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Author (up) Allen, J. J.; Schnyer, R. N.; Chambers, A. S.; Hitt, S. K.; Moreno, F. A.; Manber, R. url  openurl
  Title Acupuncture for depression: a randomized controlled trial Type of Study RCT
  Year 2006 Publication The Journal of clinical psychiatry Abbreviated Journal J Clin Psychiatry  
  Volume 67 Issue 11 Pages 1665-1673  
  Keywords Acu Versus > 1 Control; Acupuncture; AcuTrials; Depression; Depressive Disorder; Individualized Acupuncture Protocol; Penetrating Sham; Manualized Acupuncture Protocol; Non Specific Acupoint Control; RCT; Sham Control; Standard Needling Depth; TCM Acupuncture Style; Traditional Diagnosis Based Point Selection; Wait-List Control  
  Abstract OBJECTIVE: To assess the efficacy of acupuncture as an intervention for major depressive disorder (MDD). METHOD: Acupuncture was examined in 151 patients with MDD (DSM-IV) who were randomly assigned to 1 of 3 groups in a double-blind randomized controlled trial. The specific intervention involved Traditional Chinese Medicine (TCM)-style acupuncture with manual stimulation for depression; the control conditions consisted of (1) a nonspecific intervention using a comparable number of legitimate acupuncture points not specifically targeted to depressive symptoms and (2) a waitlist condition, which involved waiting without intervention for 8 weeks. After 8 weeks, all patients received the depression-specific acupuncture. Each 8-week intervention regimen consisted of 12 acupuncture sessions delivered in an acupuncturist's office in the community. The primary outcome measure was the 17-item Hamilton Rating Scale for Depression. The study was conducted from February 1998 to April 2002. RESULTS: Twenty patients terminated treatment before the completion of the 8-week intervention (13%) but not differentially by study group. Random regression models of the intent-to-treat sample revealed that although patients receiving acupuncture improved more than those awaiting intervention, no evidence of differential efficacy of the depression-specific over nonspecific intervention was found. Response rates in acupuncture-treated patients were relatively low after 8 weeks (22% and 39% for specific and nonspecific intervention groups, respectively), with the response rate after the entire 16-week trial reaching 50%. CONCLUSION: Although TCM manual acupuncture is a well-tolerated intervention, results fail to support its efficacy as a monotherapy for MDD. It can't be ruled out that factors unique to the implementation of acupuncture in this research study may have limited the efficacy of interventions compared to those provided in naturalistic settings. CLINICAL TRIALS REGISTRATION: ClinicalTrials.gov identifier NCT00010517  
  Address Department of Psychology, University of Arizona, Tucson 85721-0068, USA. jallen@u.arizona.edu  
  Publisher
  Language Number of Treatments 12  
  Treatment Follow-up 16 Weeks Frequency >1/WK Number of Participants 151  
  Time in Treatment 8 Weeks Condition Depressive Disorder
  Disease Category Mental Disorders OCSI Score 77  
  Notes Approved no  
  Call Number Serial 20  
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