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Author (up) Jiping Zhang; Yu Zheng; Yanjie Wang; Shanshan Qu; Shaoqun Zhang; Chunxiao Wu; Junqi Chen; Huailiang Ouyang; Chunzhi Tang; Yong Huang url  openurl
  Title Evidence of a Synergistic Effect of Acupoint Combination: A Resting-State Functional Magnetic Resonance Imaging Study Type of Study Journal Article
  Year 2016 Publication Journal of Alternative & Complementary Medicine Abbreviated Journal Journal of Alternative & Complementary Medicine  
  Volume 22 Issue 10 Pages 800-809  
  Keywords BRAIN -- Physiology; CEREBELLUM -- Physiology; CEREBRAL cortex -- Physiology; Acupuncture; ACUPUNCTURE points; ALTERNATIVE medicine; MAGNETIC resonance imaging; PROBABILITY theory; RESEARCH -- Finance; SAMPLING (Statistics); Statistics; T-test (Statistics); DATA analysis; BODY mass index; RANDOMIZED controlled trials; PRE-tests & post-tests; BLIND experiment; DATA analysis -- Software; DESCRIPTIVE statistics; ONE-way analysis of variance; China  
  Abstract Objective: This study aimed to find evidence of a synergistic effect of acupoint combinations by analyzing different brain regions activated after acupuncture at different acupoint combinations. Methods: A total of 57 healthy subjects were randomly distributed into three groups: LR3 plus KI3 acupoints, LR3 plus sham acupoint, or LR3 alone. They underwent a magnetic resonance imaging scan before and after acupuncture. The amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) values of different brain regions were analyzed to observe changes in brain function. Results: ALFF and ReHo produced an activated area in the cerebellum posterior lobe after acupuncture at LR3 plus KI3 acupoints versus LR3 alone. ALFF and ReHo revealed altered activity in Brodmann area 10 (BA10), BA18, and brainstem pons after acupuncture at LR3 plus sham acupoint compared with at LR3 alone. A comparison of acupuncture at LR3 plus KI3 acupoints with LR3 plus sham acupoint demonstrated an increase in BA6 of ALFF and a downregulation of ReHo. Conclusions: The increased number of brain regions with altered brain activity after acupuncture at acupoint combinations versus a single acupoint are evidence of the synergistic effect of acupoint combinations. BA6 was significantly activated after acupuncture at LR3 plus KI3 acupoints compared with at LR3 plus sham acupoint, suggesting that BA6 is the specific region of synergistic effect of acupoint combinations of LR3 plus KI3 acupoints. Affected brain regions were different between acupuncture at LR3 plus sham acupoint and LR3 alone, which indicates that the sham acupoint may have some psychological effect. However, the specific mechanism of acupoint combinations requires further research.  
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  Notes Accession Number: 118649823; Source Information: Oct2016, Vol. 22 Issue 10, p800; Subject Term: BRAIN -- Physiology; Subject Term: CEREBELLUM -- Physiology; Subject Term: CEREBRAL cortex -- Physiology; Subject Term: ACUPUNCTURE; Subject Term: ACUPUNCTURE points; Subject Term: ALTERNATIVE medicine; Subject Term: MAGNETIC resonance imaging; Subject Term: PROBABILITY theory; Subject Term: RESEARCH -- Finance; Subject Term: SAMPLING (Statistics); Subject Term: STATISTICS; Subject Term: T-test (Statistics); Subject Term: DATA analysis; Subject Term: BODY mass index; Subject Term: RANDOMIZED controlled trials; Subject Term: PRE-tests & post-tests; Subject Term: BLIND experiment; Subject Term: DATA analysis -- Software; Subject Term: DESCRIPTIVE statistics; Subject Term: ONE-way analysis of variance; Subject Term: ; Geographic Subject: CHINA; Geographic Subject: ; Number of Pages: 10p; ; Illustrations: 5 Diagrams, 3 Charts; ; Document Type: Article; Approved no  
  Call Number OCOM @ refbase @ Serial 2280  
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