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Author (up) Soliman, A.; O'Driscoll, G.A.; Pruessner, J.; Joober, R.; Ditto, B.; Streicker, E.; Goldberg, Y.; Caro, J.; Rekkas, P.V.; Dagher, A. openurl 
  Title Limbic response to psychosocial stress in schizotypy: a functional magnetic resonance imaging study Type of Study Journal Article
  Year 2011 Publication Schizophr Res Abbreviated Journal  
  Volume Issue Pages 184-91 LID - 10.1016/j.s  
  Keywords Adolescent; Brain Mapping; Female; Humans; Hydrocortisone/metabolism; Image Processing, Computer-Assisted; Limbic System/*blood supply; Linear Models; *Magnetic Resonance Imaging; Male; Oxygen/blood; Personality Inventory; Psychiatric Status Rating Scales; Saliva; Schizotypal Personality Disorder/complications/*pathology; Stress, Psychological/complications/*pathology; Young Adult  
  Abstract Psychological stress causes dopamine release in the striatum and is thought to play a role in susceptibility to psychotic illness. Previous work suggests that an elevated dopaminergic response to stress may index vulnerability to psychosis in certain individuals. With functional magnetic resonance imaging, we measured stress-induced changes in brain activity in healthy individuals at elevated risk of developing psychosis. Participants were 15 controls and 25 psychometric schizotypes: 12 with positive symptom schizotypy (perceptual aberrations) and 13 with negative symptom schizotypy (physical anhedonia), as determined by questionnaires (Chapman et al., 1976; Chapman and Chapman, 1978). In the scanner, participants performed the Montreal Imaging Stress Task and a matched sensory-motor control task. Measures of self-reported stress and salivary cortisol levels were taken throughout the experiment. All three groups showed significant increases in self-reported stress and significant fMRI signal change in the striatal, limbic and cortical regions. However, the Physical Anhedonia group showed greater stress-induced striatal and limbic deactivation than the other two groups. Deactivation in the striatum was significantly correlated with Physical Anhedonia score across all subjects. Our findings suggest the presence of abnormalities in striatal response to stress in negative symptom schizotypy.  
  Publisher Copyright (c) 2011 Elsevier B.V. All rights reserved.
  Language Number of Treatments  
  Treatment Follow-up Frequency Schizophrenia research Number of Participants  
  Time in Treatment 131 Condition 1-3
  Disease Category OCSI Score  
  Notes Date of Input: 7/29/2015; Priority: Normal; McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, Canada.; eng; Web: Approved no  
  Call Number OCOM @ refbase @ Serial 1556  
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