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Author (up) Xiao Cun Yang; Tao Yin; Qian Gao; Ling Jun Kong url  doi
openurl 
  Title The Immunomodulatory Effect of Acupoint Application for Childhood Asthma: A Systematic Review and Meta-Analysis Type of Study Journal Article
  Year 2015 Publication Evidence-based Complementary & Alternative Medicine (eCAM) Abbreviated Journal Evid Based Complement Altern Med  
  Volume Issue Pages 1-8  
  Keywords Immune System; Asthma -- Therapy; Pediatric Care; Acupuncture Points; Medicine, Herbal; Asthma -- Immunology; Human; Systematic Review; Meta Analysis; Descriptive Statistics; Confidence Intervals; PubMed; Embase; Cochrane Library; China; Child; Funding Source; Data Analysis Software  
  Abstract Objective. To evaluate the evidence on the immunomodulatory effect of acupoint application for childhood asthma. Methods. Five electronic databases through October 2014 were searched. The risk of bias in eligible studies was assessed using the Cochrane Collaboration tool. Standardised mean difference (SMD) and 95% confidence intervals (CI) of random-effects model were calculated. And heterogeneity was assessed using the Cochran Q statistic and quantified with the I² index. Results. Six studies were included in our review. The aggregated results suggested that acupoint application showed the beneficial effect for childhood asthma in improving IgA (SMD, -0.83; 95% CI -1.14 to -0.52; P < 0.00001), IgE (SMD, -0.52; 95% CI -0.76 to -0.29; P < 0.001), IgG (SMD, -1.17; 95% CI -1.61 to -0.74; P < 0.0001), IL-4 (SMD, -0.57; 95% CI -0.91 to -0.23; P = 0.0009), and IFN-? (SMD, -0.38; 95% CI -0.71 to -0.04; P = 0.03) but not IgM (SMD, -0.40; 95% CI -0.98 to 0.18; P = 0.18). And the effective dose of acupoint application may be 2-6 hours/time and a total of 3 times within 4 weeks. Conclusions. This review showed the positive evidence that acupoint application had the favorable immunomodulatory effect for childhood asthma. However, more studies with long follow-up are warrant to confirm the current findings.  
  Address Department of Tuina, Second Hospital of Traditional Chinese Medicine in Jiangsu Province, Nanjing, Jiangsu 210017, China  
  Publisher Hindawi Limited
  Language Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes Accession Number: 108824942. Language: English. Entry Date: 20170222. Revision Date: 20170222. Publication Type: journal article; meta analysis; research; systematic review; tables/charts. Journal Subset: Alternative/Complementary Therapies; Biomedical; Europe; Peer Reviewed; UK & Ireland. Special Interest: Evidence-Based Practice; Pediatric Care. Grant Information: This work is supported by the Young Teacher Training Program of Education Committee of Shanghai (ZZszy12050); the Young Program of National Natural Science Foundation of China (81403496); the National Natural Science Foundation of China (81273869); the Key Discipline of Tuina of the State Administration of Traditional Chinese Medicine of China.. NLM UID: 101215021. Approved no  
  Call Number OCOM @ refbase @ 108824942 Serial 2339  
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