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Author Lee, S.M.K.; Kim, H.S.; Park, J.; Woo, J.S.; Leem, J.; Park, J.H.; Lee, S.; Chung, H.; Lee, J.M.; Kim, J.-B.; Kim, W.-S.; Kim, K.S.; Kim, W. url  doi
  Title Electroacupuncture prevents endothelial dysfunction induced by ischemia-reperfusion injury via a cyclooxygenase-2-dependent mechanism: A randomized controlled crossover trial Type of Study RCT
  Year 2017 Publication PloS one Abbreviated Journal PLoS One  
  Volume 12 Issue 6 Pages 1-13  
  Keywords AcuTrials; RCT; Cardiovascular Diseases; Reperfusion Injury; Vascular Diseases; Pilot Study; Cross-Over Design; Acu Versus Sham; Acu Versus Usual Care; Electroacupuncture; Korean Acupuncture Style; Fixed Acupuncture Protocol; Restricted Modalities; Acupuncture Only; Sham Control; Penetrating Sham; Superficial Needling Depth; Near Verum Acupoint Control  
  Abstract OBJECTIVE: Exploring clinically effective methods to reduce ischemia-reperfusion (IR) injury in humans is critical. Several drugs have shown protective effects, but studies using other interventions have been rare. Electroacupuncture (EA) has induced similar protection in several animal studies but no study has investigated how the effects could be translated and reproduced in humans. This study aimed to explore the potential effect and mechanisms of EA in IR-induced endothelial dysfunction in humans. METHODS: This is a prospective, randomized, crossover, sham-controlled trial consisting of two protocols. Protocol 1 was a crossover study to investigate the effect of EA on IR-induced endothelial dysfunction. Twenty healthy volunteers were randomly assigned to EA or sham EA (sham). Flow mediated dilation (FMD) of the brachial artery (BA), nitroglycerin-mediated endothelial independent dilation, blood pressure before and after IR were measured. In protocol 2, seven volunteers were administered COX-2 inhibitor celecoxib (200 mg orally twice daily) for five days. After consumption, volunteers underwent FMD before and after IR identical to protocol 1. RESULTS: In protocol 1, baseline BA diameter, Pre-IR BA diameter and FMD were similar between the two groups (p = NS). After IR, sham group showed significantly blunted FMD (Pre-IR: 11.41 +/- 3.10%, Post-IR: 4.49 +/- 2.04%, p < 0.001). However, EA protected this blunted FMD (Pre-IR: 10.96 +/- 5.30%, Post-IR: 9.47 +/- 5.23%, p = NS, p < 0.05 compared with sham EA after IR). In protocol 2, this protective effect was completely abolished by pre-treatment with celecoxib (Pre-IR: 11.05 +/- 3.27%; Post-IR: 4.20 +/- 1.68%, p = 0.001). CONCLUSION: EA may prevent IR-induced endothelial dysfunction via a COX-2 dependent mechanism.  
  Address Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea  
  Language English Number of Treatments 2  
  Treatment Follow-up N/A Frequency 1/WK Number of Participants 20  
  Time in Treatment 2 Weeks Condition Reperfusion Injury
  Disease Category Cardiovascular Diseases OCSI Score  
  Notes PMID:28591155; PMCID:PMC5462401 Approved no  
  Call Number OCOM @ refbase @ Serial 2418  
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