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Author (up) Rashidi, B. H.; Tehrani, E. S.; Hamedani, N. A.; Pirzadeh, L. url  doi
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  Title Effects of acupuncture on the outcome of in vitro fertilisation and intracytoplasmic sperm injection in women with polycystic ovarian syndrome Type of Study RCT
  Year 2013 Publication Acupuncture in medicine : journal of the British Medical Acupuncture Society Abbreviated Journal Acupunct Med  
  Volume 31 Issue Pages 151-  
  Keywords AcuTrials; RCT; Genital Diseases, Female; Infertility, Female; Polycystic Ovarian Syndrome; Reproductive Techniques, Assisted; In Vitro Fertilization; Acu + Usual Care Versus Usual Care; Acupuncture; TCM Acupuncture Style; Fixed Acupuncture Protocol; Restricted Modalities, Acupuncture Only; Usual Care Control, Multimodality; Fertilization In Vitro  
  Abstract BACKGROUND: Different mechanisms have been described for the effects of acupuncture on fertility. Acupuncture may mediate neurotransmitter release, which results in the stimulation of gonadotrophin-releasing hormone secretion. The production of neurotransmitters such as endogenous opioids may also inhibit central nervous system outflow and biological stress response. Acupuncture may also stimulate blood flow to the uterus by inhibiting uterine central sympathetic nerve activity. Despite some evidence suggesting beneficial effects of acupuncture on in vitro fertilisation (IVF) success rates, recent clinical trials could not duplicate these effects, especially in patients who are infertile with polycystic ovarian syndrome (PCOS) who are undergoing IVF. METHODS: A total of 62 women with PCOS undergoing IVF/intracytoplasmic sperm injection (ICSI) at Shayamehr IVF Clinic in Tehran (Iran) participated in a randomised, controlled trial. Participants were randomly allocated to one of two groups: there were 31 women each in the acupuncture (group I) and control groups (group II). Acupuncture based on traditional Chinese medicine was performed in group I versus no adjunctive treatment in group II. All acupuncture procedures were performed in five sessions: start of downregulation, start of stimulation, 2 days before ovum pick-up, and immediately before and after embryo transfer. We measured the rate of oocytes in metaphase II, the fertilisation rate and the quality of embryos. RESULTS: Our results showed a statistically higher mean of good quality embryos in group I compared with group II (p=0.044). However, the mean number of metaphase II oocytes retrieved and fertilisation rate were similar between the two groups. We also could not find any significant differences among clinical, biochemical or ongoing pregnancy rates. CONCLUSIONS: Acupuncture at an early stage of oocyte recruitment may have a beneficial effect on embryo quality. However, it seems to have no significant effect on other IVF/ICSI outcomes of women with PCOS. TRIAL REGISTRATION NUMBER: (IRCT ID: 201011275181N4).  
  Address Department of Obstetrics and Gynecology, Vali-e-Asr Reproductive Health Research Centre, Tehran University of Medical Sciences, , Tehran, Iran.  
  Publisher
  Language Number of Treatments 5  
  Treatment Follow-up 18 Weeks Frequency 1/WK Number of Participants 62  
  Time in Treatment 5 Weeks Condition Fertilization In Vitro
  Disease Category Reproductive Techniques, Assisted OCSI Score  
  Notes Approved no  
  Call Number Serial 974  
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