||Objective: to study the influence of acupuncture on cytokine levels in chronic pelvic pain syndrome. Methods: 60 patients were randomized into the acupuncture group (n = 30) and the control group (n = 30). In the control group, the oral medication Terazosin Hydrochloride was assigned, while patients in the acupuncture group were also treated with acupuncture therapy. Tumor necrosis factor (TN F-a), interleukin 13 (1L-113) levels were tested before the treatment and 1 month after treatment. Selected acupoints were Guanyuan (CV4), Zhongji (CV3), Huiyin (CV!), Yinlingquan (S P9, bilateral) and Xuehai (SPIO, bilat-eral). Results: after treatment, the expressions of TN F-a, IL-113 were significantly reduced in both groups, with the acupuncture group being more obviously decreased. Conclusion: acupuncture can regulate the TN F-a and I L-1 f3 levels in patients with chronic pelvic pain syndrome, mitigating the chemotaxis of inflammatory cells.