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Author (up) Berman, B. M.; Lao, L.; Langenberg, P.; Lee, W. L.; Gilpin, A. M.; Hochberg, M. C. url  openurl
  Title Effectiveness of acupuncture as adjunctive therapy in osteoarthritis of the knee: A randomized, controlled trial Type of Study RCT
  Year 2004 Publication Annals of internal medicine Abbreviated Journal Ann Intern Med  
  Volume 141 Issue 12 Pages 901-910  
  Keywords Acu Versus > 1 Control; Acupuncture; AcuTrials; Arthritis; Electroacupuncture; Fixed Acupuncture Protocol; Penetrating Sham; Non Penetrating Sham, Mechanical; Osteoarthritis; Osteoarthritis, Knee; Pain; RCT; Restricted Modalities, Acupuncture Only; Sham Acupoint Control; Sham Control; Standard Needling Depth; Usual Care Control, Educational; Verum Acupoint Control  
  Abstract BACKGROUND: Evidence on the efficacy of acupuncture for reducing the pain and dysfunction of osteoarthritis is equivocal. OBJECTIVE: To determine whether acupuncture provides greater pain relief and improved function compared with sham acupuncture or education in patients with osteoarthritis of the knee. DESIGN: Randomized, controlled trial. SETTING: Two outpatient clinics (an integrative medicine facility and a rheumatology facility) located in academic teaching hospitals and 1 clinical trials facility. PATIENTS: 570 patients with osteoarthritis of the knee (mean age [+/-SD], 65.5 +/- 8.4 years). INTERVENTION: 23 true acupuncture sessions over 26 weeks. Controls received 6 two-hour sessions over 12 weeks or 23 sham acupuncture sessions over 26 weeks. MEASUREMENTS: Primary outcomes were changes in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain and function scores at 8 and 26 weeks. Secondary outcomes were patient global assessment, 6-minute walk distance, and physical health scores of the 36-Item Short-Form Health Survey (SF-36). RESULTS: Participants in the true acupuncture group experienced greater improvement in WOMAC function scores than the sham acupuncture group at 8 weeks (mean difference, -2.9 [95% CI, -5.0 to -0.8]; P = 0.01) but not in WOMAC pain score (mean difference, -0.5 [CI, -1.2 to 0.2]; P = 0.18) or the patient global assessment (mean difference, 0.16 [CI, -0.02 to 0.34]; P > 0.2). At 26 weeks, the true acupuncture group experienced significantly greater improvement than the sham group in the WOMAC function score (mean difference, -2.5 [CI, -4.7 to -0.4]; P = 0.01), WOMAC pain score (mean difference, -0.87 [CI, -1.58 to -0.16];P = 0.003), and patient global assessment (mean difference, 0.26 [CI, 0.07 to 0.45]; P = 0.02). LIMITATIONS: At 26 weeks, 43% of the participants in the education group and 25% in each of the true and sham acupuncture groups were not available for analysis. CONCLUSIONS: Acupuncture seems to provide improvement in function and pain relief as an adjunctive therapy for osteoarthritis of the knee when compared with credible sham acupuncture and education control groups  
  Address University of Maryland School of Medicine, Baltimore, Maryland 21207, USA  
  Publisher
  Language Number of Treatments 23  
  Treatment Follow-up N/A Frequency <1/WK Number of Participants 570  
  Time in Treatment 26 Weeks Condition Osteoarthritis, Knee
  Disease Category Arthritis OCSI Score 90  
  Notes Approved no  
  Call Number Serial 69  
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