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Author Bao, C. H.; Zhao, J. M.; Liu, H. R.; Lu, Y.; Zhu, Y. F.; Shi, Y.; Weng, Z. J.; Feng, H.; Guan, X.; Li, J.; Chen, W. F.; Wu, L. Y.; Jin, X. M.; Dou, C. Z.; Wu, H. G.
Title Randomized controlled trial: Moxibustion and acupuncture for the treatment of Crohn's disease Type of Study RCT
Year 2014 Publication World journal of gastroenterology : WJG Abbreviated Journal World J Gastroenterol
Volume 20 Issue 31 Pages 11000-
Keywords AcuTrials; Gastrointestinal Diseases; Crohn Disease; RCT; Fixed Acupuncture Protocol; Restricted Modalities, Acupuncture + Other; Sham Control; Penetrating Sham; Superficial Needling Depth; Near Verum Acupoint Control; Acu Versus Sham; Acupuncture; Moxibustion; Moxa; Warming Needle; Indirect Moxibustion; TCM Acupuncture Style
Abstract AIM: To evaluate the clinical efficacy and safety of acupuncture and moxibustion for the treatment of active Crohn's disease (CD). METHODS: Ninety-two patients were equally and randomly divided into the treatment group and received herb-partitioned moxibustion combined with acupuncture, and the control group received wheat bran-partitioned moxibustion combined with superficial acupuncture. The patients received three treatment sessions per week for 12 wk and were followed up for 24 wk. The main outcome was evaluated using the CD Activity Index (CDAI) score, and the secondary outcomes were evaluated using laboratory indicators such as hemoglobin (HGB), C-reactive protein (CRP), erythrocyte sedimentation rate, quality-of-life, endoscopic ratings, and intestinal histology scores. RESULTS: The CDAI scores of both the treatment and control groups were significantly reduced after treatment compared with those measured before treatment. However, the degree of improvement in the treatment group was significantly greater than that of the control group. The improvement in symptoms in patients of the treatment group was sustained at follow-up, whereas that of the control group was not. The overall efficacy of the treatment was significantly greater than that of the control. Both groups demonstrated significant improvements in quality-of-life ratings after treatment, but the improvement was significantly greater in the treatment group than in the control group. In addition, the patients in the treatment group showed significantly increased HGB and significantly decreased CRP levels and histopathological scores at the end of treatment, whereas the control group did not exhibit significant changes. CONCLUSION: Moxibustion with acupuncture provided significant therapeutic benefits in patients with active CD beyond the placebo effect and is therefore an effective and safe treatment for active CD.
Address Key Laboratory of Acupuncture-Moxibustion and Immunological Effects, Shanghai University of Traditional Chinese Medicine, Shanghai 200030, China.
Publisher
Language Number of Treatments 36
Treatment Follow-up 24 Weeks Frequency >1/WK Number of Participants 92
Time in Treatment 12 Weeks Condition Crohn Disease
Disease Category Gastrointestinal Diseases OCSI Score
Notes Approved no
Call Number Serial 58
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