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Author (up) Chassot, M.; Dussan-Sarria, J.A.; Sehn, F.C.; Deitos, A.; de Souza, A.; Vercelino, R.; Torres, I.L.; Fregni, F.; Caumo, W. doi  openurl
  Title Electroacupuncture analgesia is associated with increased serum brain-derived neurotrophic factor in chronic tension-type headache: a randomized, sham controlled, crossover trial Type of Study Journal Article
  Year 2015 Publication BMC Complement Altern Med Abbreviated Journal  
  Volume Issue Pages 144  
  Keywords Headache Disorders; Tension-Type Headache; Rct; Cross-Over Design; Acu + Usual Care Versus Sham + Usual Care; Electroacupuncture; Unspecified Acupuncture Style; Fixed Acupuncture Protocol; Restricted Modalities, Acupuncture Only; Sham Control; Non Penetrating Sham, Electrical; Verum Acupoint Control  
  Abstract BACKGROUND: Chronic tension-type headache (CTTH) is characterized by almost daily headaches and central sensitization, for which electroacupuncture (EA) might be effective. The central nervous system (CNS) plasticity can be tracked in serum using the brain-derived neurotrophic factor (BDNF), a neuroplasticity mediator. Thus, we tested the hypothesis that EA analgesia in CTTH is related to neuroplasticity indexed by serum BDNF. METHODS: We enrolled females aged 18-60 years with CTTH in a randomized, blinded, placebo-controlled crossover trial, comparing ten EA sessions applied for 30 minutes (2-10 Hz, intensity by tolerance) in cervical areas twice per week vs. a sham intervention. Treatment periods were separated by two washout weeks. Pain on the 10-cm visual analog scale (VAS) and serum BDNF were assessed as primary outcomes. RESULTS: Thirty-four subjects underwent randomization, and twenty-nine completed the protocol. EA was superior to sham to alleviate pain (VAS scores 2.38 +/- 1.77 and 3.02 +/- 2.49, respectively, P = 0.005). The VAS scores differed according to the intervention sequence, demonstrating a carryover effect (P < 0.05). Using multiple regression, serum BDNF was adjusted for the Hamilton depression rating scale (HDRS) and the VAS scores (r-squared = 0.07, standard beta coefficients = -0.2 and -0.14, respectively, P < 0.001). At the end of the first intervention period, the adjusted BDNF was higher in the EA phase (29.31 +/- 3.24, 27.53 +/- 2.94 ng/mL, Cohen's d = 0.55). CONCLUSION: EA analgesia is related to neuroplasticity indexed by the adjusted BDNF. EA modulation of pain and BDNF occurs according to the CNS situation at the moment of its administration, as it was related to depression and the timing of its administration.  
  Address Post-Graduate Program in Medical Sciences, School of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil. Email:  
  Language Number of Treatments 10  
  Treatment Follow-up N/A Frequency >1/WK Number of Participants 34  
  Time in Treatment 5 Weeks Condition Tension-Type Headache
  Disease Category Headache Disorders OCSI Score  
  Notes Date of Input: 6/23/2015; Date Modified: 7/23/2015; Availability: --In File--; Priority: Normal; Tension-Type Headache; Post-Graduate Program in Medical Sciences, School of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil. Email:; eng; Web: Approved no  
  Call Number OCOM @ refbase @ Serial 1605  
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