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Author (up) Pastore, L. M.; Williams, C. D.; Jenkins, J.; Patrie, J. T.
Title True and Sham Acupuncture Produced Similar Frequency of Ovulation and Improved LH to FSH Ratios in Women with Polycystic Ovary Syndrome Type of Study RCT
Year 2011 Publication The Journal of clinical endocrinology and metabolism Abbreviated Journal J Clin Endocrinol Metab
Volume Issue Pages -
Keywords AcuTrials; RCT; Genital Diseases, Female; Polycystic Ovarian Syndrome; Acu Versus Sham; Acupuncture; TCM Acupuncture Style; Fixed Acupuncture Protocol; Restricted Modalities, Acupuncture Only; Sham Control; Non Penetrating Sham, Mechanical; Sham Acupoint Control; Women's Health
Abstract Context: Acupuncture may represent a nonpharmaceutical treatment for women with polycystic ovary syndrome (PCOS), based on four studies. Objective: The objective of the study was to determine whether true, as compared with sham, acupuncture normalizes pituitary gonadotropin hormones and increases ovulatory frequency in women with PCOS. Design: This was a randomized, double-blind, sham-controlled clinical trial (5 month protocol). Setting: The study was conducted in central Virginia. Participants: Eighty-four reproductive-aged women completed the intervention. Eligibility required a PCOS diagnosis and no hormonal intervention 60 d before enrollment. Interventions: Intervention included 12 sessions of true or sham acupuncture (Park sham device) for 8 wk. Main Outcome Measures: Serum LH and FSH at baseline, after intervention, and 3 months later were measured. Ovulation was measured with weekly urine or blood samples. Results: Both arms demonstrated a similar mean ovulation rate over the 5 months (0.37/month among n = 40 true acupuncture and 0.40/month among n = 44 sham participants, P = 0.6), similar LH to FSH ratio improvement (-0.5 and -0.8 true and sham, respectively, P < 0.04 after intervention vs. baseline) and a similar decline in LH over the 5-month protocol (P < 0.05). Neither arm experienced a change in FSH. There were seven pregnancies (no difference by intervention, P = 0.7). Lower fasting insulin and free testosterone were highly correlated with a higher ovulation rate within the true acupuncture group only (P = 0.03), controlling for prestudy menstrual frequency and body mass index. Conclusion: We were unable to discern a difference between the true and sham acupuncture protocols for these women with PCOS, and both groups had a similar improvement in their LH/FSH ratio.
Address Departments of Obstetrics/Gynecology (L.M.P.), Physical Medicine and Rehabilitation (J.J.), and Public Health Sciences (J.T.P.), University of Virginia, Charlottesville, Virginia 22908; Reproductive Medicine and Surgery Center of Virginia (C.D.W.), C
Language Number of Treatments 12
Treatment Follow-up 12 Weeks Frequency >1/WK Number of Participants 96
Time in Treatment 8 Weeks Condition Polycystic Ovarian Syndrome
Disease Category Genital Diseases, Female OCSI Score
Notes Approved no
Call Number Serial 938
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