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Author (up) Wang, X.; Wang, Z.; Liu, J.; Chen, J.; Liu, X.; Nie, G.; Byun, J.-S.; Liang, Y.; Park, J.; Huang, R.; Liu, M.; Liu, B.; Kong, J. url  doi
  Title Repeated acupuncture treatments modulate amygdala resting state functional connectivity of depressive patients Type of Study Journal Article
  Year 2016 Publication NeuroImage. Clinical Abbreviated Journal Neuroimage Clin  
  Volume 12 Issue Pages 746-752  
  Keywords Acupuncture; Amygdala; Combination effect; Depression; Fluoxetine; Limbic system; Resting-state functional connectivity  
  Abstract As a widely-applied alternative therapy, acupuncture is gaining popularity in Western society. One challenge that remains, however, is incorporating it into mainstream medicine. One solution is to combine acupuncture with other conventional, mainstream treatments. In this study, we investigated the combination effect of acupuncture and the antidepressant fluoxetine, as well as its underlying mechanism using resting state functional connectivity (rsFC) in patients with major depressive disorders. Forty-six female depressed patients were randomized into a verum acupuncture plus fluoxetine or a sham acupuncture plus fluoxetine group for eight weeks. Resting-state fMRI data was collected before the first and last treatments. Results showed that compared with those in the sham acupuncture treatment, verum acupuncture treatment patients showed 1) greater clinical improvement as indicated by Montgomery-Asberg Depression Rating Scale (MADRS) and Self-Rating Depression Scale (SDS) scores; 2) increased rsFC between the left amygdala and subgenual anterior cingulate cortex (sgACC)/preguenual anterior cingulate cortex (pgACC); 3) increased rsFC between the right amygdala and left parahippocampus (Para)/putamen (Pu). The strength of the amygdala-sgACC/pgACC rsFC was positively associated with corresponding clinical improvement (as indicated by a negative correlation with MADRS and SDS scores). Our findings demonstrate the additive effect of acupuncture to antidepressant treatment and suggest that this effect may be achieved through the limbic system, especially the amygdala and the ACC.  
  Address Psychiatry Department, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA  
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes PMID:27812501; PMCID:PMC5079358 Approved no  
  Call Number OCOM @ refbase @ Serial 2117  
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