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Author Oka, H.; Matsudaira, K.; Takano, Y.; Kasuya, D.; Niiya, M.; Tonosu, J.; Fukushima, M.; Oshima, Y.; Fujii, T.; Tanaka, S.; Inanami, H. url  doi
openurl 
  Title A comparative study of three conservative treatments in patients with lumbar spinal stenosis: lumbar spinal stenosis with acupuncture and physical therapy study (LAP study) Type of Study Journal Article
  Year 2018 Publication BMC Complementary and Alternative Medicine Abbreviated Journal BMC Complement Altern Med  
  Volume 18 Issue 1 Pages 19  
  Keywords *Acupuncture Therapy; Aged; Conservative Treatment; Female; Humans; Lumbar Vertebrae/*physiopathology; Male; Patient Satisfaction; *Physical Therapy Modalities; Spinal Stenosis/*physiopathology/*therapy; Acupuncture; Conservative management; Exercise; Lumbar spinal stenosis; Medication; Zurich claudication questionnaire  
  Abstract BACKGROUND: Although the efficiency of conservative management for lumbar spinal stenosis (LSS) has been examined, different conservative management approaches have not been compared. We have performed the first comparative trial of three types of conservative management (medication with acetaminophen, exercise, and acupuncture) in Japanese patients with LSS. METHODS: Patients with L5 root radiculopathy associated with LSS who visited our hospital for surgical treatment were enrolled between December 2011 and January 2014. In this open-label study, patients were assigned to three treatment groups (medication, exercise, acupuncture) according to the visit time. The primary outcomes were Zurich claudication questionnaire (ZCQ) scores before and after 4 weeks of treatment. Least square mean analysis was used to assess the following dependent variables in the treatment groups: changes in symptom severity and physical function scores of the ZCQ and the ZCQ score of patient's satisfaction after treatment. RESULTS: Thirty-eight, 40, and 41 patients were allocated to the medication, exercise, and acupuncture groups, respectively. No patient underwent surgical treatment during the study period. The symptom severity scores of the ZCQ improved significantly after treatment in the medication (p = 0.048), exercise (p = 0.003), and acupuncture (p = 0.04) groups. The physical function score improved significantly in the acupuncture group (p = 0.045) but not in the medication (p = 0.20) and exercise (p = 0.29) groups. The mean reduction in the ZCQ score for physical function was significantly greater for acupuncture than for exercise. The mean ZCQ score for treatment satisfaction was significantly greater for acupuncture than for medication. CONCLUSIONS: Acupuncture was significantly more effective than physical exercise according to the physical function score of the ZCQ and than medication according to the satisfaction score. The present study provides new important information that will aid decision making in LSS treatment. TRIAL REGISTRATION: This study was registered with the UMIN Clinical Trials Registry ( UMIN000006957 ).  
  Address Department of Orthopedic Surgery, Iwai Orthopaedic Medical Hospital, Tokyo, Japan  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes PMID:29351748; PMCID:PMC5775532 Approved no  
  Call Number OCOM @ refbase @ Serial 2438  
Permanent link to this record
 

 
Author Oka, H.; Matsudaira, K.; Takano, Y.; Kasuya, D.; Niiya, M.; Tonosu, J.; Fukushima, M.; Oshima, Y.; Fujii, T.; Tanaka, S.; Inanami, H. url  doi
openurl 
  Title A comparative study of three conservative treatments in patients with lumbar spinal stenosis: lumbar spinal stenosis with acupuncture and physical therapy study (LAP study) Type of Study Journal Article
  Year 2018 Publication BMC Complementary and Alternative Medicine Abbreviated Journal BMC Complement Altern Med  
  Volume 18 Issue 1 Pages 19  
  Keywords *Acupuncture Therapy; Aged; Conservative Treatment; Female; Humans; Lumbar Vertebrae/*physiopathology; Male; Patient Satisfaction; *Physical Therapy Modalities; Spinal Stenosis/*physiopathology/*therapy; Acupuncture; Conservative management; Exercise; Lumbar spinal stenosis; Medication; Zurich claudication questionnaire  
  Abstract BACKGROUND: Although the efficiency of conservative management for lumbar spinal stenosis (LSS) has been examined, different conservative management approaches have not been compared. We have performed the first comparative trial of three types of conservative management (medication with acetaminophen, exercise, and acupuncture) in Japanese patients with LSS. METHODS: Patients with L5 root radiculopathy associated with LSS who visited our hospital for surgical treatment were enrolled between December 2011 and January 2014. In this open-label study, patients were assigned to three treatment groups (medication, exercise, acupuncture) according to the visit time. The primary outcomes were Zurich claudication questionnaire (ZCQ) scores before and after 4 weeks of treatment. Least square mean analysis was used to assess the following dependent variables in the treatment groups: changes in symptom severity and physical function scores of the ZCQ and the ZCQ score of patient's satisfaction after treatment. RESULTS: Thirty-eight, 40, and 41 patients were allocated to the medication, exercise, and acupuncture groups, respectively. No patient underwent surgical treatment during the study period. The symptom severity scores of the ZCQ improved significantly after treatment in the medication (p = 0.048), exercise (p = 0.003), and acupuncture (p = 0.04) groups. The physical function score improved significantly in the acupuncture group (p = 0.045) but not in the medication (p = 0.20) and exercise (p = 0.29) groups. The mean reduction in the ZCQ score for physical function was significantly greater for acupuncture than for exercise. The mean ZCQ score for treatment satisfaction was significantly greater for acupuncture than for medication. CONCLUSIONS: Acupuncture was significantly more effective than physical exercise according to the physical function score of the ZCQ and than medication according to the satisfaction score. The present study provides new important information that will aid decision making in LSS treatment. TRIAL REGISTRATION: This study was registered with the UMIN Clinical Trials Registry ( UMIN000006957 ).  
  Address Department of Orthopedic Surgery, Iwai Orthopaedic Medical Hospital, Tokyo, Japan  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes PMID:29351748; PMCID:PMC5775532 Approved no  
  Call Number OCOM @ refbase @ Serial 2479  
Permanent link to this record
 

 
Author Oka, H.; Matsudaira, K.; Takano, Y.; Kasuya, D.; Niiya, M.; Tonosu, J.; Fukushima, M.; Oshima, Y.; Fujii, T.; Tanaka, S.; Inanami, H. url  doi
openurl 
  Title A comparative study of three conservative treatments in patients with lumbar spinal stenosis: lumbar spinal stenosis with acupuncture and physical therapy study (LAP study) Type of Study Journal Article
  Year 2018 Publication BMC Complementary and Alternative Medicine Abbreviated Journal BMC Complement Altern Med  
  Volume 18 Issue 1 Pages 19  
  Keywords *Acupuncture Therapy; Aged; Conservative Treatment; Female; Humans; Lumbar Vertebrae/*physiopathology; Male; Patient Satisfaction; *Physical Therapy Modalities; Spinal Stenosis/*physiopathology/*therapy; Acupuncture; Conservative management; Exercise; Lumbar spinal stenosis; Medication; Zurich claudication questionnaire  
  Abstract BACKGROUND: Although the efficiency of conservative management for lumbar spinal stenosis (LSS) has been examined, different conservative management approaches have not been compared. We have performed the first comparative trial of three types of conservative management (medication with acetaminophen, exercise, and acupuncture) in Japanese patients with LSS. METHODS: Patients with L5 root radiculopathy associated with LSS who visited our hospital for surgical treatment were enrolled between December 2011 and January 2014. In this open-label study, patients were assigned to three treatment groups (medication, exercise, acupuncture) according to the visit time. The primary outcomes were Zurich claudication questionnaire (ZCQ) scores before and after 4 weeks of treatment. Least square mean analysis was used to assess the following dependent variables in the treatment groups: changes in symptom severity and physical function scores of the ZCQ and the ZCQ score of patient's satisfaction after treatment. RESULTS: Thirty-eight, 40, and 41 patients were allocated to the medication, exercise, and acupuncture groups, respectively. No patient underwent surgical treatment during the study period. The symptom severity scores of the ZCQ improved significantly after treatment in the medication (p = 0.048), exercise (p = 0.003), and acupuncture (p = 0.04) groups. The physical function score improved significantly in the acupuncture group (p = 0.045) but not in the medication (p = 0.20) and exercise (p = 0.29) groups. The mean reduction in the ZCQ score for physical function was significantly greater for acupuncture than for exercise. The mean ZCQ score for treatment satisfaction was significantly greater for acupuncture than for medication. CONCLUSIONS: Acupuncture was significantly more effective than physical exercise according to the physical function score of the ZCQ and than medication according to the satisfaction score. The present study provides new important information that will aid decision making in LSS treatment. TRIAL REGISTRATION: This study was registered with the UMIN Clinical Trials Registry ( UMIN000006957 ).  
  Address Department of Orthopedic Surgery, Iwai Orthopaedic Medical Hospital, Tokyo, Japan  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes PMID:29351748; PMCID:PMC5775532 Approved no  
  Call Number OCOM @ refbase @ Serial 2520  
Permanent link to this record
 

 
Author Oka, H.; Matsudaira, K.; Takano, Y.; Kasuya, D.; Niiya, M.; Tonosu, J.; Fukushima, M.; Oshima, Y.; Fujii, T.; Tanaka, S.; Inanami, H. url  doi
openurl 
  Title A comparative study of three conservative treatments in patients with lumbar spinal stenosis: lumbar spinal stenosis with acupuncture and physical therapy study (LAP study) Type of Study Journal Article
  Year 2018 Publication BMC Complementary and Alternative Medicine Abbreviated Journal BMC Complement Altern Med  
  Volume 18 Issue 1 Pages 19  
  Keywords *Acupuncture Therapy; Aged; Conservative Treatment; Female; Humans; Lumbar Vertebrae/*physiopathology; Male; Patient Satisfaction; *Physical Therapy Modalities; Spinal Stenosis/*physiopathology/*therapy; Acupuncture; Conservative management; Exercise; Lumbar spinal stenosis; Medication; Zurich claudication questionnaire  
  Abstract BACKGROUND: Although the efficiency of conservative management for lumbar spinal stenosis (LSS) has been examined, different conservative management approaches have not been compared. We have performed the first comparative trial of three types of conservative management (medication with acetaminophen, exercise, and acupuncture) in Japanese patients with LSS. METHODS: Patients with L5 root radiculopathy associated with LSS who visited our hospital for surgical treatment were enrolled between December 2011 and January 2014. In this open-label study, patients were assigned to three treatment groups (medication, exercise, acupuncture) according to the visit time. The primary outcomes were Zurich claudication questionnaire (ZCQ) scores before and after 4 weeks of treatment. Least square mean analysis was used to assess the following dependent variables in the treatment groups: changes in symptom severity and physical function scores of the ZCQ and the ZCQ score of patient's satisfaction after treatment. RESULTS: Thirty-eight, 40, and 41 patients were allocated to the medication, exercise, and acupuncture groups, respectively. No patient underwent surgical treatment during the study period. The symptom severity scores of the ZCQ improved significantly after treatment in the medication (p = 0.048), exercise (p = 0.003), and acupuncture (p = 0.04) groups. The physical function score improved significantly in the acupuncture group (p = 0.045) but not in the medication (p = 0.20) and exercise (p = 0.29) groups. The mean reduction in the ZCQ score for physical function was significantly greater for acupuncture than for exercise. The mean ZCQ score for treatment satisfaction was significantly greater for acupuncture than for medication. CONCLUSIONS: Acupuncture was significantly more effective than physical exercise according to the physical function score of the ZCQ and than medication according to the satisfaction score. The present study provides new important information that will aid decision making in LSS treatment. TRIAL REGISTRATION: This study was registered with the UMIN Clinical Trials Registry ( UMIN000006957 ).  
  Address Department of Orthopedic Surgery, Iwai Orthopaedic Medical Hospital, Tokyo, Japan  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes PMID:29351748; PMCID:PMC5775532 Approved no  
  Call Number OCOM @ refbase @ Serial 2561  
Permanent link to this record
 

 
Author Oka, H.; Matsudaira, K.; Takano, Y.; Kasuya, D.; Niiya, M.; Tonosu, J.; Fukushima, M.; Oshima, Y.; Fujii, T.; Tanaka, S.; Inanami, H. url  doi
openurl 
  Title A comparative study of three conservative treatments in patients with lumbar spinal stenosis: lumbar spinal stenosis with acupuncture and physical therapy study (LAP study) Type of Study Journal Article
  Year 2018 Publication BMC Complementary and Alternative Medicine Abbreviated Journal BMC Complement Altern Med  
  Volume 18 Issue 1 Pages 19  
  Keywords *Acupuncture Therapy; Aged; Conservative Treatment; Female; Humans; Lumbar Vertebrae/*physiopathology; Male; Patient Satisfaction; *Physical Therapy Modalities; Spinal Stenosis/*physiopathology/*therapy; Acupuncture; Conservative management; Exercise; Lumbar spinal stenosis; Medication; Zurich claudication questionnaire  
  Abstract BACKGROUND: Although the efficiency of conservative management for lumbar spinal stenosis (LSS) has been examined, different conservative management approaches have not been compared. We have performed the first comparative trial of three types of conservative management (medication with acetaminophen, exercise, and acupuncture) in Japanese patients with LSS. METHODS: Patients with L5 root radiculopathy associated with LSS who visited our hospital for surgical treatment were enrolled between December 2011 and January 2014. In this open-label study, patients were assigned to three treatment groups (medication, exercise, acupuncture) according to the visit time. The primary outcomes were Zurich claudication questionnaire (ZCQ) scores before and after 4 weeks of treatment. Least square mean analysis was used to assess the following dependent variables in the treatment groups: changes in symptom severity and physical function scores of the ZCQ and the ZCQ score of patient's satisfaction after treatment. RESULTS: Thirty-eight, 40, and 41 patients were allocated to the medication, exercise, and acupuncture groups, respectively. No patient underwent surgical treatment during the study period. The symptom severity scores of the ZCQ improved significantly after treatment in the medication (p = 0.048), exercise (p = 0.003), and acupuncture (p = 0.04) groups. The physical function score improved significantly in the acupuncture group (p = 0.045) but not in the medication (p = 0.20) and exercise (p = 0.29) groups. The mean reduction in the ZCQ score for physical function was significantly greater for acupuncture than for exercise. The mean ZCQ score for treatment satisfaction was significantly greater for acupuncture than for medication. CONCLUSIONS: Acupuncture was significantly more effective than physical exercise according to the physical function score of the ZCQ and than medication according to the satisfaction score. The present study provides new important information that will aid decision making in LSS treatment. TRIAL REGISTRATION: This study was registered with the UMIN Clinical Trials Registry ( UMIN000006957 ).  
  Address Department of Orthopedic Surgery, Iwai Orthopaedic Medical Hospital, Tokyo, Japan  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes PMID:29351748; PMCID:PMC5775532 Approved no  
  Call Number OCOM @ refbase @ Serial 2602  
Permanent link to this record
 

 
Author Oka, H.; Matsudaira, K.; Takano, Y.; Kasuya, D.; Niiya, M.; Tonosu, J.; Fukushima, M.; Oshima, Y.; Fujii, T.; Tanaka, S.; Inanami, H. url  doi
openurl 
  Title A comparative study of three conservative treatments in patients with lumbar spinal stenosis: lumbar spinal stenosis with acupuncture and physical therapy study (LAP study) Type of Study Journal Article
  Year 2018 Publication BMC Complementary and Alternative Medicine Abbreviated Journal BMC Complement Altern Med  
  Volume 18 Issue 1 Pages 19  
  Keywords *Acupuncture Therapy; Aged; Conservative Treatment; Female; Humans; Lumbar Vertebrae/*physiopathology; Male; Patient Satisfaction; *Physical Therapy Modalities; Spinal Stenosis/*physiopathology/*therapy; Acupuncture; Conservative management; Exercise; Lumbar spinal stenosis; Medication; Zurich claudication questionnaire  
  Abstract BACKGROUND: Although the efficiency of conservative management for lumbar spinal stenosis (LSS) has been examined, different conservative management approaches have not been compared. We have performed the first comparative trial of three types of conservative management (medication with acetaminophen, exercise, and acupuncture) in Japanese patients with LSS. METHODS: Patients with L5 root radiculopathy associated with LSS who visited our hospital for surgical treatment were enrolled between December 2011 and January 2014. In this open-label study, patients were assigned to three treatment groups (medication, exercise, acupuncture) according to the visit time. The primary outcomes were Zurich claudication questionnaire (ZCQ) scores before and after 4 weeks of treatment. Least square mean analysis was used to assess the following dependent variables in the treatment groups: changes in symptom severity and physical function scores of the ZCQ and the ZCQ score of patient's satisfaction after treatment. RESULTS: Thirty-eight, 40, and 41 patients were allocated to the medication, exercise, and acupuncture groups, respectively. No patient underwent surgical treatment during the study period. The symptom severity scores of the ZCQ improved significantly after treatment in the medication (p = 0.048), exercise (p = 0.003), and acupuncture (p = 0.04) groups. The physical function score improved significantly in the acupuncture group (p = 0.045) but not in the medication (p = 0.20) and exercise (p = 0.29) groups. The mean reduction in the ZCQ score for physical function was significantly greater for acupuncture than for exercise. The mean ZCQ score for treatment satisfaction was significantly greater for acupuncture than for medication. CONCLUSIONS: Acupuncture was significantly more effective than physical exercise according to the physical function score of the ZCQ and than medication according to the satisfaction score. The present study provides new important information that will aid decision making in LSS treatment. TRIAL REGISTRATION: This study was registered with the UMIN Clinical Trials Registry ( UMIN000006957 ).  
  Address Department of Orthopedic Surgery, Iwai Orthopaedic Medical Hospital, Tokyo, Japan  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes PMID:29351748; PMCID:PMC5775532 Approved no  
  Call Number OCOM @ refbase @ Serial 2639  
Permanent link to this record
 

 
Author Oka, H.; Matsudaira, K.; Takano, Y.; Kasuya, D.; Niiya, M.; Tonosu, J.; Fukushima, M.; Oshima, Y.; Fujii, T.; Tanaka, S.; Inanami, H. url  doi
openurl 
  Title A comparative study of three conservative treatments in patients with lumbar spinal stenosis: lumbar spinal stenosis with acupuncture and physical therapy study (LAP study) Type of Study Journal Article
  Year 2018 Publication BMC Complementary and Alternative Medicine Abbreviated Journal BMC Complement Altern Med  
  Volume 18 Issue 1 Pages 19  
  Keywords *Acupuncture Therapy; Aged; Conservative Treatment; Female; Humans; Lumbar Vertebrae/*physiopathology; Male; Patient Satisfaction; *Physical Therapy Modalities; Spinal Stenosis/*physiopathology/*therapy; Acupuncture; Conservative management; Exercise; Lumbar spinal stenosis; Medication; Zurich claudication questionnaire  
  Abstract BACKGROUND: Although the efficiency of conservative management for lumbar spinal stenosis (LSS) has been examined, different conservative management approaches have not been compared. We have performed the first comparative trial of three types of conservative management (medication with acetaminophen, exercise, and acupuncture) in Japanese patients with LSS. METHODS: Patients with L5 root radiculopathy associated with LSS who visited our hospital for surgical treatment were enrolled between December 2011 and January 2014. In this open-label study, patients were assigned to three treatment groups (medication, exercise, acupuncture) according to the visit time. The primary outcomes were Zurich claudication questionnaire (ZCQ) scores before and after 4 weeks of treatment. Least square mean analysis was used to assess the following dependent variables in the treatment groups: changes in symptom severity and physical function scores of the ZCQ and the ZCQ score of patient's satisfaction after treatment. RESULTS: Thirty-eight, 40, and 41 patients were allocated to the medication, exercise, and acupuncture groups, respectively. No patient underwent surgical treatment during the study period. The symptom severity scores of the ZCQ improved significantly after treatment in the medication (p = 0.048), exercise (p = 0.003), and acupuncture (p = 0.04) groups. The physical function score improved significantly in the acupuncture group (p = 0.045) but not in the medication (p = 0.20) and exercise (p = 0.29) groups. The mean reduction in the ZCQ score for physical function was significantly greater for acupuncture than for exercise. The mean ZCQ score for treatment satisfaction was significantly greater for acupuncture than for medication. CONCLUSIONS: Acupuncture was significantly more effective than physical exercise according to the physical function score of the ZCQ and than medication according to the satisfaction score. The present study provides new important information that will aid decision making in LSS treatment. TRIAL REGISTRATION: This study was registered with the UMIN Clinical Trials Registry ( UMIN000006957 ).  
  Address Department of Orthopedic Surgery, Iwai Orthopaedic Medical Hospital, Tokyo, Japan  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes PMID:29351748; PMCID:PMC5775532 Approved no  
  Call Number OCOM @ refbase @ Serial 2680  
Permanent link to this record
 

 
Author Oka, H.; Matsudaira, K.; Takano, Y.; Kasuya, D.; Niiya, M.; Tonosu, J.; Fukushima, M.; Oshima, Y.; Fujii, T.; Tanaka, S.; Inanami, H. url  doi
openurl 
  Title A comparative study of three conservative treatments in patients with lumbar spinal stenosis: lumbar spinal stenosis with acupuncture and physical therapy study (LAP study) Type of Study Journal Article
  Year 2018 Publication BMC Complementary and Alternative Medicine Abbreviated Journal BMC Complement Altern Med  
  Volume 18 Issue 1 Pages 19  
  Keywords *Acupuncture Therapy; Aged; Conservative Treatment; Female; Humans; Lumbar Vertebrae/*physiopathology; Male; Patient Satisfaction; *Physical Therapy Modalities; Spinal Stenosis/*physiopathology/*therapy; Acupuncture; Conservative management; Exercise; Lumbar spinal stenosis; Medication; Zurich claudication questionnaire  
  Abstract BACKGROUND: Although the efficiency of conservative management for lumbar spinal stenosis (LSS) has been examined, different conservative management approaches have not been compared. We have performed the first comparative trial of three types of conservative management (medication with acetaminophen, exercise, and acupuncture) in Japanese patients with LSS. METHODS: Patients with L5 root radiculopathy associated with LSS who visited our hospital for surgical treatment were enrolled between December 2011 and January 2014. In this open-label study, patients were assigned to three treatment groups (medication, exercise, acupuncture) according to the visit time. The primary outcomes were Zurich claudication questionnaire (ZCQ) scores before and after 4 weeks of treatment. Least square mean analysis was used to assess the following dependent variables in the treatment groups: changes in symptom severity and physical function scores of the ZCQ and the ZCQ score of patient's satisfaction after treatment. RESULTS: Thirty-eight, 40, and 41 patients were allocated to the medication, exercise, and acupuncture groups, respectively. No patient underwent surgical treatment during the study period. The symptom severity scores of the ZCQ improved significantly after treatment in the medication (p = 0.048), exercise (p = 0.003), and acupuncture (p = 0.04) groups. The physical function score improved significantly in the acupuncture group (p = 0.045) but not in the medication (p = 0.20) and exercise (p = 0.29) groups. The mean reduction in the ZCQ score for physical function was significantly greater for acupuncture than for exercise. The mean ZCQ score for treatment satisfaction was significantly greater for acupuncture than for medication. CONCLUSIONS: Acupuncture was significantly more effective than physical exercise according to the physical function score of the ZCQ and than medication according to the satisfaction score. The present study provides new important information that will aid decision making in LSS treatment. TRIAL REGISTRATION: This study was registered with the UMIN Clinical Trials Registry ( UMIN000006957 ).  
  Address Department of Orthopedic Surgery, Iwai Orthopaedic Medical Hospital, Tokyo, Japan  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes PMID:29351748; PMCID:PMC5775532 Approved no  
  Call Number OCOM @ refbase @ Serial 2725  
Permanent link to this record
 

 
Author Oka, H.; Matsudaira, K.; Takano, Y.; Kasuya, D.; Niiya, M.; Tonosu, J.; Fukushima, M.; Oshima, Y.; Fujii, T.; Tanaka, S.; Inanami, H. url  doi
openurl 
  Title A comparative study of three conservative treatments in patients with lumbar spinal stenosis: lumbar spinal stenosis with acupuncture and physical therapy study (LAP study) Type of Study Journal Article
  Year 2018 Publication BMC Complementary and Alternative Medicine Abbreviated Journal BMC Complement Altern Med  
  Volume 18 Issue 1 Pages 19  
  Keywords *Acupuncture Therapy; Aged; Conservative Treatment; Female; Humans; Lumbar Vertebrae/*physiopathology; Male; Patient Satisfaction; *Physical Therapy Modalities; Spinal Stenosis/*physiopathology/*therapy; Acupuncture; Conservative management; Exercise; Lumbar spinal stenosis; Medication; Zurich claudication questionnaire  
  Abstract BACKGROUND: Although the efficiency of conservative management for lumbar spinal stenosis (LSS) has been examined, different conservative management approaches have not been compared. We have performed the first comparative trial of three types of conservative management (medication with acetaminophen, exercise, and acupuncture) in Japanese patients with LSS. METHODS: Patients with L5 root radiculopathy associated with LSS who visited our hospital for surgical treatment were enrolled between December 2011 and January 2014. In this open-label study, patients were assigned to three treatment groups (medication, exercise, acupuncture) according to the visit time. The primary outcomes were Zurich claudication questionnaire (ZCQ) scores before and after 4 weeks of treatment. Least square mean analysis was used to assess the following dependent variables in the treatment groups: changes in symptom severity and physical function scores of the ZCQ and the ZCQ score of patient's satisfaction after treatment. RESULTS: Thirty-eight, 40, and 41 patients were allocated to the medication, exercise, and acupuncture groups, respectively. No patient underwent surgical treatment during the study period. The symptom severity scores of the ZCQ improved significantly after treatment in the medication (p = 0.048), exercise (p = 0.003), and acupuncture (p = 0.04) groups. The physical function score improved significantly in the acupuncture group (p = 0.045) but not in the medication (p = 0.20) and exercise (p = 0.29) groups. The mean reduction in the ZCQ score for physical function was significantly greater for acupuncture than for exercise. The mean ZCQ score for treatment satisfaction was significantly greater for acupuncture than for medication. CONCLUSIONS: Acupuncture was significantly more effective than physical exercise according to the physical function score of the ZCQ and than medication according to the satisfaction score. The present study provides new important information that will aid decision making in LSS treatment. TRIAL REGISTRATION: This study was registered with the UMIN Clinical Trials Registry ( UMIN000006957 ).  
  Address Department of Orthopedic Surgery, Iwai Orthopaedic Medical Hospital, Tokyo, Japan  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes PMID:29351748; PMCID:PMC5775532 Approved no  
  Call Number OCOM @ refbase @ Serial 2766  
Permanent link to this record
 

 
Author Oka, H.; Matsudaira, K.; Takano, Y.; Kasuya, D.; Niiya, M.; Tonosu, J.; Fukushima, M.; Oshima, Y.; Fujii, T.; Tanaka, S.; Inanami, H. url  doi
openurl 
  Title A comparative study of three conservative treatments in patients with lumbar spinal stenosis: lumbar spinal stenosis with acupuncture and physical therapy study (LAP study) Type of Study Journal Article
  Year 2018 Publication BMC Complementary and Alternative Medicine Abbreviated Journal BMC Complement Altern Med  
  Volume 18 Issue 1 Pages 19  
  Keywords *Acupuncture Therapy; Aged; Conservative Treatment; Female; Humans; Lumbar Vertebrae/*physiopathology; Male; Patient Satisfaction; *Physical Therapy Modalities; Spinal Stenosis/*physiopathology/*therapy; Acupuncture; Conservative management; Exercise; Lumbar spinal stenosis; Medication; Zurich claudication questionnaire  
  Abstract BACKGROUND: Although the efficiency of conservative management for lumbar spinal stenosis (LSS) has been examined, different conservative management approaches have not been compared. We have performed the first comparative trial of three types of conservative management (medication with acetaminophen, exercise, and acupuncture) in Japanese patients with LSS. METHODS: Patients with L5 root radiculopathy associated with LSS who visited our hospital for surgical treatment were enrolled between December 2011 and January 2014. In this open-label study, patients were assigned to three treatment groups (medication, exercise, acupuncture) according to the visit time. The primary outcomes were Zurich claudication questionnaire (ZCQ) scores before and after 4 weeks of treatment. Least square mean analysis was used to assess the following dependent variables in the treatment groups: changes in symptom severity and physical function scores of the ZCQ and the ZCQ score of patient's satisfaction after treatment. RESULTS: Thirty-eight, 40, and 41 patients were allocated to the medication, exercise, and acupuncture groups, respectively. No patient underwent surgical treatment during the study period. The symptom severity scores of the ZCQ improved significantly after treatment in the medication (p = 0.048), exercise (p = 0.003), and acupuncture (p = 0.04) groups. The physical function score improved significantly in the acupuncture group (p = 0.045) but not in the medication (p = 0.20) and exercise (p = 0.29) groups. The mean reduction in the ZCQ score for physical function was significantly greater for acupuncture than for exercise. The mean ZCQ score for treatment satisfaction was significantly greater for acupuncture than for medication. CONCLUSIONS: Acupuncture was significantly more effective than physical exercise according to the physical function score of the ZCQ and than medication according to the satisfaction score. The present study provides new important information that will aid decision making in LSS treatment. TRIAL REGISTRATION: This study was registered with the UMIN Clinical Trials Registry ( UMIN000006957 ).  
  Address Department of Orthopedic Surgery, Iwai Orthopaedic Medical Hospital, Tokyo, Japan  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes PMID:29351748; PMCID:PMC5775532 Approved no  
  Call Number OCOM @ refbase @ Serial 2807  
Permanent link to this record
 

 
Author Oka, H.; Matsudaira, K.; Takano, Y.; Kasuya, D.; Niiya, M.; Tonosu, J.; Fukushima, M.; Oshima, Y.; Fujii, T.; Tanaka, S.; Inanami, H. url  doi
openurl 
  Title A comparative study of three conservative treatments in patients with lumbar spinal stenosis: lumbar spinal stenosis with acupuncture and physical therapy study (LAP study) Type of Study Journal Article
  Year 2018 Publication BMC Complementary and Alternative Medicine Abbreviated Journal BMC Complement Altern Med  
  Volume 18 Issue 1 Pages 19  
  Keywords *Acupuncture Therapy; Aged; Conservative Treatment; Female; Humans; Lumbar Vertebrae/*physiopathology; Male; Patient Satisfaction; *Physical Therapy Modalities; Spinal Stenosis/*physiopathology/*therapy; Acupuncture; Conservative management; Exercise; Lumbar spinal stenosis; Medication; Zurich claudication questionnaire  
  Abstract BACKGROUND: Although the efficiency of conservative management for lumbar spinal stenosis (LSS) has been examined, different conservative management approaches have not been compared. We have performed the first comparative trial of three types of conservative management (medication with acetaminophen, exercise, and acupuncture) in Japanese patients with LSS. METHODS: Patients with L5 root radiculopathy associated with LSS who visited our hospital for surgical treatment were enrolled between December 2011 and January 2014. In this open-label study, patients were assigned to three treatment groups (medication, exercise, acupuncture) according to the visit time. The primary outcomes were Zurich claudication questionnaire (ZCQ) scores before and after 4 weeks of treatment. Least square mean analysis was used to assess the following dependent variables in the treatment groups: changes in symptom severity and physical function scores of the ZCQ and the ZCQ score of patient's satisfaction after treatment. RESULTS: Thirty-eight, 40, and 41 patients were allocated to the medication, exercise, and acupuncture groups, respectively. No patient underwent surgical treatment during the study period. The symptom severity scores of the ZCQ improved significantly after treatment in the medication (p = 0.048), exercise (p = 0.003), and acupuncture (p = 0.04) groups. The physical function score improved significantly in the acupuncture group (p = 0.045) but not in the medication (p = 0.20) and exercise (p = 0.29) groups. The mean reduction in the ZCQ score for physical function was significantly greater for acupuncture than for exercise. The mean ZCQ score for treatment satisfaction was significantly greater for acupuncture than for medication. CONCLUSIONS: Acupuncture was significantly more effective than physical exercise according to the physical function score of the ZCQ and than medication according to the satisfaction score. The present study provides new important information that will aid decision making in LSS treatment. TRIAL REGISTRATION: This study was registered with the UMIN Clinical Trials Registry ( UMIN000006957 ).  
  Address Department of Orthopedic Surgery, Iwai Orthopaedic Medical Hospital, Tokyo, Japan  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes PMID:29351748; PMCID:PMC5775532 Approved no  
  Call Number OCOM @ refbase @ Serial 2848  
Permanent link to this record
 

 
Author Oka, H.; Matsudaira, K.; Takano, Y.; Kasuya, D.; Niiya, M.; Tonosu, J.; Fukushima, M.; Oshima, Y.; Fujii, T.; Tanaka, S.; Inanami, H. url  doi
openurl 
  Title A comparative study of three conservative treatments in patients with lumbar spinal stenosis: lumbar spinal stenosis with acupuncture and physical therapy study (LAP study) Type of Study Journal Article
  Year 2018 Publication BMC Complementary and Alternative Medicine Abbreviated Journal BMC Complement Altern Med  
  Volume 18 Issue 1 Pages 19  
  Keywords *Acupuncture Therapy; Aged; Conservative Treatment; Female; Humans; Lumbar Vertebrae/*physiopathology; Male; Patient Satisfaction; *Physical Therapy Modalities; Spinal Stenosis/*physiopathology/*therapy; Acupuncture; Conservative management; Exercise; Lumbar spinal stenosis; Medication; Zurich claudication questionnaire  
  Abstract BACKGROUND: Although the efficiency of conservative management for lumbar spinal stenosis (LSS) has been examined, different conservative management approaches have not been compared. We have performed the first comparative trial of three types of conservative management (medication with acetaminophen, exercise, and acupuncture) in Japanese patients with LSS. METHODS: Patients with L5 root radiculopathy associated with LSS who visited our hospital for surgical treatment were enrolled between December 2011 and January 2014. In this open-label study, patients were assigned to three treatment groups (medication, exercise, acupuncture) according to the visit time. The primary outcomes were Zurich claudication questionnaire (ZCQ) scores before and after 4 weeks of treatment. Least square mean analysis was used to assess the following dependent variables in the treatment groups: changes in symptom severity and physical function scores of the ZCQ and the ZCQ score of patient's satisfaction after treatment. RESULTS: Thirty-eight, 40, and 41 patients were allocated to the medication, exercise, and acupuncture groups, respectively. No patient underwent surgical treatment during the study period. The symptom severity scores of the ZCQ improved significantly after treatment in the medication (p = 0.048), exercise (p = 0.003), and acupuncture (p = 0.04) groups. The physical function score improved significantly in the acupuncture group (p = 0.045) but not in the medication (p = 0.20) and exercise (p = 0.29) groups. The mean reduction in the ZCQ score for physical function was significantly greater for acupuncture than for exercise. The mean ZCQ score for treatment satisfaction was significantly greater for acupuncture than for medication. CONCLUSIONS: Acupuncture was significantly more effective than physical exercise according to the physical function score of the ZCQ and than medication according to the satisfaction score. The present study provides new important information that will aid decision making in LSS treatment. TRIAL REGISTRATION: This study was registered with the UMIN Clinical Trials Registry ( UMIN000006957 ).  
  Address Department of Orthopedic Surgery, Iwai Orthopaedic Medical Hospital, Tokyo, Japan  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes PMID:29351748; PMCID:PMC5775532 Approved no  
  Call Number OCOM @ refbase @ Serial 2889  
Permanent link to this record
 

 
Author Oka, H.; Matsudaira, K.; Takano, Y.; Kasuya, D.; Niiya, M.; Tonosu, J.; Fukushima, M.; Oshima, Y.; Fujii, T.; Tanaka, S.; Inanami, H. url  doi
openurl 
  Title A comparative study of three conservative treatments in patients with lumbar spinal stenosis: lumbar spinal stenosis with acupuncture and physical therapy study (LAP study) Type of Study Journal Article
  Year 2018 Publication BMC Complementary and Alternative Medicine Abbreviated Journal BMC Complement Altern Med  
  Volume 18 Issue 1 Pages 19  
  Keywords *Acupuncture Therapy; Aged; Conservative Treatment; Female; Humans; Lumbar Vertebrae/*physiopathology; Male; Patient Satisfaction; *Physical Therapy Modalities; Spinal Stenosis/*physiopathology/*therapy; Acupuncture; Conservative management; Exercise; Lumbar spinal stenosis; Medication; Zurich claudication questionnaire  
  Abstract BACKGROUND: Although the efficiency of conservative management for lumbar spinal stenosis (LSS) has been examined, different conservative management approaches have not been compared. We have performed the first comparative trial of three types of conservative management (medication with acetaminophen, exercise, and acupuncture) in Japanese patients with LSS. METHODS: Patients with L5 root radiculopathy associated with LSS who visited our hospital for surgical treatment were enrolled between December 2011 and January 2014. In this open-label study, patients were assigned to three treatment groups (medication, exercise, acupuncture) according to the visit time. The primary outcomes were Zurich claudication questionnaire (ZCQ) scores before and after 4 weeks of treatment. Least square mean analysis was used to assess the following dependent variables in the treatment groups: changes in symptom severity and physical function scores of the ZCQ and the ZCQ score of patient's satisfaction after treatment. RESULTS: Thirty-eight, 40, and 41 patients were allocated to the medication, exercise, and acupuncture groups, respectively. No patient underwent surgical treatment during the study period. The symptom severity scores of the ZCQ improved significantly after treatment in the medication (p = 0.048), exercise (p = 0.003), and acupuncture (p = 0.04) groups. The physical function score improved significantly in the acupuncture group (p = 0.045) but not in the medication (p = 0.20) and exercise (p = 0.29) groups. The mean reduction in the ZCQ score for physical function was significantly greater for acupuncture than for exercise. The mean ZCQ score for treatment satisfaction was significantly greater for acupuncture than for medication. CONCLUSIONS: Acupuncture was significantly more effective than physical exercise according to the physical function score of the ZCQ and than medication according to the satisfaction score. The present study provides new important information that will aid decision making in LSS treatment. TRIAL REGISTRATION: This study was registered with the UMIN Clinical Trials Registry ( UMIN000006957 ).  
  Address Department of Orthopedic Surgery, Iwai Orthopaedic Medical Hospital, Tokyo, Japan  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes PMID:29351748; PMCID:PMC5775532 Approved no  
  Call Number OCOM @ refbase @ Serial 2930  
Permanent link to this record
 

 
Author Xu, Y.; Zhao, W.; Li, T.; Bu, H.; Zhao, Z.; Zhao, Y.; Song, S. url  doi
openurl 
  Title Effects of acupoint-stimulation for the treatment of primary dysmenorrhoea compared with NSAIDs: a systematic review and meta-analysis of 19 RCTs Type of Study Systematic Review
  Year 2017 Publication BMC Complementary and Alternative Medicine Abbreviated Journal BMC Complement Altern Med  
  Volume 17 Issue 436 Pages 1-12  
  Keywords AcuTrials; Systematic Review; Menstruation Disturbances; Dysmenorrhea; Women's Health; Gynecology; Acupuncture; Auricular Acupressure; Moxibustion; Direct Moxibustion; Indirect Moxibustion; Moxa; Electroacupuncture; Non-Steroidal Anti-Inflammatory Drugs; NSAIDs  
  Abstract BACKGROUND: Primary dysmenorrhoea (PD), defined as painful menses in women with normal pelvic anatomy, is one of the most common gynaecological syndromes. Acupoint-stimulation could potentially be an effective intervention for PD. Our aim was to determine the effectiveness of acupoint-stimulation compared with Non-Steroidal Anti-Inflammatory Drugs (NASIDs) in the treatment of PD. METHODS: Six databases were searched to December 2014. Sixteen studies involving 1679 PD patients were included. We included randomized controlled trials that compared acupoint-stimulation with NASIDs for the treatment of PD. The main outcomes assessed were clinical effectiveness rate, symptom score, visual analogue score, variation in peripheral blood prostaglandin F2alpha (PGF2alpha) and side effects. All analyses were performed using Comprehensive Meta-Analysis statistical software. RESULTS: (1) The total efficacy was better than control group: odds ratio = 5.57; 95% confidence interval (95% CI) = 3.96, 7.83; P < 0.00001; (2) The effect of intervention was positive in relieving the severity of PD symptoms: mean difference (MD) = 2.99; 95%CI = 2.49, 3.49; P < 0.00001; (3) No statistical difference existed between two groups in terms of a reduction in the VAS: MD = 1.24; 95%CI = -3.37, 5.85; P = 0.60; (4) The effect of intervention on the variation in peripheral blood PGF2alpha between two groups was positive: MD = 7.55; 95%CI = 4.29,10.82; P < 0.00001; (5) The side effects of control groups was more than the acupoint-stimulation group: OR = 0.03; 95%CI =0.00,0.22; P = 0.0005. CONCLUSIONS: According to this article, acupoint-stimulation can relieve pain effectively in the treatment of PD and offers advantages in increasing the overall effectiveness.  
  Address Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition Dysmenorrhea
  Disease Category Menstruation Disturbances OCSI Score  
  Notes PMID:28859645; PMCID:PMC5580316 Approved no  
  Call Number OCOM @ refbase @ Serial 2411  
Permanent link to this record
 

 
Author Wang, T.; Xu, C.; Pan, K.; Xiong, H. url  doi
openurl 
  Title Acupuncture and moxibustion for chronic fatigue syndrome in traditional Chinese medicine: a systematic review and meta-analysis Type of Study Systematic Review
  Year 2017 Publication BMC Complementary and Alternative Medicine Abbreviated Journal BMC Complement Altern Med  
  Volume 17 Issue 1 Pages 163  
  Keywords AcuTrials; Systematic Review; Nervous System Diseases; Fatigue Syndrome, Chronic  
  Abstract BACKGROUND: As the etiology of chronic fatigue syndrome (CFS) is unclear and the treatment is still a big issue. There exists a wide range of literature about acupuncture and moxibustion (AM) for CFS in traditional Chinese medicine (TCM). But there are certain doubts as well in the effectiveness of its treatment due to the lack of a comprehensive and evidence-based medical proof to dispel the misgivings. Current study evaluated systematically the effectiveness of acupuncture and moxibustion treatments on CFS, and clarified the difference among them and Chinese herbal medicine, western medicine and sham-acupuncture. METHODS: We comprehensively reviewed literature including PubMed, EMBASE, Cochrane library, CBM (Chinese Biomedical Literature Database) and CNKI (China National Knowledge Infrastructure) up to May 2016, for RCT clinical research on CFS treated by acupuncture and moxibustion. Traditional direct meta-analysis was adopted to analyze the difference between AM and other treatments. Analysis was performed based on the treatment in experiment and control groups. Network meta-analysis was adopted to make comprehensive comparisons between any two kinds of treatments. The primary outcome was total effective rate, while relative risks (RR) and 95% confidence intervals (CI) were used as the final pooled statistics. RESULTS: A total of 31 randomized controlled trials (RCTs) were enrolled in analyses. In traditional direct meta-analysis, we found that in comparison to Chinese herbal medicine, CbAM (combined acupuncture and moxibustion, which meant two or more types of acupuncture and moxibustion were adopted) had a higher total effective rate (RR (95% CI), 1.17 (1.09 ~ 1.25)). Compared with Chinese herbal medicine, western medicine and sham-acupuncture, SAM (single acupuncture or single moxibustion) had a higher total effective rate, with RR (95% CI) of 1.22 (1.14 ~ 1.30), 1.51 (1.31-1.74), 5.90 (3.64-9.56). In addition, compared with SAM, CbAM had a higher total effective rate (RR (95% CI), 1.23 (1.12 ~ 1.36)). In network meta-analyses, similar results were recorded. Subsequently, we ranked all treatments from high to low effective rate and the order was CbAM, SAM, Chinese herbal medicine, western medicine and sham-acupuncture. CONCLUSIONS: In the treatment of CFS, CbAM and SAM may have better effect than other treatments. However, the included trials have relatively poor quality, hence high quality studies are needed to confirm our finding.  
  Address Department of Epidemiology, College of Preventive Medicine, Third Military Medical University, Gaotanyan Road 30, Shapingba District, Chongqing, 400038, China. hongyanxiong@126.com  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category Nervous System Diseases OCSI Score  
  Notes PMID:28335756; PMCID:PMC5363012 Approved yes  
  Call Number OCOM @ refbase @ Serial 2188  
Permanent link to this record
 

 
Author Kim, B.H.; Kim, K.; Nam, H.J. url  doi
openurl 
  Title A comparative study on the effects of systemic manual acupuncture, periauricular electroacupuncture, and digital electroacupuncture to treat tinnitus: A randomized, paralleled, open-labeled exploratory trial Type of Study RCT
  Year 2017 Publication BMC Complementary and Alternative Medicine Abbreviated Journal BMC Complement Altern Med  
  Volume 17 Issue 1 Pages 85  
  Keywords AcuTrials; RCT; Ear Diseases; Tinnitus; Hearing Disorders; Acu Versus Acu; Acupuncture; Electroacupuncture; Auricular Electroacupuncture; TCM Acupuncture Style; CAM Control; Fixed Acupuncture Protocol; Traditional Diagnosis Based Point Selection; Restricted Modalities, Acupuncture Only  
  Abstract BACKGROUND: Many previous studies of electroacupuncture used combined therapy of electroacupuncture and systemic manual acupuncture, so it was uncertain which treatment was effective. This study evaluated and compared the effects of systemic manual acupuncture, periauricular electroacupuncture and distal electroacupuncture for treating patients with tinnitus. METHODS: A randomized, parallel, open-labeled exploratory trial was conducted. Subjects aged 20-75 years who had suffered from idiopathic tinnitus for > 2 weeks were recruited from May 2013 to April 2014. The subjects were divided into three groups by systemic manual acupuncture group (MA), periauricular electroacupuncture group (PE), and distal electroacupuncture group (DE). The groups were selected by random drawing. Nine acupoints (TE 17, TE21, SI19, GB2, GB8, ST36, ST37, TE3 and TE9), two periauricular acupoints (TE17 and TE21), and four distal acupoints (TE3, TE9, ST36, and ST37) were selected. The treatment sessions were performed twice weekly for a total of eight sessions over 4 weeks. Outcomes were the tinnitus handicap inventory (THI) score and the loud and uncomfortable visual analogue scales (VAS). Demographic and clinical characteristics of all participants were compared between the groups upon admission using one-way analysis of variance (ANOVA). One-way ANOVA was used to evaluate the THI, VAS loud, and VAS uncomfortable scores. The least significant difference test was used as a post-hoc test. RESULTS: Thirty-nine subjects were eligible and their data were analyzed. No difference in THI and VAS loudness scores was observed in between groups. The VAS uncomfortable scores decreased significantly in MA and DE compared with those in PE. Within the group, all three treatments showed some effect on THI, VAS loudness scores and VAS uncomfortable scores after treatment except DE in THI. CONCLUSIONS: There was no statistically significant difference between systemic manual acupuncture, periauricular electroacupuncture and distal electroacupuncture in tinnitus. However, all three treatments had some effect on tinnitus within the group before and after treatment. Systemic manual acupuncture and distal electroacupuncture have some effect on VAS uncomfortable. TRIAL REGISTRATION: KCT0001991 by CRIS (Clinical Research Information Service), 2016-8-1, retrospectively registered.  
  Address Department of Ophthalmology, Otorhinolaryngology of Korean Medicine, College of Korean Medicine, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul, 130-701, Republic of Korea. ophthrl@khu.ac.kr  
  Publisher
  Language English Number of Treatments 8  
  Treatment Follow-up Frequency >1/WK Number of Participants 42  
  Time in Treatment 4 Weeks Condition Tinnitus
  Disease Category Ear Diseases OCSI Score  
  Notes PMID:28143471; PMCID:PMC5282839 Approved yes  
  Call Number OCOM @ refbase @ Serial 2189  
Permanent link to this record
 

 
Author Dos Santos Maciel, L.Y.; Dos Santos Leite, P.M.; Neto, M.L.P.; Mendonca, A.C.R.; de Araujo, C.C.A.; da Hora Santos Souza, J.; DeSantana, J.M. url  doi
openurl 
  Title Comparison of the placebo effect between different non-penetrating acupuncture devices and real acupuncture in healthy subjects: a randomized clinical trial Type of Study RCT
  Year 2016 Publication BMC Complementary and Alternative Medicine Abbreviated Journal BMC Complement Altern Med  
  Volume 16 Issue 1 Pages 518  
  Keywords AcuTrials; RCT; Healthy Subjects; Acupuncture; Placebo; Acu Versus > 1 Control; Fixed Acupuncture Protocol; Acupuncture Only; Sham Control; Non Penetrating Sham, Mechanical; Verum Acupoint Control  
  Abstract BACKGROUND: Several studies have used placebo acupuncture methods in recent years as a way for blinding therapeutic effect of acupuncture, however placebo method selection has not followed enough methodological criteria to the point of stabilishing a consensus of what should be the best method to be used. This study aimed to evaluate the effectiveness of three different placebo acupuncture methods for blinding applied in healthy subjects. METHODS: This study was approved by the Ethics Committee of the Federal University of Sergipe with the number 47193015.5.0000.5546 and all individuals participating in the study signed a free and informed consent. For this study, 321 healthy volunteers were randomly divided into seven groups using the abdominal point stomach (ST) 25 and seven groups using the lumbar point bladder (Bl) 52 for stimulation. For real acupuncture procedure, three different methods of placebo acupuncture plus a mix between real acupuncture and placebo applied in the same individual, totaling fourteen groups in this study. Outcome assessments were performed before and immediately after applying the technique. Investigator who assessed variables had no knowledgement about the method was applied. Identification, weight and height were measured before puncture by using. At the end, subjects were asked if they believed they were receiving real or placebo acupuncture. RESULTS: There was no significant difference between groups for the perception about the type o stimulation (wheter real or placebo puncture). Percentage of subjects who reported to have received real acupuncture in the abdominal point was 69.56% in real group, 86.95% in group Park Sham, 82.60% in needle + foam, 91.30% in insertion and removal, 78.26% in real + Park Sham, 86.36% in real + needle and foam, 86.95% in real + insertion and removal, and for the lumbar point was 86.36% in real group, 86.95% in group Park Sham, 69.56% in needle + foam, 72% in insertion and removal, 86.95% in real + Park Sham, 81.81% in real + needle and foam and 78.26% in real + insertion and removal. CONCLUSION: All placebo acupuncture methods proposed in this study were equally effective for bliding the study participants using either abdominal or lumbar acupoints, and none of the placebo methods presented benefit compared to the other to be used in future clinical trials. ETHICS COMMITTEE: Federal University of Sergipe (UFS), number of approval: 47193015.5.0000.5546 TRIAL REGISTRATION: ensaiosclinicos.gov.br RBR-3w2p32 Registered in 28th January 2016.  
  Address Professor of the Department of Physical Therapy and Post Graduate Programs in Health Sciences and Physiological Sciences, Federal University of Sergipe, Rua Claudio Batista, s/n. Bairro Santo Antonio, CEP 49060-100, Aracaju, Sergipe, Brasil. desantana@pq.cnpq.br  
  Publisher
  Language English Number of Treatments 1  
  Treatment Follow-up Frequency N/A Number of Participants 321  
  Time in Treatment 1 Day Condition Healthy Subjects
  Disease Category Healthy Subjects OCSI Score  
  Notes PMID:27978834; PMCID:PMC5159982 Approved yes  
  Call Number OCOM @ refbase @ Serial 2190  
Permanent link to this record
 

 
Author Qin, Z.; Zang, Z.; Wu, J.; Zhou, J.; Liu, Z. url  doi
openurl 
  Title Efficacy of acupuncture for chronic prostatitis/chronic pelvic pain syndromes: study protocol for a randomized, sham acupuncture-controlled trial Type of Study Journal Article
  Year 2016 Publication BMC Complementary and Alternative Medicine Abbreviated Journal BMC Complement Altern Med  
  Volume 16 Issue 1 Pages 440  
  Keywords Acupuncture; Chronic prostatitis/chronic pelvic pain syndrome; Efficacy; Randomized controlled trial  
  Abstract BACKGROUND: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) affects many adult men worldwide. The currently available therapies offer little or no proven benefit for CP/CPPS. We designed this study to assess the efficacy of acupuncture therapy for the treatment of CP/CPPS. METHODS: This study is designed as a randomized, sham acupuncture-controlled trial. We will compare patients with CP/CPPS in an acupuncture group and a sham acupuncture group. Sixty-eight patients will be randomly allocated to receive acupuncture or sham acupuncture. The treatments will consist of 30-min sessions, three times weekly, for 8 weeks. The primary outcome measure is change in the weekly mean National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) total score from baseline through the 8-week treatment period. Secondary measures include the NIH-CPSI subscale scores, the total International Prostate Symptom Score (IPSS), patients' response rate, and patient satisfaction after treatment. We will also assess changes in the NIH-CPSI total score from baseline at the 20th and 32nd week of follow-up. DISCUSSION: This is a randomized, sham-controlled trial of acupuncture treatment for CP/CPPS. The results of this trial will provide more evidence on whether acupuncture is efficacious for treating CP/CPPS. TRIAL REGISTRATION: Clinical Trials.gov NCT02588274.  
  Address Department of Acupuncture, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China. liuzhishun@aliyun.com  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes PMID:27821109; PMCID:PMC5100285 Approved no  
  Call Number OCOM @ refbase @ Serial 2114  
Permanent link to this record
 

 
Author Shiue, H.-S.; Lee, Y.-S.; Tsai, C.-N.; Chang, H.-H. url  doi
openurl 
  Title Treatment of allergic rhinitis with acupoint herbal plaster: an oligonucleotide chip analysis Type of Study Journal Article
  Year 2016 Publication BMC Complementary and Alternative Medicine Abbreviated Journal BMC Complement Altern Med  
  Volume 16 Issue 1 Pages 436  
  Keywords Acupoint herbal plaster; Allergic rhinitis; Oligonucleotide chip  
  Abstract BACKGROUND: Allergic rhinitis is regarded as an imbalanced Th1/Th2 cell-mediated response. The present study used microarray analysis to compare gene expression levels between allergic rhinitis patients before and after a series of acupoint herbal plaster applications. METHODS: In this experimental pilot study, volunteers experiencing sneezing, runny nose, and congestion for more than 9 months in the year following initial diagnoses were included after diagnostic confirmation by otolaryngologists to exclude patients with sinusitis and nasal polyps. Patients with persistent allergic rhinitis each received four acupoint herbal plaster treatments applied using the moxibustion technique. Clinical outcomes were evaluated using the Rhinitis Quality of Life Questionnaire (RQLQ). Peripheral blood samples were analyzed using an ImmunoCAP Phadiatop test, and patients were classified as phadiatop (Ph)-positive or -negative. Microarray results were analyzed for genes that were differentially expressed between (1) Ph-positive and -negative patients treated with herbal plaster; and (2) before and after herbal plaster treatment in the Ph-positive patient group. Unsupervised and supervised methods were used for gene-expression data analysis. RESULTS: Nineteen Ph-positive and four Ph-negative participants with persistent allergic rhinitis were included in the study. RQLQ results indicated that the 19 Ph-positive volunteers experienced improvement in six of seven categories following acupoint herbal plaster treatments, whereas the four Ph-negative participants reported improvement in only two categories. Hierarchical clustering and principle component analysis of the gene expression profiles of Ph-positive and -negative participants indicated the groups exhibited distinct physiological responses to acupoint herbal treatment. Evaluation of gene networks using MetaCore identified that the “Immune responseIL-13 signaling via JAK-STAT” and the “InflammationInterferon signaling” were down- and up-regulated, respectively, among Ph-positive subjects. CONCLUSIONS: In this preliminary study, we find that the IL-13 immune response via JAK-STAT signaling and interferon inflammation signaling were down- and upregulated, respectively, in the Ph-positive group. Further studies are required to verify these pathways in Ph-positive patients, and to determine the mechanism of such pathway dysregulation. TRIAL REGISTRATION: ClinicalTrials.gov: NCT02486159 . Registered 30 Jun 2015.  
  Address Departments of Chinese Medicine, China Medical University Hospital, Taichung, Taiwan. tcmchh55@gmail.com  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes PMID:27814709; PMCID:PMC5097372 Approved no  
  Call Number OCOM @ refbase @ Serial 2116  
Permanent link to this record
 

 
Author Wang, S.; Yang, H.; Zhang, J.; Zhang, B.; Liu, T.; Gan, L.; Zheng, J. url  doi
openurl 
  Title Efficacy and safety assessment of acupuncture and nimodipine to treat mild cognitive impairment after cerebral infarction: a randomized controlled trial Type of Study Journal Article
  Year 2016 Publication BMC Complementary and Alternative Medicine Abbreviated Journal BMC Complement Altern Med  
  Volume 16 Issue Pages 361  
  Keywords Acupuncture; Cerebral infarction; Mild cognitive impairment; Montreal Cognitive Assessment scale; Nimodipine  
  Abstract BACKGROUND: Cerebral infarction frequently leads to mild cognitive impairment (MCI). Prompt management of MCI can prevent vascular dementia and improve patient outcome. This single center randomized controlled trial aims to investigate the efficacy and safety of acupuncture and nimodipine to treat post-cerebral infarction MCI. METHODS: A total of 126 Chinese patients with post-cerebral infarction MCI recruited from the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine between April 2013 and June 2014 were randomized at 1:1: 1 ratio into nimodipine alone (30 mg/time and 3 times daily), acupuncture alone (30 min/time, 6 times/week), and nimodipine + acupuncture groups. The treatments were 3 months. Cognitive function was evaluated using Montreal Cognitive Assessment (MoCA) scale at enrollment interview, at the end of 3-month therapy, and at the post-treatment 3-month follow-up. RESULTS: The per-protocol set included 39, 40, and 40 patients from nimodipine alone, acupuncture alone, and the combination group, respectively, was analyzed. Intra-group comparison revealed that MoCA score at the follow-up improved significantly by 15.8 +/- 10.9, 20.9 +/- 13.8 %, and 30.2 +/- 19.7 % compared with the baseline MoCA for nimodipine alone, acupuncture alone, and the combination group, respectively. Inter-group comparison demonstrated that the combination therapy improved MoCA score (5.5 +/- 2.2) at significantly higher extent than nimodipine alone (3.1 +/- 1.8) and acupuncture alone (4.3 +/- 2.3) at the follow-up (All P < 0.05), and significantly higher proportion of patients in acupuncture alone group (80 %) and the combination therapy group (90 %) than in nimodipine alone group (56.4 %) showed >/=12 % MoCA score improvement compared with the baseline MoCA (All P < 0.05). No adverse event was reported during the study. CONCLUSION: Acupuncture may be used as an additional therapy to conventional pharmacological treatment to further improve the clinical outcomes of patients with post-cerebral infarction MCI. TRIAL REGISTRATION: The study was registered at the Chinese Clinical Trial Registry ( http://www.chictr.org.cn/ , Unique Identifier: ChiCTR-IOR-15007366 ). The date of registration is November 4, 2015.  
  Address Department of Acupuncture, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China. jgzheng2008@163.com  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes PMID:27623621; PMCID:PMC5022140 Approved no  
  Call Number OCOM @ refbase @ Serial 2155  
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