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Author Yap, M.S.; Nathan, K.R.; Yeo, Y.; Lim, L.W.; Poh, C.L.; Richards, M.; Lim, W.L.; Othman, I.; Heng, B.C. url  doi
openurl 
  Title Neural Differentiation of Human Pluripotent Stem Cells for Nontherapeutic Applications: Toxicology, Pharmacology, and In Vitro Disease Modeling Type of Study Journal Article
  Year 2015 Publication Stem Cells Int Abbreviated Journal  
  Volume Issue Pages 105172 Lid-10.1155/2015/105172  
  Keywords  
  Abstract Human pluripotent stem cells (hPSCs) derived from either blastocyst stage embryos (hESCs) or reprogrammed somatic cells (iPSCs) can provide an abundant source of human neuronal lineages that were previously sourced from human cadavers, abortuses, and discarded surgical waste. In addition to the well-known potential therapeutic application of these cells in regenerative medicine, these are also various promising nontherapeutic applications in toxicological and pharmacological screening of neuroactive compounds, as well as for in vitro modeling of neurodegenerative and neurodevelopmental disorders. Compared to alternative research models based on laboratory animals and immortalized cancer-derived human neural cell lines, neuronal cells differentiated from hPSCs possess the advantages of species specificity together with genetic and physiological normality, which could more closely recapitulate in vivo conditions within the human central nervous system. This review critically examines the various potential nontherapeutic applications of hPSC-derived neuronal lineages and gives a brief overview of differentiation protocols utilized to generate these cells from hESCs and iPSCs.  
  Address  
  Publisher
  Language Number of Treatments  
  Treatment Follow-up Frequency Stem cells international Number of Participants  
  Time in Treatment (down) 2015 Condition
  Disease Category OCSI Score  
  Notes Date of Input: 6/25/2015; Priority: Normal; Department of Biological Sciences, Faculty of Science & Technology, Sunway University, No. 5 Jalan Universiti, 47500 Bandar Sunway, Selangor Darul Ehsan, Malaysia.; Department of Biological Sciences, Faculty of Science & Technology, Sunway Un; eng; Web: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=26089911 Approved no  
  Call Number OCOM @ refbase @ Serial 1589  
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Author Soliman, A.; O'Driscoll, G.A.; Pruessner, J.; Joober, R.; Ditto, B.; Streicker, E.; Goldberg, Y.; Caro, J.; Rekkas, P.V.; Dagher, A. openurl 
  Title Limbic response to psychosocial stress in schizotypy: a functional magnetic resonance imaging study Type of Study Journal Article
  Year 2011 Publication Schizophr Res Abbreviated Journal  
  Volume Issue Pages 184-91 LID - 10.1016/j.s  
  Keywords Adolescent; Brain Mapping; Female; Humans; Hydrocortisone/metabolism; Image Processing, Computer-Assisted; Limbic System/*blood supply; Linear Models; *Magnetic Resonance Imaging; Male; Oxygen/blood; Personality Inventory; Psychiatric Status Rating Scales; Saliva; Schizotypal Personality Disorder/complications/*pathology; Stress, Psychological/complications/*pathology; Young Adult  
  Abstract Psychological stress causes dopamine release in the striatum and is thought to play a role in susceptibility to psychotic illness. Previous work suggests that an elevated dopaminergic response to stress may index vulnerability to psychosis in certain individuals. With functional magnetic resonance imaging, we measured stress-induced changes in brain activity in healthy individuals at elevated risk of developing psychosis. Participants were 15 controls and 25 psychometric schizotypes: 12 with positive symptom schizotypy (perceptual aberrations) and 13 with negative symptom schizotypy (physical anhedonia), as determined by questionnaires (Chapman et al., 1976; Chapman and Chapman, 1978). In the scanner, participants performed the Montreal Imaging Stress Task and a matched sensory-motor control task. Measures of self-reported stress and salivary cortisol levels were taken throughout the experiment. All three groups showed significant increases in self-reported stress and significant fMRI signal change in the striatal, limbic and cortical regions. However, the Physical Anhedonia group showed greater stress-induced striatal and limbic deactivation than the other two groups. Deactivation in the striatum was significantly correlated with Physical Anhedonia score across all subjects. Our findings suggest the presence of abnormalities in striatal response to stress in negative symptom schizotypy.  
  Address  
  Publisher Copyright (c) 2011 Elsevier B.V. All rights reserved.
  Language Number of Treatments  
  Treatment Follow-up Frequency Schizophrenia research Number of Participants  
  Time in Treatment (down) 131 Condition 1-3
  Disease Category OCSI Score  
  Notes Date of Input: 7/29/2015; Priority: Normal; McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, Canada.; eng; Web: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=21705195 Approved no  
  Call Number OCOM @ refbase @ Serial 1556  
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Author Shen, M.; Chapman, R.S.; Vermeulen, R.; Tian, L.; Zheng, T.; Chen, B.E.; Engels, E.A.; He, X.; Blair, A.; Lan, Q. openurl 
  Title Coal use, stove improvement, and adult pneumonia mortality in Xuanwei, China: a retrospective cohort study Type of Study Journal Article
  Year 2009 Publication Environ Health Perspect Abbreviated Journal  
  Volume Issue Pages 261-6 LID - 10.1289/ehp.  
  Keywords Adult; Aged; Aged, 80 and over; China/epidemiology; Coal/*adverse effects; Cohort Studies; Female; *Household Articles; Humans; Male; Middle Aged; Pneumonia/chemically induced/*epidemiology/*mortality; Retrospective Studies; Risk Factors; Pmc – Pmc2649229; Oid – Nlm: Pmc2649229; Oto – Notnlm; OT – coal; OT – cohort study; OT – indoor air pollution; OT – pneumonia  
  Abstract BACKGROUND: In Xuanwei County, China, unvented indoor coal burning is strongly associated with increased risk of lung cancer and chronic obstructive pulmonary disease. However, the impact of coal burning and stove improvement on risk of pneumonia is not clear. METHODS: We conducted a retrospective cohort study among all farmers born 1917 through 1951 and living in Xuanwei as of 1 January 1976. The analysis included a total of 42,422 cohort members. Follow-up identified all deaths in the cohort from 1976 through 1996. Ages at entry into and at exit from follow-up ranged from 24 to 59 years and from 25 to 80 years, respectively. The record search detected 225 deaths from pneumonia, and 32,332 (76%) were alive as of 31 December 1996. We constructed multivariable Cox models (time variable = age) to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). RESULTS: Use of coal, especially smokeless coal, was positively associated with pneumonia mortality. Annual tonnage and lifetime duration of smoky and smokeless coal use were positively associated with pneumonia mortality. Stove improvement was associated with a 50% reduction in pneumonia deaths (smoky coal users: HR, 0.521; 95% CI, 0.340-0.798; smokeless coal users: HR, 0.449; 95% CI, 0.215-0.937). CONCLUSIONS: Our analysis is the first to suggest that indoor air pollution from unvented coal burning is an important risk factor for pneumonia death in adults and that improving ventilation by installing a chimney is an effective measure to decrease it.  
  Address  
  Publisher
  Language Number of Treatments  
  Treatment Follow-up Frequency Environmental health perspectives Number of Participants  
  Time in Treatment (down) 117 Condition 2
  Disease Category OCSI Score  
  Notes Date of Input: 7/29/2015; Priority: Normal; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland 20892-7240 , USA. shenmi@mail.nih.gov; eng; Web: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=19270797 Approved no  
  Call Number OCOM @ refbase @ Serial 1553  
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Author Choy, Y.M.; Tso, W.W.; Fung, K.P.; Leung, K.C.; Tsang, Y.F.; Lee, C.Y.; Tsang, D. openurl 
  Title Suppression of narcotic withdrawals and plasma ACTH by auricular electroacupunture Type of Study Journal Article
  Year 1978 Publication Biochemical and biophysical research communications Abbreviated Journal Biochem Biophys Res Commun  
  Volume Issue Pages 305-309  
  Keywords  
  Abstract  
  Address  
  Publisher
  Language Number of Treatments  
  Treatment Follow-up Frequency Biochemical and biophysical research communications Number of Participants  
  Time in Treatment (down) 82 Condition 1
  Disease Category OCSI Score  
  Notes Date of Input: 5/21/2015; Date Modified: 5/21/2015; Priority: Normal; eng; Web: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=208557 Approved no  
  Call Number OCOM @ refbase @ Serial 1680  
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Author Renghi, A.; Gramaglia, L.; Ciarlo, M.; Cerioli, S.; Albani, A. openurl 
  Title [Fast track in abdominal aortic surgery] Type of Study Journal Article
  Year 2001 Publication Minerva Anestesiol Abbreviated Journal  
  Volume Issue Pages 441-446  
  Keywords Aged; Aortic Aneurysm, Abdominal/*surgery; Critical Pathways; Humans  
  Abstract BACKGROUND: The aim of this work is to evaluate the efficacy of a new perioperative approach to improve the outcome and to reduce hospitalisation after abdominal aortic surgery. METHODS: EXPERIMENTAL DESIGN: observational study on patients operated from October 1996 to October 1997 (Group 1996), and from November 1997 to November 1998 (group 1998). CENTRE: Anaesthesiology Department of Regional Hospital. PATIENTS: historical group: 56 patients surgically treated with abdominal aortic bypass in 1996. CASE CONTROL GROUP: 58 patients surgically treated with abdominal aortic bypass in 1998. INTERVENTION: group 1996: maintenance of anaesthesia with forane and fentanyl; postoperative infusion of mepivacaine 1% through lumbar epidural catheter. GROUP 1998: preoperative anaesthesia through thoracic (T 4) epidural catheter with infusion of bupivacaine 0.5%; maintenance of anaesthesia with propofol, fentanyl and infusion of bupivacaine 0.125%; postoperative infusion of bupivacaine 0.125%, early rehabilitation care (early removal of nasogastric tube and urinary catheter, early deambulation, feeding and physiotherapy). EVALUATION: analgesia efficacy, day of deambulation, day of removal of the urinary catheter and the nasogastric tube, day of bowel canalization, day of discharge, major complications. RESULTS: In group 1998 analgesia was better. Furthermore a significant improvement consisted in the earlier removal of the nasogastric tube and the urinary catheter, earlier return of the gastrointestinal function and earlier deambulation. The length of stay is significantly reduced. In group 1998 we have less complications. CONCLUSIONS: Total intra-venous anaesthesia associated with a thoracic epidural anaesthesia, connected with early rehabilitation may improve the outcome and reduce the length of stay in patients submitted to abdominal aortic surgery.  
  Address  
  Publisher
  Language Number of Treatments  
  Treatment Follow-up Frequency Minerva anestesiologica Number of Participants  
  Time in Treatment (down) 67 Condition 6
  Disease Category OCSI Score  
  Notes Date of Input: 7/23/2015; Priority: Normal; Ospedale degli Infermi, Biella, Italy.; ita; Web: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11533542 Approved no  
  Call Number OCOM @ refbase @ Serial 1562  
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Author Wei, H.; Xu, J.; Jiang, Z.; Ye, S.; Song, H.; Ning, X.; Huang, H.; Chen, W.; Pei, J.; Jiang, N.; Chen, S.; Du, H. url  doi
openurl 
  Title Effect of a Traditional Chinese Medicine combined therapy on adolescent idiopathic scoliosis: a randomized controlled trial Type of Study RCT
  Year 2015 Publication Journal of Traditional Chinese Medicine = Chung i tsa Chih Ying wen pan / Sponsored by All-China Association of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine Abbreviated Journal J Tradit Chin Med  
  Volume 35 Issue 5 Pages 514-519  
  Keywords AcuTrials; RCT; Bone Diseases; Scoliosis; Musculoskeletal Diseases; Needle-Knife Surgery; Acupotomology; Semi-Individualized Acupuncture Protocol; Symptom Based Point Selection; Usual Care Control, Physical  
  Abstract OBJECTIVE: To evaluate the effectiveness of a combined Traditional Chinese Medicine (TCM) therapy versus conventional treatment on adolescent idiopathic scoliosis. METHODS: One hundred twenty outpatients with mild and moderate adolescent idiopathic scoliosis were randomly divided into a TCM group (TCMG) and a brace group (CG). TCMG patients underwent Daoyin, Tuina, and acupotomology therapies. CG patients were treated with a Milwaukee brace. Each patient's Cobb angle was measured after 12 and 24 months of treatment, and pulmonary function was determined after 12 months of treatment. Average electromyogram (AEMG) ratio of the surface electromyogram was measured after 6 and 12 months of treatment and followed-up after 18 and 24 months. RESULTS: The Cobb angle significantly decreased in both groups after 12 months of treatment compared with before treatment (P< 0.05). The percentages of original Cobb angle in TCMG and CG were 51.4% and 47.8% (P > 0.05) after 12 months and 62.5% and 34.7% (P < 0.05) after 24 months, respectively. Pulmonary function significantly improved after 12 months in TCMG (P < 0.05) but significantly decreased in CG (P < 0.05). The AEMG ratio was significantly lower (P < 0.01) and tended to remain at 1 after stopping treatment in TCMG, but increased in CG (P < 0.05). CONCLUSION: TCM combined therapy can prevent the progression of scoliosis. The AEMG ratio is a promising index that could replace radiography in the evaluation of treatment effect and progression in scoliosis.  
  Address Department of Tuina, Zhejiang Provincial Hospital of Traditional Chinese Medicine, The First Clinical Medicine College of Zhejiang University of Traditional Chinese Medicine, Hangzhou 310006, China  
  Publisher
  Language English Number of Treatments 104  
  Treatment Follow-up 104 Weeks Frequency >1/WK Number of Participants 120  
  Time in Treatment (down) 52 Weeks Condition Scoliosis
  Disease Category Bone Diseases OCSI Score  
  Notes PMID:26591680 Approved yes  
  Call Number OCOM @ refbase @ Serial 2009  
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Author Christensen, B. V.; Iuhl, I. U.; Vilbek, H.; Bulow, H. H.; Dreijer, N. C.; Rasmussen, H. F. url  openurl
  Title Acupuncture treatment of severe knee osteoarthrosis. A long-term study Type of Study RCT
  Year 1992 Publication Acta anaesthesiologica Scandinavica Abbreviated Journal Acta Anaesthesiol Scand  
  Volume 36 Issue 6 Pages 519-525  
  Keywords Acu Versus Wait List; Acupuncture; Analgesia; AcuTrials; Arthritis; Fixed Acupuncture Protocol; Osteoarthritis, Knee; Pain; RCT; Restricted Modalities, Acupuncture Only; TCM Acupuncture Style; Wait-List Control  
  Abstract PURPOSE: Acupuncture treatment of patients waiting for arthroplasty surgery. METHODS: 29 patients with a total of 42 osteoarthritic knees were randomized to two groups. Group A was treated while Group B served as a no-treatment control group. After 9 weeks Group B was treated too. Analgesic consumption, pain and objective measurements were registered. All objective measures were done by investigators who were “blinded” as to Group A & B. In the second part of the study 17 patients (26 knees) continued with treatments once a month. Registration of analgesic consumption, pain and objective measurements continued. Total study period 49 weeks. RESULTS: Comparing Group A to B there was a significant reduction in pain, analgesic consumption and in most objective measures. In Group A + B combined there was an 80% subjective improvement, and a significantly increased knee range movement – an increase mainly in the worst knees. Results were significantly better in those who had not been ill for a long time. In the second part of the study, it was shown that it was possible to maintain the improvements. CONCLUSIONS: Acupuncture can ease the discomfort while waiting for an operation and perhaps even serve as an alternative to surgery. Seven patients have responded so well that at present they do not want an operation. (USD 9000 saved per operation)  
  Address Department of Anaesthesiology, Central Hospital, Nykobing-Falster, Denmark  
  Publisher
  Language Number of Treatments 18  
  Treatment Follow-up N/A Frequency <1/WK Number of Participants 29  
  Time in Treatment (down) 50 Weeks Condition Osteoarthritis, Knee
  Disease Category Arthritis OCSI Score  
  Notes Approved no  
  Call Number Serial 190  
Permanent link to this record
 

 
Author Wang, J.; Sun, K.; Wu, X. url  doi
openurl 
  Title Effect of Individualized Needling on Gross Mother Function in Cerebral Palsy Infants Type of Study RCT
  Year 2013 Publication Journal of Acupuncture and Tuina Science Abbreviated Journal J Acupunct Tuina Sci  
  Volume 11 Issue 1 Pages 13-18  
  Keywords AcuTrials; RCT; Cerebral Palsy; Nervous System Diseases; Acu Versus CAM Control; Acupuncture; Scalp Acupuncture; Jin's Needling; Dry Needling, With Acupuncture Needle; Semi-Individualized Acupuncture Protocol; Symptom Based Point Selection; Restricted Modalities, Acupuncture Only; Acu Versus Acu; Jiao Scalp Acupuncture; Pediatrics; Lin Scalp Acupuncture  
  Abstract OBJECTIVE: To observe the effect of individualized needling protocol (on the basis of functional brain mapping and standardized syndrome differentiation in Chinese medicine) on gross motor fuctions of infants with cerebral palsy (CP) and thus study the innovative means of combining acupuncture with rehabilitation management technique. METHOD: A total of 74 CP infants were randomized into a treament group and a control group, 37 in each group. Combined individualized needling and rehabilitation training were used in the treatment group, versus combined Jin's needling (16 brain-benefiting points) and rehabilitation training in the control group. For both groups, acupuncture treament was conducted once every other day and rehabilitation training every day. The dynamic changes of gross motor functions before treatment and after every 1-month treament were measured and assessed using the Gross Motor Fuction Measure (GMFM)-66. RESULTS: After treatment, the GMFM scores were significantly increased in both groups (P<0.01); there were no between-group statistical differences in increased range of the GMFM scores (P>0.05); the treatment protocol was not interacted with the treatment time; and the GMFM scores for spastic CP infants were better in the treatment group than that in the control group (P<0.05). CONCLUSION: Combined scalp acupuncture and rehabilitation training can produce positive effects on gross motor function of CP infants. Individualized needling can obtain better effects than 16 brain-benefiting points in improving the gross motor functions of spastic CP infants. KEY WORDS: Scalp Acupuncture; Scalp Stimulation Areas; Cerebral Palsy; Syndrome Differentiation Treatment; Standardization of Syndrome Differentiation; Child, Preschool;  
  Address Rehabilitation Department Tianshan Hospital of Traditional Chinese Medicine, Changing District of Shanghai, Shanghai 200051, China  
  Publisher
  Language Number of Treatments 108  
  Treatment Follow-up N/A Frequency >1/WK Number of Participants 74  
  Time in Treatment (down) 36 Weeks Condition Cerebral Palsy
  Disease Category Nervous System Diseases OCSI Score  
  Notes Approved no  
  Call Number Serial 1243  
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Author Wang, S.; Qian, Y.F.; Fan, X.N.; Zhang, Y.N.; Wei, Y.Y.; Zhang, X.; Wu, H.Q.; Li, Y.J.; Liu, J.; Shi, X.M. openurl 
  Title [Experimental study on Shuigou (GV 26) of inhibiting effect for neuronal necrosis in rats: morphological evidence of the specificity of acupoint] Type of Study Journal Article
  Year 2009 Publication Zhongguo Zhen Jiu Abbreviated Journal  
  Volume Issue Pages 733-738  
  Keywords Acupuncture Points; *Acupuncture Therapy; Animals; Brain Ischemia/*pathology/physiopathology/*therapy; Disease Models, Animal; Humans; Male; Necrosis; Neurons/*pathology/ultrastructure; Random Allocation; Rats; Rats, Wistar  
  Abstract OBJECTIVE: To investigate the effect of acupoint Shuigou (GV 26) and non-acupoint on inhibiting the neuronal necrosis induced by the middle cerebral artery obstruction (MCAO) in rats through the morphological observation. METHODS: Forty two healthy adult male Wistar rats were randomly divided into a normal group, false-ope ration group, model control group, non-acupuncture group, Shuigou-acupuncture group and non-acupoint acupuncture group, 7 rats in each group. Besides the normal and false-operation groups, the experimental modal of MCAO was established in the other groups by using the Zea-Longa thread method. Acupoint Shuigou (GV 26) and non-acupoint (below the costal region) were selected respectively in the Shuigou-acupuncture group and non-acupoint acupuncture group for puncturing at 180 times/min for 5 seconds. Its effect was estimated by measuring the rate of the neuronal necrosis at the level of the light microscope and the degree of the neuronal necrosis at the level of the electron microscope. RESULTS: (1) At the level of the light microscope, comparing with the model control group (0.66 +/- 0.18), of the neuronal necrosis there were no significant differences in the rate of neuronal necrosis in the non-acupuncture group (0.67 +/- 0.34) and non-acupoint acupuncture group (0.59 +/- 0.11) (both P > 0.05), while it was significantly decreased in the Shuigou-acupuncture group (0.200 +/- 12) (P < 0.05). It indicates that no intervention and wrong (non-acupoint) intervention could light the damage of the neurons, however, only right intervention (Shuigou, GV 26) can obviously decrease the rate of the neuronal necrosis, showing with the specificity of acupoint. (2) At the level of the electron microscope, the ultrastructure of the involved neurons in the non-acupuncture group and non-acupoint acupuncture group is similar to that of the model control group, showing with the serious edema and structure damage. In contrast, the ultrastructure of the involved neurons in the Shuigou-acupuncture group is similar to that of the normal group and false-operation group, showing with light neuronal damage. CONCLUSION: Acupuncturing Shuigou (GV 26) could protect the involved neurons and inhibit the neuronal necrosis induced by the MCAO in rats, but acupuncturing the non-acupoint couldn't, which imply that there is the specificity of acupoint in the acupuncture.  
  Address  
  Publisher
  Language Number of Treatments  
  Treatment Follow-up Frequency Zhongguo zhen jiu = Chinese acupuncture & moxibustion Number of Participants  
  Time in Treatment (down) 29 Condition 9
  Disease Category OCSI Score  
  Notes Date of Input: 6/25/2015; Priority: Normal; Tianjin Key Laboratory of Acupuncture and Moxibustion, Tianjin Institute of Acupuncture and Moxibustion, Tianjin 300193, China.; chi; Web: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=19803243 Approved no  
  Call Number OCOM @ refbase @ Serial 1574  
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Author Berman, B. M.; Lao, L.; Langenberg, P.; Lee, W. L.; Gilpin, A. M.; Hochberg, M. C. url  openurl
  Title Effectiveness of acupuncture as adjunctive therapy in osteoarthritis of the knee: A randomized, controlled trial Type of Study RCT
  Year 2004 Publication Annals of internal medicine Abbreviated Journal Ann Intern Med  
  Volume 141 Issue 12 Pages 901-910  
  Keywords Acu Versus > 1 Control; Acupuncture; AcuTrials; Arthritis; Electroacupuncture; Fixed Acupuncture Protocol; Penetrating Sham; Non Penetrating Sham, Mechanical; Osteoarthritis; Osteoarthritis, Knee; Pain; RCT; Restricted Modalities, Acupuncture Only; Sham Acupoint Control; Sham Control; Standard Needling Depth; Usual Care Control, Educational; Verum Acupoint Control  
  Abstract BACKGROUND: Evidence on the efficacy of acupuncture for reducing the pain and dysfunction of osteoarthritis is equivocal. OBJECTIVE: To determine whether acupuncture provides greater pain relief and improved function compared with sham acupuncture or education in patients with osteoarthritis of the knee. DESIGN: Randomized, controlled trial. SETTING: Two outpatient clinics (an integrative medicine facility and a rheumatology facility) located in academic teaching hospitals and 1 clinical trials facility. PATIENTS: 570 patients with osteoarthritis of the knee (mean age [+/-SD], 65.5 +/- 8.4 years). INTERVENTION: 23 true acupuncture sessions over 26 weeks. Controls received 6 two-hour sessions over 12 weeks or 23 sham acupuncture sessions over 26 weeks. MEASUREMENTS: Primary outcomes were changes in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain and function scores at 8 and 26 weeks. Secondary outcomes were patient global assessment, 6-minute walk distance, and physical health scores of the 36-Item Short-Form Health Survey (SF-36). RESULTS: Participants in the true acupuncture group experienced greater improvement in WOMAC function scores than the sham acupuncture group at 8 weeks (mean difference, -2.9 [95% CI, -5.0 to -0.8]; P = 0.01) but not in WOMAC pain score (mean difference, -0.5 [CI, -1.2 to 0.2]; P = 0.18) or the patient global assessment (mean difference, 0.16 [CI, -0.02 to 0.34]; P > 0.2). At 26 weeks, the true acupuncture group experienced significantly greater improvement than the sham group in the WOMAC function score (mean difference, -2.5 [CI, -4.7 to -0.4]; P = 0.01), WOMAC pain score (mean difference, -0.87 [CI, -1.58 to -0.16];P = 0.003), and patient global assessment (mean difference, 0.26 [CI, 0.07 to 0.45]; P = 0.02). LIMITATIONS: At 26 weeks, 43% of the participants in the education group and 25% in each of the true and sham acupuncture groups were not available for analysis. CONCLUSIONS: Acupuncture seems to provide improvement in function and pain relief as an adjunctive therapy for osteoarthritis of the knee when compared with credible sham acupuncture and education control groups  
  Address University of Maryland School of Medicine, Baltimore, Maryland 21207, USA  
  Publisher
  Language Number of Treatments 23  
  Treatment Follow-up N/A Frequency <1/WK Number of Participants 570  
  Time in Treatment (down) 26 Weeks Condition Osteoarthritis, Knee
  Disease Category Arthritis OCSI Score 90  
  Notes Approved no  
  Call Number Serial 69  
Permanent link to this record
 

 
Author Gang, O.; Wang, L.; Wang, D.; Zhuo, T.; Shen, Z. url  openurl
  Title The effect of acupuncture on bone mineral density in postmenopausal women Type of Study RCT
  Year 2002 Publication Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan / sponsored by All-China Association of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine Abbreviated Journal J Tradit Chin Med  
  Volume 22 Issue 1 Pages 9-11  
  Keywords Acu + Usual Care Versus Usual Care; Acupuncture; AcuTrials; Fixed Acupuncture Protocol; Osteoporosis; Osteoporosis, Postmenopausal; RCT; Restricted Modalities, Acupuncture Only; Usual Care Control, Pharmaceutical; TCM Acupuncture Style; Women's Health; Climacteric  
  Abstract  
  Address Second Clinical Medical College, Nanjing University of Traditional Chinese Medicine, Nanjing 210029  
  Publisher
  Language Number of Treatments 84  
  Treatment Follow-up N/A Frequency >1/WK Number of Participants 42  
  Time in Treatment (down) 25 Weeks Condition Osteoporosis, Postmenopausal
  Disease Category Climacteric OCSI Score  
  Notes Approved no  
  Call Number Serial 356  
Permanent link to this record
 

 
Author Allais, G.; De Lorenzo, C.; Quirico, P. E. openurl 
  Title Acupuncture versus flunarizine in the prophylactic treatment of migraine without aura:a randomized controlled trial Type of Study RCT
  Year 1997 Publication Cephalalgia : an international journal of headache Abbreviated Journal Cephalalgia  
  Volume 17 Issue Pages 442-443  
  Keywords Acu Versus Usual Care; Acupuncture; AcuTrials; Fixed Acupuncture Protocol; Migraine; RCT; Restricted Modalities, Acupuncture Only; Usual Care Control, Pharmaceutical; TCM Acupuncture Style; Headache Disorders  
  Abstract  
  Address  
  Publisher
  Language Number of Treatments 12  
  Treatment Follow-up N/A Frequency <1/WK Number of Participants 120  
  Time in Treatment (down) 24 Weeks Condition Migraine
  Disease Category Headache Disorders OCSI Score  
  Notes Approved no  
  Call Number Serial 16  
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Author Allais, G.; De Lorenzo, C.; Quirico, P. E.; Airola, G.; Tolardo, G.; Mana, O.; Benedetto, C. url  openurl
  Title Acupuncture in the prophylactic treatment of migraine without aura: a comparison with flunarizine Type of Study RCT
  Year 2002 Publication Headache Abbreviated Journal Headache  
  Volume 42 Issue 9 Pages 855-861  
  Keywords Acu Versus Usual Care; Acupuncture; AcuTrials; Fixed Acupuncture Protocol; Migraine; Pain; RCT; Restricted Modalities, Acupuncture Only; Usual Care Control, Pharmaceutical; TCM Acupuncture Style; Headache Disorders  
  Abstract Objectives.-In a randomized controlled trial extending over 6 months, we evaluated the effectiveness of acupuncture versus flunarizine in the prophylactic treatment of migraine without aura. Methods.-One hundred sixty women with migraines were randomly assigned to acupuncture treatment (group A, n = 80) or to an oral therapy with flunarizine (group F, n = 80). In group A, acupuncture was carried out in weekly sessions for the first 2 months and then once a month for the next 4 months. The same acupoints were used at each treatment: LR3 Taichong, SP6 Sanyinjiao, ST36 Zusanli, CV12 Zhongwan, LI4 Hegu, PC6 Neiguan, GB20 Fengchi, GB14 Yangbai, EX-HN5 Taiyang, GV20 Baihui. In group F, 10 mg flunarizine were given daily for the first 2 months and then for 20 days per month for the next 4 months. Results.-The frequency of attacks and use of symptomatic drugs significantly decreased during treatment in both groups. The number of attacks after 2 and 4 months of therapy was significantly lower in group A than in group F, and analgesic consumption was significantly lower in group A at 2 months of treatment. At 6 months no such differences existed between the two treatment groups. Pain intensity was significantly reduced only by acupuncture treatment. Side effects were significantly less frequent in group A. Conclusions.-Acupuncture proved to be adequate for migraine prophylaxis. Relative to flunarizine, acupuncture treatment exhibited greater effectiveness in the first months of therapy and superior tolerability  
  Address  
  Publisher
  Language Number of Treatments 12  
  Treatment Follow-up N/A Frequency <1/WK Number of Participants 150  
  Time in Treatment (down) 24 Weeks Condition Migraine
  Disease Category Headache Disorders OCSI Score 69  
  Notes Approved no  
  Call Number Serial 17  
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Author Duncan, B.; Donough-Means, S.; Worden, K.; Schnyer, R.; Andrews, J.; Meaney, F. J. url  openurl
  Title Effectiveness of osteopathy in the cranial field and myofascial release versus acupuncture as complementary treatment for children with spastic cerebral palsy: a pilot study Type of Study RCT
  Year 2008 Publication The Journal of the American Osteopathic Association Abbreviated Journal J Am Osteopath Assoc  
  Volume 108 Issue 10 Pages 559-570  
  Keywords Acupuncture; AcuTrials; Cerebral Palsy; Motor Function; Myofascial Release; Pediatrics; Pilot Study; RCT; Wait-List Control; Acu Versus > 1 Control; CAM Control; Osteopathic Medicine; Nervous System Diseases; Auricular Acupuncture; Scalp Acupuncture; TCM Acupuncture Style; Individualized Acupuncture Protocol; Restricted Modalities, Acupuncture Only; Symptom Based Point Selection  
  Abstract CONTEXT: Case reports and clinical trials have indicated that osteopathic manipulative treatment (OMT) may improve motor function and quality of life for children with cerebral palsy. OBJECTIVE: To assess the effectiveness of osteopathy in the cranial field, myofascial release, or both versus acupuncture in children with moderate to severe spastic cerebral palsy, as measured by several outcomes instruments in a randomized controlled trial. METHODS: Children between the ages of 20 months and 12 years with moderate to severe spastic cerebral palsy were enrolled in a single-blind, randomized wait-list control pilot study. There were three arms in the study: OMT (ie, osteopathy in the cranial field, myofascial release, or both, using direct or indirect methods), acupuncture, and control (ie, nontherapeutic attention). Children who were initially randomly assigned to the control arm were subsequently randomly reassigned to the intervention arms, increasing the sample size. Outcome measures included standard instruments used in the evaluation of children with cerebral palsy. Less traditional measures were also used, including serial evaluations by an independent blind osteopathic physician and visual analog scale assessments by an independent osteopathic physician and the parents or guardians. A total of 11 outcome variables were analyzed. RESULTS: Fifty-five patients were included in the study. Individual analyses of the 11 outcome variables revealed statistically significant improvement in two mobility measures for patients who received OMT--the total score of Gross Motor Function Measurement and the mobility domain of Functional Independence Measure for Children (P<.05). No statistically significant improvements were seen among patients in the acupuncture treatment arm. CONCLUSIONS: A series of treatments using osteopathy in the cranial field, myofascial release, or both improved motor function in children with moderate to severe spastic cerebral palsy. These results can be used to guide future research into the effectiveness of OMT or acupuncture in treating children with spastic cerebral palsy  
  Address Department of Pediatrics at University of Arizona Health Sciences Center in Tucson, AZ, USA. brduncan@email.arizona.edu  
  Publisher
  Language Number of Treatments 30  
  Treatment Follow-up N/A Frequency >1/WK Number of Participants 55  
  Time in Treatment (down) 24 Weeks Condition Cerebral Palsy
  Disease Category Nervous System Diseases OCSI Score  
  Notes Approved no  
  Call Number Serial 268  
Permanent link to this record
 

 
Author Teng, H.; Liu, Y.; Wang, J.; Xie, Y. openurl 
  Title Therapeutic Efficacy Observation on Electroacupuncture for Ovulatory Dysfunctional Infertility Type of Study RCT
  Year 2012 Publication Journal of Acupuncture and Tuina Science Abbreviated Journal J Acupunct Tuina Sci  
  Volume 10 Issue 2 Pages 81-84  
  Keywords AcuTrials; Genital Diseases, Female; Infertility, Female; Women's Health; Gynecology; RCT; Acu Versus Usual Care; Electroacupuncture; TCM Acupuncture Style; Semi-Individualized Acupuncture Protocol; Symptom Based Point Selection; Restricted Modalities, Acupuncture Only; Usual Care Control, Pharmaceutical  
  Abstract Objective: To observe the clinical effect of electroacupuncture for ovulatory dysfunctional infertility by ovulation stimulation. Methods: A total of 65 patients were randomly allocated into a treatment group (38 cases) and a control group (27 cases). Acupuncture plus electric stimulation was employed in the treatment group, whereas oral Clomifene Citrate Tablets in the control group, 50 mg per day. Results: After six months (2 sessions) of treatment, the cure rate in the treatment group was 76.3%, versus 48.1% in the control group, showing a significant difference between the two groups (P<0.05). Conclusion: Electroacupuncture can obtain better cure rate than oral Clomifene Citrate Tablets for infertility via ovulation stimulation.  
  Address Department of Traditional Chinese Medicine, Shenzhen Maternal and Child Healthcare Hospital, Guangdong 518032, P. R. China. ftfy21cn@21cn.com  
  Publisher
  Language Number of Treatments  
  Treatment Follow-up Frequency >1/WK Number of Participants 65  
  Time in Treatment (down) 24 Weeks Condition Infertility, Female
  Disease Category Genital Diseases, Female OCSI Score  
  Notes Approved no  
  Call Number Serial 1154  
Permanent link to this record
 

 
Author Zheng, Y. H.; Wang, X. H.; Lai, M. H.; Yao, H.; Liu, H.; Ma, H. X. url  doi
openurl 
  Title Effectiveness of abdominal acupuncture for patients with obesity-type polycystic ovary syndrome: a randomized controlled trial Type of Study RCT
  Year 2013 Publication Journal of alternative and complementary medicine (New York, N.Y.) Abbreviated Journal J Altern Complement Med  
  Volume 19 Issue 9 Pages 740-745  
  Keywords AcuTrials; RCT; Genital Diseases, Female; Polycystic Ovarian Syndrome; Acu Versus Usual Care; Acupuncture; TCM Acupuncture Style; Fixed Acupuncture Protocol; Restricted Modalities, Acupuncture Only; Usual Care Control, Pharmaceutical  
  Abstract Abstract Objective: To assess the effectiveness of abdominal acupuncture at the endocrine and metabolic level in patients with obesity-type polycystic ovary syndrome (PCOS). Methods: Eighty-six women from the First Affiliated Hospital of Guangzhou Medical College with a diagnosis of PCOS (body-mass index [BMI] >/=25 kg/m(2)) were randomly assigned to receive 6 months of abdominal acupuncture (once a day) or oral metformin (250 mg three times daily in the first week, followed by 500 mg three times daily thereafter). BMI, waist-to-hip ratio (WHR), ovarian volume, menstrual frequency, homeostasis model assessment for insulin resistance (HOMA-IR), and Ferriman-Gallwey score were measured at the beginning of the study and after 6 months of treatment. Luteotrophic hormone (LH), testosterone, follicle-stimulating hormone (FSH), fasting blood glucose, 2-hour Postprandial blood glucose, fasting insulin, 2-hour postprandial blood insulin, total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were also assessed. Results: According to the results at baseline and 6 months, BMI, WHR, Ferriman-Gallwey score, ovarian volume, luteotrophic hormone, ratio of luteotrophic hormone to follicle-stimulating hormone, testosterone, LDL-C, triglycerides, total cholesterol, fasting blood glucose, 2-hour postprandial blood glucose, fasting insulin, 2-hour postprandial blood insulin, and HOMA-IR were reduced significantly in the two groups (p<0.05). Menstrual frequency and HDL-C (p<0.05) increased significantly in both groups; follicle-stimulating hormone also increased in both groups, but the change was not significant (p>0.05). The acupuncture group showed considerable advantages over the metformin group in terms of reduced BMI and WHR and increases in menstrual frequency (p<0.05). Conclusion: Abdominal acupuncture and metformin improved the endocrine and metabolic function of patients with obesity-type PCOS. Abdominal acupuncture may be more effective in improving menstrual frequency, BMI, and WHR, with few adverse effects.  
  Address First Affiliated Hospital of Guangzhou Medical College , Guangzhou, China .  
  Publisher
  Language Number of Treatments 48  
  Treatment Follow-up N/A Frequency >1/WK Number of Participants 86  
  Time in Treatment (down) 24 Weeks Condition Polycystic Ovarian Syndrome
  Disease Category Genital Diseases, Female OCSI Score  
  Notes Approved no  
  Call Number Serial 1476  
Permanent link to this record
 

 
Author Dias, Marcio; Vellarde, Guillermo, Coca; Olej, Beni url  doi
openurl 
  Title Effects of electroacupuncture on stress-related symptoms in medical students: a randomised placebo-controlled study Type of Study RCT
  Year 2014 Publication Acupuncture in Medicine Abbreviated Journal Acupunct Med  
  Volume 32 Issue 1 Pages 4-11  
  Keywords Mental Disorders; Stress, Psychological; RCT; Fixed Acupuncture Protocol; Restricted Modalities, Acupuncture Only; Electroacupuncture; TCM Acupuncture Style; Acu Versus > 1 Control; TENS; Sham Control; Non Penetrating Sham, Electrical; Verum Acupoint Control; Transcutaneous Electric Nerve Stimulation; No Treatment Control  
  Abstract Objective To assess the effects of electroacupuncture (EA) on relieving stress-related symptoms--sleep disorders, anxiety, depression and burnout--in medical students. Methods Eighty-two students were randomised into an EA treatment group (n=30), a sham TENS group (n=18) and an untreated control group (n=34). EA was applied at a continuous frequency of 2 Hz to the limbs, face, ears and scalp for 20 min once a week, over 6-8 weeks. Sham transcutaneous electrical nerve stimulation (TENS) was performed on similar sites for the same number of times in each session and for the same length of time. Outcome measurements included a comparison of the indices obtained by different self-applied questionnaires before and after treatment. The surveys used were the Mini-Sleep Questionnaire (MSQ), Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), the Beck Depression and Anxiety Inventories (BDI and BAI) and the Maslach Burnout Inventory--Student Survey (MBISS), in addition to the Quality of Life Questionnaire--abbreviated version (WHOQOL-bref). Results EA significantly improved scores on the MSQ, PSQI, BDI and the cynicism and academic efficacy (AE) dimensions of the MBI-SS in relation to the control. Sleep quality (MSQ) improved from 36.9 (SD 7.6) to 25.0 (5.7) with EA, 37.6 (6.0) to 32.1 (6.9) with sham TENS, and 36.5 (5.9) to 33.6 (6.7) in the controls (p=0.0000). Compared with the sham TENS group, EA significantly reduced scores on the PSQI. Score improvements in the sham TENS group in relation to control group were significant in the MSQ, BDI and AE. In the EA group, the number of students with better scores after intervention was significantly higher for the MSQ, PSQI, ESS and BAI. This only occurred for the MSQ in the sham TENS group and for the MSQ and ESS in the control group. Conclusions EA significantly reduced stress-related mental symptoms. The improvement obtained by sham TENS compared with the control group confirmed the presence of a placebo effect resulting from the treatment ritual.  
  Address Clinical Research Unit, Antonio Pedro University Hospital, Rua Marques do Parana, 303, 40. Predio da Emergencia, Niteroi, RJ 24033-210. Brazil. mdiasmdias@gmail.com  
  Publisher
  Language Number of Treatments 22  
  Treatment Follow-up N/A Frequency 1/WK Number of Participants 82  
  Time in Treatment (down) 22 Weeks Condition Stress, Psychological
  Disease Category Mental Disorders OCSI Score  
  Notes Approved no  
  Call Number Serial 242  
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Author Itoh, K.; Hirota, S.; Katsumi, Y.; Ochi, H.; Kitakoji, H. url  openurl
  Title Trigger point acupuncture for treatment of knee osteoarthritis – a preliminary RCT for a pragmatic trial Type of Study RCT
  Year 2008 Publication Acupuncture in medicine : journal of the British Medical Acupuncture Society Abbreviated Journal Acupunct Med  
  Volume 26 Issue 1 Pages 17-26  
  Keywords Acu Versus > 1 Control; Acupuncture; AcuTrials; Arthritis; Fixed Acupuncture Protocol; Non Penetrating Sham, Mechanical; Osteoarthritis, Knee; Pain; RCT; Restricted Modalities, Acupuncture Only; Sham Control; TCM Acupuncture Style; Trigger Point Acupuncture Style; Verum Acupoint Control  
  Abstract BACKGROUND: There is evidence for the efficacy of acupuncture treatment in knee osteoarthritis, but it remains unclear which acupuncture modes are most effective. We evaluated the effects of trigger point acupuncture on pain and quality of life in knee osteoarthritis patients, compared with acupuncture at standard points, and sham acupuncture.METHODS: Thirty patients (27 women, 3 men; aged 61-82 years) with non-radiating knee osteoarthritis pain for at least six months and normal neurological examination were randomised to one of three groups for the study period of 21 weeks. Each group received five acupuncture treatment sessions. The standard acupuncture point group (n=10) received treatment at traditional acupuncture points for knee pain; the trigger point acupuncture group (n=10) received treatment at trigger points; and the third group (n=10) received sham acupuncture treatment at the trigger points. Outcome measures were pain intensity (visual analogue scale, VAS) and WOMAC index (Western Ontario and McMaster Universities Arthritis Index). The groups were compared by the area under the curve method. RESULTS: Five patients dropped out of the study because of lack of improvement, and one patient (in the trigger point acupuncture group) dropped out because of deterioration of symptoms; the remaining 24 patients were included in the analysis. After treatment, the trigger point acupuncture group reported less pain intensity on VAS than the standard acupuncture or sham treatment group, but both the trigger point acupuncture and standard acupuncture groups reported improvement of function of knee. There was a significant reduction in pain intensity between pre-treatment and five weeks after treatment for the trigger point acupuncture (P<0.01) and standard acupuncture groups (P<0.01) included in the analysis, but not for the sham treatment group. Group comparison using the area under the curves demonstrated a significant difference only between trigger point acupuncture and sham treatment groups analysed (P<0.025 for VAS, and P<0.031 for WOMAC). CONCLUSION: These results suggest that trigger point acupuncture therapy may be more effective for osteoarthritis of the knee in some elderly patients than standard acupuncture therapy  
  Address  
  Publisher
  Language Number of Treatments 5  
  Treatment Follow-up N/A Frequency 1/WK Number of Participants 30  
  Time in Treatment (down) 21 Weeks Condition Osteoarthritis, Knee
  Disease Category Arthritis OCSI Score  
  Notes Approved no  
  Call Number Serial 505  
Permanent link to this record
 

 
Author Ma, R. h.; Sha, G. e.; Liu, X. m. openurl 
  Title Acupuncture Treatment of Amenorrhea due to Medication: Clinical Observation of 117 Cases Type of Study RCT
  Year 1999 Publication International Journal of Clinical Acupuncture Abbreviated Journal Int J Clin Acupunct  
  Volume 10 Issue 1 Pages 105-109  
  Keywords Acu Versus Usual Care; Acupuncture; AcuTrials; Amenorrhea; Electroacupuncture; Menstruation Disturbances; Moxibustion; RCT; Restricted Modalities, Acupuncture + Other; Semi-Individualized Acupuncture Protocol; Usual Care Control, Pharmaceutical; TCM Acupuncture Style; Traditional Diagnosis Based Point Selection; Women's Health  
  Abstract Controlled study of acupuncture treatment of amenorrhea due to medications has shown a better and a more enduring effect than the usual hormonal approach. The absence of side effects usually seen with hormone administration is another merit of this approach. It is thought to act on the root of the pathogenetic mechanisms rather than working as substitutes as the hormonal preparations.  
  Address  
  Publisher
  Language Number of Treatments 120  
  Treatment Follow-up 24 Weeks Frequency >1/WK Number of Participants 215  
  Time in Treatment (down) 21 Weeks Condition Amennorhea
  Disease Category Menstruation Disturbances OCSI Score  
  Notes Approved no  
  Call Number Serial 789  
Permanent link to this record
 

 
Author Soliman, N. openurl 
  Title Comparative Study Treating Attention-Deficit/Hyperactivity Disorder (ADHD) Patients Using the New Multiphase Hand Acupuncture Microsystem and Koryo Hand Therapy System Type of Study RCT
  Year 2007 Publication Medical acupuncture Abbreviated Journal Med Acupunct  
  Volume 19 Issue 2 Pages 109-111  
  Keywords CAM Control; Acu Versus CAM Control; Acu Versus Acu; Acupuncture; AcuTrials; ADHD; Attention Deficit Disorder; Behavior Disorders; Korean Hand Acupuncture Style; Koryo Hand Therapy; Other Acupuncture Style; Pediatrics; RCT; Restricted Modalities, Acupuncture Only; Semi-Individualized Acupuncture Protocol  
  Abstract  
  Address  
  Publisher
  Language Number of Treatments 20  
  Treatment Follow-up N/A Frequency 1/WK Number of Participants 40  
  Time in Treatment (down) 20 Weeks Condition ADHD
  Disease Category Mental Disorders OCSI Score  
  Notes Approved no  
  Call Number Serial 1088  
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