||Objective: To observe clinical therapeutic effects of combined needling at Shu- and Mu-points on climacteric syndrome. Methods: Sixty-five cases of climacteric syndrome were randomly divided into 3 groups: an observation group treated by combined needling at Shu- and Mu-points, a conventional acupuncture group and a medication group. The therapeutic effects were compared among the 3 groups. Results: The total effective rate was respectively 93.3%, 80.0%, and 66.7%, in the observation group, conventional acupuncture group and medication group, with a significant difference among the 3 groups (P<0.05). Conclusion: The therapeutic effect of combined needling at Shu- and Mu-points was significantly better than that of conventional acupuncture and medication.