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Author (up) You, X.-M.; Mo, X.-S.; Ma, L.; Zhong, J.-H.; Qin, H.-G.; Lu, Z.; Xiang, B.-D.; Wu, F.-X.; Zhao, X.-H.; Tang, J.; Pang, Y.-H.; Chen, J.; Li, L.-Q. url  doi
  Title Randomized Clinical Trial Comparing Efficacy of Simo Decoction and Acupuncture or Chewing Gum Alone on Postoperative Ileus in Patients With Hepatocellular Carcinoma After Hepatectomy Type of Study RCT
  Year 2015 Publication Medicine Abbreviated Journal Medicine (Baltimore)  
  Volume 94 Issue 45 Pages e1968  
  Keywords AcuTrials; RCT; Gastrointestinal Diseases; Ileus; Acu Versus > 1 Control; Acupuncture Point Injection; Herbal Formula; Fixed Acupuncture Protocol; Restricted Modalities; Acupuncture + Other; CAM Control; No Treatment Control  
  Abstract To compare the efficacy of simo decoction (SMD) combined with acupuncture at the tsusanli acupoint or chewing gum alone for treating postoperative ileus in patients with hepatocellular carcinoma (HCC) after hepatectomy.In postoperative ileus, a frequent complication following hepatectomy, bowel function recovery is delayed, which increases length of hospital stay. Studies suggest that chewing gum may reduce postoperative ileus; SMD and acupuncture at the tsusanli acupoint have long been used in China to promote bowel movement.Patients with primary HCC undergoing hepatectomy between January 2015 and August 2015 were randomized to receive SMD and acupuncture (n = 55) or chewing gum (n = 53) or no intervention (n = 54) starting on postoperative day 1 and continuing for 6 consecutive days or until flatus. Primary endpoints were occurrence of postoperative ileus and length of hospital stay; secondary endpoints were surgical complications.Groups treated with SMD and acupuncture or with chewing gum experienced significantly shorter time to first peristalsis, flatus, and defecation than the no-intervention group (all P < 0.05). Hospital stay was significantly shorter in the combined SMD and acupuncture group (mean 14.0 d, SD 4.9) than in the no-intervention group (mean 16.5 d, SD 6.8; P = 0.014), while length of stay was similar between the chewing gum group (mean 14.7, SD 6.2) and the no-intervention group (P = 0.147). Incidence of grades I and II complications was slightly lower in both intervention groups than in the no-intervention group.The combination of SMD and acupuncture may reduce incidence of postoperative ileus and shorten hospital stay in HCC patients after hepatectomy. Chewing gum may also reduce incidence of ileus but does not appear to affect hospital stay. ( registration number: NCT02438436.).  
  Address From the Hepatobiliary Surgery Department, Affiliated Tumor Hospital of Guangxi Medical University (XMY, XSM, LM, JHZ, HGQ, ZL, BDX, FXW, YHP, JT, XHZ, JC, LQL); and Guangxi Liver Cancer Diagnosis and Treatment Engineering and Technology Research Center, Nanning, PR China (XMY, LM, JHZ, BDX, FXW, YHP, JT, XHZ, JC, LQL)  
  Language English Number of Treatments 6  
  Treatment Follow-up Frequency >1/WK Number of Participants 181  
  Time in Treatment 6 Days Condition Ileus
  Disease Category Gastrointestinal Diseases OCSI Score  
  Notes PMID:26559269 Approved yes  
  Call Number OCOM @ refbase @ Serial 2015  
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