toggle visibility Search & Display Options

Select All    Deselect All
 |   | 
Details
   print

Deprecated: preg_replace(): The /e modifier is deprecated, use preg_replace_callback instead in /home/acutrialsocom/public_html/refbase-ocom/includes/include.inc.php on line 5275
  Records Links
Author (up) Sastry, P.; Hardman, G.; Page, A.; Parker, R.; Goddard, M.; Large, S.; Jenkins, D.P. url  doi
openurl 
  Title Mesenteric ischaemia following cardiac surgery: the influence of intraoperative perfusion parameters Type of Study Journal Article
  Year 2014 Publication Interact Cardiovasc Thorac Surg Abbreviated Journal  
  Volume Issue Pages 419-24 LID - 10.1093/icv  
  Keywords Aged; Aged, 80 and over; Cardiac Surgical Procedures/*adverse effects/mortality; Cause of Death; England; Female; Hospital Mortality; Humans; Incidence; Logistic Models; Male; Mesenteric Ischemia/diagnosis/*etiology/mortality; Odds Ratio; *Perfusion/adverse effects; Retrospective Studies; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome; Vasoconstrictor Agents/therapeutic use; Oto – Notnlm; OT – Cardiac surgery; OT – Intestinal ischaemia; OT – Mesenteric ischaemia  
  Abstract OBJECTIVES: Mesenteric ischaemia (MesI) remains a rare but lethal complication following cardiac surgery. Previously identified risk factors for MesI mortality (age, poor left ventricular (LV) function, cardiopulmonary bypass time and blood loss) are non-specific and cannot necessarily be modified. This study aims to identify potentially modifiable risk factors for MesI mortality through analysis of peri- and intraoperative perfusion data. METHODS: Patients who underwent cardiac surgery between 2006 and 2011 at Papworth Hospital were retrospectively divided into 3 outcome categories: death caused by MesI; death due to other causes and survival to discharge. A published MesI risk calculator was used to estimate risk of MesI for each patient and then to create 3 cohorts of matched patients from each outcome group. Pre-, intra- and postoperative variables were collected and conditional logistic regression methods were used to identify parameters associated specifically with MesI deaths after cardiac surgery. RESULTS: A total of 10 409 patients underwent cardiac surgery between 2006 and 2011. The incidence of MesI was 0.3% (30 patients). Two hundred and sixty-one patients died of non-MesI causes and 10 118 survived. It was possible to identify 25 patients in each group at equivalent risk of MesI. The following parameters were found to be associated with MesI mortality: recent myocardial infarction [odds ratio (OR) 4.98, 95% confidence interval (CI) 1.58-15.71, P = 0.01], standard EuroSCORE (OR 1.12, 95% CI 1.03-1.21, P = 0.01), vasopressor dose on bypass (OR 1.28, 95% CI 1.04-1.57, P = 0.02), metaraminol dose on bypass (OR 1.52, 95% CI 1.12-2.06, P = 0.01) and lowest documented mean arterial pressure (OR 0.90, 95% CI 0.83-0.97, P = 0.01). No other intraoperative perfusion-related parameters (e.g. flow, average activated clotting time or pressure) were associated with MesI mortality. CONCLUSIONS: Our study not only confirms previously known predictive factors, but also demonstrates a new association between intraoperative vasopressor use and MesI mortality.  
  Address  
  Publisher (c) The Author 2014. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.
  Language Number of Treatments  
  Treatment Follow-up Frequency Interactive cardiovascular and thoracic surgery Number of Participants  
  Time in Treatment 19 Condition 3
  Disease Category OCSI Score  
  Notes Date of Input: 8/27/2015; Priority: Normal; Department of Cardiothoracic Surgery, Papworth Hospital, Cambridge, UK.; Department of Cardiothoracic Surgery, Papworth Hospital, Cambridge, UK.; Department of Cardiothoracic Surgery, Papworth Hospital, Cambridge, UK.; Department of Public Health and; eng; Web: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=24939960 Approved no  
  Call Number OCOM @ refbase @ Serial 1513  
Permanent link to this record
 

 
Author (up) Shen, M.; Chapman, R.S.; Vermeulen, R.; Tian, L.; Zheng, T.; Chen, B.E.; Engels, E.A.; He, X.; Blair, A.; Lan, Q. openurl 
  Title Coal use, stove improvement, and adult pneumonia mortality in Xuanwei, China: a retrospective cohort study Type of Study Journal Article
  Year 2009 Publication Environ Health Perspect Abbreviated Journal  
  Volume Issue Pages 261-6 LID - 10.1289/ehp.  
  Keywords Adult; Aged; Aged, 80 and over; China/epidemiology; Coal/*adverse effects; Cohort Studies; Female; *Household Articles; Humans; Male; Middle Aged; Pneumonia/chemically induced/*epidemiology/*mortality; Retrospective Studies; Risk Factors; Pmc – Pmc2649229; Oid – Nlm: Pmc2649229; Oto – Notnlm; OT – coal; OT – cohort study; OT – indoor air pollution; OT – pneumonia  
  Abstract BACKGROUND: In Xuanwei County, China, unvented indoor coal burning is strongly associated with increased risk of lung cancer and chronic obstructive pulmonary disease. However, the impact of coal burning and stove improvement on risk of pneumonia is not clear. METHODS: We conducted a retrospective cohort study among all farmers born 1917 through 1951 and living in Xuanwei as of 1 January 1976. The analysis included a total of 42,422 cohort members. Follow-up identified all deaths in the cohort from 1976 through 1996. Ages at entry into and at exit from follow-up ranged from 24 to 59 years and from 25 to 80 years, respectively. The record search detected 225 deaths from pneumonia, and 32,332 (76%) were alive as of 31 December 1996. We constructed multivariable Cox models (time variable = age) to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). RESULTS: Use of coal, especially smokeless coal, was positively associated with pneumonia mortality. Annual tonnage and lifetime duration of smoky and smokeless coal use were positively associated with pneumonia mortality. Stove improvement was associated with a 50% reduction in pneumonia deaths (smoky coal users: HR, 0.521; 95% CI, 0.340-0.798; smokeless coal users: HR, 0.449; 95% CI, 0.215-0.937). CONCLUSIONS: Our analysis is the first to suggest that indoor air pollution from unvented coal burning is an important risk factor for pneumonia death in adults and that improving ventilation by installing a chimney is an effective measure to decrease it.  
  Address  
  Publisher
  Language Number of Treatments  
  Treatment Follow-up Frequency Environmental health perspectives Number of Participants  
  Time in Treatment 117 Condition 2
  Disease Category OCSI Score  
  Notes Date of Input: 7/29/2015; Priority: Normal; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland 20892-7240 , USA. shenmi@mail.nih.gov; eng; Web: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=19270797 Approved no  
  Call Number OCOM @ refbase @ Serial 1553  
Permanent link to this record
Select All    Deselect All
 |   | 
Details
   print

Save Citations:
Export Records: