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Author (up) Stener-Victorin, E.; Baghaei, F.; Holm, G.; Janson, P. O.; Olivecrona, G.; Lonn, M.; Manneras-Holm, L. url  openurl
  Title Effects of acupuncture and exercise on insulin sensitivity, adipose tissue characteristics, and markers of coagulation and fibrinolysis in women with polycystic ovary syndrome: secondary analyses of a randomized controlled trial Type of Study RCT
  Year 2012 Publication Fertility and sterility Abbreviated Journal Fertil Steril  
  Volume 97 Issue 2 Pages 501-508  
  Keywords AcuTrials; RCT; Genital Diseases, Female; Polycystic Ovarian Syndrome; Acu Versus > 1 Control; Electroacupuncture; Unspecified Acupuncture Style; Fixed Acupuncture Protocol; Restricted Modalities, Acupuncture Only; No Treatment Control; Usual Care Control, Physical  
  Abstract OBJECTIVE: To investigate the possible effects of low-frequency electroacupuncture (EA) and physical exercise on markers of coagulation and fibrinolysis, insulin sensitivity, and adipose tissue characteristics in women with polycystic ovary syndrome (PCOS). DESIGN: Secondary analyses of a prospective, randomized controlled clinical trial. SETTING: Department of Physiology and Department of Obstetrics and Gynecology, University of Gothenburg. PATIENT(S): Eighty-four women with PCOS were randomized. INTERVENTION(S): Women with PCOS were randomized to 16 weeks of low-frequency EA (14 treatments), physical exercise (at least 3 times/wk), or no intervention. MAIN OUTCOME MEASURE(S): Anthropometrics, circulating coagulation and fibrinolytic markers, insulin sensitivity (euglycemic hyperinsulinemic clamp), hemodynamics, and adipose tissue morphology/function recorded at baseline, after 16 weeks of intervention, and after a 16-week follow-up. RESULT(S): In the low-frequency EA group, circulating plasminogen activator inhibitor 1 activity decreased by 21.8% after 16 weeks of intervention and by 31.1% at the 16-week follow-up and differed from the physical exercise and the no intervention groups. The EA group had decreases in circulating fibrinogen and tissue plasminogen activator (t-PA), sagittal diameter, and diastolic blood pressure after treatment, and fibrinogen remained lower at the 16-week follow-up. In the physical exercise group, lipoprotein lipase activity increased and diastolic blood pressure decreased after treatment, and both diastolic and systolic blood pressure were lower at follow-up. No other variables were affected. CONCLUSION(S): Low-frequency EA counteracted a possible prothrombotic state in women with PCOS, as reflected by a decrease in plasminogen activator inhibitor 1 activity. Despite within-group improvements, there were no between-group differences in anthropometric, metabolic, or hemodynamic variables after 16 weeks of EA or physical exercise at the dose/intensity studied.  
  Address Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Obstetrics and Gynecology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Ha  
  Language Number of Treatments 14  
  Treatment Follow-up 16 Weeks Frequency <1/WK Number of Participants 84  
  Time in Treatment 16 Weeks Condition Polycystic Ovarian Syndrome
  Disease Category Genital Diseases, Female OCSI Score  
  Notes Approved no  
  Call Number Serial 1104  
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