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Author (up) Wayne, P. M.; Kerr, C. E.; Schnyer, R. N.; Legedza, A. T.; Savetsky-German, J.; Shields, M. H.; Buring, J. E.; Davis, R. B.; Conboy, L. A.; Highfield, E.; Parton, B.; Thomas, P.; Laufer, M. R. url  openurl
  Title Japanese-style acupuncture for endometriosis-related pelvic pain in adolescents and young women: results of a randomized sham-controlled trial Type of Study RCT
  Year 2008 Publication Abbreviated Journal J Pediatr Adolesc Gynecol  
  Volume 21 Issue 5 Pages 247-257  
  Keywords Acu Versus Sham; Acupuncture; AcuTrials; Endometritis; Japanese Acupuncture Style; Manualized Acupuncture Protocol; Non Penetrating Sham, Mechanical; Pelvic Pain; RCT; Sham Acupoint Control; Sham Control; Traditional Diagnosis Based Point Selection; Women's Health; Genital Diseases, Female; Endometriosis  
  Abstract STUDY OBJECTIVE: To assess feasibility, and collect preliminary data for a subsequent randomized, sham-controlled trial to evaluate Japanese-style acupuncture for reducing chronic pelvic pain and improving health-related quality of life (HRQOL) in adolescents with endometriosis. DESIGN: Randomized, sham-controlled trial. SETTINGS: Tertiary-referral hospital. PARTICIPANTS: Eighteen young women (13-22y) with laparoscopically-diagnosed endometriosis-related chronic pelvic pain. INTERVENTIONS: A Japanese style of acupuncture and a sham acupuncture control. Sixteen treatments were administered over 8 weeks. MAIN OUTCOME MEASURES: Protocol feasibility, recruitment numbers, pain not associated with menses or intercourse, and multiple HRQOL instruments including Endometriosis Health Profile, Pediatric Quality of Life, Perceived Stress, and Activity Limitation. RESULTS: Fourteen participants (out of 18 randomized) completed the study per protocol. Participants in the active acupuncture group (n = 9) experienced an average 4.8 (SD = 2.4) point reduction on a 11 point scale (62%) in pain after 4 weeks, which differed significantly from the control group's (n = 5) average reduction of 1.4 (SD = 2.1) points (P = 0.004). Reduction in pain in the active group persisted through a 6-month assessment; however, after 4 weeks, differences between the active and control group decreased and were not statistically significant. All HRQOL measures indicated greater improvements in the active acupuncture group compared to the control; however, the majority of these trends were not statistically significant. No serious adverse events were reported. CONCLUSION: Preliminary estimates indicate that Japanese-style acupuncture may be an effective, safe, and well-tolerated adjunct therapy for endometriosis-related pelvic pain in adolescents. A more definitive trial evaluating Japanese-style acupuncture in this population is both feasible and warranted  
  Address Harvard Medical School, Osher Research Center, Boston, Massachusetts 02215, USA. peter_wayne@hms.harvard.edu  
  Publisher
  Language Number of Treatments 16  
  Treatment Follow-up 16 Weeks Frequency >1/WK Number of Participants 18  
  Time in Treatment 8 Weeks Condition Endometriosis
  Disease Category Genital Diseases, Female OCSI Score  
  Notes Approved no  
  Call Number Serial 1277  
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