|   | 
Details
   web

Deprecated: preg_replace(): The /e modifier is deprecated, use preg_replace_callback instead in /home/acutrialsocom/public_html/refbase-ocom/includes/include.inc.php on line 5275
Records
Author Wang, S.; Qian, Y.-fei; Fan, X.-nong; Zhang, Y.-nan; Wei, Y.-yuan; Zhang, X.; Wu, H.-qun; Li, Y.-jie; Liu, J.; Shi, X.-min
Title [Experimental study on Shuigou (GV 26) of inhibiting effect for neuronal necrosis in rats: morphological evidence of the specificity of acupoint] Type of Study Journal Article
Year 2009 Publication Zhongguo Zhen jiu = Chinese Acupuncture & Moxibustion Abbreviated Journal Zhongguo Zhen Jiu
Volume 29 Issue 9 Pages 733-738
Keywords Acupuncture Points; *Acupuncture Therapy; Animals; Brain Ischemia/*pathology/physiopathology/*therapy; Disease Models, Animal; Humans; Male; Necrosis; Neurons/*pathology/ultrastructure; Random Allocation; Rats; Rats, Wistar
Abstract OBJECTIVE: To investigate the effect of acupoint Shuigou (GV 26) and non-acupoint on inhibiting the neuronal necrosis induced by the middle cerebral artery obstruction (MCAO) in rats through the morphological observation. METHODS: Forty two healthy adult male Wistar rats were randomly divided into a normal group, false-ope ration group, model control group, non-acupuncture group, Shuigou-acupuncture group and non-acupoint acupuncture group, 7 rats in each group. Besides the normal and false-operation groups, the experimental modal of MCAO was established in the other groups by using the Zea-Longa thread method. Acupoint Shuigou (GV 26) and non-acupoint (below the costal region) were selected respectively in the Shuigou-acupuncture group and non-acupoint acupuncture group for puncturing at 180 times/min for 5 seconds. Its effect was estimated by measuring the rate of the neuronal necrosis at the level of the light microscope and the degree of the neuronal necrosis at the level of the electron microscope. RESULTS: (1) At the level of the light microscope, comparing with the model control group (0.66 +/- 0.18), of the neuronal necrosis there were no significant differences in the rate of neuronal necrosis in the non-acupuncture group (0.67 +/- 0.34) and non-acupoint acupuncture group (0.59 +/- 0.11) (both P > 0.05), while it was significantly decreased in the Shuigou-acupuncture group (0.200 +/- 12) (P < 0.05). It indicates that no intervention and wrong (non-acupoint) intervention could light the damage of the neurons, however, only right intervention (Shuigou, GV 26) can obviously decrease the rate of the neuronal necrosis, showing with the specificity of acupoint. (2) At the level of the electron microscope, the ultrastructure of the involved neurons in the non-acupuncture group and non-acupoint acupuncture group is similar to that of the model control group, showing with the serious edema and structure damage. In contrast, the ultrastructure of the involved neurons in the Shuigou-acupuncture group is similar to that of the normal group and false-operation group, showing with light neuronal damage. CONCLUSION: Acupuncturing Shuigou (GV 26) could protect the involved neurons and inhibit the neuronal necrosis induced by the MCAO in rats, but acupuncturing the non-acupoint couldn't, which imply that there is the specificity of acupoint in the acupuncture.
Address Tianjin Key Laboratory of Acupuncture and Moxibustion, Tianjin Institute of Acupuncture and Moxibustion, Tianjin 300193, China
Publisher
Language Chinese Number of Treatments
Treatment Follow-up Frequency Number of Participants
Time in Treatment Condition
Disease Category OCSI Score
Notes PMID:19803243 Approved no
Call Number OCOM @ refbase @ Serial 1805
Permanent link to this record
 

 
Author Wang, S.; Qian, Y.F.; Fan, X.N.; Zhang, Y.N.; Wei, Y.Y.; Zhang, X.; Wu, H.Q.; Li, Y.J.; Liu, J.; Shi, X.M.
Title [Experimental study on Shuigou (GV 26) of inhibiting effect for neuronal necrosis in rats: morphological evidence of the specificity of acupoint] Type of Study Journal Article
Year 2009 Publication Zhongguo Zhen Jiu Abbreviated Journal
Volume Issue Pages 733-738
Keywords Acupuncture Points; *Acupuncture Therapy; Animals; Brain Ischemia/*pathology/physiopathology/*therapy; Disease Models, Animal; Humans; Male; Necrosis; Neurons/*pathology/ultrastructure; Random Allocation; Rats; Rats, Wistar
Abstract OBJECTIVE: To investigate the effect of acupoint Shuigou (GV 26) and non-acupoint on inhibiting the neuronal necrosis induced by the middle cerebral artery obstruction (MCAO) in rats through the morphological observation. METHODS: Forty two healthy adult male Wistar rats were randomly divided into a normal group, false-ope ration group, model control group, non-acupuncture group, Shuigou-acupuncture group and non-acupoint acupuncture group, 7 rats in each group. Besides the normal and false-operation groups, the experimental modal of MCAO was established in the other groups by using the Zea-Longa thread method. Acupoint Shuigou (GV 26) and non-acupoint (below the costal region) were selected respectively in the Shuigou-acupuncture group and non-acupoint acupuncture group for puncturing at 180 times/min for 5 seconds. Its effect was estimated by measuring the rate of the neuronal necrosis at the level of the light microscope and the degree of the neuronal necrosis at the level of the electron microscope. RESULTS: (1) At the level of the light microscope, comparing with the model control group (0.66 +/- 0.18), of the neuronal necrosis there were no significant differences in the rate of neuronal necrosis in the non-acupuncture group (0.67 +/- 0.34) and non-acupoint acupuncture group (0.59 +/- 0.11) (both P > 0.05), while it was significantly decreased in the Shuigou-acupuncture group (0.200 +/- 12) (P < 0.05). It indicates that no intervention and wrong (non-acupoint) intervention could light the damage of the neurons, however, only right intervention (Shuigou, GV 26) can obviously decrease the rate of the neuronal necrosis, showing with the specificity of acupoint. (2) At the level of the electron microscope, the ultrastructure of the involved neurons in the non-acupuncture group and non-acupoint acupuncture group is similar to that of the model control group, showing with the serious edema and structure damage. In contrast, the ultrastructure of the involved neurons in the Shuigou-acupuncture group is similar to that of the normal group and false-operation group, showing with light neuronal damage. CONCLUSION: Acupuncturing Shuigou (GV 26) could protect the involved neurons and inhibit the neuronal necrosis induced by the MCAO in rats, but acupuncturing the non-acupoint couldn't, which imply that there is the specificity of acupoint in the acupuncture.
Address
Publisher
Language Number of Treatments
Treatment Follow-up Frequency Zhongguo zhen jiu = Chinese acupuncture & moxibustion Number of Participants
Time in Treatment 29 Condition 9
Disease Category OCSI Score
Notes Date of Input: 6/25/2015; Priority: Normal; Tianjin Key Laboratory of Acupuncture and Moxibustion, Tianjin Institute of Acupuncture and Moxibustion, Tianjin 300193, China.; chi; Web: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=19803243 Approved no
Call Number OCOM @ refbase @ Serial 1574
Permanent link to this record