linkoping, Sweden. margareta.sandberg@lio.se  
  Publisher
  Language Number of Treatments 14  
  Treatment Follow-up 24 Weeks Frequency >1/WK Number of Participants 30  
  Time in Treatment 12 Weeks Condition Postmenopause
  Disease Category Climacteric OCSI Score 72  
  Notes Approved no  
  Call Number Serial 1013  
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Author Nedstrand, E.; Wijma, K.; Wyon, Y.; Hammar, M. url  openurl
  Title Vasomotor symptoms decrease in women with breast cancer randomized to treatment with applied relaxation or electro-acupuncture: a preliminary study Type of Study RCT
  Year 2005 Publication Abbreviated Journal Climacteric  
  Volume (down) 8 Issue 3 Pages 243-250  
  Keywords CAM Control; Acu Versus CAM Control; Acupuncture; AcuTrials; Applied Relaxation; Breast Cancer; Cancer; Electroacupuncture; Fixed Acupuncture Protocol; Hot Flashes; Postmenopause; RCT; Relaxation; Restricted Modalities, Acupuncture Only; TCM Acupuncture Style; Vasomotor Symptoms; Women's Health; Neoplasms  
  Abstract OBJECTIVE: To evaluate the effect of applied relaxation and electro-acupuncture on vasomotor symptoms in women treated for breast cancer. METHODS: Thirty-eight postmenopausal women with breast cancer and vasomotor symptoms were randomized to treatment with electro-acupuncture (n = 19) or applied relaxation (n = 19) during 12 weeks. The number of hot flushes was registered daily in a logbook before and during treatment and after 3 and 6 months of follow-up. RESULTS: Thirty-one women completed 12 weeks of treatment and 6 months of follow-up. After 12 weeks of applied relaxation, the number of flushes/24 h had decreased from 9.2 (95% confidence interval (CI) 6.6-11.9) at baseline to 4.5 (95% CI 3.2-5.8) and to 3.9 (95% CI 1.8-6.0) at 6 months follow-up (n = 14). The flushes/24 h were reduced from 8.4 (95% CI 6.6-10.2) to 4.1 (95% CI 3.0-5.2) after 12 weeks of treatment with electro-acupuncture and to 3.5 (95% CI 1.7-5.3) after 6 months follow-up (n = 17). In both groups, the mean Kupperman Index score was significantly reduced after treatment and remained unchanged 6 months after end of treatment. CONCLUSION: We suggest that applied relaxation and electro-acupuncture should be further evaluated as possible treatments for vasomotor symptoms in postmenopausal women with breast cancer  
  Address Division of Obstetrics and Gynecology and Unit of Medical Psychology, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linkoping, Sweden  
  Publisher
  Language Number of Treatments 14  
  Treatment Follow-up 24 Weeks Frequency >1/WK Number of Participants 38  
  Time in Treatment 12 Weeks Condition Hot Flashes
  Disease Category Neoplasms OCSI Score  
  Notes Approved no  
  Call Number Serial 902  
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Author Crew, K. D.; Capodice, J. L.; Greenlee, H.; Apollo, A.; Jacobson, J. S.; Raptis, G.; Blozie, K.; Sierra, A.; Hershman, D. L. url  openurl
  Title Pilot study of acupuncture for the treatment of joint symptoms related to adjuvant aromatase inhibitor therapy in postmenopausal breast cancer patients Type of Study RCT
  Year 2007 Publication Abbreviated Journal J Cancer S  
  Volume (down) 1 Issue 4 Pages 283-291  
  Keywords Acu Versus No Treatment; Acupuncture; AcuTrials; Aromatase Inhibitor Therapy; Auricular Acupuncture; Breast Cancer; Cancer; Cross-Over Design; No Treatment Control; Pain; Pilot Study; Postmenopause; RCT; Semi-Individualized Acupuncture Protocol; TCM Acupuncture Style; Traditional Diagnosis Based Point Selection; Neoplasms; Arthritis  
  Abstract INTRODUCTION: Aromatase inhibitors (AIs) have become the standard of care for the adjuvant treatment of postmenopausal, hormone-sensitive breast cancer. However, patients receiving AIs may experience joint symptoms, which may lead to early discontinuation of this effective therapy. We hypothesize that acupuncture is a safe and effective treatment for AI-induced arthralgias. METHODS: Postmenopausal women with early-stage breast cancer who had self-reported musculoskeletal pain related to adjuvant AI therapy were randomized in a crossover study to receive acupuncture twice weekly for 6 weeks followed by observation or vice-versa. The intervention included full body and auricular acupuncture, and a joint-specific point prescription. Outcome measures included the Brief Pain Inventory-Short Form (BPI-SF), Western Ontario and McMaster Universities Osteoarthritis (WOMAC) index, the Functional Assessment of Cancer Therapy-General (FACT-G) quality of life measure, and serum levels of inflammatory markers, IL-1 beta and TNF-alpha. RESULTS: Twenty-one women were enrolled and two discontinued early. From baseline to the end of treatment, patients reported improvement in the mean BPI-SF worst pain scores (5.3 to 3.3, p = 0.01), pain severity (3.7 to 2.5, p = 0.02), and pain-related functional interference (3.1 to 1.7, p = 0.02), as well as the WOMAC function subscale and FACT-G physical well-being (p = 0.02 and 0.04, respectively). No adverse events were reported. DISCUSSION/CONCLUSIONS: In this pilot study, acupuncture reduced AI-related joint symptoms and improved functional ability and was well-tolerated. IMPLICATIONS FOR CANCER SURVIVORS: Musculoskeletal side effects are common among breast cancer survivors on adjuvant AI therapy, therefore, effective treatments are needed for symptom relief and to improve adherence to these life-saving medications  
  Address Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA  
  Publisher
  Language Number of Treatments 12  
  Treatment Follow-up 6 Weeks Frequency >1/WK Number of Participants 21  
  Time in Treatment 6 Weeks Condition Arthritis
  Disease Category Neoplasms OCSI Score  
  Notes Approved no  
  Call Number Serial 211  
Permanent link to this record
 

 
Author Kim, D. I.; Jeong, J. C.; Kim, K. H.; Rho, J. J.; Choi, M. S.; Yoon, S. H.; Choi, S. M.; Kang, K. W.; Ahn, H. Y.; Lee, M. S. url  openurl
  Title Acupuncture for hot flushes in perimenopausal and postmenopausal women: a randomised, sham-controlled trial Type of Study RCT
  Year 2011 Publication Acupuncture in medicine : journal of the British Medical Acupuncture Society Abbreviated Journal Acupunct Med  
  Volume (down) Issue Pages -  
  Keywords AcuTrials; RCT; Climacteric; Hot Flashes; Perimenopause; Postmenopause; Acu Versus Sham; Acupuncture; Korean Acupuncture Style; Sham Control; Penetrating Sham; Standard Needling Depth; Near Verum Acupoint Control; Fixed Acupuncture Protocol; Restricted Modalities, Acupuncture Only  
  Abstract OBJECTIVES: To determine the effect of acupuncture in treating hot flushes in perimenopausal or postmenopausal women. METHODS: The study was a randomised single-blind sham-controlled clinical trial. Perimenopausal or postmenopausal women with moderate or severe hot flushes were randomised to receive real or sham acupuncture. Both groups underwent a 4-week run-in period before the treatment. The real acupuncture group received 11 acupuncture treatments for 7 weeks, and the control group underwent sham acupuncture on non-acupuncture points during the same period. Both groups were followed for 8 weeks after the end of treatment period. Changes from baseline in the hot flush scores at week 7, measured by multiplying the hot flush frequency and severity, were the primary outcome. Hot flush frequency, severity and menopause-related symptoms measured with the Menopause Rating Scale Questionnaire were regarded as secondary outcomes. RESULTS: 54 participants were randomised into the real acupuncture group (n=27) and the sham acupuncture group (n=27). The mean change in hot flush scores was -6.4+/-5.2 in the real acupuncture group and -5.6+/-9.2 in the sham group at week 7 from values at the start of the acupuncture treatment (10.0+/-8.1 vs 11.7+/-12.6), respectively (p=0.0810). No serious adverse events were observed during the whole study period. CONCLUSIONS: Compared to sham acupuncture, acupuncture failed to show significantly different effects on the hot flush scores but showed partial benefits on the hot flush severity. Further consideration is needed to develop appropriate strategies for distinguishing non-specific effects from observed overall effectiveness of acupuncture for hot flushes. Whether acupuncture has point-specific effects for hot flushes should be also considered in designing future researches.  
  Address 1Department of Obstetrics and Gynecology, College of Traditional Korean Medicine, Dongguk University, Seoul, South Korea.  
  Publisher
  Language Number of Treatments 11  
  Treatment Follow-up 8 Weeks Frequency >1/WK Number of Participants 54  
  Time in Treatment 7 Weeks Condition Hot Flashes
  Disease Category Climacteric OCSI Score  
  Notes Approved no  
  Call Number Serial 567  
Permanent link to this record
 

 
Author Lin, C. H.; Lin, Y. M.; Liu, C. F. url  openurl
  Title Electrical acupoint stimulation changes body composition and the meridian systems in postmenopausal women with obesity Type of Study RCT
  Year 2010 Publication The American journal of Chinese medicine Abbreviated Journal Am J Chin Med  
  Volume (down) 38 Issue 4 Pages 683-694  
  Keywords AcuTrials; Climacteric; Postmenopause; Obesity; Nutritional and Metabolic Diseases; RCT; Acu Versus No Treatment; Electroacupuncture; TCM Acupuncture Style; Fixed Acupuncture Protocol; Restricted Modalities, Acupuncture Only; No Treatment Control; Weight Loss  
  Abstract This study evaluates the effects of electrical stimulation on body composition and the meridian system in postmenopausal women with obesity. Forty-one postmenopausal women were recruited in Taiwan. The body composition was used as a screening test for obesity (percentage of body fat: &gt; 30%, waist circumference: &gt; 80 cm). The experimental group (EG, n = 20) received modulated middle-frequency electrical stimulation treatment for 20 min twice a week for 12 consecutive weeks at the Zusanli (ST36) and Sanyinjiao (SP6) acupoints. The control group (CG, n = 21) did not receive any intervention. The measurements of body composition and the meridian system were recorded for both groups in the pre- and post-study. The results showed that the data of body composition (weight, waist and hip circumference, percentage of body fat, and percentage of lean muscle mass) changed considerably in the EG (p &lt; 0.05); however, no significant difference was observed in the CG. The left triple burner meridian changed notably in both EG and CG throughout the study (p &lt; 0.05), however there was no difference between the two groups in the overall mean value, up-down ratio, qi and blood ratio, and yin-yang ratio. Our findings suggest that modulated middle-frequency electrical stimulation could help to improve body composition in postmenopausal women with obesity, potentially providing them with better care and health by integrating Western medicine and traditional Chinese medicine.  
  Address Department of Nursing, Ching Kuo Institute of Management and Health, Keelung, Taiwan.  
  Publisher
  Language Number of Treatments 24  
  Treatment Follow-up N/A Frequency >1/WK Number of Participants 41  
  Time in Treatment 12 Weeks Condition Postmenopause
  Disease Category Climacteric OCSI Score  
  Notes Approved no  
  Call Number Serial 713  
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Author Nir, Y.; Huang, M. I.; Schnyer, R.; Chen, B.; Manber, R. url  openurl
  Title Acupuncture for postmenopausal hot flashes Type of Study RCT
  Year 2006 Publication Abbreviated Journal Maturitas  
  Volume (down) Issue Pages -  
  Keywords Acu Versus Sham; Acupuncture; AcuTrials; Hot Flashes; Semi-Individualized Acupuncture Protocol; Menopause; Non Penetrating Sham, Mechanical; Pilot Study; RCT; Sham Acupoint Control; Sham Control; TCM Acupuncture Style; Traditional Diagnosis Based Point Selection; Women's Health; Climacteric; Postmenopause; Restricted Modalities, Acupuncture Only  
  Abstract OBJECTIVE: To determine whether individually tailored acupuncture is an effective treatment option for reducing postmenopausal hot flashes and improving quality of life. METHODS: In a randomized, placebo-controlled pilot study, 29 postmenopausal participants averaging at least seven moderate to severe hot flashes per 24h, with a baseline estradiol concentration of less than 50pg/mL and a normal TSH level, were randomized to receive 7 weeks (nine treatment sessions) of either active acupuncture or placebo acupuncture (placebo needles that did not penetrate the skin at sham acupuncture points). Participants recorded hot flashes in logs that were reported daily. Global indices of the severity and frequency of hot flashes were derived from the participants' daily logs. RESULTS: Participants receiving the active treatment had a greater reduction in hot flash severity (24.5+/-30.7%) compared to those receiving placebo (4.4+/-17.1%, P=0.042). Within group repeated measures analyses of variance revealed a significant reduction in hot flash severity in the active (P=0.042), but not in the placebo treatment group (P=0.15). Although there was no significant group difference in the reduction of hot flash frequency between the active (42.4+/-32.2%) and placebo groups (32.0+/-26.5%; P>/=0.352), within group repeated measures analyses of variance revealed that the reduction was statistically significant in both groups (P</=0.001). CONCLUSIONS: Standardized, individually tailored acupuncture treatment was associated with significantly greater decrease in the severity, but not the frequency, of hot flashes, in symptomatic postmenopausal women when compared to placebo acupuncture of equal duration. Future, larger scale, studies are needed  
  Address Stanford University School of Medicine, United States  
  Publisher
  Language Number of Treatments 9  
  Treatment Follow-up 5 Weeks Frequency >1/WK Number of Participants 29  
  Time in Treatment 7 Weeks Condition Hot Flashes
  Disease Category Climacteric OCSI Score 70  
  Notes Approved no  
  Call Number Serial 913  
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Author Venzke, L.; Calvert, J. F., Jr.; Gilbertson, B. url  openurl
  Title A randomized trial of acupuncture for vasomotor symptoms in post-menopausal women Type of Study RCT
  Year 2010 Publication Complementary therapies in medicine Abbreviated Journal Complement Ther Med  
  Volume (down) 18 Issue 2 Pages 59-66  
  Keywords Climacteric; Postmenopause; RCT; Acu Versus Sham; Acupuncture; Electroacupuncture; TCM Acupuncture Style; Semi-Individualized Acupuncture Protocol; Sham Control; Non Penetrating Sham, Mechanical; Sham Acupoint Control; AcuTrials; Hot Flashes; Traditional Diagnosis Based Point Selection; Restricted Modalities, Acupuncture Only  
  Abstract OBJECTIVE: The goal of this study was to determine whether acupuncture would relieve the vasomotor symptoms of post-menopausal women. DESIGN: A randomized, single-blind trial. SETTING: A small city in a rural area of Eastern Oregon. INTERVENTIONS: Women were recruited into the study from the community by advertising or physician referral. All study subjects were in non-surgical menopause and medically stable. Study subjects were randomly assigned to receive 12 weeks of treatment with either Chinese Traditional Medicine (TCM) acupuncture (n=27) or shallow needle (sham) acupuncture (n=24). OUTCOME MEASURES: Study participants kept a diary recording their hot flashes each day. At baseline, study participants filled out Greene Climacteric Scales and the Beck Depression and Anxiety Inventories. These same outcomes were also measured at week 4 of treatment and at 1 week and 12 weeks after treatment. The number of hot flashes and the numeric scores on the Climacteric Scales and the Beck inventories were compared between the verum and shallow needling groups using two-way repeated measures. RESULTS: Both groups of women showed statistically significant improvement on all study parameters. However, there was no difference between the improvement in the shallow needle and verum acupuncture groups. Study subjects were not able to guess which group they had been assigned to. CONCLUSIONS: This study showed that both shallow needling and verum acupuncture were effective treatments of post-menopausal vasomotor symptoms. Study subjects were not able to distinguish shallow needling from real TCM acupuncture. Shallow needling may have therapeutic effects in itself reducing its utility as a “placebo” control for verum acupuncture. This result is consistent with other published studies.  
  Address Klamath Pain Clinic, Klamath Falls, OR 97601, USA.  
  Publisher
  Language Number of Treatments 16  
  Treatment Follow-up 12 Weeks Frequency >1/WK Number of Participants 51  
  Time in Treatment 12 Weeks Condition Postmenopause
  Disease Category Climacteric OCSI Score  
  Notes Approved no  
  Call Number Serial 1208  
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Author Wyon, Y.; Lindgren, R.; Lundeberg, T. openurl 
  Title Effects of Acupuncture on Climacteric Vasomotor Symptoms, Quality of Life, and Urinary Excretion of Neuropeptides amoung Postmenopausal Women Type of Study RCT
  Year 1995 Publication Abbreviated Journal Menopause  
  Volume (down) 2 Issue 1 Pages 3-12  
  Keywords Acu Versus Sham; Acupuncture; AcuTrials; Climacteric; Electroacupuncture; Fixed Acupuncture Protocol; Hot Flashes; Penetrating Sham; Menopause; Night Sweats; Postmenopause; RCT; Restricted Modalities, Acupuncture Only; Superficial Needling Depth; TCM Acupuncture Style; Verum Acupoint Control; Women's Health;  
  Abstract Most perimenopausal women suffer from vasomotor symptoms. Changes in central opioid activity have been proposed to be involved in the mechanisms of hot flushes after menopause. Because acupuncture increases central opioid activity, it may affect postmenopausal hot flushes. The aim was to study if and to what extent two different kinds of acupuncture affected postmenopausal hot flushes, urinary excretion of certain neuropeptides, and quality of life in a group of postmenopausal women. Twenty-four women with natural menopause and hot flushes were included. Twenty-one women completed the study. One group was randomized to electroacupuncture at 2 Hz, whereas the other group was treated with another form of acupuncture (i.e., superficial needle insertion) for a total of 8 weeks. All women daily registered the number and severity of flushes from 1 month before to 3 months after treatment. They completed Quality of Life questionnaires before, during, and after treatment. Twenty-four-hour urine was sampled before, during, and after treatment and analyzed for neuropeptides using radioimmunoassay methods. The number of flushes decreased significantly by >50% in both groups and remained decreased in the group receiving electroacupuncture, whereas in the superficial-needle-insertion group, the number of flushes increased again during the 3 months after treatment. The Kupperman Index decreased significantly in both groups during and after treatment. The excretion of the potent vasodilating neuropeptide calcitonin gene-related peptide-like immunoreactivity decreased significantly during treatment. Acupuncture significantly affects hot flushes and sweating episodes after menopause, with effects persisting at least 3 months after the end of treatment. Changes in calcitonin gene-related peptide, which is a very potent vasodilator, could be involved in the mechanisms behind hot flushes. (C)1995The North American Menopause Society  
  Address  
  Publisher
  Language Number of Treatments 10  
  Treatment Follow-up 12 Weeks Frequency >1/WK Number of Participants 21  
  Time in Treatment 8 Weeks Condition Postmenopause
  Disease Category Climacteric OCSI Score  
  Notes Approved no  
  Call Number Serial 1336  
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Author Wyon, Y.; Wijma, K.; Nedstrand, E.; Hammar, M. url  openurl
  Title A comparison of acupuncture and oral estradiol treatment of vasomotor symptoms in postmenopausal women Type of Study RCT
  Year 2004 Publication Abbreviated Journal Climacteric  
  Volume (down) 7 Issue 2 Pages 153-164  
  Keywords CAM Control; Acu Versus > 1 Control; AcuTrials; Electroacupuncture; Hot Flashes; Penetrating Sham; Near Verum Acupoint Control; RCT; Relaxation Techniques; Restricted Modalities, Acupuncture Only; Superficial Needling Depth; Usual Care Control, Pharmaceutical; Usual Care Control, Physical; Fixed Acupuncture Protocol; TCM Acupuncture Style; Women's Health; Climacteric; Postmenopause  
  Abstract OBJECTIVE: To compare the effects of electro-acupuncture with oral estradiol and superficial needle insertion on hot flushes in postmenopausal women. MATERIAL AND METHODS: Forty-five postmenopausal women with vasomotor symptoms were randomized to electro-acupuncture, superficial needle insertion or oral estradiol treatment during 12 weeks, with 6 months' follow-up. The number and severity of flushes were registered daily and the Kupperman index and a general estimate of climacteric symptoms were completed before, during and after therapy. RESULTS: In the electro-acupuncture group, the mean number of flushes/24 h decreased from 7.3 to 3.5 (ANOVA, p < 0.001). Eleven of the 15 women had at least a 50% decrease in number of flushes (with a mean decrease of 82%). Superficial needle insertion decreased the number of flushes/24 h from 8.1 to 3.8 (p < 0.001). In seven out of 13 women, the number of flushes decreased by at least 50% (mean decrease 83%). In the estrogen group, the number of flushes decreased from 8.4 to 0.8 (p < 0.001). The decrease in number of flushes persisted during the 24-week follow-up period in all treatment groups. The Kupperman index and the general climacteric symptom score decreased, and remained unchanged 24 weeks after treatment in all groups (p < 0.001). Electro-acupuncture decreased the number of flushes/24 h significantly over time, but not to the same extent as the estrogen treatment. No significant difference in effect was found between electro-acupuncture and the superficial needle insertion. CONCLUSION: We suggest that acupuncture is a viable alternative treatment of vasomotor symptoms in postmenopausal women and cannot recommend superficial needle insertion as an inactive control treatment  
  Address Faculty of Health Sciences, University Hospital, Linkoping, Sweden  
  Publisher
  Language Number of Treatments 14  
  Treatment Follow-up 24 Weeks Frequency 1/WK Number of Participants 45  
  Time in Treatment 12 Weeks Condition Hot Flashes
  Disease Category Climacteric OCSI Score 68  
  Notes Approved no  
  Call Number Serial 1337  
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Author Zaborowska, E.; Brynhildsen, J.; Damberg, S.; Fredriksson, M.; Lindh-Astrand, L.; Nedstrand, E.; Wyon, Y.; Hammar, M. url  openurl
  Title Effects of acupuncture, applied relaxation, estrogens and placebo on hot flushes in postmenopausal women: an analysis of two prospective, parallel, randomized studies Type of Study RCT
  Year 2007 Publication Abbreviated Journal Climacteric  
  Volume (down) 10 Issue 1 Pages 38-45  
  Keywords CAM Control; Acu Versus > 1 Control; Acupuncture; AcuTrials; Applied Relaxation; Electroacupuncture; Fixed Acupuncture Protocol; Hot Flashes; RCT; Women's Health; Climacteric; Postmenopause; Menopause  
  Abstract OBJECTIVE: To assess if transdermal or oral estrogens, acupuncture and applied relaxation decrease the number of menopausal hot flushes/24 h and improve climacteric symptoms, as assessed by the Kupperman index, more than transdermal placebo treatment. SETTING: An outpatient clinic at a Swedish university hospital. METHODS: A total of 102 postmenopausal women were recruited to two studies performed in parallel. In Study I, the women were randomized between transdermal placebo or estrogen treatment and, in Study II, between oral estrogens, acupuncture or applied relaxation for 12 weeks. Climacteric symptoms were measured with daily logbooks on hot flushes. Women completed the assessment questionnaire for the Kupperman index at baseline and after 12 weeks. RESULTS: The number of flushes/24 h decreased significantly after 4 and 12 weeks in all groups except the placebo group. Both at 4 and 12 weeks, acupuncture decreased the number of flushes more (p<0.05; p<0.01, respectively) than placebo. At 12 weeks, applied relaxation decreased the number of flushes more (p<0.05) than placebo. The Kupperman index score decreased in all groups except the placebo group. The decrease in score was significantly greater in all treatment groups than in the placebo group (p<0.01). CONCLUSION: Acupuncture and applied relaxation both reduced the number of hot flushes significantly better than placebo and should be further evaluated as alternatives to hormone therapy in women with menopausal vasomotor complaints  
  Address Division of Obstetrics and Gynecology, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, University Hospital, Linkoping, Sweden  
  Publisher
  Language Number of Treatments 14  
  Treatment Follow-up N/A Frequency 1/WK Number of Participants 102  
  Time in Treatment 12 Weeks Condition Hot Flashes
  Disease Category Climacteric OCSI Score 56  
  Notes Approved no  
  Call Number Serial 1415  
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