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Author (up) Yongfang Guo; Mingqing Xing; Wenjuan Sun; Xiaoyan Yuan; Hongyan Dai; Huamin Ding url  doi
  Title Plasma nesfatin-1 level in obese patients after acupuncture: a randomised controlled trial Type of Study Journal Article
  Year 2014 Publication Acupuncture in Medicine Abbreviated Journal Acupuncture Med  
  Volume 32 Issue 4 Pages 313-317  
  Keywords Obesity -- Blood; Acupuncture -- Evaluation; Nerve Tissue Proteins -- Blood; Calcium Binding Proteins -- Blood; Proteins -- Blood; Treatment Outcomes; Randomized Controlled Trials; Human; Male; Female; Data Analysis Software; T-Tests; Mann-Whitney U Test; Descriptive Statistics; Pearson's Correlation Coefficient; Middle Age; Adult; Funding Source  
  Abstract Background Nesfatin-1 is an anorexigenic hormone suggested to regulate obesity. Objective To investigate the relationship between nesfatin-1 level and anthropometric and metabolic parameters in obese patients, and examine the change in plasma nesfatin-1 level after acupuncture treatment. Methods 64 obese adult patients without diabetes and 58 normal weight control subjects were enrolled in this study. The obese patients were randomly divided into an acupuncture plus diet group (n=32) and a diet only group (n=32). Measurements were repeated after 45 days. Results Body mass index (BMI), waist and hip circumferences, serum insulin, lipoprotein and insulin resistance measures were significantly higher, and plasma nesfatin-1 level was significantly lower, in obese patients than in normal weight controls. In addition, negative correlations were found between plasma nesfatin-1 level and BMI, waist and hip circumferences. Weight reduction in participants after acupuncture and diet restriction was 7.0% and 4.3%, respectively. Plasma nesfatin-1 level increased from 2.75±1.16 to 3.44±1.28 ng/mL and from 2.86±1.07 to 3.23±1.06 ng/mL in acupuncture and diet groups, respectively; the difference was significant, p<0.05. Conclusions Plasma nesfatin-1 level is reduced in obese adults, and is increased after acupuncture. The beneficial effect of acupuncture on obesity is associated with increased plasma nesfatin-1 level.  
  Address Department of Traditional Chinese Medicine, Qingdao Municipal Hospital, Qingdao, China  
  Publisher BMJ Publishing Group
  Language Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes Accession Number: 103988642. Language: English. Entry Date: 20140815. Revision Date: 20150710. Publication Type: Journal Article; research; tables/charts; randomized controlled trial. Journal Subset: Alternative/Complementary Therapies; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. Grant Information: National Natural Science Foundation of China.. NLM UID: 9304117. Approved no  
  Call Number OCOM @ refbase @ 103988642 Serial 2370  
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