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Author Man, S. C.; Hung, B. H.; Ng, R. M.; Yu, X. C.; Cheung, H.; Fung, M. P.; Li, L. S.; Leung, K. P.; Leung, K. P.; Tsang, K. W.; Ziea, E.; Wong, V. T.; Zhang, Z. J. url  doi
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  Title A pilot controlled trial of a combination of dense cranial electroacupuncture stimulation and body acupuncture for post-stroke depression Type of Study RCT
  Year 2014 Publication BMC complementary and alternative medicine Abbreviated Journal BMC Complement Altern Med  
  Volume 14 Issue Pages 255-  
  Keywords RCT; Mental Disorders; Depressive Disorder; Depression; Pilot Study; Acu + Usual Care Versus Sham + Usual Care; Scalp Electroacupuncture; Electroacupuncture; TCM Acupuncture Style; Fixed Acupuncture Protocol; Restricted Modalities, Acupuncture + Other; Sham Control; Non Penetrating Sham, Electrical; Verum Acupoint Control  
  Abstract BACKGROUND: Our previous studies have demonstrated the treatment benefits of dense cranial electroacupuncture stimulation (DCEAS), a novel brain stimulation therapy in patients with major depression, postpartum depression and obsessive-compulsive disorder. The purpose of the present study was to further evaluate the effectiveness of DCEAS combined with body acupuncture and selective serotonin reuptake inhibitors (SSRIs) in patients with post-stroke depression (PSD). METHODS: In a single-blind, randomized controlled trial, 43 patients with PSD were randomly assigned to 12 sessions of DCEAS plus SSRI plus body electroacupuncture (n = 23), or sham (non-invasive cranial electroacupuncture, n-CEA) plus SSRI plus body electroacupuncture (n = 20) for 3 sessions per week over 4 weeks. Treatment outcomes were measured using the 17-item Hamilton Depression Rating Scale (HAMD-17), the Clinical Global Impression – Severity scale (CGI-S) and Barthel Index (BI), a measure used to evaluate movement ability associated with daily self-caring activity. RESULTS: DCEAS produced a significantly greater reduction of both HAMD-17 and CGI-S as early as week 1 and CGI-S at endpoint compared to n-CEA, but subjects of n-CEA group exhibited a significantly greater improvement on BI at week 4 than DCEAS. Incidence of adverse events was not different in the two groups. CONCLUSIONS: These results indicate that DCEAS could be effective in reducing stroke patients' depressive symptoms. Superficial electrical stimulation in n-CEA group may be beneficial in improving movement disability of stroke patients. A combination of DCEAS and body acupuncture can be considered a treatment option for neuropsychiatric sequelae of stroke. TRIAL REGISTRATION: http://www.clinicaltrials.gov, NCT01174394.  
  Address The School of Chinese Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, China. zhangzj@hku.hk.  
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  Language Number of Treatments (down) 12  
  Treatment Follow-up N/A Frequency >1/WK Number of Participants 43  
  Time in Treatment 4 Weeks Condition Depressive Disorder
  Disease Category Mental Disorders OCSI Score  
  Notes Approved no  
  Call Number Serial 812  
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