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Author (up) Dickman, R.; Schiff, E.; Holland, A.; Wright, C.; Sarela, S. R.; Han, B.; Fass, R. url  openurl
  Title Acupuncture vs. doubling the PPI dose in refractory heartburn Type of Study RCT
  Year 2007 Publication Alimentary pharmacology & therapeutics Abbreviated Journal Aliment Pharmacol Ther  
  Volume Issue Pages -  
  Keywords Acu + Usual Care Versus Usual Care; Acupuncture; AcuTrials; Gastroesophageal Reflux; Gastrointestinal Diseases; RCT; Restricted Modalities, Acupuncture Only; Semi-Individualized Acupuncture Protocol; Usual Care Control, Pharmaceutical; TCM Acupuncture Style; Traditional Diagnosis Based Point Selection  
  Abstract Background and Aims: The current standard of care in PPI failure is to double the PPI dose, despite limited therapeutic gain. The aim of the study was to determine the efficacy of adding acupuncture versus doubling the PPI dose in GERD patients who failed symptomatically on PPI once daily. Methods: Thirty patients with classic heartburn symptoms who continued to be symptomatic on standard-dose PPI were enrolled into the study. All participants underwent upper endoscopy while on PPI once daily. Subsequently, patients were randomized to either adding acupuncture to their PPI or doubling the PPI dose over a period of four weeks. Acupuncture was delivered twice a week by an expert. Results: The two groups did not differ in demographic parameters. The acupuncture + PPI group demonstrated a significant decrease in the mean daytime heartburn, nighttime heartburn, and acid regurgitation scores at the end of treatment as compared to baseline, while the double-dose PPI group did not demonstrate a significant change in their clinical endpoints. Mean general health score was only significantly improved in the acupuncture + PPI group. Conclusions: Adding acupuncture is more effective than doubling the PPI dose in controlling GERD-related symptoms in patients who failed standard-dose PPI  
  Address The Neuroenteric Clinical Research Group, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, AZ, USA  
  Language Number of Treatments 10  
  Treatment Follow-up N/A Frequency >1/WK Number of Participants 30  
  Time in Treatment 4 Weeks Condition Gastroesophageal Reflux
  Disease Category Gastrointestinal Diseases OCSI Score  
  Notes Approved no  
  Call Number Serial 244  
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