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Author (up) Bjordal, J. M.; Johnson, M. I.; Lopes-Martins, R. A.; Bogen, B.; Chow, R.; Ljunggren, A. E. url  openurl
  Title Short-term efficacy of physical interventions in osteoarthritic knee pain. A systematic review and meta-analysis of randomised placebo-controlled trials Type of Study Systematic Review
  Year 2007 Publication Abbreviated Journal BMC Musculoskelet Disord  
  Volume 8 Issue 1 Pages 51-  
  Keywords Acupuncture; AcuTrials; Arthritis; Electroacupuncture; Laser Acupuncture; Magnets; Osteoarthritis, Knee; Pain; Systematic Review; Transcutaneous Electric Nerve Stimulation; TENS; Meta-Analysis  
  Abstract ABSTRACT: BACKGROUND: Treatment efficacy of physical agents in osteoarthritis of the knee (OAK) pain has been largely unknown, and this systematic review was aimed at assessing their short-term efficacies for pain relief. Aims and methods: Systematic review with meta-analysis of efficacy within 1-4 weeks and 5-12 weeks. RESULTS: 36 randomised placebo-controlled trials (RCTs) were identified with 2434 patients where 1391 patients received active treatment. 33 trials satisfied three or more out of five methodological criteria (Jadad scale). The patient sample had a mean age of 65.1 years and mean baseline pain of 62.9 mm on a 100 mm visual analogue scale (VAS). Within 4 weeks of the commencement of treatment manual acupuncture, static magnets and ultrasound therapies did not offer statistically significant short-term pain relief over placebo. Pulsed electromagnetic fields offered a small reduction in pain of 6.9 mm [95% CI: 2.2 to 11.6] (n=487). Transcutaneous electrical nerve stimulation (TENS, including interferential currents), electro-acupuncture (EA) and low level laser therapy (LLLT) offered clinically relevant pain relieving effects of 18.8 mm [95% CI: 9.6 to 28.1] (n=414), 21.9 mm [95% CI: 17.3 to 26.5] (n=73) and 17.7 mm[95% CI: 8.1 to 27.3] (n=343) on VAS respectively versus placebo control. In a subgroup analysis of trials with assumed optimal doses, short-term efficacy increased to 22.2 mm [95% CI: 18.1 to 26.3] for TENS, and 24.2 mm [95% CI: 17.3 to 31.3] for LLLT on VAS. Follow-up data up to 12 weeks were sparse, but positive effects seemed to persist for at least 4 weeks after the course of LLLT, EA and TENS treatment was stopped. CONCLUSION: TENS, EA and LLLT administered with optimal doses in an intensive 2-4 week treatment regimen, seem to offer clinically relevant short-term pain relief for OAK  
  Address  
  Publisher
  Language Number of Treatments  
  Treatment Follow-up N/A Frequency N/A Number of Participants  
  Time in Treatment N/A Condition Osteoarthritis,Knee
  Disease Category Arthritis OCSI Score  
  Notes Approved no  
  Call Number Serial 76  
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