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Author (up) Zhuang, L.; Yang, Z.; Zeng, X.; Zhua, X.; Chen, Z.; Liu, L.; Meng, Z.
Title The Preventive and Therapeutic Effect of Acupuncture for Radiation-Induced Xerostomia in Patients With Head and Neck Cancer: A Systematic Review Type of Study Systematic Review
Year 2012 Publication Integrative cancer therapies Abbreviated Journal Integr Cancer Ther
Volume Issue Pages -
Keywords AcuTrials; Systematic Review; Neoplasms; Xerostomia; Acupuncture; Dry Mouth; Cancer
Abstract Background. METHODS: Some studies suggest that acupuncture may be beneficial. Objectives. The authors evaluated the preventive and therapeutic effect of acupuncture for radiation-induced xerostomia among patients with head and neck cancer. Methods. PUBMED, EMBASE, Cochrane Library, CBM, CAJD, Wan Fang database, and VIP Database for Chinese Technical Periodicals were electronically searched, in conjunction with further manual search for relevant articles. Studies that met the inclusion criteria were systematically evaluated. RESULTS: Three randomized controlled trials (RCTs) investigating the therapeutic effect of acupuncture were included. One RCT on the preventive effect of acupuncture was found. Because of the considerable variation among included studies, meta-analysis was not possible. Two included RCTs used placebo controls, and both observed significant improvement in the salivary flow rates between acupuncture and control groups. However, no significant differences were found. Three included RCTs suggested that acupuncture for radiation-induced xerostomia can improve patients' subjective symptoms. The only study evaluating the preventive effect of acupuncture for radiation-induced xerostomia showed positive changes in salivary flow rates (both unstimulated and stimulated) and dry mouth -related symptoms. Acupuncture treatment was well tolerated by all patients and no severe adverse effects were seen. CONCLUSIONS: Insufficient evidence is available to judge whether acupuncture is safe and whether it is effective in preventing or treating radiation-induced xerostomia. Significant research remains to be done before acupuncture can be recommended for routine use in radiation-induced xerostomia.
Address Fudan University Shanghai Cancer Center, Shanghai, China; Shanghai Medical College, Fudan University, Shanghai, China.
Language Number of Treatments
Treatment Follow-up Frequency Number of Participants
Time in Treatment Condition Xerostomia
Disease Category Neoplasms OCSI Score
Notes Approved no
Call Number Serial 1495
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