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Author (up) Andreescu, C.; Glick, R. M.; Emeremni, C. A.; Houck, P. R.; Mulsant, B. H. url  openurl
  Title Acupuncture for the treatment of major depressive disorder: a randomized controlled trial Type of Study RCT
  Year 2011 Publication The Journal of clinical psychiatry Abbreviated Journal J Clin Psychiatry  
  Volume 72 Issue 8 Pages 1129-1135  
  Keywords AcuTrials; Mental Disorders; Depressive Disorder, Major; Acu Versus Sham; Electroacupuncture; TCM Acupuncture Style; Fixed Acupuncture Protocol; Restricted Modalities, Acupuncture Only; Sham Control; Penetrating Sham; Standard Needling Depth; Sham Acupoint Control; Depression  
  Abstract BACKGROUND: Over 50% of patients with major depressive disorder (MDD) either do not tolerate or do not respond to antidepressant medications. Several preliminary studies have shown the benefits of acupuncture in the treatment of depression. We sought to determine whether a 2-point electroacupuncture protocol (verum acupuncture) would be beneficial for MDD, in comparison to needling at nonchannel scalp points with sham electrostimulation (control acupuncture). METHOD: Fifty-three subjects aged 18-80 years, recruited via advertisement or referral, were included in the primary analysis of our randomized controlled trial, which was conducted from March 2004 through May 2007 at UPMC Shadyside, Center for Complementary Medicine, in Pittsburgh, Pennsylvania. Inclusion criteria were mild or moderate MDD (according to the Structured Clinical Interview for DSM-IV Axis I Disorders) and a score of 14 or higher on the Hamilton Depression Rating Scale (HDRS). Exclusion criteria included severe MDD, seizure disorder or risk for seizure disorder, psychosis, bipolar disorder, chronic MDD, treatment-resistent MDD, and history of substance abuse in the prior 6 months. Patients were randomized to receive twelve 30-minute sessions of verum versus control acupuncture over 6 to 8 weeks. The HDRS was the primary outcome measure. The UKU Side Effect Rating Scale was used to assess for adverse effects. RESULTS: Twenty-eight subjects were randomized to verum electroacupuncture and 25 to control acupuncture. The 2 groups did not differ with regard to gender, age, or baseline severity of depression. Both groups improved, with mean (SD) absolute HDRS score decreases of -6.6 (5.9) in the verum group and -7.6 (6.6) in the control group, corresponding to 37.5% and 41.3% relative decreases from baseline. There were no serious adverse events associated with either intervention, and endorsement of adverse effects was similar in the 2 groups. CONCLUSIONS: We were unable to demonstrate a specific effect of electroacupuncture. Electroacupuncture and control acupuncture were equally well tolerated, and both resulted in similar absolute and relative improvement in depressive symptoms as measured by the HDRS. TRIAL REGISTRATION: Identifier: NCT00071110.  
  Address Department of Psychiatry University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Center for Integrative Medicine, UPMC Shadyside, Pittsburgh, Pennsylvania.  
  Language Number of Treatments 12  
  Treatment Follow-up N/A Frequency >1/WK Number of Participants 57  
  Time in Treatment 6 Weeks Condition Depressive Disorder, Major
  Disease Category Mental Disorders OCSI Score  
  Notes Approved no  
  Call Number Serial 31  
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