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Author (up) Nedeljkovic, M.; Tian, L.; Ji, P.; Deglon-Fischer, A.; Stute, P.; Ocon, E.; Birkhauser, M.; Ausfeld-Hafter, B. url  doi
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  Title Effects of acupuncture and Chinese herbal medicine (Zhi Mu 14) on hot flushes and quality of life in postmenopausal women: results of a four-arm randomized controlled pilot trial Type of Study RCT
  Year 2014 Publication Menopause (New York, N.Y.) Abbreviated Journal Menopause  
  Volume 21 Issue 1 Pages 15-24  
  Keywords Climacteric; Hot Flashes; Menopause; Postmenopause; RCT; Pilot Study; Acu Versus > 1 Control; Acupuncture; Herbal Formula; TCM Acupuncture Style; Semi-Individualized Acupuncture Protocol; Traditional Diagnosis Based Point Selection; Restricted Modalities, Acupuncture Only; Sham Control; Penetrating Sham; Superficial Needling Depth; Sham Acupoint Control; CAM Control; Placebo Herbal Formula  
  Abstract OBJECTIVE: The aim of this study was to evaluate the feasibility of a clinical trial investigating the effects of acupuncture (AP) and Chinese herbal medicine (CHM) on hot flushes and quality of life in postmenopausal women. METHODS: Forty postmenopausal women reporting at least 20 hot flushes per week were enrolled in a randomized controlled trial. They were randomly allocated to receive traditional Chinese medicine (TCM) AP, sham AP, verum CHM, or placebo CHM for 12 weeks. Follow-up assessment was conducted 12 weeks after intervention. Primary outcome measures included hot flush frequency and severity. As a secondary outcome measure, the severity of menopausal symptoms was assessed using the Menopause Rating Scale (MRS) II. RESULTS: TCM AP induced a significant decline in all outcome measures from pretreatment to posttreatment compared with sham AP (hot flush frequency, P = 0.016; hot flush severity, P = 0.013; MRS, P < 0.001). In the TCM AP group, a larger decrease in MRS scores persisted from pretreatment to follow-up (P = 0.048). No significant differences were noted between the verum CHM group and the placebo CHM group. Compared with the verum CHM group, there was a significant decrease in MRS scores (P = 0.002) and a trend toward a stronger decrease in hot flush severity (P = 0.06) in the TCM AP group from pretreatment to posttreatment. CONCLUSIONS: TCM AP is superior to sham AP and verum CHM in reducing menopausal symptoms, whereas verum CHM shows no significant improvements when compared with placebo CHM.  
  Address Institute of Complementary Medicine KIKOM, University of Bern, Bern, Switzerland  
  Publisher
  Language Number of Treatments 12  
  Treatment Follow-up 12 Weeks Frequency 1/WK Number of Participants 40  
  Time in Treatment 12 Weeks Condition Hot Flashes
  Disease Category Climacteric OCSI Score  
  Notes Approved no  
  Call Number Serial 901  
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