||Objective: to observe the clinical curative effect of acupuncture at Shangjuxu (ST37)'in treating irritable bowel syndrome. Methods: 60 patients with irritable bowel syndrome were randomly divided into the acupuncture group (the treatment group, n = 30) and the oral medication group (the control group, n = 30); symptoms such as abdominal pain, diarrhea, abdominal distension were observed. Results: in the treatment group, 18 patients were cured, and 8 patients showed improvement; the total effective rate was 86.67%; in the control group, 13 patients were cured, and 7 patients showed improvement; the total effective rate was 66.67%. There were significant differences of the total effective rate between two groups (P< 0.05). The intes-tinal symptoms score were statistically significant in both groups before and after the treatment (P < 0.05), and between the treatment group and the control group after the treatment (P< 0.05). Conclusion: acupunc-ture at Shangjuxu (ST37) remarkably improved the symptoms of abdominal pain, diarrhea, and abdominal distension in patients with diarrhea type irritable bowel syndrome.