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Author Qu, S. S.; Huang, Y.; Zhang, Z. J.; Chen, J. Q.; Lin, R. Y.; Wang, C. Q.; Li, G. L.; Wong, H. K.; Zhao, C. H.; Pan, J. Y.; Guo, S. C.; Zhang, Y. C. url  doi
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  Title A 6-week randomized controlled trial with 4-week follow-up of acupuncture combined with paroxetine in patients with major depressive disorder Type of Study RCT
  Year 2013 Publication Journal of psychiatric research Abbreviated Journal J Psychiatr Res  
  Volume 47 Issue 6 Pages 726-732  
  Keywords AcuTrials; RCT; Mental Disorders; Depressive Disorder, Major; Depression; Acu Versus > 1 Control; Acu Versus Acu; Acu + Usual Care Versus Usual Care; Electroacupuncture; TCM Acupuncture Style; Fixed Acupuncture Protocol; Restricted Modalities, Acupuncture Only; CAM Control; Usual Care Control, Pharmaceutical; Mental Illness  
  Abstract Acupuncture possesses the antidepressant potential. In this 6-week randomized controlled trial with 4-week follow-up, 160 patients with major depressive disorder (MDD) were randomly assigned to paroxetine (PRX) alone (n = 48) or combined with 18 sessions of manual acupuncture (MA, n = 54) or electrical acupuncture (EA, n = 58). Treatment outcomes were measured mainly using the 17-item Hamilton Depression Rating Scale (HAMD-17), Self-rating Depression Scale (SDS), clinical response and remission rates. Average PRX dose taken and proportion of patients who required an increased PRX dose due to symptom aggravation were also obtained. Both additional MA and EA produced a significantly greater reduction from baseline in score on HAMD-17 and SDS at most measure points from week 1 through week 6 compared to PRX alone. The clinical response was markedly greater in MA (69.8%) and EA (69.6%) groups than the group treated with PRX alone (41.7%, P = 0.004). The proportion of patients who required an increase dose of PRX due to symptom aggravation was significantly lower with MA (5.7%) and EA (8.9%) than PRX alone (22.9%, P = 0.019). At 4 weeks follow-up after completion of acupuncture treatment, patients with EA, but not MA, continued to show significantly greater clinical improvement. Incidence of adverse events was not different in the three groups. Our study indicates that acupuncture can accelerate the clinical response to selective serotonin reuptake inhibitors (SSRIs) and prevent the aggravation of depression. Electrical acupuncture may have a long-lasting enhancement of the antidepressant effects (Trial Registration: ChiCTR-TRC-08000278).  
  Address School of Traditional Chinese Medicine, Southern Medical University, 1023 Shatai Road, Guangzhou, Guangdong 510515, China.  
  Publisher
  Language Number of Treatments 18  
  Treatment Follow-up 4 Weeks Frequency >1/WK Number of Participants 160  
  Time in Treatment 6 Weeks Condition Depressive Disorder, Major
  Disease Category Mental Disorders OCSI Score  
  Notes Approved no  
  Call Number Serial 966  
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