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Author (up) Painovich, J. M.; Shufelt, C. L.; Azziz, R.; Yang, Y.; Goodarzi, M. O.; Braunstein, G. D.; Karlan, B. Y.; Stewart, P. M.; Merz, C. N. url  openurl
  Title A pilot randomized, single-blind, placebo-controlled trial of traditional acupuncture for vasomotor symptoms and mechanistic pathways of menopause Type of Study RCT
  Year 2012 Publication Menopause (New York, N.Y.) Abbreviated Journal Menopause  
  Volume 19 Issue 1 Pages 54-61  
  Keywords AcuTrials; Climacteric; Menopause; RCT; Pilot Study; Acu Versus > 1 Control; Acupuncture; TCM Acupuncture Style; Fixed Acupuncture Protocol; Restricted Modalities, Acupuncture Only; Sham Control; Non Penetrating Sham, Mechanical; Near Verum Acupoint Control; Wait-List Control  
  Abstract OBJECTIVE: The aim of this study was to conduct a pilot study for the feasibility of planning a definitive clinical trial comparing traditional acupuncture (TA) with sham acupuncture (SA) and waiting control (WC) on menopause-related vasomotor symptoms (VMS), quality of life, and the hypothalamic-pituitary-adrenal axis in perimenopausal and postmenopausal women. METHODS: Thirty-three perimenopausal and postmenopausal women with at least seven VMS daily were randomized to TA, SA, or WC. The TA and SA groups were given three treatments per week for 12 weeks. Outcomes included the number and severity of VMS, Menopause-Specific Quality of Life Questionnaire, Beck Depression Inventory, Spielberg State-Trait Anxiety Instrument, Pittsburgh Quality Sleep Index, 24-hour urine cortisol and metabolites, and adrenocorticotropic hormone stimulation testing. RESULTS: Both the TA and SA groups demonstrated improved VMS trends compared with the WC group (Delta -3.5 +/- 3.00 vs -4.1 +/- 3.79 vs -1.2 +/- 2.4, respectively; P = 20) and significantly improved Menopause-Specific Quality of Life Questionnaire vasomotor scores (Delta -1.5 +/- 2.02 vs -1.8 +/- 1.52 vs -0.3 +/- 0.64, respectively; P = 0.04). There were no psychosocial group differences. Exit 24-hour urinary measures were lower in the TA versus the SA or WC group in total cortisol metabolites (4,658.9 +/- 1,670.9 vs 7,735.8 +/- 3,747.9 vs 5,166.0 +/- 2,234.5, P = 0.03; respectively) and dehydroepiandrosterone (41.4 +/- 27.46, 161.2 +/- 222.77, and 252.4 +/- 385.40, respectively; P = 0.05). The response data on adrenocorticotropic hormone stimulation cortisol also trended in the hypothesized direction (P = 0.17). CONCLUSIONS: Both TA and SA reduce VMS frequency and severity and improve VMS-related quality of life compared with WC; however, TA alone may impact the hypothalamic-pituitary-adrenal axis. This association is viewed as preliminary and hypothesis generating and should be explored in a large clinical trial.  
  Address Department of Medicine, Cedars-Sinai Heart Institute, Los Angeles, CA, USA; Georgia Health Sciences University, Augusta, GA, USA; Departments of Endocrinology, Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, USA;  
  Language Number of Treatments 36  
  Treatment Follow-up N/A Frequency >1/WK Number of Participants 33  
  Time in Treatment 12 Weeks Condition Menopause
  Disease Category Climacteric OCSI Score  
  Notes Approved no  
  Call Number Serial 923  
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