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Author (up) Rithirangsriroj, K.; Manchana, T.; Akkayagorn, L. doi  openurl
  Title Efficacy of acupuncture in prevention of delayed chemotherapy induced nausea and vomiting in gynecologic cancer patients Type of Study Journal Article
  Year 2015 Publication Gynecol Oncol Abbreviated Journal  
  Volume 136 Issue 1 Pages 82-86  
  Keywords Neoplasms; Chemotherapy Side Effects; Cancer; Antineoplastic Agents; Nausea and Vomiting; Chemotherapy Induced Nausea and Vomiting; Rct; Cross-Over Design; Acu + Usual Care Versus Usual Care; Acupuncture; TCM Acupuncture Style; Fixed Acupuncture Protocol; Restricted Modalities, Acupuncture Only; Usual Care Control, Pharmaceutical  
  Abstract OBJECTIVE: To compare the efficacy between acupuncture and ondansetron in the prevention of delayed chemotherapy induced nausea and vomiting (CINV). METHODS: 70 patients were randomized to receive either 1) acupuncture at P6 point before chemotherapy infusion or 2) ondansetron 8 mg intravenously 30 min before chemotherapy infusion in their first cycle with cross-over of antiemetic regimen in the consecutive cycle. All patients received dexamethasone 5mg orally twice a day for 3 days. Patients were given additional does of ondansetron 4 mg orally every 12h if they experienced emesis. Emetic episode, severity of nausea score of 0-10 and adverse events were recorded. Complete response was defined as no nausea, no vomiting and no requirement of additional antiemetic drugs. FACT-G scale was used to evaluate quality of life (QOL) 7 days after each cycle of chemotherapy. RESULTS: The acupuncture group had a significantly higher rate of complete response in the prevention of delayed CINV (52.8% and 35.7%, P = 0.02). Compared to another group, the acupuncture group reported significantly lower delayed nausea (45.7% and 65.7%, P = 0.004), nausea score (P < 0.001) and fewer dosages of additional oral ondansetron (P = 0.002). Adverse effects were also significantly lower in the acupuncture group with less frequent constipation (P = 0.02) and insomnia (P = 0.01). Overall FACT-G scores were significantly higher in the acupuncture group. CONCLUSION: Acupuncture is effective in preventing delayed CINV and in promoting better QOL. With fewer adverse effects, it may be used as an alternative treatment option for CINV.  
  Language Number of Treatments 2  
  Treatment Follow-up 1 Weeks Frequency >1/WK Number of Participants 70  
  Time in Treatment 2 Days Condition Chemotherapy side-effects
  Disease Category Neoplasms OCSI Score  
  Notes Date of Input: 4/7/2015; Date Modified: 5/7/2015; Availability: --In File--; Priority: Normal; Chemotherapy Side Effects; Gynecologic Oncology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand; eng SI – TCTR/20131105001; Web: Approved no  
  Call Number OCOM @ refbase @ Serial 1696  
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