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Author (up) Shen, J.; Wenger, N.; Glaspy, J.; Hays, R. D.; Albert, P. S.; Choi, C.; Shekelle, P. G. url  openurl
  Title Electroacupuncture for control of myeloablative chemotherapy-induced emesis: A randomized controlled trial Type of Study RCT
  Year 2000 Publication Abbreviated Journal JAMA  
  Volume 284 Issue 21 Pages 2755-2761  
  Keywords Acu Versus > 1 Control; AcuTrials; Breast Cancer; Breast Neoplasms; Cancer; Chemotherapy; Electroacupuncture; Emesis; Fixed Acupuncture Protocol; Penetrating Sham; Nausea; Non Specific Acupoint Control; RCT; Restricted Modalities, Acupuncture Only; Superficial Needling Depth; Sham Control; Usual Care Control, Pharmaceutical; TCM Acupuncture Style; Vomiting; Women's Health  
  Abstract CONTEXT: High-dose chemotherapy poses considerable challenges to emesis management. Although prior studies suggest that acupuncture may reduce nausea and emesis, it is unclear whether such benefit comes from the nonspecific effects of attention and clinician-patient interaction. OBJECTIVE: To compare the effectiveness of electroacupuncture vs minimal needling and mock electrical stimulation or antiemetic medications alone in controlling emesis among patients undergoing a highly emetogenic chemotherapy regimen. DESIGN: Three-arm, parallel-group, randomized controlled trial conducted from March 1996 to December 1997, with a 5-day study period and a 9-day follow-up. SETTING: Oncology center at a university medical center. PATIENTS: One hundred four women (mean age, 46 years) with high-risk breast cancer. INTERVENTIONS: Patients were randomly assigned to receive low-frequency electroacupuncture at classic antiemetic acupuncture points once daily for 5 days (n = 37); minimal needling at control points with mock electrostimulation on the same schedule (n = 33); or no adjunct needling (n = 34). All patients received concurrent triple antiemetic pharmacotherapy and high-dose chemotherapy (cyclophosphamide, cisplatin, and carmustine). MAIN OUTCOME MEASURES: Total number of emesis episodes occurring during the 5-day study period and the proportion of emesis-free days, compared among the 3 groups. RESULTS: The number of emesis episodes occurring during the 5 days was lower for patients receiving electroacupuncture compared with those receiving minimal needling or pharmacotherapy alone (median number of episodes, 5, 10, and 15, respectively; P<.001). The electroacupuncture group had fewer episodes of emesis than the minimal needling group (P<.001), whereas the minimal needling group had fewer episodes of emesis than the antiemetic pharmacotherapy alone group (P =.01). The differences among groups were not significant during the 9-day follow-up period (P =.18). CONCLUSIONS: In this study of patients with breast cancer receiving high-dose chemotherapy, adjunct electroacupuncture was more effective in controlling emesis than minimal needling or antiemetic pharmacotherapy alone, although the observed effect had limited duration. JAMA. 2000;284:2755-2761  
  Address National Institutes of Health, Laboratory of Clinical Studies/NIAAA, Room 6 S-240, Mail Stop 1610, 10 Center Dr, Bldg 10, Bethesda, MD 20892-1610, USA  
  Language Number of Treatments 5  
  Treatment Follow-up 1.5 Weeks Frequency >1/WK Number of Participants 104  
  Time in Treatment 1 Week Condition Vomiting, Anticipatory
  Disease Category Vomiting OCSI Score 87  
  Notes Approved no  
  Call Number Serial 1035  
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