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Author (up) Zhou, J.; Peng, W.; Xu, M.; Li, W.; Liu, Z. url  doi
  Title The effectiveness and safety of acupuncture for patients with Alzheimer disease: a systematic review and meta-analysis of randomized controlled trials Type of Study Journal Article
  Year 2015 Publication Medicine (Baltimore) Abbreviated Journal  
  Volume 94 Issue 22 Pages e933  
  Keywords AcuTrials; Systematic Review; Mental Disorders; Alzheimer Disease; Alzheimer's Disease; Acupuncture  
  Abstract The use of acupuncture for treating Alzheimer disease (AD) has been increasing in frequency over recent years. As more studies are conducted on the use of acupuncture for treating AD, it is necessary to re-assess the effectiveness and safety of this practice. The objective of this study was to assess the effectiveness and safety of acupuncture for treating AD. Central Register of Controlled Trials (CENTRAL), PubMed, MEDLINE, Embase, PsycINFO, Chinese Biomedicine Literature (CBM), Chinese Medical Current Content (CMCC) and China National Knowledge Infrastructure (CNKI) were searched from their inception to June 2014. Randomized controlled trials (RCTs) with AD treated by acupuncture or by acupuncture combined with 1 kind of drugs were included. Two authors extracted data independently. The continuous data were expressed as mean differences (MD) with 95% confidence intervals (CIs). Weighted MD (WMD) was used instead of standardized MD (SMD) when the same scales were used. Adverse reactions related to acupuncture were also investigated. Ten randomized controlled trials with a total of 585 participants were included in the meta-analysis. The combined results of 6 trials showed that acupuncture was better than drugs at improving scores on the Mini Mental State Examination (MMSE) scale (MD 1.05, 95% CI 0.16-1.93). Evidence from the pooled results of 3 trials showed that acupuncture plus donepezil was more effective than donepezil alone at improving the MMSE scale score (MD 2.37, 95% CI 1.53-3.21). Out of 141 clinical trials, 2 trials reported the incidence of adverse reactions related to acupuncture. Seven out of 3416 patients had adverse reactions related to acupuncture during or after treatment; the reactions were described as tolerable and not severe. Acupuncture may be more effective than drugs and may enhance the effect of drugs for treating AD in terms of improving cognitive function. Acupuncture may also be more effective than drugs at improving AD patients' ability to carry out their daily lives. Moreover, acupuncture is safe for treating people with AD. PROTOCOL REGISTRATION: PROSPERO CRD42014009619.Protocol published in BMJ-open.  
  Address Department of Acupuncture, Guang'anmen Hospital, China Academy of Chinese Medical Sciences (JZ, WP, WL, ZL)  
  Language Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition Alzheimer Disease
  Disease Category Mental Disorders OCSI Score  
  Notes Date of Input: 6/23/2015; Date Modified: 6/30/2015; Availability: --In File--; Priority: Normal; From the Department of Acupuncture (JZ, WP, WL, ZL), Guang'anmen Hospital, China Academy of Chinese Medical Sciences; Beijing University of Chinese Medicine (JZ, WL); and Department of Neurology (MX), Xuan Wu Hospital, Capital Medical University, Bei; eng; Web: Approved no  
  Call Number OCOM @ refbase @ Serial 1617  
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