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Author  |
Alizadeh, R.; Esmaeili, S.; Shoar, S.; Bagheri-Hariri, S.; Shoar, N. |
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Title |
Acupuncture in preventing postoperative nausea and vomiting: efficacy of two acupuncture points versus a single one |
Type of Study |
RCT |
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Year |
2014 |
Publication |
Journal of acupuncture and meridian studies |
Abbreviated Journal |
J Acupunct Meridian Stud |
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Volume |
7 |
Issue |
2 |
Pages |
71-75 |
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Keywords |
RCT; Vomiting; Postoperative Nausea and Vomiting; PONV; Acu Versus CAM Control; Acu Versus Acu; Acupuncture; TCM Acupuncture Style; Fixed Acupuncture Protocol; Restricted Modalities, Acupuncture Only; CAM Control; Anesthesiology |
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Abstract |
Despite recent advances in anesthesiology and postoperative care, postoperative nausea and vomiting are common complaints. Although acupuncture techniques have received attention in anesthesiology, the ideal technique and selection of the most appropriate acupuncture points are still under debate. This study compared the efficacy of two simultaneous acupuncture points with that of a single point in the prevention and treatment of postoperative nausea and vomiting following general anesthesia through a double-blind, randomized, controlled trial involving 227 surgical patients undergoing general anesthesia who were randomly assigned into two groups. The first group received acupuncture by stimulation only on the PC6 point (single group), and the second group underwent concomitant stimulation of the PC6 and the L14 acupuncture points (combined group) during surgery under general anesthesia. The prevalences of postoperative nausea and vomiting were compared between the two groups. No significant differences were observed between the two groups (p>0.05). Of 115 patients in the combined group, 80 (69.6%) complained about nausea and vomiting compared with 96 (85.7%) in the single group, a significantly lower proportion (p<0.05). Our findings favor a combination of PC6 and LI4 stimulation for the treatment of postoperative nausea and vomiting. |
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Address |
Department of Anesthesiology and Intensive Care, AJA University of Medical Sciences, Tehran, Iran |
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Publisher |
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Language |
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Number of Treatments |
1 |
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Treatment Follow-up |
N/A |
Frequency |
N/A |
Number of Participants |
227 |
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Time in Treatment |
1 Day |
Condition |
Postoperative Nausea and Vomiting |
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Disease Category |
Vomiting |
OCSI Score |
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Notes |
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Approved |
no |
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Call Number |
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Serial |
15 |
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Author |
An, L. X.; Chen, X.; Ren, X. J.; Wu, H. F. |
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Title |
Electro-Acupuncture Decreases Postoperative Pain and Improves Recovery in Patients Undergoing a Supratentorial Craniotomy |
Type of Study |
RCT |
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Year |
2014 |
Publication |
The American Journal of Chinese Medicine |
Abbreviated Journal |
Am J Chin Med |
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Volume |
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Issue |
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Pages |
1-11 |
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Keywords |
Acu + Usual Care Versus Usual Care; RCT; Anesthesia and Analgesia; Pain, Postoperative; Fixed Acupuncture Protocol; Restricted Modalities, Acupuncture Only; PONV; Postoperative Nausea and Vomiting; Electroacupuncture; TCM Acupuncture Style; Usual Care Control, Pharmaceutical |
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Abstract |
We performed this study to examine the effect of electro-acupuncture (EA) on postoperative pain, postoperative nausea and vomiting (PONV) and recovery in patients after a supratentorial tumor resection. Eighty-eight patients requiring a supratentorial tumor resection were anesthetized with sevoflurane and randomly allocated to a no treatment group (Group C) or an EA group (Group A). After anesthesia induction, the patients in Group A received EA at LI4 and SJ5, at BL63 and LR3 and at ST36 and GB40 on the same side as the craniotomy. The stimulation was continued until the end of the operation. Patient-controlled intravenous analgesia (PCIA) was used for the postoperative analgesia. The postoperative pain scores, PONV, the degree of dizziness and appetite were recorded. In the first 6 hours after the operation, the mean total bolus, the effective times of PCIA bolus administrations and the VAS scores were much lower in the EA group (p < 0.05). In the EA group, the incidence of PONV and degree of dizziness and feeling of fullness in the head within the first 24 hours after the operation was much lower than in the control group (p < 0.05). In the EA group, more patients had a better appetite than did the patients in group C (51.2% vs. 27.5%) (p < 0.05). The use of EA in neurosurgery patients improves the quality of postoperative analgesia, promotes appetite recovery and decreases some uncomfortable sensations, such as dizziness and feeling of fullness in the head. |
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Address |
Department of Anesthesia, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China. |
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Publisher |
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Language |
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Number of Treatments |
1 |
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Treatment Follow-up |
N/A |
Frequency |
N/A |
Number of Participants |
88 |
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Time in Treatment |
1 Day |
Condition |
Pain, Postoperative |
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Disease Category |
Anesthesia and Analgesia |
OCSI Score |
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Notes |
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Approved |
no |
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Call Number |
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Serial |
25 |
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Author |
Arvidsdotter, T.; Marklund, B.; Taft, C. |
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Title |
Six-month effects of integrative treatment, therapeutic acupuncture and conventional treatment in alleviating psychological distress in primary care patients--follow up from an open, pragmatic randomized controlled trial |
Type of Study |
RCT |
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Year |
2014 |
Publication |
BMC complementary and alternative medicine |
Abbreviated Journal |
BMC Complement Altern Med |
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Volume |
14 |
Issue |
210 |
Pages |
1-10 |
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Keywords |
RCT; Mental Disorders; Anxiety; Depression; Depressive Disorder; Stress, Psychological; Acu Versus > 1 Control; Acupuncture; Usual Care Control, Multimodality; CAM Control; Salutogenic Counseling |
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Abstract |
BACKGROUND: To evaluate and compare 6-month effects of 8 weeks of an integrative treatment (IT), therapeutic acupuncture (TA), and conventional treatment (CT) in reducing symptoms of anxiety, depression and in improving health-related quality of life (HRQL) and sense of coherence (SOC) in psychologically distressed primary care patients. METHODS: Patients who had participated in an open, pragmatic randomized controlled trial were followed up six months after treatment. The study sample consisted of 120 adults (40 per treatment arm) aged 20 to 55 years referred from four different primary health care centres in western Sweden for psychological distress. Assessments were made at baseline after eight weeks and after 24 weeks. Anxiety and depression were evaluated with the Hospital Anxiety and Depression scale (HADS), HRQL with the SF-36 Mental Component Summary scores (MCS) and SOC with the Sense of Coherence-13 questionnaire. RESULTS: No baseline differences were found between groups on any outcome variable. At 24 weeks, IT and TA had significantly better values than CT on all variables. All three groups showed significant improvements from baseline on all variables, except HAD depression in CT; however, improvements were significantly greater in IT and TA than in CT. IT and TA did not differ on any outcome variable. Effect sizes were large in IT and TA for all variables and small or moderate in CT. Improvements on all variables seen after 8-weeks of IT and TA remained stable at 24 weeks and the CT group improved on HAD anxiety. CONCLUSIONS: IT and TA seem to be more beneficial than CT in reducing anxiety, depression, and in improving quality of life and sense of coherence after 24 weeks of follow up in patients with psychological distress. More research is needed to confirm these results. TRIAL REGISTRATION: ISRCTN trial number NCT01631500. |
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Address |
Institute of Health and Care Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. tina.arvidsdotter@vgregion.se. |
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Publisher |
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Language |
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Number of Treatments |
8 |
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Treatment Follow-up |
24 Weeks |
Frequency |
1/WK |
Number of Participants |
120 |
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Time in Treatment |
8 Weeks |
Condition |
Depressive Disorder |
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Disease Category |
Mental Disorders |
OCSI Score |
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Notes |
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Approved |
no |
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Call Number |
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Serial |
38 |
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Author |
Aydogmus, Y.; Sunay, M.; Arslan, H.; Aydin, A.; Adiloglu, A. K.; Sahin, H. |
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Title |
Acupuncture versus Solifenacin for Treatment of Overactive Bladder and Its Correlation with Urine Nerve Growth Factor Levels: A Randomized, Placebo-Controlled Clinical Trial |
Type of Study |
RCT |
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Year |
2014 |
Publication |
Urologia internationalis |
Abbreviated Journal |
Urol Int |
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Volume |
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Issue |
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Pages |
- |
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Keywords |
RCT; Urologic Diseases; Urinary Bladder, Overactive; Urgency; Urinary Frequency; Acu Versus > 1 Control; Acupuncture; TCM Acupuncture Style; Fixed Acupuncture Protocol; Restricted Modalities, Acupuncture Only; Usual Care Control, Pharmaceutical; Sham Control; Non Penetrating Sham, Mechanical; Verum Acupoint Control |
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Abstract |
Objective: To determine whether acupuncture is effective as an overactive bladder (OAB) treatment compared with solifenacin and placebo, and to investigate its relation with urine nerve growth factor (NGF) levels. Patients and Methods: The study was conducted with methodological rigor based on the Consolidated Standards of Reporting Trials criteria. 90 female patients with OAB were included and randomly assigned to a solifenacin, acupuncture or placebo group. The medicated group received solifenacin 5 mg/day; the acupuncture and placebo groups were treated twice a week for 4 weeks. Symptom scores, quality of life scores, frequency of micturition and urine NGF levels were used to assess treatment efficiency. Results: The study was completed with 82 patients (n = 30 in the solifenacin group, n = 28 in the acupuncture group and n = 24 in the placebo group). After treatment, comparison of the medical and acupuncture therapy groups with the placebo group showed significant differences between recovery concerning quality of life (p < 0.001 and p < 0.01, respectively) and symptom scores (p < 0.001 and p < 0.001, respectively). The decrease of NGF levels after treatment compared to before treatment was determined in each group (solifenacin, acupuncture, placebo group; p < 0.001, p < 0.001, p = 0.359, respectively). Sufficient symptomatic improvement was not achieved in 8 patients in the acupuncture group. Therefore, comparisons were assessed twice with and without including these patients, and NGF levels in the acupuncture group were higher than at first comparison in which all patients in the acupuncture group were included. Conclusions: In patients with OAB in whom anticholinergic treatment is contraindicated, acupuncture may be considered another treatment option. (c) 2014 S. Karger AG, Basel. |
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Address |
Clinic of Urology, Department of Acupuncture and Department of Microbiology, Ministry of Health Ankara Training and Research Hospital, Ankara, Turkey. |
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Publisher |
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Language |
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Number of Treatments |
8 |
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Treatment Follow-up |
N/A |
Frequency |
>1/WK |
Number of Participants |
90 |
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Time in Treatment |
4 Weeks |
Condition |
Urinary Bladder, Overactive |
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Disease Category |
Urologic Diseases |
OCSI Score |
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Notes |
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Approved |
no |
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Call Number |
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Serial |
49 |
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Author |
Baccetti, S.; Da Fre, M.; Becorpi, A.; Faedda, M.; Guerrera, A.; Monechi, M. V.; Munizzi, R. M.; Parazzini, F. |
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Title |
Acupuncture and traditional chinese medicine for hot flushes in menopause: a randomized trial |
Type of Study |
RCT |
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Year |
2014 |
Publication |
Journal of alternative and complementary medicine (New York, N.Y.) |
Abbreviated Journal |
J Altern Complement Med |
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Volume |
20 |
Issue |
7 |
Pages |
550-557 |
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Keywords |
RCT; Climacteric; Hot Flashes; Menopause; Hot Flushes; Acu Versus CAM Control; Diet; Tuina; Chinese Massage; Self Massage; Plum Blossom; Seven Star Needles; Acupuncture; Electroacupuncture; TCM Acupuncture Style; Semi-Individualized Acupuncture Protocol; Traditional Diagnosis Based Point Selection; Symptom Based Point Selection; Restricted Modalities, Acupuncture + Other; Whole Systems |
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Abstract |
OBJECTIVE: To evaluate the effect of acupuncture on hot flushes and other menopause-related symptoms used in an integrated system, including such therapeutic techniques as diet therapy and Tuina self-massage. DESIGN: Randomized trial. SETTING: Outpatient center. PARTICIPANTS: One hundred women in spontaneous menopause with at least three episodes of hot flushes daily were randomly allocated to two treatment groups (50 per group): Women in group A were given diet, self-massage training, and treatment with acupuncture, and women in group B (the control group) were given the same diet and self-massage training, but treatment with acupuncture started 6 weeks after they were enrolled into the study. INTERVENTION: Acupuncture treatments were scheduled twice weekly for 6 consecutive weeks. OUTCOME MEASURES: Mean change in frequency and/or intensity in menopause-related symptoms were estimated by questionnaire after treatment at week 4. RESULTS: Treatment with acupuncture significantly reduced the occurrence of hot flushes and sudden sweating (p<.001). Other symptoms (sleep disorders, tightness in the chest, irritability, bone pain, feeling depressed) significantly improved. CONCLUSIONS: Acupuncture in an integrated system that includes therapeutic techniques such as diet therapy and Tuina self-massage can be used to treat hot flushes and selected symptoms in postmenopausal women. |
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Address |
Referring Center for Complementary Medicine , Tuscany Region, San Donnino, Campi Bisenzio, Italy |
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Publisher |
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Language |
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Number of Treatments |
12 |
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Treatment Follow-up |
16 Weeks |
Frequency |
>1/WK |
Number of Participants |
100 |
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Time in Treatment |
6 Weeks |
Condition |
Hot Flashes |
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Disease Category |
Climacteric |
OCSI Score |
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Notes |
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Approved |
no |
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Call Number |
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Serial |
50 |
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Author |
Baeumler, P.I.; Fleckenstein, J.; Takayama, S.; Simang, M.; Seki, T.; Irnich, D. |
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Title |
Effects of acupuncture on sensory perception: a systematic review and meta-analysis |
Type of Study |
Systematic Review |
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Year |
2014 |
Publication |
PLoS One |
Abbreviated Journal |
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Volume |
9 |
Issue |
12 |
Pages |
e113731 |
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Keywords |
Healthy Subjects; Anesthesia and Analgesia; Pain; Sensory Perception; Pressure Pain Threshold; Systematic Review; Meta-Analysis; Acupuncture |
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Abstract |
BACKGROUND: The effect of acupuncture on sensory perception has never been systematically reviewed; although, studies on acupuncture mechanisms are frequently based on the idea that changes in sensory thresholds reflect its effect on the nervous system. METHODS: Pubmed, EMBASE and Scopus were screened for studies investigating the effect of acupuncture on thermal or mechanical detection or pain thresholds in humans published in English or German. A meta-analysis of high quality studies was performed. RESULTS: Out of 3007 identified articles 85 were included. Sixty five studies showed that acupuncture affects at least one sensory threshold. Most studies assessed the pressure pain threshold of which 80% reported an increase after acupuncture. Significant short- and long-term effects on the pressure pain threshold in pain patients were revealed by two meta-analyses including four and two high quality studies, respectively. In over 60% of studies, acupuncture reduced sensitivity to noxious thermal stimuli, but measuring methods might influence results. Few but consistent data indicate that acupuncture reduces pin-prick like pain but not mechanical detection. Results on thermal detection are heterogeneous. Sensory threshold changes were equally frequent reported after manual acupuncture as after electroacupuncture. Among 48 sham-controlled studies, 25 showed stronger effects on sensory thresholds through verum than through sham acupuncture, but in 9 studies significant threshold changes were also observed after sham acupuncture. Overall, there is a lack of high quality acupuncture studies applying comprehensive assessments of sensory perception. CONCLUSIONS: Our findings indicate that acupuncture affects sensory perception. Results are most compelling for the pressure pain threshold, especially in pain conditions associated with tenderness. Sham acupuncture can also cause such effects. Future studies should incorporate comprehensive, standardized assessments of sensory profiles in order to fully characterize its effect on sensory perception and to explore the predictive value of sensory profiles for the effectiveness of acupuncture. |
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Address |
Multidisciplinary Pain Center, Department of Anaesthesiology, University of Munich (LMU), Munich, Germany. |
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Publisher |
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Language |
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Number of Treatments |
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Treatment Follow-up |
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Frequency |
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Number of Participants |
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Time in Treatment |
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Condition |
Anesthesia and Analgesia |
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Disease Category |
Healthy Subjects |
OCSI Score |
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Notes |
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Approved |
yes |
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Call Number |
OCOM @ refbase @ |
Serial |
1698 |
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Author |
Bahrami-Taghanaki, H.; Liu, Y.; Azizi, H.; Khorsand, A.; Esmaily, H.; Bahrami, A.; Xiao Zhao, B. |
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Title |
A randomized, controlled trial of acupuncture for chronic low-back pain |
Type of Study |
RCT |
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Year |
2014 |
Publication |
Alternative therapies in health and medicine |
Abbreviated Journal |
Altern Ther Health Med |
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Volume |
20 |
Issue |
3 |
Pages |
13-19 |
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Keywords |
RCT; Back Pain, Chronic; Back Pain; Musculoskeletal Diseases; LBP; Acu Versus CAM Control; Acu Versus Acu; Acupuncture; TCM Acupuncture Style; Time Method Acupuncture; Individualized Acupuncture Protocol; Traditional Diagnosis Based Point Selection; Symptom Based Point Selection; Restricted Modalities, Acupuncture Only; Eight Confluent Points; CAM Control; Pain |
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Abstract |
BACKGROUND: Chronic low-back pain (cLBP) is a common condition throughout the world, and acupuncture is widely sought for treatment. As clinical evidence for the benefits of acupuncture grows, acupuncture for cLBP is receiving increased recognition and acceptance by both patients and professionals. Time method acupuncture has been previously researched with respect to chronic gastritis. OBJECTIVE: For individuals with cLBP in the current study, the research team examined the efficacy of adding confluent acupoints, related to the daytime period in time method acupuncture, to regular acupuncture and also evaluated the persistence of the benefits of such acupuncture in comparison with regular acupuncture. DESIGN: The study was a randomized, controlled trial (RCT). SETTING: The setting was an outpatient clinic of the Dongzhimen Hospital in Beijing, China. PARTICIPANTS: Participants were Chinese men and women with cLBP. INTERVENTION: Sixty participants were randomly divided into 2 groups to receive acupuncture. The control group received a treatment that followed a routine acupuncture (RA) protocol, while the intervention group received a treatment that followed an RA protocol plus acupuncture in confluent points related to time (TA). OUTCOME MEASURES: The research team measured the change in participants' scores using the visual analogue scale (VAS), the number of therapy sessions needed, the number of days that participants were absent from work during the treatment period and at 12 wk posttreatment, and the number of pain relapses between the end of treatment and the 4- and 12-wk follow-ups. RESULTS: VAS scores decreased from 69.6 +/- 7.9 to 11.8 +/- 4.9 in the intervention group compared with a decrease from 69.2 +/- 8.0 to 15.7 +/- 10.0 in the control group (P = .001). The intervention group received fewer therapy sessions (8.1 +/- 2.0) than did the control group (10.1 +/- 2.0, P < .001). Compared with the controls, the intervention group showed fewer days absent from work (0.5 vs 1.4; P = .03) and fewer pain relapses (4.0 vs 7.0; P = .04) at the 12-wk follow-up. In the 2 groups combined, VAS decreased from 69.4 +/- 7.9 before the first session of acupuncture to 13.8 +/- 8.0 after the last session (P < .001), and the number of therapy sessions needed for pain relief was 9.1 +/- 2.2. CONCLUSION: Accompanying routine acupuncture with time method acupuncture can enhance the efficacy of treatment and the persistence of its benefits in individuals with cLBP. |
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Address |
Mashhad University of Medical Sciences (MUMS), Mashhad, Iran. |
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Publisher |
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Language |
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Number of Treatments |
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Treatment Follow-up |
12 Weeks |
Frequency |
>1/WK |
Number of Participants |
60 |
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Time in Treatment |
N/A |
Condition |
Back Pain, Chronic |
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Disease Category |
Back Pain |
OCSI Score |
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Notes |
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Approved |
no |
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Call Number |
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Serial |
51 |
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Author |
Bai, Y.; Guo, Y.; Wang, H.; Chen, B.; Wang, Z.; Liu, Y.; Zhao, X.; Li, Y. |
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Title |
Efficacy of acupuncture on fibromyalgia syndrome: a meta-analysis |
Type of Study |
Systematic Review |
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Year |
2014 |
Publication |
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan / sponsored by All-China Association of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine |
Abbreviated Journal |
J Tradit Chin Med |
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Volume |
34 |
Issue |
4 |
Pages |
381-391 |
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Keywords |
Systematic Review; Nervous System Diseases; Fibromyalgia; Acupuncture; Electroacupuncture; Moxibustion |
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Abstract |
OBJECTIVE: To comprehensively evaluate the effectiveness of acupuncture as a treatment for fibromyalgia syndrome. METHODS: Two review authors independently selected the trials for the Meta-analysis, assessed their methodological quality and extracted relevant data. A quality assessment was conducted according to the Cochrane Review Handbook 5.0. RevMan 5.0.20 software was used in the statistical analysis. RESULTS: A total of 523 trials were reviewed and 9 trials were selected for Meta-analysis. (a) Compared acupuncture with sham acupuncture, there was a significant difference in the visual analogue scale, but no difference in the pressure pain threshold. Additionally, and there was a difference in the fibromyalgia impact questionnaire and the multidisciplinary pain inventory after 4 weeks of treatment, but no difference after 7 weeks of therapy. There was no difference in the numerical rating scale in weeks 3, 8 and 13. (b) Acupuncture versus drugs. There were differences in the VAS after 20 days of acupuncture and moxibustion treatment comparing with the drug amitriptyline, and after 4 weeks of acupuncture and moxibustion treatment comparing with the drug fluoxetine and amitriptyline. There were also differences in the number of tender points when comparing acupuncture with amitriptyline or fluoxetine. There was no difference in total efficiency when comparing acupuncture with amitriptyline after 4 weeks of treatment, but there were differences between the two groups 45 days after treatment. There were also differences in total efficiency comparing acupuncture with fluoxetine, and when comparing 4 weeks post-treatment of acupuncture with a combination of amitriptyline, oryzanol and vitamin B. (c) A comparison of acupuncture, drugs and exercise with drugs and exercise showed PPT differences in months 3 and 6. There was no difference between the two comparison groups after follow-up visits in months 12 and 24. CONCLUSION: Compared with sham acupuncture, there was not enough evidence to prove the efficacy of acupuncture therapy for the treatment of fibromyalgia. Some evidence testified that the effectiveness of acupuncture therapy for fibromyalgia was superior to drugs; however, the included trials were not of high quality or had high bias risks. Acupuncture combined with drugs and exercise could increase pain thresholds in the short-term, but there is a need for higher quality randomized controlled trials to further confirm this. |
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Address |
Acupuncture and Moxibustion College, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China; Qibo Research Institute of Traditional Chinese Medicine, Qingyang Hospital of Traditional Chinese Medicine, Gansu 745000, China. |
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Publisher |
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Language |
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Number of Treatments |
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Treatment Follow-up |
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Frequency |
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Number of Participants |
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Time in Treatment |
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Condition |
Fibromyalgia |
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Disease Category |
Nervous System Diseases |
OCSI Score |
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Notes |
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Approved |
no |
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Call Number |
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Serial |
53 |
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Author |
Bao, C. H.; Zhao, J. M.; Liu, H. R.; Lu, Y.; Zhu, Y. F.; Shi, Y.; Weng, Z. J.; Feng, H.; Guan, X.; Li, J.; Chen, W. F.; Wu, L. Y.; Jin, X. M.; Dou, C. Z.; Wu, H. G. |
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Title |
Randomized controlled trial: Moxibustion and acupuncture for the treatment of Crohn's disease |
Type of Study |
RCT |
| |
Year |
2014 |
Publication |
World journal of gastroenterology : WJG |
Abbreviated Journal |
World J Gastroenterol |
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Volume |
20 |
Issue |
31 |
Pages |
11000- |
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Keywords |
AcuTrials; Gastrointestinal Diseases; Crohn Disease; RCT; Fixed Acupuncture Protocol; Restricted Modalities, Acupuncture + Other; Sham Control; Penetrating Sham; Superficial Needling Depth; Near Verum Acupoint Control; Acu Versus Sham; Acupuncture; Moxibustion; Moxa; Warming Needle; Indirect Moxibustion; TCM Acupuncture Style |
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Abstract |
AIM: To evaluate the clinical efficacy and safety of acupuncture and moxibustion for the treatment of active Crohn's disease (CD). METHODS: Ninety-two patients were equally and randomly divided into the treatment group and received herb-partitioned moxibustion combined with acupuncture, and the control group received wheat bran-partitioned moxibustion combined with superficial acupuncture. The patients received three treatment sessions per week for 12 wk and were followed up for 24 wk. The main outcome was evaluated using the CD Activity Index (CDAI) score, and the secondary outcomes were evaluated using laboratory indicators such as hemoglobin (HGB), C-reactive protein (CRP), erythrocyte sedimentation rate, quality-of-life, endoscopic ratings, and intestinal histology scores. RESULTS: The CDAI scores of both the treatment and control groups were significantly reduced after treatment compared with those measured before treatment. However, the degree of improvement in the treatment group was significantly greater than that of the control group. The improvement in symptoms in patients of the treatment group was sustained at follow-up, whereas that of the control group was not. The overall efficacy of the treatment was significantly greater than that of the control. Both groups demonstrated significant improvements in quality-of-life ratings after treatment, but the improvement was significantly greater in the treatment group than in the control group. In addition, the patients in the treatment group showed significantly increased HGB and significantly decreased CRP levels and histopathological scores at the end of treatment, whereas the control group did not exhibit significant changes. CONCLUSION: Moxibustion with acupuncture provided significant therapeutic benefits in patients with active CD beyond the placebo effect and is therefore an effective and safe treatment for active CD. |
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Address |
Key Laboratory of Acupuncture-Moxibustion and Immunological Effects, Shanghai University of Traditional Chinese Medicine, Shanghai 200030, China. |
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Publisher |
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Language |
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Number of Treatments |
36 |
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Treatment Follow-up |
24 Weeks |
Frequency |
>1/WK |
Number of Participants |
92 |
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Time in Treatment |
12 Weeks |
Condition |
Crohn Disease |
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Disease Category |
Gastrointestinal Diseases |
OCSI Score |
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Notes |
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Approved |
no |
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Call Number |
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Serial |
58 |
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| Permanent link to this record |
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Author |
Bao, T.; Cai, L.; Snyder, C.; Betts, K.; Tarpinian, K.; Gould, J.; Jeter, S.; Medeiros, M.; Chumsri, S.; Bardia, A.; Tan, M.; Singh, H.; Tkaczuk, K. H.; Stearns, V. |
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Title |
Patient-reported outcomes in women with breast cancer enrolled in a dual-center, double-blind, randomized controlled trial assessing the effect of acupuncture in reducing aromatase inhibitor-induced musculoskeletal symptoms |
Type of Study |
RCT |
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Year |
2014 |
Publication |
Cancer |
Abbreviated Journal |
Cancer |
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| |
Volume |
120 |
Issue |
3 |
Pages |
381-389 |
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| |
Keywords |
Neoplasms; Breast Neoplasms; Breast Cancer; Women's Health; RCT; Fixed Acupuncture Protocol; Restricted Modalities, Acupuncture Only; Sham Control; Non Penetrating Sham, Mechanical; Near Verum Acupoint Control; TCM Acupuncture Style; Acupuncture; Acu Versus Sham; Cancer |
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Abstract |
BACKGROUND: Aromatase inhibitors (AIs) have been associated with decrements in patient-reported outcomes (PROs). The objective of this study was to assess whether real acupuncture (RA), compared with sham acupuncture (SA), improves PROs in patients with breast cancer who are receiving an adjuvant AI. METHODS: Postmenopausal women with a stage 0 through III breast cancer who received an AI and had treatment-associated musculoskeletal symptoms were randomized to receive 8 weekly RA versus SA in a dual-center, randomized controlled trial. The National Surgical Adjuvant Breast and Bowel Project (NSABP) menopausal symptoms questionnaire, the Center for Epidemiological Studies Depression (CESD) scale, the Hospital Anxiety and Depression Scale (HADS), the Pittsburgh Sleep Quality Index (PSQI), the hot flash daily diary, the Hot Flash-Related Daily Interference Scale (HFRDI), and the European quality-of-life survey (EuroQol) were used to assess PROs at baseline and at 4weeks, 8 weeks, and 12 weeks. RESULTS: The intention-to-treat analysis included 23 patients in the RA arm and 24 patients in the SA arm. There were no significant differences in baseline characteristics between the 2 groups. Compared with baseline, scores in the RA arm improved significantly at week 8 on the CESD (P = .022), hot flash severity (P = .006), hot flash frequency (P = .011), the HFRDI (P = .014), and NSABP menopausal symptoms (P = .022); scores in the SA arm improved significantly on the EuroQol (P = .022),the HFRDI (P = .043), and NSABP menopausal symptoms (P = .005). Post-hoc analysis indicated that African American patients (n = 9) benefited more from RA than SA compared with non-African American patients (n = 38) in reducing hot flash severity (P < .001) and frequency (P < .001) scores. CONCLUSIONS: Both RA and SA were associated with improvement in PROs among patients with breast cancer who were receiving AIs, and no significant difference was detected between arms. Racial differences in response to acupuncture warrant further study. Cancer 2014;120:381-389. (c) 2013 American Cancer Society. |
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Address |
University of Maryland Greenebaum Cancer Center, Baltimore, Maryland. |
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Publisher |
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Language |
|
Number of Treatments |
8 |
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| |
Treatment Follow-up |
12 Weeks |
Frequency |
1/WK |
Number of Participants |
47 |
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| |
Time in Treatment |
8 Weeks |
Condition |
Breast Neoplasms |
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Disease Category |
Neoplasms |
OCSI Score |
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Notes |
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Approved |
no |
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Call Number |
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Serial |
60 |
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| Permanent link to this record |
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Author |
Bao, T.; Goloubeva, O.; Pelser, C.; Porter, N.; Primrose, J.; Hester, L.; Sadowska, M.; Lapidus, R.; Medeiros, M.; Lao, L.; Dorsey, S.G.; Badros, A.Z. |
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| |
Title |
A pilot study of acupuncture in treating bortezomib-induced peripheral neuropathy in patients with multiple myeloma |
Type of Study |
RCT |
| |
Year |
2014 |
Publication |
Integr Cancer Ther |
Abbreviated Journal |
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| |
Volume |
13 |
Issue |
5 |
Pages |
396-404 |
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| |
Keywords |
Neoplasms; Peripheral Neuropathy; Peripheral Nervous System Diseases; Chemotherapy Side Effects; Observational Study; Cancer |
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Abstract |
BACKGROUND: Peripheral neuropathy is the dose limiting toxicity of bortezomib in patients with multiple myeloma (MM). OBJECTIVES: To examine the safety, feasibility and efficacy of acupuncture in reducing bortezomib-induced peripheral neuropathy (BIPN) symptoms. METHODS: Patients with MM experiencing persistent BIPN >/=grade 2 despite adequate medical intervention and discontinuation of bortezomib received 10 acupuncture treatments for 10 weeks (2x/week for 2 weeks, 1x/week for 4 weeks, and then biweekly for 4 weeks). Responses were assessed by the Clinical Total Neuropathy Score (TNSc), Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (FACT/GOG-Ntx) questionnaire, and the Neuropathy Pain Scale (NPS). Repeated-measures analysis of variance was used to test for monotonic decline in scores on each of the measures. Serial serum levels of proinflammatory and neurotrophic cytokines were obtained at baseline and weeks 1, 2, 4, 8, and 14. RESULTS: Twenty-seven patients with MM were enrolled in the trial. There were no adverse events associated with the acupuncture treatments. TNSc data were deemed invalid and therefore were not reported. At weeks 10 and 14, FACT/GOG-Ntx and NPS showed significant reduction suggesting decreased pain, and improved function (P values were <.0001 for both FACT/GOG-Ntx and NPS at weeks 10 and 14). However, nerve conduction studies did not significantly change between baseline assessment and end of study. There was no correlation in serum cytokines for responders versus none responders. CONCLUSIONS: Acupuncture is safe, feasible and produces subjective improvements in patients' symptoms. A follow-up randomized controlled trial is warranted. |
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Address |
The University of Maryland School of Medicine, Baltimore, MD, USA baot@mskcc.org.; The University of Maryland School of Medicine, Baltimore, MD, USA. |
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Publisher |
(c) The Author(s) 2014. |
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Language |
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Number of Treatments |
10 |
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| |
Treatment Follow-up |
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Frequency |
>1/WK |
Number of Participants |
27 |
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| |
Time in Treatment |
8 Weeks |
Condition |
Chemotherapy Side Effects |
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Disease Category |
Neoplasms |
OCSI Score |
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Notes |
Date of Input: 2/26/2015; Date Modified: 3/10/2015; Priority: Normal; Chemotherapy Side Effects; The University of Maryland School of Medicine, Baltimore, MD, USA baot@mskcc.org.; The University of Maryland School of Medicine, Baltimore, MD, USA.; eng; Web: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=24867959 |
Approved |
no |
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Call Number |
OCOM @ refbase @ |
Serial |
1745 |
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| Permanent link to this record |
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Author |
Boyuan, Z.; Yang, C.; Ke, C.; Xueyong, S.; Sheng, L. |
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Title |
Efficacy of acupuncture for psychological symptoms associated with opioid addiction: a systematic review and meta-analysis |
Type of Study |
Systematic Review |
| |
Year |
2014 |
Publication |
Evidence-Based Complementary and Alternative Medicine : ECAM |
Abbreviated Journal |
Evid Based Complement Alternat Med |
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| |
Volume |
2014 |
Issue |
|
Pages |
313549 |
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Keywords |
AcuTrials; Substance-Related Disorders; Opioid-Related Disorders; Drug Addiction; Substance Abuse; Mental Disorders; Psychological Symptoms; Anxiety; Depression; Depressive Disorder; Systematic Review; Meta-analysis |
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Abstract |
This review systematically assessed the clinical evidence for and against acupuncture as a treatment for psychological symptoms associated with opioid addiction. The database was accessed from MEDLINE and China Knowledge Resource Integrated Database. We included all randomized clinical trials published in Chinese and English regardless of their controls. Meta-analysis was performed using the RevMan software, version 5.2. We conducted a literature search of 16 databases from their inception to January 2014. Four studies from Western countries did not report any clinical gains in the treatment of psychological symptoms associated with opioid addiction. 10 of 12 studies from China have reported positive findings regarding the use of acupuncture to treat the psychological symptoms associated with opioid addiction. The methodological quality of the included studies was poor. The meta-analysis indicated that there was a significant difference between the treatment group and the control group for anxiety and depression associated with opioid addiction, although groups did not differ on opioid craving. This review and meta-analysis could not confirm that acupuncture was an effective treatment for psychological symptoms associated with opioid addiction. However, considering the potential of acupuncture demonstrated in the included studies, further rigorous randomized controlled trials with long followup are warranted. |
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Address |
Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 200032, China |
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Publisher |
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Language |
English |
Number of Treatments |
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Treatment Follow-up |
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Frequency |
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Number of Participants |
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Time in Treatment |
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Condition |
Opioid-Related Disorders |
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Disease Category |
Substance-Related Disorders |
OCSI Score |
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Notes |
PMID:25530779; PMCID:PMC4235186 |
Approved |
yes |
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Call Number |
OCOM @ refbase @ |
Serial |
2110 |
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| Permanent link to this record |
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Author |
Chang, W.-D.; Lai, P.-T.; Tsou, Y.-A. |
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Title |
Analgesic effect of manual acupuncture and laser acupuncture for lateral epicondylalgia: a systematic review and meta-analysis |
Type of Study |
Systematic Review |
| |
Year |
2014 |
Publication |
The American Journal of Chinese Medicine |
Abbreviated Journal |
Am J Chin Med |
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Volume |
42 |
Issue |
6 |
Pages |
1301-1314 |
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Keywords |
AcuTrials; Systematic Review; Meta-analysis; Sprains and Strains; Tennis Elbow; Musculoskeletal Diseases; Lateral Epicondylitis; Acupuncture; Laser Acupuncture |
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Abstract |
Lateral epicondylalgia is a common orthopedic disorder. In traditional Chinese medicine, acupuncture is often used for treating lateral epicondylalgia. Laser acupuncture, compared with manual acupuncture, has more advantages because it is painless, aseptic and safe. However, the analgesic effect of manual acupuncture and laser acupuncture on lateral epicondylalgia has rarely been explored. We conducted a systematic review and meta-analysis to compare the analgesic effect of laser acupuncture and manual acupuncture for the treatment of lateral epicondylalgia. We investigated studies published in the Medline, PubMed, and CINAHL databases from January 1980 to December 2013. This review included 9 randomized articles. Six of them examined manual acupuncture and the others focused on laser acupuncture. We analyzed the meta-analysis results regarding the analgesic effect of the treatment, and observed substantial differences in 4 articles related to manual acupuncture. Manual acupuncture is effective in short-term pain relief for the treatment of lateral epicondylalgia; however, its long-term analgesic effect is unremarkable. A suitable acupuncture point and depth can be used to treat lateral epicondylalgia. Manual acupuncture applied on lateral epicondylalgia produced stronger evidence of an analgesic effect than did laser acupuncture, and further study on the analgesic effect of laser acupuncture is required. |
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Address |
Department of Sports Medicine, China Medical University, Taichung City, Taiwan, R.O.C |
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Publisher |
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Language |
English |
Number of Treatments |
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Treatment Follow-up |
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Frequency |
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Number of Participants |
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Time in Treatment |
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Condition |
Tennis Elbow |
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Disease Category |
Sprains and Strains |
OCSI Score |
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Notes |
PMID:25384448 |
Approved |
yes |
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Call Number |
OCOM @ refbase @ |
Serial |
2105 |
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| Permanent link to this record |
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Author |
Chao, G.-Q.; Zhang, S. |
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Title |
Effectiveness of acupuncture to treat irritable bowel syndrome: a meta-analysis |
Type of Study |
Systematic Review |
| |
Year |
2014 |
Publication |
World Journal of Gastroenterology |
Abbreviated Journal |
World J Gastroenterol |
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Volume |
20 |
Issue |
7 |
Pages |
1871-1877 |
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Keywords |
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Abstract |
AIM: To evaluate the efficacy of acupuncture for treatment of irritable bowel syndrome (IBS) through meta-analysis of randomized controlled trials. METHODS: We searched MEDLIINE, PubMed, Scopus, Web of Science, and Cochrane Central Register of Controlled Trials from 1966 to February 2013 for double-blind, placebo-controlled trials investigating the efficacy of acupuncture in the management of IBS. Studies were screened for inclusion based on randomization, controls, and measurable outcomes reported. We used the modified Jadad score for assessing the quality of the articles. STATA 11.0 and Revman 5.0 were used for meta-analysis. Publication bias was assessed by Begg's and Egger's tests. RESULTS: Six randomized, placebo-controlled clinical trials met the criteria and were included in the meta-analysis. The modified Jadad score of the articles was > 3, and five articles were of high quality. We analyzed the heterogeneity and found that these studies did not cause heterogeneity in our meta-analysis. Begg's test showed P = 0.707 and Egger's test showed P = 0.334. There was no publication bias in our meta-analysis (Begg's test, P = 0.707; Egger's test, P = 0.334). From the forest plot, the diamond was on the right side of the vertical line and did not intersect with the line. The pooled relative risk for clinical improvement with acupuncture was 1.75 (95%CI: 1.24-2.46, P = 0.001). Using the two different systems of STATA 11.0 and Revman 5.0, we confirmed the significant efficacy of acupuncture for treating IBS. CONCLUSION: Acupuncture exhibits clinically and statistically significant control of IBS symptoms. |
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Address |
Guan-Qun Chao, Department of Family Medicine, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310006, Zhejiang Province, China |
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Publisher |
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Language |
English |
Number of Treatments |
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Treatment Follow-up |
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Frequency |
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Number of Participants |
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Time in Treatment |
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Condition |
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Disease Category |
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OCSI Score |
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Notes |
PMID:24587665; PMCID:PMC3930986 |
Approved |
no |
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Call Number |
OCOM @ refbase @ |
Serial |
2160 |
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| Permanent link to this record |
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Author |
Chao, Maria, T.; Callens, Mary, L.; Wade, Christine, M.; Abercrombie, Priscilla, D.; Gomolak, Denise |
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Title |
An innovative acupuncture treatment for primary dysmenorrhea: a randomized, crossover pilot study |
Type of Study |
RCT |
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Year |
2014 |
Publication |
Alternative Therapies in Health & Medicine |
Abbreviated Journal |
Altern Ther Health Med |
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Volume |
20 |
Issue |
1 |
Pages |
49-56 |
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Keywords |
AcuTrials; Menstruation Disturbances; Women's Health; Gynecology; Dysmenorrhea; RCT; Pilot Study; Cross-Over Design; Fixed Acupuncture Protocol; Restricted Modalities, Acupuncture Only; Sham Control; Penetrating Sham; Standard Needling Depth; Sham Acupoint Control; Acu Versus Sham; Acupuncture; TCM Acupuncture Style |
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Abstract |
Context · Dysmenorrhea, the occurrence of painful menstrual cramping of the uterus, is a major cause of activity restriction and absences from school and work among young women. Standard pharmaceuticals used to treat dysmenorrhea are not effective for all women and have side effects that limit their use. Studies elsewhere have shown beneficial effects for use of vitamin K1 as an acupoint treatment, but the acceptability of this treatment to women in the United States has been unknown. Objective · The study intended to examine the feasibility, acceptability, and preliminary effects of acupuncture point injection of vitamin K1 as an alternative treatment for primary dysmenorrhea among US women. Design · The research team conducted a pilot study using a blinded, randomized, crossover trial design. Setting · The study took place at the University of California, San Francisco (UCSF). Participants · The study was conducted in the San Francisco Bay Area among women 18 to 25 y of age who had been diagnosed with primary dysmenorrhea. Fourteen women completed all of the study's visits. Intervention · Women with primary dysmenorrhea were randomized into 2 groups to receive bilateral injections of vitamin K1 in the Spleen-6 (SP-6) acupuncture point at the start of menstruation and then, following a 2-mo washout period, saline in a nonacupuncture point at the start of menstruation. One group received the vitamin K1 injection first, while the other group received the saline injection first. Outcome Measure · Dysmenorrhea pain intensity was measured using a 0-10 numeric rating scale (NRS), before and after injections. Results · Women had an average 2.5-point decrease in pain after a vitamin K1 injection in the SP-6 acupoint (P < .001), as compared with a 1.8-point decrease after a saline injection (P < .001). Change scores for vitamin K1, as compared with a saline injection, approached statistical significance (P < .10). Intensity and duration of menstrual symptoms, as measured by the Cox retrospective symptom scale, also decreased following injections. After participating, 94% of the women remained agreeable to receiving the injection therapy, and 77% reported they would come every month were the treatment available. Conclusions · Findings suggested high acceptability for an acupuncture point injection of vitamin K1 as treatment for primary dysmenorrhea among young women in San Francisco. Pain decreased with both treatments, with a trend toward greater pain reduction for the vitamin K1/SP-6 injection. This finding is consistent with outcomes from the Obstetrics and Gynecology Hospital in Shanghai, China, where the protocol was developed. |
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Address |
chaom@ocim.ucsf.edu |
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Publisher |
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Language |
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Number of Treatments |
1 |
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Treatment Follow-up |
8 Weeks |
Frequency |
N/A |
Number of Participants |
14 |
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Time in Treatment |
1 Day |
Condition |
Dysmennorhea |
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Disease Category |
Menstruation Disturbances |
OCSI Score |
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Notes |
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Approved |
no |
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Call Number |
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Serial |
132 |
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Author |
Chen, W. T.; Chang, F. C.; Chen, Y. H.; Lin, J. G. |
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Title |
An Evaluation of Electroacupuncture at the Weizhong Acupoint (BL-40) as a Means of Relieving Pain Induced by Extracorporeal Shock Wave Lithotripsy |
Type of Study |
RCT |
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Year |
2014 |
Publication |
Evidence-based complementary and alternative medicine : eCAM |
Abbreviated Journal |
Evid Based Complement Alternat Med |
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Volume |
2014 |
Issue |
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Pages |
- |
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Keywords |
AcuTrials; RCT; Urologic Diseases; Urinary Calculi; Urinary Stones; Pain; Acu + Usual Care Versus > 1 Control; TCM Acupuncture Style; Fixed Acupuncture Protocol; Restricted Modalities, Acupuncture Only; Usual Care Control, Pharmaceutical; Sham Control; Penetrating Sham; Standard Needling Depth; Near Verum Acupoint Control; Electroacupuncture |
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Abstract |
Background. Extracorporeal shock wave lithotripsy (ESWL) is the preferred option for urolithiasis treatment. However, intensities of pain may be induced and the sedative anesthetic or analgesics were usually needed. The aim of this study was to develop an improved acupuncture-assisted anesthesia approach in pain relief. Methods. We conducted a single-blind, randomized controlled study in China Medical University Hospital. Patients treated by ESWL due to upper urolithiasis were randomly divided into control group, sham-EA group, and 100 Hz EA group. The high frequency electroacupuncture (EA) was applied at the Weizhong acupoint (100 Hz EA group) for 20 minutes prior to the ESWL. In the sham-EA group, the same procedures were performed as those of 100 Hz EA group but no electric current was given to stimulate the acupoints. In the control group, no action was taken before operation. The information including the numbers and dosage of analgesic requirements, pain score, vital signs, and the satisfaction of procedure was collected. Results. A total of 74 subjects were recruited and we found that the interval to the first request analgesic, the number/total dosage of additional analgesic, recovery time from anesthesia, and the satisfaction were all better in both the 100 Hz EA and the sham-EA group. The 100 Hz EA also showed better relief of painful sensations by delaying the onset of pain. Conclusions. The 100 Hz EA and the sham-EA can effectively relieve pain due to ESWL as well as reducing the dosage of opium analgesic used. |
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Address |
Department of Chinese Medicine, Taiwan Landseed Hospital, No. 77, Kwang-Tai Road, Ping-jen City, Tao-Yuan County 32405, Taiwan. |
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Publisher |
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Language |
|
Number of Treatments |
1 |
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Treatment Follow-up |
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Frequency |
N/A |
Number of Participants |
74 |
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Time in Treatment |
1 Day |
Condition |
Urinary Calculi |
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Disease Category |
Urologic Diseases |
OCSI Score |
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Notes |
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Approved |
no |
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Call Number |
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Serial |
147 |
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Author |
Cheong, K. B.; Zhang, J. P.; Huang, Y. |
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Title |
The effectiveness of acupuncture in postoperative gastroparesis syndrome – A systematic review and meta-analysis |
Type of Study |
Systematic Review |
| |
Year |
2014 |
Publication |
Complementary therapies in medicine |
Abbreviated Journal |
Complement Ther Med |
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Volume |
22 |
Issue |
4 |
Pages |
767-786 |
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Keywords |
Systematic Review; Gastrointestinal Diseases; Gastroparesis; Acupuncture; Postoperative; PGS |
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Abstract |
BACKGROUND: Postoperative gastroparesis syndrome (PGS) which is mainly manifested as delayed gastric emptying is often caused by upper abdominal and sometimes lower abdominal surgery. In view of the side effects of drugs therapy, the search of supplementary and alternative has been of increasing interest. OBJECTIVE: This paper included a systematic review and meta-analysis on the use of acupuncture and acupoints selection in PGS. Quality for meta-analysis was evaluated using GRADE while each trial was assessed with CONSORT and STRICTA for TCM. METHODS: Randomized controlled trials (RCTs) comparing acupuncture with non-acupuncture treatment were identified from databases PubMed, EBSCO, Ovid, Cochrane, CNKI and Wanfangdata. Meta-analysis on eligible studies was performed using fixed-effects model with RevMan 5.2. Results were expressed as relative risk (RR) for dichotomous data, and 95% confidence interval (CI) were calculated. RESULTS: Of the 348 studies reviewed, 16 RCTs met the inclusion criteria for review while 7 RCTs, 188 patients (intervention) and 182 patients (control) met the criteria for meta-analysis. Both acupuncture and acupuncture combined with medication showed significant higher total effective rate than control (usual care/medication); with (RR 1.27, 95% CI 1.13, 1.44; P<0.0001) and (RR 1.37, 95% CI 1.18, 1.58; P<0.0001) respectively. All included RCTs reported positive effect of acupuncture in PGS treatment. ST36, CV12 and PC6 seemed to be the common acupoints selected. CONCLUSIONS: The results suggested acupuncture might be effective to improve PGS, however, a definite conclusion could not be drawn due to low quality of trials. Further large-scale, high-quality randomized clinical trials are needed to validate this. STUDY REGISTRATION: PROSPERO CRD42013005485. |
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Address |
School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, Guangdong, China. |
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Publisher |
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Language |
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Number of Treatments |
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Treatment Follow-up |
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Frequency |
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Number of Participants |
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Time in Treatment |
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Condition |
Gastroparesis |
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Disease Category |
Gastrointestinal Diseases |
OCSI Score |
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Notes |
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Approved |
no |
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Call Number |
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Serial |
156 |
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| Permanent link to this record |
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Author |
Cheuk, D. K.; Wong, V. |
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Title |
Acupuncture for epilepsy |
Type of Study |
Systematic Review |
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Year |
2014 |
Publication |
The Cochrane database of systematic reviews [electronic resource] |
Abbreviated Journal |
Cochrane Database Syst Rev |
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Volume |
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Issue |
5 |
Pages |
- |
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Keywords |
Systematic Review; Nervous System Diseases; Epilepsy; Acupuncture |
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Abstract |
BACKGROUND: Acupuncture is increasingly used in people with epilepsy. It remains unclear whether existing evidence is rigorous enough to support its use. This is an update of a Cochrane review first published in 2008. OBJECTIVES: To determine the effectiveness and safety of acupuncture in people with epilepsy. SEARCH METHODS: We searched the Cochrane Epilepsy Group Specialised Register (June 2013) and the Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library (2013, Issue 5), MEDLINE, EMBASE, CINAHL, AMED and other databases (from inception to June 2013). We reviewed reference lists from relevant trials. We did not impose any language restrictions. SELECTION CRITERIA: Randomised controlled trials (RCTs) comparing acupuncture with placebo or sham treatment, antiepileptic drugs or no treatment; or comparing acupuncture plus other treatments with the same other treatments, involving people of any age with any type of epilepsy. DATA COLLECTION AND ANALYSIS: We used standard methodological procedures expected by The Cochrane Collaboration. MAIN RESULTS: We included 17 RCTs with 1538 participants that had a wide age range and were suffering mainly from generalized epilepsy. The duration of treatment varied from 7.5 weeks to 1 year. All included trials had a high risk of bias with short follow-up. Compared with Chinese herbs, needle acupuncture plus Chinese herbs was not effective in achieving at least 50% reduction in seizure frequency (80% in control group versus 90% in intervention group, RR 1.13, 95% CI 0.97 to 1.31, 2 trials; assumed risk 500 per 1000, corresponding risk 485 to 655 per 1000). Compared with valproate, needle acupuncture plus valproate was not effective in achieving freedom from seizures (44% in control group versus 42.7% in intervention group, RR 0.97, 95% CI 0.72 to 1.30, 2 trials; assumed risk 136 per 1000, corresponding risk 97 to 177 per 1000) or at least 50% reduction in seizure frequency (69.3% in control group versus 81.3% in intervention group, RR 1.34, 95% CI 0.52 to 3.48, 2 trials; assumed risk 556 per 1000, corresponding risk 289 to 1000 per 1000) but may have achieved better quality of life (QOL) after treatment (QOLIE-31 score (higher score indicated better QOL) mean 170.22 points in the control group versus 180.32 points in the intervention group, MD 10.10 points, 95% CI 2.51 to 17.69 points, 1 trial). Compared with phenytoin, needle acupuncture was not effective in achieving at least 50% reduction in seizure frequency (70% in control group versus 94.4% in intervention group, RR 1.43, 95% CI 0.46 to 4.44, 2 trials; assumed risk 700 per 1000, corresponding risk 322 to 1000 per 1000). Compared with valproate, needle acupuncture was not effective in achieving seizure freedom (14.1% in control group versus 25.2% in intervention group, RR 1.75, 95% CI 0.93 to 3.27, 2 trials; assumed risk 136 per 1000, corresponding risk 126 to 445 per 1000) but may be effective in achieving at least 50% reduction in seizure frequency (55.3% in control group versus 73.7% in intervention group, RR 1.32, 95% CI 1.05 to 1.66, 2 trials; assumed risk 556 per 1000, corresponding risk 583 to 923 per 1000) and better QOL after treatment (QOLIE-31 score mean 172.6 points in the control group versus 184.64 points in the intervention group, MD 12.04 points, 95% CI 4.05 to 20.03 points, 1 trial). Compared with antiepileptic drugs, catgut implantation at acupoints plus antiepileptic drugs was not effective in achieving seizure freedom (13% in control group versus 19.6% in intervention group, RR 1.51, 95% CI 0.93 to 2.43, 4 trials; assumed risk 127 per 1000, corresponding risk 118 to 309 per 1000) but may be effective in achieving at least 50% reduction in seizure frequency (63.1% in control group versus 82% in intervention group, RR 1.42, 95% CI 1.07 to 1.89, 5 trials; assumed risk 444 per 1000, corresponding risk 475 to 840 per 1000) and better QOL after treatment (QOLIE-31 score (higher score indicated worse quality of life) mean 53.21 points in the control group versus 45.67 points in the intervention group, MD -7.54 points, 95% CI -14.47 to -0.61 points, 1 trial). Compared with valproate, catgut implantation may be effective in achieving seizure freedom (8% in control group versus 19.7% in intervention group, RR 2.82, 95% CI 1.61 to 4.94, 4 trials; assumed risk 82 per 1000, corresponding risk 132 to 406 per 1000) and better QOL after treatment (QOLIE-31 score (higher score indicated better quality of life) mean 172.6 points in the control group versus 191.33 points in the intervention group, MD 18.73 points, 95% CI 11.10 to 26.36 points, 1 trial) but not at least 50% reduction in seizure frequency (65.6% in control group versus 91.7% in intervention group, RR 1.31, 95% CI 0.94 to 1.84, 4 trials; assumed risk 721 per 1000, corresponding risk 677 to 1000 per 1000). Acupuncture did not have excess adverse events compared to control treatment in the included trials. AUTHORS' CONCLUSIONS: Available RCTs are small, heterogeneous and have high risk of bias. The current evidence does not support acupuncture for treating epilepsy. |
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Address |
Department of Pediatrics and Adolescent Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, China. |
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Number of Treatments |
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Treatment Follow-up |
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Frequency |
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Number of Participants |
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Time in Treatment |
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Condition |
Epilepsy |
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Disease Category |
Nervous System Diseases |
OCSI Score |
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Notes |
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Approved |
yes |
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Call Number |
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Serial |
165 |
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| Permanent link to this record |
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Author |
Cho, J. H.; Nam, D. H.; Kim, K. T.; Lee, J. H. |
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Title |
Acupuncture with non-steroidal anti-inflammatory drugs (NSAIDs) versus acupuncture or NSAIDs alone for the treatment of chronic neck pain: an assessor-blinded randomised controlled pilot study |
Type of Study |
RCT |
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Year |
2014 |
Publication |
Acupuncture in medicine: journal of the British Medical Acupuncture Society |
Abbreviated Journal |
Acupunct Med |
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Volume |
32 |
Issue |
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Pages |
17-23 |
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Keywords |
AcuTrials; RCT; Neck Pain; Pilot Study; Acu Versus > 1 Control; Acupuncture; TCM Acupuncture Style; Fixed Acupuncture Protocol; Restricted Modalities, Acupuncture Only; Usual Care Control, Pharmaceutical; Musculoskeletal Diseases |
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Abstract |
OBJECTIVE: To investigate the feasibility and sample size required for a full-scale randomised controlled trial of the effectiveness of acupuncture with non-steroidal anti-inflammatory drugs (NSAIDs) for chronic neck pain compared with acupuncture or NSAID treatment alone. METHODS: A total of 45 patients with chronic neck pain participated in the study. For 3 weeks the acupuncture with NSAIDs treatment group took NSAIDs (zaltoprofen, 80 mg) daily while receiving acupuncture treatment three times a week. The acupuncture treatment group received treatment three times a week and the NSAID treatment group took NSAIDs daily. The primary outcomes were to determine the feasibility and to calculate the sample size. As secondary outcomes, pain intensity and pain-related symptoms for chronic neck pain were measured. RESULTS: With regard to enrolment and dropout rates, 88.2% of patients consented to be recruited to the trial and 15.6% of participants were lost to follow-up. The sample size for a full-scale trial was estimated to be 120 patients. Although preliminary, there was a significant change in the visual analogue scale (VAS) for neck pain intensity between the baseline measurement and each point of assessment in all groups. However, there was no difference in VAS scores between the three groups. CONCLUSIONS: This pilot study has provided the feasibility and sample size for a full-scale trial of acupuncture with NSAIDs for chronic neck pain compared with acupuncture or NSAID treatment alone. Further research is needed to validate the effects of acupuncture with NSAIDs. CLINICAL TRIAL REGISTRATION: NIH ClinicalTrials.gov NCT01205958. |
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Address |
Department of Korean Rehabilitation Medicine, Kyung Hee University Hospital at Gangdong, Seoul, Korea. |
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Number of Treatments |
9 |
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Treatment Follow-up |
N/A |
Frequency |
>1/WK |
Number of Participants |
45 |
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Time in Treatment |
3 Weeks |
Condition |
Neck Pain |
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Disease Category |
Neck Pain |
OCSI Score |
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Notes |
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Approved |
no |
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Call Number |
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172 |
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Author |
Cho, Y. H.; Kim, C. K.; Heo, K. H.; Lee, M. S.; Ha, I. H.; Son, D. W.; Choi, B. K.; Song, G. S.; Shin, B. C. |
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Title |
Acupuncture for Acute Postoperative Pain after Back Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials. |
Type of Study |
Systematic Review |
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Year |
2014 |
Publication |
Pain practice : the official journal of World Institute of Pain |
Abbreviated Journal |
Pain Pract |
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Volume |
15 |
Issue |
3 |
Pages |
279-291 |
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Keywords |
Systematic Review; Anesthesia and Analgesia; Pain, Postoperative; Back Pain, Acute; Acupuncture; Back Surgery; Meta-Analysis; Pain |
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Abstract |
OBJECTIVES: Acupuncture is commonly used as a complimentary treatment for pain management. However, there has been no systematic review summarizing the current evidence concerning the effectiveness of acupuncture for acute postoperative pain after back surgery. This systematic review aimed at evaluating the effectiveness of acupuncture treatment for acute postoperative pain (</=1 week) after back surgery. METHODS: We searched 15 electronic databases without language restrictions. Two reviewers independently assessed studies for eligibility and extracted data, outcomes, and risk of bias. Random effect meta-analyses and subgroup analyses were performed. RESULTS: Five trials, including 3 of high quality, met our inclusion criteria. The meta-analysis showed positive results for acupuncture treatment of pain after surgery in terms of the visual analogue scale (VAS) for pain intensity 24 hours after surgery, when compared to sham acupuncture (standard mean difference -0.67 (-1.04 to -0.31), P = 0.0003), whereas the other meta-analysis did not show a positive effect of acupuncture on 24-hour opiate demands when compared to sham acupuncture (standard mean difference -0.23 (-0.58 to 0.13), P = 0.21). CONCLUSION: Our systematic review finds encouraging but limited evidence for the effectiveness of acupuncture treatment for acute postoperative pain after back surgery. Further rigorously designed clinical trials are required. |
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Address |
School of Korean Medicine, Pusan National University, Yangsan, Republic of Korea. |
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Language |
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Number of Treatments |
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Treatment Follow-up |
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Frequency |
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Number of Participants |
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Time in Treatment |
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Condition |
Pain, Postoperative |
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Disease Category |
Anesthesia and Analgesia |
OCSI Score |
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Notes |
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Approved |
no |
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Call Number |
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Serial |
179 |
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