||OBJECTIVE: To observe the clinical effects of a combination of acupuncture and drug administration for non-specific acute lumbar sprain. METHODS: Sixty-nine cases were randomly allocated into a combination group, an acupuncture group, and a drug group according to the visiting sequence. Patients in the acupuncture group (n=24) were treated with acupuncture daily for 5 d, 20 patients in the drug group were treated with oral Diclofenac Sodium, 50 mg per time, twice per day, for 5 d, and 25 patients in the combination group were treated with methods in both the acupuncture group and the drug group. The Numerical Rating Scale (NRS) and the Roland-Morris Disability Questionnaire (RMDQ) were used to evaluate the therapeutic effects. RESULTS: All patients in the three groups got improvement in pain and movement, the combination group had the best effects (P<0.01), and there was no significant difference between the acupuncture group and the drug group. CONCLUSION: Combination of acupuncture and drug has a better effect than single acupuncture or routine treatment of Diclofenac Sodium on acute lumbar sprain.