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Author (up) Mitchell, A.J.; Hall, R.W.; Golianu, B.; Yates, C.; Williams, D.K.; Chang, J.; Anand, K.J.S. url  doi
openurl 
  Title Does noninvasive electrical stimulation of acupuncture points reduce heelstick pain in neonates? Type of Study
  Year 2016 Publication Acta Paediatrica (Oslo, Norway : 1992) Abbreviated Journal Acta Paediatr  
  Volume 105 Issue 12 Pages 1434-1439  
  Keywords Blood Specimen Collection/*adverse effects; Double-Blind Method; *Electroacupuncture; Humans; *Infant, Newborn; Neonatal Screening/*adverse effects; Pain/*prevention & control; * Nesap; * Pipp; *Neonates; *Pain; *Sucrose  
  Abstract AIM: Noninvasive electrical stimulation at acupuncture points (NESAP) for analgesia is used in children, but has not been widely studied in neonates. The purpose of this study was to determine whether NESAP alone or in combination with sucrose relieved heelstick pain in neonates. METHODS: Term neonates (n = 162) receiving routine heelsticks for newborn screening were enrolled following parental consent. All infants received facilitated tucking and non-nutritive sucking. Neonates were randomised to standard care, sucrose, NESAP or sucrose plus NESAP. NESAP (3.5 mA, 10 Hz) or sham was administered over four acupuncture points. The Premature Infant Pain Profile (PIPP), heart rate variability (HRV) and salivary cortisol were used to measure heelstick pain. RESULTS: PIPP scores among all four treatment groups increased during heelstick, F (9,119) = 1.95, p = 0.05 and NESAP therapy had no significant effect on PIPP scores. However, PIPP scores from baseline to heelstick increased the most in the two groups not receiving sucrose (p < 0.01). Mean PIPP scores remained below five during the heelstick in all four groups, indicating minimal or no pain. Differences in HRV and salivary cortisol among groups were insignificant. CONCLUSION: NESAP at 3.5 mA, 10 Hz is not effective in relieving pain during heelsticks in neonates.  
  Address Stanford University and Lucile Packard Children's Hospital Stanford, Palo Alto, CA, USA  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes PMID:27607517; PMCID:PMC5118154 Approved no  
  Call Number OCOM @ refbase @ Serial 2168  
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